2024
The pathoanatomy of medial ligamentous disruption in the dislocated and multiple ligament injured knee
Park N, Moran J, Petit L, Kahan J, McLaughlin W, Joo P, Lee M, Green J, Vasavada K, Chalem I, Jokl P, Alaia M, Medvecky M. The pathoanatomy of medial ligamentous disruption in the dislocated and multiple ligament injured knee. The Knee 2024, 52: 246-254. PMID: 39642762, DOI: 10.1016/j.knee.2024.11.002.Peer-Reviewed Original ResearchVastus medialis obliqueSuperficial medial collateral ligamentPosterior oblique ligamentInjury patternsMedial patellofemoral ligamentLigament injuriesMedial patellofemoral ligament tearMedial knee ligamentsLevel 1 trauma centerMechanism of injuryInjury detailsNeurovascular statusMultiple ligament injured kneeDistal avulsionInjured kneeLigament injured kneeTrauma centerMedial collateral ligamentZone of injuryKnee ligamentsLigament disruptionOblique ligamentMidsubstance tearsProximal avulsionPatellofemoral ligamentPathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI)
White L, Conrad S, Alexander J. Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI). Pathophysiology 2024, 31: 583-595. PMID: 39449524, PMCID: PMC11503381, DOI: 10.3390/pathophysiology31040042.Peer-Reviewed Original ResearchManual ventilationLung injuryManual hyperventilationOperator-dependent skillsShort-term ventilationMechanism of injuryManikin-based studyBag valve maskAmerican Heart AssociationEuropean Resuscitation CouncilHyperventilated patientsMechanical ventilationHemodynamic alterationsHealthcare providersHeart AssociationPatient populationResuscitation effortsGastric regurgitationResuscitation CouncilCardiopulmonary resuscitationVentilation parametersPatientsInjury processAcute barotraumaVentilationImprovement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis
Sujijantarat N, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Jiang J, Hengartner A, Shekhar A, Amllay A, Nowicki K, Hebert R, Gilmore E, Sheth K, King J, Matouk C. Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis. Clinical Neurology And Neurosurgery 2024, 246: 108555. PMID: 39357321, DOI: 10.1016/j.clineuro.2024.108555.Peer-Reviewed Original ResearchStudy-level meta-analysisRate of improvementCN deficitsMeta-analysisIntracranial aneurysmsCN palsySystematic reviewFactors associated with recoveryPooled rateRandom-effects meta-analysisCranial nervesManual citation searchingEffects meta-analysisRate of clinical improvementCranial nerve palsyMechanism of injuryIncreased rate of improvementFlow diversionRare presenting symptomSymptomatic intracranial aneurysmsTreatment of intracranial aneurysmsCitation searchingPalsyNerve palsyRetrospective reviewInvestigating the Bone Bruise Patterns in Pediatric Patients With Contact and Noncontact Acute Anterior Cruciate Ligament Tears: A Multicenter Study
Moran J, Amaral J, Lee M, Jones R, Gross P, Katz L, Wang A, Carrino J, Jimenez A, Chhabra B, Kan J, Smith B, Gladstein A, McKay S, LaPrade R, Fabricant P, Medvecky M. Investigating the Bone Bruise Patterns in Pediatric Patients With Contact and Noncontact Acute Anterior Cruciate Ligament Tears: A Multicenter Study. The American Journal Of Sports Medicine 2024, 52: 2456-2463. PMID: 39101652, DOI: 10.1177/03635465241264282.Peer-Reviewed Original ResearchMagnetic resonance imagingMechanism of injuryBone bruise patternPreoperative MRI scansACL tearsBone bruisesNoncontact ACL tearsPediatric patientsPresence of bone bruiseMeniscus tearsFat-suppressed T2-weighted imagesAcute anterior cruciate ligament tearsLocation of bone bruisesMRI scansAnterior cruciate ligament (ACL) tearsIpsilateral knee injuriesAnterior cruciate ligament tearsPrimary ACL reconstruction surgeryMagnetic resonance imaging scansConcomitant medial meniscus tearLateral meniscus tearsMedial meniscus tearCruciate ligament tearsT2-weighted imagesNoncontact mechanism of injuryContribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study
