2025
The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINECraniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesExperiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis
Shahar G. Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Psychoanalytic Psychology 2025, 42: 123-127. DOI: 10.1037/pap0000533.Peer-Reviewed Original ResearchThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsEditorial: Where are the Trials on Adolescent Self-Harm and Suicide?
Kumpf K, Bloch M. Editorial: Where are the Trials on Adolescent Self-Harm and Suicide? Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40088968, DOI: 10.1016/j.jaac.2025.03.002.Peer-Reviewed Original ResearchNonsuicidal self-injurySelf-harmModerators of treatment effectsRandomized controlled trialsPublic health problemEvidence-based treatmentsAdolescent self-harmPrevent self-harmSelf-injuryHealth problemsRandom-effects meta-analysisRandom-effects meta-analysis of studiesTherapeutic interventionsSuicideMeta-analysis of studiesSource of morbidityAdolescentsIndividual patient dataSecondary analysisTreatment effectsNo significant differenceControlled trialsAggregate dataMeta-analysisEffective treatmentOutcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalEpidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies
Tzoumas A, Sagris M, Xenos D, Ntoumaziou A, Kyriakoulis I, Kakargias F, Liaqat W, Nagraj S, Patel R, Korosoglou G, Tousoulis D, Tsioufis K, Kokkinidis D, Palaiodimos L. Epidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies. The American Journal Of Cardiology 2025, 244: 67-88. PMID: 40015544, DOI: 10.1016/j.amjcard.2025.02.023.Peer-Reviewed Original ResearchInfective endocarditisCausative microorganismsMortality of infective endocarditisEpidemiological profileTricuspid valve IEViridans group streptococciMortality rateRandom-effects model meta-analysisMeta-analysisProfile of IEShort-term mortality rateIncidence of health-careSystematic reviewIncreasingly prevalent conditionGroup streptococciAffected valvePubMed/MEDLINE databaseMitral valveStaphylococcus speciesAortic valveCardiac valvesIncreased incidenceStreptococci speciesEnterococci speciesS. aureusMachine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis
Narimani-Javid R, Moradi M, Mahalleh M, Najafi-Vosough R, Arzhangzadeh A, Khalique O, Mojibian H, Kuno T, Mohsen A, Alam M, Shafiei S, Khansari N, Shaghaghi Z, Nozhat S, Hosseini K, Hosseini S. Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Computed Tomography 2025 PMID: 39988511, DOI: 10.1016/j.jcct.2025.02.004.Peer-Reviewed Original ResearchArea under the curveDiagnostic odds ratioDiagnostic performanceComputed tomography-derived fractional flow reserveDiagnostic performance of FFRCTHemodynamically significant coronary artery stenosisSignificant coronary artery stenosisMeta-analysisPer-patient levelReceiver operating characteristic curveCoronary artery diseaseCoronary artery stenosisPer-vessel levelFractional flow reserveNoninvasive diagnostic techniquesMachine learningInvasive FFRPooled specificityArtery diseaseArtery stenosisFlow reserveOdds ratioCochrane LibraryFFRCTPatientsThe Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis.
