2025
Do the effects of interventions aimed at the prevention of childhood obesity reduce inequities? A re-analysis of randomized trial data from two Cochrane reviews
Palmer J, Davies A, Spiga F, Heitmann B, Jago R, Summerbell C, Higgins J, Group T, Astrup A, Filho V, Benden M, Boddy L, Bogart L, Brown B, Carlin A, Carrascosa D, Chai L, Drummy C, Duncan S, Ebbeling C, Martos E, Fairclough S, Fulkerson J, Gentile D, Gruber M, Grydeland M, Ha A, Mourad C, Gilstad-Hayden K, Hill D, Hoor G, Hurley K, Hurst A, Hwalla N, Ickovics J, Jolly K, Kain J, Kobel S, Kovacs V, Kriemler S, Kuroko S, Lana A, Levy T, Sánchez-López M, Lubans D, Lynch B, Madsen K, Marcus C, Humarán M, Morales-Ruan C, Morgan P, Müller I, Newton R, Nicholl A, O'Connor T, Pate R, Peña S, Robbins L, Puder J, Robinson T, Rosário R, Rosenkranz R, Sacheck J, Salmon J, Seguin-Fowler R, Sherwood N, Takacs H, Taylor R, Wang H, Wang H, Whittemore R, Wilksch S, Yin Z, Zhou Z, Breheny K, Caldwell D, Dawson S, Gao Y, Hillier-Brown F, Hodder R, Larsen S, Moore T, Nobles J, Phillips S, Savović J, Thorsteinsdottir F, Tomlinson E, Wolfenden L. Do the effects of interventions aimed at the prevention of childhood obesity reduce inequities? A re-analysis of randomized trial data from two Cochrane reviews. EClinicalMedicine 2025, 81: 103130. PMID: 40115176, PMCID: PMC11925530, DOI: 10.1016/j.eclinm.2025.103130.Peer-Reviewed Original ResearchNational Institute for Health and Care ResearchEffectiveness of interventionsPhysical activityCochrane reviewFactors associated with inequalityPrevent childhood obesityAged 5People aged 5Public healthSocio-economic statusBoys aged 5Health inequalitiesHealthy eatingYounger age groupsStandardized BMICare researchChildhood obesityIntervention effectsRandomized trial dataBMI effectsPrevent obesityMeta-analysesBaseline measurementsYear oldsBMITranscatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials
Reddy R, Howard J, Mack M, Reardon M, Jørgensen T, Hørsted Thyregod H, Toff W, Van Mieghem N, Vora A, Makkar R, Kapadia S, Forrest J, Leon M, Ahmad Y. Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2025, 85: 926-940. PMID: 40044297, DOI: 10.1016/j.jacc.2024.12.031.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementLower-risk patientsAortic valve replacementPooled survival analysisValve replacementIndividual participant dataPairwise meta-analysesFollow-upMeta-analysis of randomized controlled trialsLonger-term clinical outcomesReduced hazard of deathSevere aortic stenosisFixed effect assumptionsComposite of deathLonger-term follow-upAll-cause deathMean survival time modelsMeta-analysesHazard of deathRate of strokeRandomized controlled trialsSurvival time modelFrailty termProportional odds modelExperiencing Housing Instability in Rural North America and Access to Health Care and Supportive Services: A Scoping Review.
