2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressure
2023
Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism.
Toma C, Jaber W, Weinberg M, Bunte M, Khandhar S, Stegman B, Gondi S, Chambers J, Amin R, Leung D, Kado H, Brown M, Sarosi M, Bhat A, Castle J, Savin M, Siskin G, Rosenberg M, Fanola C, Horowitz J, Pollak J. Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism. EuroIntervention 2023, 18: 1201-1212. PMID: 36349702, PMCID: PMC9936254, DOI: 10.4244/eij-d-22-00732.Peer-Reviewed Original ResearchConceptsHigh-risk PEDevice-related deathsPulmonary artery pressureMajor adverse eventsAdverse eventsMechanical thrombectomyFlowTriever SystemArtery pressureUS cohortLarge real-world populationMean pulmonary artery pressureImmediate haemodynamic improvementIntraprocedural adverse eventsPrimary safety endpointRight ventricle/Favorable safety profileIntensive care unitPulmonary embolism treatmentReal-world populationDyspnoea improvementHaemodynamic improvementMajor bleedingRisk PECardiac indexCause mortality
2021
Pulmonary Hypertension in Obstructive Sleep Apnea
Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.Peer-Reviewed Original ResearchMean pulmonary artery pressurePulmonary hypertensionChronic obstructive pulmonary diseaseMild pulmonary arterial hypertensionPulmonary artery pressurePulmonary arterial hypertensionThird of patientsChronic lung diseaseObstructive pulmonary diseaseObstructive sleep apneaTreatment of OSADaytime hypoxemiaArterial hypertensionArtery pressureObesity hypoventilationHeart failurePulmonary diseaseSleep apneaLung diseaseHypertensionOSAPatientsDiseaseCurrent definitionHypoxemiaImaging of Pulmonary Hypertension in Adults: A Position Paper from the Fleischner Society
Remy-Jardin M, Ryerson C, Schiebler M, Leung A, Wild J, Hoeper M, Alderson P, Goodman L, Mayo J, Haramati L, Ohno Y, Thistlethwaite P, van Beek E, Knight S, Lynch D, Rubin G, Humbert M. Imaging of Pulmonary Hypertension in Adults: A Position Paper from the Fleischner Society. Radiology 2021, 298: 203108. PMID: 33399507, DOI: 10.1148/radiol.2020203108.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPulmonary hypertensionSystematic reviewCause of PHComplications of PHEvaluation of PHManagement of PHMean pulmonary artery pressureChronic thromboembolic pulmonary hypertensionTreatment of PHPulmonary artery pressureThromboembolic pulmonary hypertensionManagement of patientsSimilar pathophysiologic mechanismsUtility of CTSimultaneous joint publicationArtery pressurePathophysiologic mechanismsTherapeutic managementMultidisciplinary assessmentHemodynamic characteristicsFleischner SocietyWorking GroupTreatment planningKey roleNuclear medicineImaging of pulmonary hypertension in adults: a position paper from the Fleischner Society
Remy-Jardin M, Ryerson C, Schiebler M, Leung A, Wild J, Hoeper M, Alderson P, Goodman L, Mayo J, Haramati L, Ohno Y, Thistlethwaite P, van Beek E, Knight S, Lynch D, Rubin G, Humbert M. Imaging of pulmonary hypertension in adults: a position paper from the Fleischner Society. European Respiratory Journal 2021, 57: 2004455. PMID: 33402372, DOI: 10.1183/13993003.04455-2020.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPulmonary hypertensionSystematic reviewCause of PHComplications of PHEvaluation of PHManagement of PHMean pulmonary artery pressureChronic thromboembolic pulmonary hypertensionTreatment of PHFleischner SocietyPulmonary artery pressureThromboembolic pulmonary hypertensionManagement of patientsSimilar pathophysiologic mechanismsUtility of CTArtery pressurePathophysiologic mechanismsTherapeutic managementHaemodynamic characteristicsMultidisciplinary assessmentWorking GroupTreatment planningHypertensionKey rolePosition paper
2018
Perioperative pulmonary thromboembolism
Ruohoniemi DM, Sista AK, Doany CF, Heerdt PM. Perioperative pulmonary thromboembolism. Current Opinion In Anaesthesiology 2018, 31: 75-82. PMID: 29206697, DOI: 10.1097/aco.0000000000000550.Peer-Reviewed Original ResearchConceptsSubmassive pulmonary emboliCatheter-directed therapyPulmonary emboliSystemic anticoagulationIntervention efficacyMean pulmonary artery pressurePerioperative pulmonary thromboembolismPulmonary artery pressureCurrent treatment optionsWarrants further investigationInadequacy of treatmentArtery pressurePulmonary thromboembolismPostoperative patientsPulmonary embolismRelative contraindicationSurgical patientsAggressive interventionIntraoperative embolizationPerioperative patientsTreatment optionsOptimizing therapyPromising efficacyElevated riskVentricular monitoring
2015
Pulmonary vascular response patterns during exercise in interstitial lung disease