Guillot J, Justice A, Gordon K, Skanderson M, Pariente A, Bezin J, Rentsch C. Contribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study. Journal Of General Internal Medicine 2024, 39: 3261-3270. PMID: 38831248, PMCID: PMC11618606, DOI: 10.1007/s11606-024-08817-4.Peer-Reviewed Original ResearchMiddle-aged patientsRisk of mortalityVeterans AffairsChronic medicationsVA patient populationIntegrated healthcare systemNational cohort studyAssociated with increased mortalityMiddle-aged individualsMechanism of injuryMiddle-aged peopleAssociated with mortalityInappropriate medicationsBeers criteriaHealthcare systemAttenuate riskCohort studyClinical characteristicsGeneral populationHyperpolypharmacyFollow-upPolypharmacyPatient populationBackgroundThe roleCox modelGender Differences in Achilles Tendon Ruptures—A Retrospective Study and a Review of the Literature
Hartman H, Cacace A, Leatherman H, Ashkani-Esfahani S, Guss D, Waryasz G, DiGiovanni C, Gianakos A. Gender Differences in Achilles Tendon Ruptures—A Retrospective Study and a Review of the Literature. The Journal Of Foot & Ankle Surgery 2024, 63: 614-620. PMID: 38763172, DOI: 10.1053/j.jfas.2024.04.005.Peer-Reviewed Original ResearchSport involvementPostoperative complicationsAchilles tendon ruptureSystematic reviewRetrospective studyFunctional outcomesRevision surgeryRisk factorsCross-sectional clinical studyRevision rateTendon ruptureSex-specific risk factorsIndependent risk factorPoor functional outcomeSports participationMechanism of injurySystematic literature reviewFemale patientsRetrospective analysisFollow-upClinical studiesInjury managementFemale sexIncreased incidenceLevel III
2023
A multicenter evaluation of pediatric emergency department injury visits during the COVID-19 pandemic
Hanson H, Formica M, Laraque-Arena D, Zonfrillo M, Desai P, O’Neil J, Unni P, Johnson E, Cobb P, Agarwal M, Beckworth K, Schroter S, Strotmeyer S, Donnelly K, Middelberg L, Morse A, Dodington J, Latuska R, Anderson B, Lawson K, Valente M, Levas M, Kiragu A, Monroe K, Ruest S, Lee L, Charyk Stewart T, Attridge M, Haasz M, Jafri M, McIntire A, Rogers S, Uspal N, Blanchard A, Hazeltine M, Riech T, Jennissen C, Model L, Fu Q, Clukies L, Juang D, Ruda M, Prince J, Chao S, Yorkgitis B, Pomerantz W. A multicenter evaluation of pediatric emergency department injury visits during the COVID-19 pandemic. Injury Epidemiology 2023, 10: 66. PMID: 38093383, PMCID: PMC10717699, DOI: 10.1186/s40621-023-00476-z.Peer-Reviewed Original ResearchPediatric emergency departmentInjury-related visitsPED visitsInjury visitsMean Injury Severity ScoreCOVID-19 pandemicCut/pierceInjury prevention initiativesInjury Severity ScoreMain study outcomeMechanism of injuryProportion of injuriesCross-sectional studyCause of deathMotor vehicle occupantsMethodsThis multicenterInjury hospitalizationsEmergency departmentInjury patternsRevision codesSeverity scoreChildren 1International ClassificationMulticenter evaluationInjuryEpidemiologic trends of domestic violence–related ocular injuries among pediatric patients: data from the Nationwide Emergency Department Sample 2008-2017
Andoh J, Miguez S, Andoh S, Mehta S, Mir T, Chen E, Jain S, Teng C, Nwanyanwu K. Epidemiologic trends of domestic violence–related ocular injuries among pediatric patients: data from the Nationwide Emergency Department Sample 2008-2017. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2023, 27: 335.e1-335.e8. PMID: 37931837, PMCID: PMC10859911, DOI: 10.1016/j.jaapos.2023.09.008.Peer-Reviewed Original ResearchConceptsOcular injuriesHospital stayED encountersMedian chargePediatric emergency department patientsCommon ocular diagnosisEye/adnexaMedian hospital stayEmergency department patientsMechanism of injuryInpatient hospital stayCross-sectional studyLow socioeconomic statusLowest income quartileSpecific social determinantsPediatric patientsAnnual incidenceDepartment patientsMedicaid insuranceMedian lengthTrauma hospitalSecondary diagnosisOcular diagnosisEpidemiologic trendsPatientsImaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination.