McCarty T, Shah R, Allencherril R, Moon N, Njei B. The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis. Journal Of Clinical Gastroenterology 2025 PMID: 39998988, DOI: 10.1097/mcg.0000000000002148.Peer-Reviewed Original ResearchConvolutional neural networkMalignant biliary stricturesAI-based systemsArtificial intelligence (AI)-based algorithmImage processing speedEndoscopic retrograde cholangiopancreatographyBiliary stricturesComputer visionPooled sensitivityNeural networkMachine learningDiagnostic performanceMeta-analysisIntelligent combinationIndeterminate biliary stricturesDiagnostic odds ratioImprove diagnostic yieldReceiver operating characteristic curveSystematic reviewOperating characteristics curveProcessing speedDiagnostic yieldRetrograde cholangiopancreatographyDiagnostic accuracyWorking group methodologyEfficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis
Chow R, Basu A, Kaur J, Hui D, Im J, Prsic E, Boldt G, Lock M, Eng L, Ng T, Zimmermann C, Scotte F. Efficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis. Supportive Care In Cancer 2025, 33: 193. PMID: 39953210, PMCID: PMC11828838, DOI: 10.1007/s00520-025-09251-w.Peer-Reviewed Original ResearchConceptsChemotherapy-induced nausea and vomitingEfficacy of cannabinoidsTHC:CBDMeta-analysisPrevention of chemotherapy-induced nausea and vomitingProphylaxis of chemotherapy-induced nausea and vomitingChemotherapy-induced nausea and vomiting controlControlled trialsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsNausea and vomitingChemotherapy-induced nauseaMethodsA literature searchCochrane Central RegisterComplete responseRandomized controlled trialsNo vomitingAdjunctive therapyRescue medicationAntiemetic regimensComposite endpointSubgroup analysisCannabinoidSecondary preventionCauses of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential
Bulletti F, Sciorio R, Conforti A, De Luca R, Bulletti C, Palagiano A, Berrettini M, Scaravelli G, Pierson R. Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential. Frontiers In Endocrinology 2025, 15: 1429193. PMID: 40028443, PMCID: PMC11867936, DOI: 10.3389/fendo.2024.1429193.Peer-Reviewed Original ResearchConceptsAssisted reproductive technologyPGT-AImplantation rateImplant successEmbryo transferEndometrial receptivityMeta-analysisMeta-analysis of subgroupsTime of endometrial receptivityGestational carrierMonths of unprotected sexual intercourseReduced embryo implantationPreimplantation genetic testingOlder womenImprove implantation ratesEmbryo implantation potentialUnprotected sexual intercourseOdds of implantationSystematic reviewComprehensive literature searchEmbryo euploidyEuploid embryosDiagnostic hysteroscopyRisk of biasIVF-ETThe Impact of Place-Based Approaches Addressing Mental Health and Substance Use Among Adolescents: A Systematic Review of the Literature
Rehill N, Halvorsrud K, Shand J, Fonagy P, Raine R. The Impact of Place-Based Approaches Addressing Mental Health and Substance Use Among Adolescents: A Systematic Review of the Literature. Public Health Reviews 2025, 45: 1607955. PMID: 40027468, PMCID: PMC11867790, DOI: 10.3389/phrs.2024.1607955.Peer-Reviewed Original ResearchPlace-based approachMental health outcomesMental healthHealth outcomesSubstance useYoung peopleComplex health challengesMulti-sectoral actionHigher quality evaluationsPeer-reviewed evidenceAssessed study qualityAlcohol use outcomesStudy qualityHealth challengesStudy designSubstance-useSystematic reviewBinge-drinkingHealthDrug useMeta-analysisDelayed initiationWellbeingAdolescentsPublished studiesAdvanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis
Tang W, Khalili L, Gong R, Souvignier M, Wang X, Murray S, Chavez G, Nordmann-Gomes A, Geraldino-Pardilla L, Gartshteyn Y, Clancy R, Nikpour M, Askanase A. Advanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis. Seminars In Arthritis And Rheumatism 2025, 71: 152661. PMID: 39985848, DOI: 10.1016/j.semarthrit.2025.152661.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMSK-USIdentified articlesMeasurement propertiesSystematic literature reviewWork-related disabilityUS synovitisLiterature reviewAdvanced imagingEvaluation of handMSK manifestationsOutcome measuresAdvanced imaging modalitiesSystematic reviewCochrane LibraryMeta-analysisLiterature searchLupus arthritisLupus patientsMSKPooled analysisJoint symptomsImaging abnormalitiesClinical trialsJoint manifestationsANTIPSYCHOTIC AGENTS IN ANXIETY DISORDERS: AN UMBRELLA REVIEW