Degani-Costa L, Levarge B, Digumarthy S, Eisman A, Harris R, Lewis G. Pulmonary vascular response patterns during exercise in interstitial lung disease. European Respiratory Journal 2015, 46: 738-749. PMID: 25976688, DOI: 10.1183/09031936.00191014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnaerobic ThresholdCardiac OutputChi-Square DistributionCohort StudiesExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLinear ModelsLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedPredictive Value of TestsPrognosisReference ValuesRespiratory Function TestsRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeVascular ResistanceConceptsInterstitial lung diseasePulmonary vascular dysfunctionPulmonary artery pressureAbnormal pulmonary vascular responseInvasive cardiopulmonary exercise testingInterstitial lung disease patientsPulmonary vascular responsePeak oxygen consumptionPulmonary hypertensionAssociated with lower peak oxygen consumptionLung diseaseVascular responsesAbnormal pulmonary artery pressureMean pulmonary artery pressureLow peak oxygen consumptionMinute ventilation/carbon dioxide productionOvert pulmonary hypertensionPulmonary vascular diseaseVentilation/carbon dioxide productionExercise oxygen desaturationPulmonary function testsCardiopulmonary exercise testingBody mass indexMean PAPOxygen desaturation
2014
Risk Factors for Death in 632 Patients with Sickle Cell Disease in the United States and United Kingdom
Gladwin M, Barst R, Gibbs J, Hildesheim M, Sachdev V, Nouraie M, Hassell K, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Castro O, Taylor J, Goldsmith J, Kato G, Gordeuk V, Machado R, Investigators and Patients O. Risk Factors for Death in 632 Patients with Sickle Cell Disease in the United States and United Kingdom. PLOS ONE 2014, 9: e99489. PMID: 24988120, PMCID: PMC4079316, DOI: 10.1371/journal.pone.0099489.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, Sickle CellBlood Flow VelocityBlood PressureCohort StudiesCreatinineFemaleFerritinsFollow-Up StudiesHemolysisHumansHypertension, PulmonaryKaplan-Meier EstimateMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProportional Hazards ModelsRisk FactorsSeverity of Illness IndexUnited KingdomUnited StatesWalkingConceptsTricuspid regurgitation velocitySickle cell diseaseNT-proBNPCell diseaseMean pulmonary artery pressurePg/Pulmonary artery systolic pressurePulmonary artery pressureRisk of deathCause of mortalityPositive predictive valuePg/mLArtery pressurePulmonary hypertensionChronic transfusionScreening cohortHemolytic markersSystolic pressureCumulative survivalMale genderRisk factorsHigh riskPredictive valueClass IIIPatientsComprehensive Assessment of Right Ventricular Function in Patients with Pulmonary Hypertension with Global Longitudinal Peak Systolic Strain Derived from Multiple Right Ventricular Views
Rajagopal S, Forsha DE, Risum N, Hornik CP, Poms AD, Fortin TA, Tapson VF, Velazquez EJ, Kisslo J, Samad Z. Comprehensive Assessment of Right Ventricular Function in Patients with Pulmonary Hypertension with Global Longitudinal Peak Systolic Strain Derived from Multiple Right Ventricular Views. Journal Of The American Society Of Echocardiography 2014, 27: 657-665.e3. PMID: 24656881, DOI: 10.1016/j.echo.2014.02.001.Peer-Reviewed Original ResearchConceptsRV longitudinal peak systolic strainLongitudinal peak systolic strainPulmonary hypertensionRight ventricular functionRV functionPeak systolic strainFour-chamber viewRight ventricleRV dysfunctionClinical characteristicsWalk distanceVentricular functionSystolic strainGlobal longitudinal peak systolic strainTricuspid annular plane systolic excursionAssessment of PHMean pulmonary artery pressurePulmonary capillary wedge pressureRV myocardial performance indexAnnular plane systolic excursionRegional RV dysfunctionCapillary wedge pressurePulmonary artery pressureCohort of patientsMyocardial performance index
2012
Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom
Gladwin M, Barst R, Gibbs J, Hildesheim M, Sachdev V, Nouraie M, Hassell K, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Zhang Y, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Castro O, Taylor J, Goldsmith J, Gordeuk V, Kato G, Machado R. Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom. Blood 2012, 120: 3240. DOI: 10.1182/blood.v120.21.3240.3240.Peer-Reviewed Original ResearchTricuspid regurgitant jet velocityHigher tricuspid regurgitant jet velocityProportional hazards regression analysisHigher NT-proBNPUnadjusted hazard ratioNT-proBNPHazards regression analysisSickle cell diseasePulmonary hypertensionRisk factorsGlaxo Smith KlineAspartate aminotransferaseHazard ratioCell diseaseCox proportional hazards regression analysisMean pulmonary artery pressureSix-minute walk distanceSickle cell disease patientsPopulation screening studiesPulmonary artery pressureRight heart catheterizationRegurgitant jet velocityRisk of deathDoppler echocardiographic measurementsScreening studyTranscriptomic analysis reveals atrial KCNE1 down‐regulation following lung lobectomy
Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. Transcriptomic analysis reveals atrial KCNE1 down‐regulation following lung lobectomy. Journal Of Molecular And Cellular Cardiology 2012, 53: 350-353. PMID: 22641150, PMCID: PMC3418454, DOI: 10.1016/j.yjmcc.2012.05.010.Peer-Reviewed Original ResearchConceptsEffective refractory periodLone atrial fibrillationAtrial fibrillationPostoperative AFLung lobectomyLeft atriumNew-onset postoperative atrial fibrillationMean pulmonary artery pressurePostoperative atrial fibrillationPulmonary vascular resistanceUpper lung lobectomyPulmonary artery pressureTelemetric ECGArtery pressureVascular resistanceMajor surgeryHemodynamic variablesFunction polymorphismLA tissuesRefractory periodWestern blottingProtein levelsGene sequence variantsMolecular changesLobectomy
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002
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