Roncarati J, Cusack M, True G, Browne J, Harris T, deRussy A, Tsai J, Elwy A, Byrne T, Montgomery A. Experiencing Housing Instability in Rural North America and Access to Health Care and Supportive Services: A Scoping Review. Journal Of Health Care For The Poor And Underserved 2025, 36: 21-55. PMID: 39957636, DOI: 10.1353/hpu.2025.a951583.Peer-Reviewed Original ResearchConceptsHousing instabilityPromote better health outcomesRural North AmericaMeta-Analyses ExtensionBetter health outcomesFull-text reviewPreferred Reporting ItemsExperience housing instabilityPeer-reviewed articlesHealth disparitiesHealth outcomesScoping reviewBehavioral healthHealth careRural settingsOlder personsReporting ItemsSupport servicesSystematic reviewInclusion criteriaMeta-analysesHealthService provisionRural areasRural contextANTIPSYCHOTIC AGENTS IN ANXIETY DISORDERS: AN UMBRELLA REVIEW
Freire *, Garakani A, Buono F, Salehi M, Funaro M, Klimowicz A, Sharma H, Faria C, Larkin K. ANTIPSYCHOTIC AGENTS IN ANXIETY DISORDERS: AN UMBRELLA REVIEW. The International Journal Of Neuropsychopharmacology 2025, 28: i29-i29. PMCID: PMC11814792, DOI: 10.1093/ijnp/pyae059.051.Peer-Reviewed Original ResearchSecond-generation antipsychoticsFirst-generation antipsychoticsGeneralized anxiety disorderStudies of antipsychoticsAnxiety disordersAtypical antipsychoticsAntipsychotic agentsShort-term treatment of generalized anxiety disorderTreatment of generalized anxiety disorderEfficacy of first-generation antipsychoticsTreatment-resistant anxiety disordersEfficacy of antipsychotic agentsObsessive-compulsive disorderTreatment of anxietyEffective short-term treatmentMeta-analysesManagement of anxietyAntidepressant treatmentAntipsychotic medicationPosttraumatic stressAntipsychoticsAnxietyComparing monotherapyFirst-line treatmentMeta-analysisAssociations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta‐analyses
Prudente T, Mezaiko E, Oliva H, Yamamoto‐Silva F, de Freitas Silva B, Oliva I, Risch H. Associations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta‐analyses. European Journal Of Clinical Investigation 2025, e14394. PMID: 39878420, DOI: 10.1111/eci.14394.Peer-Reviewed Original ResearchMeta-analysesUmbrella reviewUmbrella review of meta-analysesMeta-analyses of observational studiesHelicobacter pylori colonizationHigher quality primary studiesReview of meta-analysesCochrane Library of Systematic ReviewsAMSTAR 2 toolQuality primary studiesPrimary study overlapAssociated with EACPylori colonizationBiliary tractAssociated with biliary tractGastric cancerOesophageal squamous cell carcinomaSquamous cell carcinomaHelicobacter pyloriGI tract cancersGastrointestinal tract cancerPrimary studiesSystematic reviewCochrane LibraryObservational studySystematic Review and Individual Participant Data Meta-Analysis: Reducing Self-Harm in Adolescents: Pooled Treatment Effects, Study, Treatment and Participant Moderators
Wright-Hughes A, Farrin A, Fonagy P, Ougrin D, Stahl D, Wright J, Irving D, Mughal F, Truscott A, Diggins E, Chanen A, Cooney E, Carter G, Clover K, Dadds M, Diamond G, Esposito-Smythers C, Green J, Griffiths H, Hassanian-Moghaddam H, Hatcher S, Hazell P, Husein N, Kaess M, King C, Morthorst B, O'Connor R, Santamarina-Perez P, Tyrer P, Walwyn R, Cottrell D. Systematic Review and Individual Participant Data Meta-Analysis: Reducing Self-Harm in Adolescents: Pooled Treatment Effects, Study, Treatment and Participant Moderators. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 39892472, DOI: 10.1016/j.jaac.2025.01.017.Peer-Reviewed Original ResearchIndividual-Participant-DataRepeat self-harmSelf-harmEffective interventionsIPD meta-analysisMeta-analysisCore set of outcome measuresSet of outcome measuresMeta-analysesRepetition of self-harmIntervention to controlIPD meta-analysesMonths post-randomizationMeta-analysis of randomised controlled trialsSelf-harm episodesHistory of self-harmMeta-analysis of RCTsPooled treatment effectsTherapeutic intervention effectivenessSelf-harm incidentsData meta-analysisHeterogeneity of treatment effectsPublic health concernTreatment effectsIntervention effectsAuthor Response: Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Author Response: Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2025, 104: e209774. PMID: 39841951, DOI: 10.1212/wnl.0000000000209774.Peer-Reviewed Original ResearchRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder AdultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analysesSocial Determinants of Health and Suicide-Related Outcomes
Na P, Shin J, Kwak H, Lee J, Jester D, Bandara P, Kim J, Moutier C, Pietrzak R, Oquendo M, Jeste D. Social Determinants of Health and Suicide-Related Outcomes. JAMA Psychiatry 2025, 82 PMID: 39745761, DOI: 10.1001/jamapsychiatry.2024.4241.Peer-Reviewed Original ResearchSocial determinants of healthSuicide mortalitySuicide-related outcomesAssociation of social determinants of healthRisk of suicide mortalityPrevent suicideAssociated with suicide mortalitySuicidal ideationHomeless individualsMeta-analysesDeterminants of healthSuicide riskRisk factorsPublic health policiesSuicide attemptsIncarcerated female youthIntimate partner violenceSexual minority statusPrevalence of lifetime suicidal ideationIncreased suicide riskExperiences of childhood abuseSocial determinantsWeb of ScienceResearch SynthesesTailored interventions
2024
Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysis
Rassi A, Grimshaw A, Sarwal A, Sah R, Shah S, Agudelo Higuita N, Rassi F, Corbisiero M, Kyllo H, Stellern J, Kaplan S, Marcos L, Ramírez-García E, Casapia M, Hotez P, Bottazzi M, Patel S, Franco-Paredes C, Marin-Neto J, Henao-Martínez A. Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysis. EClinicalMedicine 2024, 79: 102972. PMID: 39810938, PMCID: PMC11732499, DOI: 10.1016/j.eclinm.2024.102972.Peer-Reviewed Original ResearchChronic Chagas diseaseMethodological quality of studiesCardiovascular deathQuality of studiesDisease progressionQuality of evidenceVirtual Health Library databasesRisk of bias scaleCardiovascular outcomesRandom-effects modelPooled risk ratioMeta-analysis of studiesMethodological qualityWeb of Science Core CollectionAntitrypanosomal therapyRandomized controlled studyManagement of Chagas diseaseOvid MEDLINESystematic reviewInclusion criteriaMeta-analysesRisk ratioScience Core CollectionPrimary outcomeOvid EmbaseGenetic and environment influences on childhood victimization: a systematic review and meta-analysis
Dahoun T, Peel A, Baldwin J, Coleman O, Lewis S, Wertz J, Rijsdijk F, Danese A. Genetic and environment influences on childhood victimization: a systematic review and meta-analysis. Molecular Psychiatry 2024, 1-11. PMID: 39663379, DOI: 10.1038/s41380-024-02868-z.Peer-Reviewed Original ResearchChildhood victimizationVictimization experiencesEnvironmental influencesGenetically informative designsVictimsTwin studiesGenetic influencesPhysical healthMeta-analysisQuantitative summaryPrevention targetsChildhoodAPA PsycInfoMeta-analysesEtiological factorsSystematic reviewPRISMA guidelinesInformation designEmbase databasesRisk factorsHealth effectsHealthAPAPsycINFOPer- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis.