Freire *, Garakani A, Buono F, Salehi M, Funaro M, Klimowicz A, Sharma H, Faria C, Larkin K. ANTIPSYCHOTIC AGENTS IN ANXIETY DISORDERS: AN UMBRELLA REVIEW. The International Journal Of Neuropsychopharmacology 2025, 28: i29-i29. PMCID: PMC11814792, DOI: 10.1093/ijnp/pyae059.051.Peer-Reviewed Original ResearchSecond-generation antipsychoticsFirst-generation antipsychoticsGeneralized anxiety disorderStudies of antipsychoticsAnxiety disordersAtypical antipsychoticsAntipsychotic agentsShort-term treatment of generalized anxiety disorderTreatment of generalized anxiety disorderEfficacy of first-generation antipsychoticsTreatment-resistant anxiety disordersEfficacy of antipsychotic agentsObsessive-compulsive disorderTreatment of anxietyEffective short-term treatmentMeta-analysesManagement of anxietyAntidepressant treatmentAntipsychotic medicationPosttraumatic stressAntipsychoticsAnxietyComparing monotherapyFirst-line treatmentMeta-analysisAnticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis
Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, heartjnl-2024-325288. PMID: 39915077, DOI: 10.1136/heartjnl-2024-325288.Peer-Reviewed Original ResearchPresence of patent foramen ovaleOral anticoagulantsRandomised controlled trialsCryptogenic strokeAtrial cardiopathyIschaemic strokeIschaemic stroke riskSafety of oral anticoagulantsRisk factorsSecondary prevention of cryptogenic strokeStroke riskMeta-analysisOptimal antithrombotic strategyRisk of recurrent ischaemic strokePatent foramen ovaleInteraction p valuePersonalised treatment strategiesSystematic reviewRecurrent ischaemic strokePreventing ischaemic strokeBleeding riskNo significant differenceAntithrombotic strategiesClinical characteristicsForamen ovaleObservational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82 PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associationsEnteral and parenteral nutrition in patients with cancer: complication rates compared—updated systematic review and meta-analysis
Chow R, Im J, Arends J, Del Fabbro E, Mortensen-Truscott L, Qeska D, Balaji S, Walsh C, Watson G, Lock M, Prsic E, Eng L, Zimmermann C, Bruera E. Enteral and parenteral nutrition in patients with cancer: complication rates compared—updated systematic review and meta-analysis. BMJ Supportive & Palliative Care 2025, spcare-2024-005244. PMID: 39890439, DOI: 10.1136/spcare-2024-005244.Peer-Reviewed Original ResearchCumulative meta-analysisNutrition support complicationsSystematic reviewProtein-energy malnutritionEnteral nutritionParenteral nutritionMeta-analysisRandomised controlled trialsSubgroup analysisLeave-one-out analysisStandard careEffect estimatesControlled trialsType I errorComplication rateComplicationsAdultsNutritionPatientsInfectionInfection rateCancerMortalityEndpointChildrenTrauma-related psychopathologies after extracorporeal membrane oxygenation support: A systematic review and meta-analysis.
Demory A, Broden E, Equey L, Funaro M, Sharifi M, Harpaz-Rotem I, Traube C, Karam O. Trauma-related psychopathologies after extracorporeal membrane oxygenation support: A systematic review and meta-analysis. Perfusion 2025, 2676591251317919. PMID: 39879146, DOI: 10.1177/02676591251317919.Peer-Reviewed Original ResearchPrevalence of post-traumatic stress disorderTrauma-related psychopathologyExtracorporeal membrane oxygenationPediatric ECMO patientsAdult ECMO patientsAssociated with substantial psychiatric morbidityPost-traumatic stress disorderPrevalence of PTSDECMO survivorsECMO patientsPooled prevalence of anxietyPrevalence of anxietyStress disorderPooled prevalencePrevalence of depressionPsychiatric morbidityPsychopathologyMeta-analysisExtracorporeal membrane oxygenation supportExtracorporeal membrane oxygenation useExtracorporeal membrane oxygenation survivorsMembrane oxygenation supportAnxietySystematic reviewPooled prevalence of depressionEmpathy and psychological outcomes in informal caregivers of community-dwelling older adults: A systematic review and meta-analysis
Huo M, Vu T, Yoneda T, Wei J, Abbott B, Monin J. Empathy and psychological outcomes in informal caregivers of community-dwelling older adults: A systematic review and meta-analysis. The Journals Of Gerontology Series B 2025, gbaf018. PMID: 39879125, DOI: 10.1093/geronb/gbaf018.Peer-Reviewed Original ResearchCaregiver psychological healthInformal caregiversNegative psychological outcomesPsychological outcomesCare recipientsCaregivers of community-dwelling older adultsPsychological healthCommunity-dwelling older adultsNon-significant associationPeer-reviewed studiesUnpaid careOlder adultsCaregiversSystematic reviewCareCognitive empathySignificant associationMeta-analyzedMeta-analysisLiterature searchRandom effects approachHealthInterventionOutcomesInvestigation of empathy
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