2025
Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics
Adin M, Woolf G, Hegde R, Elsamadicy A, Mendel E, Zucconi W, Pucar D, Aygün N. Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics. Skeletal Radiology 2025, 1-26. PMID: 39821683, DOI: 10.1007/s00256-024-04862-6.Peer-Reviewed Original ResearchPrimary tumorTumor mimicsImaging findingsAssessment of response to treatmentGerm cell tumorsEvaluation of systemic diseasesResponse to treatmentInsufficiency fracturesSacral massSecondary tumorsCell tumorsPretreatment evaluationDiagnostic challengeLymphoproliferative diseaseClinical detailsMalignant tumorsPrimary modalitySystemic diseaseEwing sarcomaTumorNotochordal remnantsDevelopmental entityEpidemiological factorsDiagnosisMetastasis
2024
Serum Free Light Chain Ratio Is Inversely Proportional to the Egfr, and Has Been Increasing over the Last Decade
Najarro G, Gupta V, Joseph N, Kaufman J, Nooka A, Dhodapkar M, Lonial S, Hofmeister C. Serum Free Light Chain Ratio Is Inversely Proportional to the Egfr, and Has Been Increasing over the Last Decade. Blood 2024, 144: 5142-5142. DOI: 10.1182/blood-2024-202078.Peer-Reviewed Original ResearchFree light chain ratioLight chain ratioSerum free light chain ratioSerum free light chainsFLC ratioFree light chainsFreelite assayChain ratioCKD-EPIHistory of lymphoproliferative disordersThermo FisherLight chainPeriod of 6-monthsMedian valueYears of agePlasma cell productionLymphoproliferative disordersAlpha 1-antitrypsinPrevent MMHealthy donorsLymphoproliferative diseaseBlood testsRenal clearanceSerum concentrationsEGFR
2023
A Rare Case of Methotrexate-Associated Lymphoproliferative Disease in the Orbit
Spadaro J, Perzia B, Perincheri S, Habib L. A Rare Case of Methotrexate-Associated Lymphoproliferative Disease in the Orbit. Ophthalmic Plastic And Reconstructive Surgery 2023, 40: e28-e31. PMID: 37791841, DOI: 10.1097/iop.0000000000002528.Peer-Reviewed Case Reports and Technical NotesRheumatoid arthritisLymphoproliferative diseaseIatrogenic immunodeficiency-associated lymphoproliferative disordersImmunodeficiency-associated lymphoproliferative disordersRight upper eyelid ptosisDiscontinuation of methotrexateRemission 18 monthsAtypical lymphoid infiltrateT-cell markersUpper eyelid ptosisSuperior orbital massMedication withdrawalLymphoid infiltratesIncisional biopsyLymphoproliferative disordersLow proliferation rateComplete resolutionEyelid ptosisPathologic analysisMonoclonal proliferationOrbital massRare caseCaucasian femaleClose monitoringRearrangement studiesIsoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms
Taghi Khani A, Kumar A, Sanchez Ortiz A, Radecki K, Aramburo S, Lee S, Hu Z, Damirchi B, Lorenson M, Wu X, Gu Z, Stohl W, Sanz I, Meffre E, Müschen M, Forman S, Koff J, Walker A, Swaminathan S. Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms. Communications Biology 2023, 6: 295. PMID: 36941341, PMCID: PMC10027679, DOI: 10.1038/s42003-023-04667-8.Peer-Reviewed Original ResearchConceptsHuman B-cell malignanciesB-cell malignanciesB-cell neoplasmsB cellsPathogenic B cell subsetsPRL receptorsSLE-prone miceSystemic lupus erythematosusB cell numbersB cell subsetsB cell viabilityNormal B cellsExpression of Bcl2B cell survivalB-cell transformationLupus erythematosusLymphoproliferative diseaseAutocrine prolactinMouse modelPRLR isoformsMalignancyProlactinBCL2 expressionProlactin receptorIsoform-specific knockdown
2022
Bilateral dacryoadenitis as the initial presentation of ANCA-associated vasculitis in a pediatric patient
Spadaro JZ, Sinard J, Habib L. Bilateral dacryoadenitis as the initial presentation of ANCA-associated vasculitis in a pediatric patient. Orbit 2022, 43: 231-235. PMID: 35801829, DOI: 10.1080/01676830.2022.2093920.Peer-Reviewed Original ResearchANCA-associated vasculitisPediatric patientsElevated inflammatory markersImmune-mediated vasculitisRight eye painRight lacrimal glandSuperior bulbar conjunctivaBilateral dacryoadenitisLocalized GranulomatosisEye painInflammatory markersNegative workupInitial presentationNegative serologyPalpable massAntibody levelsRare presentationChronic inflammationConjunctival petechiaeLymphoproliferative diseaseEyelid eversionBulbar conjunctivaRepeat testingLacrimal glandVasculitis