Zhang S, Kappil E, Zheng T, Boffetta P, Seyyedsalehi M. Per- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis. European Journal Of Cancer Prevention 2024 PMID: 39648934, DOI: 10.1097/cej.0000000000000935.Peer-Reviewed Original ResearchPFAS exposureStratified analysisMeta-analysisRisk of gastrointestinal cancerSystematic reviewGastrointestinal cancerModified Newcastle-Ottawa ScaleInternational Agency for Research on Cancer MonographsNewcastle-Ottawa ScaleSystematic review of literatureDose-response trendRandom-effects modelPancreatic cancerPotential confoundersIndependent reviewersYear of publicationPublication biasStudy designMeta-analysesColorectal cancerGastric cancerQuality scoresColorectalSubstance exposurePoly-fluoroalkyl substancesSynergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology
Shinozuka K, Jerotic K, Mediano P, Zhao A, Preller K, Carhart-Harris R, Kringelbach M. Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology. Translational Psychiatry 2024, 14: 485. PMID: 39632810, PMCID: PMC11618481, DOI: 10.1038/s41398-024-03187-1.Peer-Reviewed Original ResearchConceptsFunctional connectivityBetween-network functional connectivityLevels of analysisWithin-network FCBetween-drug differencesMeta-analysesD2 receptorsPsychedelic effectsSerotonergic psychedelicsNeuroimaging resultsNeuropsychiatric disordersStates of consciousnessPsychedelicsNeural fingerprintsAltered statesNeuroimagingPsilocybinHigh dosesLSDSignificantly higher ratesMolecular pharmacologySystematic reviewAddictionDepressionPhenomenologyMentalization-Based Treatment for Adolescent Depression.
Luyten P, Malcorps S, Fonagy P. Mentalization-Based Treatment for Adolescent Depression. Psychodynamic Psychiatry 2024, 52: 490-511. PMID: 39679698, DOI: 10.1521/pdps.2024.52.4.490.Peer-Reviewed Original ResearchConceptsMentalization-based treatmentHistory of attachment traumaSeverity of depressionTreatment of depressionTreatment of adolescentsMental health problemsLong-term impairmentAttachment traumaAdolescent depressionPsychological interventionsMental perspectiveDepressionAdolescentsMental approachSpectrum of severityMentalMeta-analysesSevere endHealth problemsRelated problemsEmpirical evidenceImpairmentPersonsThoughtsTreatmentImpact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis
Andiman S, Maron J, Dandolu V, Drugge E, Cosgro R, Vasey M, Spaulding G, Ricciardi F, Yaskhi G, Toal C, Shatkin J, Loike-Weinstein D, Mahmood S, Glass M, Phillips D, Sciarrino M, Sacks A, Baruch D, Cohen M, Huang A, Pollack B, Grimes C. Impact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis. International Urogynecology Journal 2024, 36: 35-58. PMID: 39607531, DOI: 10.1007/s00192-024-06004-x.Peer-Reviewed Original ResearchPulsed radiofrequency treatmentPudendal neuralgiaPost-intervention pain scoresSystematic reviewPain measurement instrumentsPreferred Reporting ItemsRadiofrequency treatmentAdverse eventsPoor-quality studiesTreatment of pudendal neuralgiaMethodsFollowing Preferred Reporting ItemsShort-term follow-upTreatment approachesChronic pelvic painReporting ItemsAssess qualityHeterogeneous patient populationMeta-analysesEligibility criteriaConfidence intervalsStatistically significant differenceNon-standard treatmentMeta-analysisPelvic painPain scoresVaginal Progesterone for the Prevention of Preterm Birth in Pregnancies with Short Cervix
Schenone C, Duncan J, Lockwood C. Vaginal Progesterone for the Prevention of Preterm Birth in Pregnancies with Short Cervix. Current Obstetrics And Gynecology Reports 2024, 14: 1. DOI: 10.1007/s13669-024-00408-8.Peer-Reviewed Original ResearchEfficacy of vaginal progesteroneVaginal progesteronePreterm birthShort cervixSingleton pregnanciesMid-trimester cervical lengthPrevention of preterm birthEffect of vaginal progesteroneVaginal progesterone gelPrevent preterm birthPrevent preterm laborReduce preterm birthPreterm birth rateVaginal micronized progesteroneMeta-analysesData meta-analysesProgesterone gelCervical lengthMultifetal gestationPreterm laborTwin gestationsEvidence-based recommendationsMicronized progesteroneObstetric historyProgesterone formulationThe menstrual cycle as a vital sign: a comprehensive review