Sánchez Tijmes F, Marschner C, de Matos J, Urzua Fresno C, Gutiérrez Chacoff J, Thavendiranathan P, Fuss C, Hanneman K. Imaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination. RadioGraphics 2023, 43: e230044. PMID: 37616171, DOI: 10.1148/rg.230044.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementGadolinium enhancementCardiac MRICOVID-19 vaccinePattern of late gadolinium enhancementCardiac complications of COVID-19MRNA-based COVID-19 vaccinesPresence of cardiovascular diseaseStress-induced cardiomyopathyMultimodality cardiac imagingBasal inferolateral wallMinority of patientsPersistent cardiac symptomsAdverse cardiovascular eventsComplications of COVID-19Chronic cardiac complicationsManifestations of COVID-19Potential mechanisms of injuryMechanism of injuryCardiovascular manifestations of COVID-19Messenger ribonucleic acidAcute COVID-19Cardiac symptomsCardiovascular manifestationsImaging findingsPoster 308: Clinical Outcomes After Multi-ligamentous Knee Injuries in Patients Over 40-Years-Old at Average 4-Years Follow-Up
Green J, Chalem I, Triana J, Rao N, Moran J, buldo-licciardi M, Jazrawi L, Campbell K, Medvecky M, Alaia M, Li Z. Poster 308: Clinical Outcomes After Multi-ligamentous Knee Injuries in Patients Over 40-Years-Old at Average 4-Years Follow-Up. Orthopaedic Journal Of Sports Medicine 2023, 11: 2325967123s00281. PMCID: PMC10392478, DOI: 10.1177/2325967123s00281.Peer-Reviewed Original ResearchMulti-ligamentous knee injuriesTegner activity scaleVisual analog scaleClinical outcomesOperative managementLysholm scoreKnee injuriesOutcome measuresMulti-center retrospective cohort studyRetrospective cohort studyLysholm knee scoreSubjective Knee FormMechanism of injuryLong-term outcomesPatient-reported outcomesPoor outcome measuresHigh-energy mechanismsRegression modelsDaily functional statusHistory of dislocationTegner scoreCohort studyKnee scoreSurgical repairSurgical treatmentA Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation
Monte A, Vest A, Reisz J, Berninzoni D, Hart C, Dylla L, D’Alessandro A, Heard K, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. Journal Of Medical Toxicology 2023, 19: 255-261. PMID: 37231244, PMCID: PMC10212224, DOI: 10.1007/s13181-023-00951-5.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTricarboxylic acid cycleMitochondrial energy productionLiver injuryGenomic dataALT elevationIdentification of genesTherapeutic doses of APAPAlanine aminotransferase elevationPredicting liver injuryDose of APAPMaltose metabolismAPAP-induced liver injuryMechanism of injuryAssociation studiesGenetic analysisRandomized controlled trialsAminotransferase elevationGenetic variantsAcid cycleClinical outcomesTherapeutic dosesMultiomics approachGenetic controlAPAP liver injuryExamining the Distribution of Bone Bruise Patterns in Contact and Noncontact Acute Anterior Cruciate Ligament Injuries