2018
Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency
Carpier JM, Lucas CL. Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency. Frontiers In Immunology 2018, 8: 2005. PMID: 29387064, PMCID: PMC5776011, DOI: 10.3389/fimmu.2017.02005.Peer-Reviewed Original ResearchPrimary immunodeficiency diseasesAPDS patientsEpstein-Barr virus infectionDefective immunoglobulin productionCell-mediated cytotoxicityRecurrent sinopulmonary infectionsFunction mutationsEBV susceptibilityPI3Kδ syndromeEBV infectionPID patientsLymphoproliferative diseaseSinopulmonary infectionsImmunoglobulin productionB lymphocyte developmentImmune disordersImmunodeficiency diseaseT cellsVirus infectionPatientsLymphocyte biologySenescence markersAntigen receptorGain of functionInfection
2016
PI3Kδ and primary immunodeficiencies
Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. PI3Kδ and primary immunodeficiencies. Nature Reviews Immunology 2016, 16: 702-714. PMID: 27616589, PMCID: PMC5291318, DOI: 10.1038/nri.2016.93.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCellular SenescenceEnzyme ActivationGene Expression RegulationHumansImmune SystemImmunityImmunologic Deficiency SyndromesLymphocyte ActivationLymphocytesMolecular Targeted TherapyMutationPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein SubunitsSignal TransductionConceptsPrimary immunodeficiencyT cellsHeterozygous mutationsAntibody replacement therapyStructural lung damageRegulatory T cellsT cell senescencePI3Kδ inhibitor idelalisibRecurrent sinopulmonary infectionsB-cell malignanciesHerpes family virusesMTOR inhibitor rapamycinPI3Kδ syndromeMost patientsLung damageLymphoma trialsReplacement therapyLymphoproliferative diseaseSinopulmonary infectionsAntibody responseP110δ catalytic subunitCell malignanciesB cellsImmune systemPatientsFacial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations
Lu B, Kojima L, Huang M, Friedmann A, Ferry J, Weinstein H. Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatric Blood & Cancer 2016, 63: 2042-2045. PMID: 27392033, DOI: 10.1002/pbc.26102.Peer-Reviewed Case Reports and Technical NotesConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaLymphoproliferative diseaseB-cell acute lymphoblastic leukemiaRight-sided facial swellingT-cell acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaHematopoietic transplantationMaintenance chemotherapyPrimary immunodeficiencyBilateral dacryoadenitisAtypical presentationFacial swellingLip lesionsNeither patientLymphoplasmacytic infiltrationT cellsFacial manifestationsFacial lesionsB cellsPatientsDe-escalationRemissionLeukemiaLesionsViruses, Immunity and Unusual Lymphoproliferative Disorders of the Chest
Law A, Shmukler A, Burns J, Haramati L. Viruses, Immunity and Unusual Lymphoproliferative Disorders of the Chest. Journal Of Computer Assisted Tomography 2016, 40: 71-79. PMID: 26484956, DOI: 10.1097/rct.0000000000000333.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnusual lymphoproliferative disorderImmune dysfunctionLymphoproliferative disordersUnusual lymphoproliferative diseaseThoracic manifestationsHistopathological findingsLymphoproliferative diseaseLymphoid tissueBenign hyperplasiaCorrect diagnosisClinical scenariosMalignant transformationDysfunctionRadiologist's skillsVirusDisordersHyperplasiaChestFindingsDiseaseDiagnosisImmunity
2015
A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes
Kumar V, Dasoveanu DC, Chyou S, Tzeng TC, Rozo C, Liang Y, Stohl W, Fu YX, Ruddle NH, Lu TT. A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes. Immunity 2015, 42: 719-730. PMID: 25902483, PMCID: PMC4591553, DOI: 10.1016/j.immuni.2015.03.015.Peer-Reviewed Original ResearchConceptsDendritic cellsImmune responseReticular cellsLymph nodesFunction of DCsOngoing immune responseCell survivalSecondary lymphoid tissuesBeta-receptor ligandsStromal reticular cellsPathogenic lymphocytesLymphoproliferative diseaseLymphocyte functionLymphoid tissueLymphocyte survivalCritical mediatorPodoplaninReceptor ligandsCell functionSurvivalLTβRDiseasePotential strategyCellsResponse
2010
A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma
Katz S, Labelle J, Godes M, Fisher J, Bird G, Walensky L. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma. Blood 2010, 116: 437. DOI: 10.1182/blood.v116.21.437.437.Peer-Reviewed Original ResearchMantle cell lymphomaCell lymphomaAggressive B-cell lymphomasDevelopment of splenomegalyRAG2-deficient miceB-cell lymphomaLymphoproliferative diseaseOrgan infiltrationMCL cell linesConventional chemotherapyHematologic cancersAnti-apoptotic proteinsBone marrowNormal parenchymaVivo modelPro-apoptotic proteinsCell-permeable peptideLymphomaPro-apoptotic activityGenetic aberrationsMiceBcl-2TUNEL positivityPro-apoptotic Bcl-2 family protein BimCaspase-3/7
2008
Incidence and Management of Colorectal Cancer in Liver Transplant Recipients
Nishihori T, Strazzabosco M, Saif MW. Incidence and Management of Colorectal Cancer in Liver Transplant Recipients. Clinical Colorectal Cancer 2008, 7: 260-266. PMID: 18650194, PMCID: PMC3755274, DOI: 10.3816/ccc.2008.n.033.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsTransplant recipientsColorectal cancerLiver transplantationPatient populationColon cancerDe novo colorectal cancerDe novo malignanciesLong-term immunosuppressionMetastatic colorectal cancerPrimary sclerosing cholangitisInflammatory bowel diseaseMajor health concernChronic rejectionNovo malignanciesProlonged immunosuppressionSclerosing cholangitisPosttransplantation periodBiologic agentsBowel diseaseCombination chemotherapyProphylactic colectomyOverall incidenceCommon malignancyLymphoproliferative disease
2004
Real-Time Quantitative Reverse Transcription-PCR for Cyclin D1 mRNA in Blood, Marrow, and Tissue Specimens for Diagnosis of Mantle Cell Lymphoma
Howe JG, Crouch J, Cooper D, Smith BR. Real-Time Quantitative Reverse Transcription-PCR for Cyclin D1 mRNA in Blood, Marrow, and Tissue Specimens for Diagnosis of Mantle Cell Lymphoma. Clinical Chemistry 2004, 50: 80-87. PMID: 14633913, DOI: 10.1373/clinchem.2003.024695.Peer-Reviewed Original ResearchConceptsMantle cell lymphomaReal-time reverse transcription PCRCases of MCLCyclin D1 mRNAQuantitative RT-PCRLymphoproliferative diseaseReverse transcription-PCRCell lymphomaD1 mRNAMicroglobulin mRNADiagnosis of MCLTranscription-PCRCyclin D1 mRNA expressionB cell-specific markersCritical diagnostic markerReal-time quantitative RT-PCRD1 mRNA expressionTime quantitative reverse transcription PCRQuantitative reverse transcription PCROvert diseaseMarrow specimensAmbiguous immunophenotypeCD19 mRNAMalignant cellsTissue specimens
2003
The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells.
Boitano A, Ellman JA, Glick GD, Opipari AW. The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells. Cancer Research 2003, 63: 6870-6. PMID: 14583485.Peer-Reviewed Original ResearchConceptsB cell linesSystemic lupus erythematosusMalignant B-cell linesMalignant B cellsPeripheral benzodiazepine receptorReactive oxygen species levelsEBV statusLupus erythematosusLymphoproliferative diseaseAntineoplastic therapyOxygen species levelsBurkitt's lymphomaAnimal modelsBenzodiazepine receptorsClinical developmentB cellsPotent antiproliferative agentBz-423Phase arrestBcl-2Expression levelsLymphomaAntiproliferative agentsCell deathDisease
2001
CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation
Nikiforow S, Bottomly K, Miller G. CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation. Journal Of Virology 2001, 75: 3740-3752. PMID: 11264363, PMCID: PMC114865, DOI: 10.1128/jvi.75.8.3740-3752.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DivisionCell SizeCells, CulturedEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFlow CytometryHerpesvirus 4, HumanHumansImmunologic MemoryLymphocyte CountReceptors, IgESerologyTacrolimusT-Lymphocyte SubsetsConceptsEpstein-Barr virusB cell proliferationT cellsB cellsB-cell lymphoproliferative diseaseRemoval of CD4Effector T cellsMemory T cellsT cell effectorsT cell surveillanceCytolytic T cellsEarly proliferative phaseCell linesImmune controlLymphoproliferative diseaseImmunodeficient hostsImmune surveillanceLymphoblastoid cell linesCD4Proliferative phaseImmortalized cell linesCD8CD23VirusInfection
2000
Bcl-2 antisense oligodeoxynucleotide therapy of Epstein-Barr virus-associated lymphoproliferative disease in severe combined immunodeficient mice.