Vollmar A, Mahalingaiah S, Jukic A. The menstrual cycle as a vital sign: a comprehensive review. F&S Reviews 2024, 6: 100081. PMID: 39906529, PMCID: PMC11790291, DOI: 10.1016/j.xfnr.2024.100081.Peer-Reviewed Original ResearchClinical practice guidelinesHealth outcomesPractice guidelinesVital signsMedical professional organizationsInclusion of systematic reviewsMenstrual cyclePatient handoutsHealth indicatorsGeneral healthHealth conditionsOptimal wellnessMenstrual cycle patternSystematic reviewMeta-analysesProfessional organizationsLiterature searchHealthScientific evidenceClinical courseReview exposureGuidelinesOutcomesIn adulthoodReviewDefining Documentation Burden (DocBurden) and Excessive DocBurden for All Health Professionals: A Scoping Review
Levy D, Withall J, Mishuris R, Tiase V, Diamond C, Douthit B, Grabowska M, Lee R, Moy A, Sengstack P, Adler-Milstein J, Detmer D, Johnson K, Cimino J, Corley S, Murphy J, Rosenbloom S, Cato K, Rossetti S. Defining Documentation Burden (DocBurden) and Excessive DocBurden for All Health Professionals: A Scoping Review. Applied Clinical Informatics 2024, 15: 898-913. PMID: 39137903, PMCID: PMC11524753, DOI: 10.1055/a-2385-1654.Peer-Reviewed Original ResearchHealth professionalsDocumentation burdenScoping reviewHealthcare teams' experiencesMeta-Analyses ExtensionReducing documentation burdenGrey literature sourcesPreferred Reporting ItemsClinician wellnessCare deliveryPatient safetyPatient careReporting ItemsSystematic reviewNational initiativesMeta-analysesHeavy workDocumentation systemPeer reviewCareTeam experienceHealthProfessionalsBurdenLiterature sourcesTranscatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials
Reddy R, Howard J, Reardon M, Thyregod H, Jorgensen T, Toff W, Forrest J, Leon M, Ahmad Y. Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials. European Heart Journal 2024, 45: ehae666.2456. DOI: 10.1093/eurheartj/ehae666.2456.Peer-Reviewed Original ResearchLower-risk patientsIndividual patient dataFollow-upNo significant differenceClinical outcomesPairwise random-effects meta-analysesNew-onset atrial fibrillationLong-term clinical outcomesSurgical aortic valve replacementKaplan-Meier survival curvesMeta-analysis of randomised controlled trialsLow-surgical riskMeta-analysesAortic valve reinterventionReconstructed individual patient dataLow surgical riskAortic valve replacementFollow-up durationSevere aortic stenosisMeta-analysisSignificant differenceCox proportional hazards regressionComposite of deathKaplan-Meier plotsLonger-term follow-upHypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis
Mohammadi A, Inanloo S, Rezaeian A, Menbari Oskouie I, Khajavi A, Mirzaei A, Ahmadi Pishkuhi M, Oliveira Reis L, Aghamir S. Hypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis. Urology Journal 2024, 21: 7943-7943. PMID: 38734965, DOI: 10.22037/uj.v21i.7943.Peer-Reviewed Original ResearchType of infectionRisk ratioDerSimonian-Laird random-effects modelTransplant-related infectionsPost-transplantation infectionsPost-transplant surveillanceSystematic reviewMeta-analysesStata version 17Preferred Reporting ItemsRandom-effects modelRenal transplantationMeasures of associationPretransplant screeningAlbumin levelsHypo-albuminemiaImpact of infectionAdult patientsWeb of ScienceHazard ratioOdds ratioViral typesViral infectionReporting ItemsInfection
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