Moran J, Lee M, Kunze K, Green J, Katz L, Wang A, McLaughlin W, Gillinov S, Jimenez A, Hewett T, LaPrade R, Medvecky M. Examining the Distribution of Bone Bruise Patterns in Contact and Noncontact Acute Anterior Cruciate Ligament Injuries. The American Journal Of Sports Medicine 2023, 51: 1155-1161. PMID: 36867053, DOI: 10.1177/03635465231159899.Peer-Reviewed Original ResearchConceptsBone bruise patternsAcute anterior cruciate ligament injuryMagnetic resonance imagingAnterior cruciate ligament injuryCruciate ligament injuryBone bruiseNoncontact injuriesLigament injuryContact injuriesACL injuryBruise patternsMedial collateral ligament injuryNoncontact mechanismFat-suppressed T2-weighted imagesMultivariate logistical regression modelIpsilateral knee injuriesCollateral ligament injuriesACL reconstruction surgeryMechanism of injuryBody mass indexNoncontact ACL injuryMedial tibiofemoral compartmentPreoperative MRI scansACL injury mechanismsPosterior cruciate ligament
2022
Baltimore pediatric ocular trauma study: Health disparities and outcomes in pediatric and adolescent open globe trauma
Chen V, Pharr C, Junn S, Kraus C, Fliotsos M, Park H, Alexander J, Woreta F, Carey G, Levin M. Baltimore pediatric ocular trauma study: Health disparities and outcomes in pediatric and adolescent open globe trauma. Injury 2022, 54: 533-539. PMID: 36384857, DOI: 10.1016/j.injury.2022.11.013.Peer-Reviewed Original ResearchConceptsTraumatic open globe injuriesOpen globe injuriesPediatric ocular trauma scoreFinal visual acuityGlobe injuriesVisual acuityUveal prolapseBlunt traumaHispanic patientsBlack patientsYounger ageOpen globe traumaResults Eighty patientsOcular Trauma ScoreRetrospective chart reviewSerious ocular injuriesMechanism of injuryJohns Hopkins HospitalMaryland Medical CenterEighty patientsInitial presentingChart reviewGlobe traumaVisual outcomeOcular injuriesInjury-Related Pediatric Emergency Department Visits in the First Year of COVID-19.
Wells J, Rodean J, Cook L, Sills M, Neuman M, Kornblith A, Jain S, Hirsch A, Goyal M, Fleegler E, DeLaroche A, Aronson P, Leonard J. Injury-Related Pediatric Emergency Department Visits in the First Year of COVID-19. Pediatrics 2022, 150 PMID: 35836331, DOI: 10.1542/peds.2021-054545.Peer-Reviewed Original ResearchConceptsInjury-related visitsInjury-related ED visitsHospital emergency departmentEmergency departmentED visitsSARS-CoV-2 pandemic periodAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicChildren's hospital emergency departmentPediatric Health Information SystemUnited States children's hospitalsPrimary discharge diagnosisMechanism of injurySprains/strainsPediatric emergency departmentCoronavirus 2 pandemicCross-sectional studySARS-CoV-2 pandemicFirst yearPatient characteristicsChildren's HospitalDischarge diagnosisInjury patternsInjury typeAdministrative databasesTraumatic Brain Injury in Honduras: The Use of a Paper‑based Surveillance System to Characterize Injuries Patterns
Johnson E, Rodriguez C, Puyana J, Bonilla-Escobar F. Traumatic Brain Injury in Honduras: The Use of a Paper‑based Surveillance System to Characterize Injuries Patterns. International Journal Of Medical Students 2022, 10: 381-386. PMID: 37378001, PMCID: PMC10299781, DOI: 10.5195/ijms.2022.1384.Peer-Reviewed Original ResearchLow-middle income countriesTraumatic brain injuryEpidemiology of traumatic brain injuryInjury Surveillance SystemProspective data collection methodsInjury surveillance toolEmergency department visitsTraffic accidentsImpact of traumatic brain injuryCross sectional reviewBrain injuryMechanism of injuryMild traumatic brain injuryDepartment visitsPenetrating knife injuryRoad traffic accidentsReferral centerIncome countriesReferral hospitalTBI-related emergency department visitsFirearm injuriesScore medianSecondary to road traffic accidentsData collection methodsSurveillance systemNonaccidental Injury in the Elderly: What Radiologists Need to Know
Badawy M, Solomon N, Elsayes KM, Soliman M, Diaz-Marchan P, Succi MD, Pourvaziri A, Lev MH, Mellnick VM, Gomez-Cintron A, Revzin MV. Nonaccidental Injury in the Elderly: What Radiologists Need to Know. RadioGraphics 2022, 42: 1358-1376. PMID: 35802501, DOI: 10.1148/rg.220017.Peer-Reviewed Original ResearchConceptsRisk factorsCorrelative imaging findingsMechanism of injuryElder abuse detectionElderly patientsLong-term psychological consequencesOrgan injuryImaging findingsRadiologist awarenessHigh prevalenceMedical attentionCare providersElder abuseOnline supplemental materialClinical concernDiagnostic imagingChild abuseInjuryVulnerable populationsSerious physical injuryLack of trainingReporting ratePhysical injuryClinical workflowMost findingsAutologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role?
Gianakos A, Okedele O, Mulcahey M, Kerkhoffs G, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role? The Journal Of Foot & Ankle Surgery 2022, 62: 96-101. PMID: 35753861, DOI: 10.1053/j.jfas.2022.05.005.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationFemale patientsOsteochondral lesionsMale patientsOsteochondral transplantationPotential gender-related differencesCartilage repair tissue (MOCART) scoreMean MOCART scoreAnkle Outcome ScoreMechanism of injuryChronic ankle instabilityTalar osteochondral lesionsGender-related differencesMean FAOSConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMOCART scoreAnkle instabilityPatientsDemographic dataTissue scoresLesionsRehabilitation strategiesFacial injury patterns in victims of intimate partner violence
Gujrathi R, Tang A, Thomas R, Park H, Gosangi B, Stoklosa HM, Lewis-O’Connor A, Seltzer SE, Boland GW, Rexrode KM, Orgill DP, Khurana B. Facial injury patterns in victims of intimate partner violence. Emergency Radiology 2022, 29: 697-707. PMID: 35505264, PMCID: PMC9064123, DOI: 10.1007/s10140-022-02052-2.Peer-Reviewed Original ResearchConceptsInjury patternsElectronic medical recordsFacial injuriesIntimate partner violenceNasal boneLeft-sided injuriesResultsThe study cohortMethodsA retrospective reviewCommon fracture siteMechanism of injuryTime of presentationFacial injury patternsPartner violenceAssociated injuriesRetrospective reviewStudy cohortMean ageFrequent siteMedical recordsUpper extremityClinical dataClinical providersFrequent locationPatientsFracture siteGender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Gianakos A, Williamson E, Mercer N, Kerkhoffs G, Kennedy J. Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. The Journal Of Foot & Ankle Surgery 2022, 62: 75-79. PMID: 35659478, DOI: 10.1053/j.jfas.2022.04.010.Peer-Reviewed Original ResearchConceptsBone marrow stimulationMale patientsFemale patientsPain scoresOsteochondral lesionsMarrow stimulationCartilage repair tissue (MOCART) scoreSymptomatic osteochondral lesionsAnkle Outcome ScoreShort Form-12Mechanism of injuryMagnetic resonance observationYears postsurgeryClinical outcomesOutcome scoresSurgical outcomesRetrospective analysisAnkle biomechanicsPatientsMedial lesionsLateral lesionsLesionsTissue scoresCartilage morphologyOutcomesCerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stress
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