Guinness M, Kenney J, Reiss M, Lacy J. Bcl-2 antisense oligodeoxynucleotide therapy of Epstein-Barr virus-associated lymphoproliferative disease in severe combined immunodeficient mice. Cancer Research 2000, 60: 5354-8. PMID: 11034070.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusPosttransplant lymphoproliferative disorderLymphoproliferative disordersBcl-2 antisenseLymphoproliferative diseaseImmunodeficient miceEpstein-Barr virus-associated lymphoproliferative diseaseBcl-2EBV-positive lymphoproliferative diseaseSequence-dependent antitumor effectsMajority of EBVAntisense oligodeoxynucleotide therapyEBV-positive malignanciesB-cell lymphoproliferationBcl-2 antisense therapyInhibition of proliferationLymphoblastoid B cellsTreatment strategiesChemoprotective effectsAntitumor effectsVitro treatmentB cellsChimeric modelDecreased expressionRational targetT‐gamma gene rearrangement and CMV mononucleosis
Mathew P, Hudnall S, Elghetany M, Payne D. T‐gamma gene rearrangement and CMV mononucleosis. American Journal Of Hematology 2000, 66: 64-66. PMID: 11426498, DOI: 10.1002/1096-8652(200101)66:1<64::aid-ajh1013>3.0.co;2-v.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralBlood CellsBone Marrow CellsClone CellsCytomegalovirusCytomegalovirus InfectionsDiagnosis, DifferentialFemaleGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansImmunoglobulin MImmunophenotypingInfectious MononucleosisLymphoproliferative DisordersMiddle AgedT-Lymphocyte SubsetsViremiaConceptsT gamma gene rearrangementCMV infectionLymphoproliferative diseaseAcute CMV infectionGene rearrangementsAtypical lymphocytosisCMV mononucleosisCMV viremiaNight sweatsIgM serologyClinical featuresLymphoid aggregatesBlood countPeripheral bloodHemolytic anemiaImmune responseBone marrowWeight lossCytomegalovirusInfectionDiseaseMononucleosisViremiaSplenomegalyLymphocytosis
1997
Epstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients
Strazzabosco M, Corneo B, Iemmolo R, Menin C, Gerunda G, Bonaldi L, Merenda R, Neri D, Poletti A, Montagna M, Del Mistro A, Faccioli A, D'Andrea E. Epstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients. Journal Of Hepatology 1997, 26: 926-934. PMID: 9126809, DOI: 10.1016/s0168-8278(97)80262-0.Peer-Reviewed Original ResearchConceptsPost-transplant lymphoproliferative diseaseLiver transplant recipientsOrthotopic liver transplant recipientsLymphoproliferative diseaseTransplant recipientsDonor originB lymphocytesDonor B lymphocytesEBV-specific probesPost-transplant lymphomaOrthotopic liver transplantEpstein-Barr virus sequencesSolid organ transplantationPossible risk factorsLympho-proliferative diseaseNeoplastic B cellsLiver transplantEBV DNAHepatic hilumProspective studyHodgkin's lymphomaPolymerase chain reactionPotential complicationsRisk factorsReal incidenceAcquired von Willebrand's disease: A concise review
Rinder M, Richard R, Rinder H. Acquired von Willebrand's disease: A concise review. American Journal Of Hematology 1997, 54: 139-145. PMID: 9034288, DOI: 10.1002/(sici)1096-8652(199702)54:2<139::aid-ajh7>3.0.co;2-y.Peer-Reviewed Original ResearchConceptsVon Willebrand factorHigh molecular weight multimersMonoclonal gammopathyAcquired von Willebrand diseaseEmergent cardiac surgeryUnderlying lymphoproliferative disorderLower functional levelUnderlying lymphoproliferative diseaseVon Willebrand diseaseIntravenous immunoglobulinCardiac surgeryLymphoproliferative disordersFactor inhibitorsAutoimmune diseasesLymphoproliferative diseaseUnderlying disorderEffective therapyBleeding diathesisIllustrative case historiesAvWDTherapeutic strategiesAntigenic levelsWillebrand diseaseReticuloendothelial systemTumor cells
1996
Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder
Rothenberg M, Weber W, Longtine J, Hafler D. Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder. Clinical Immunology 1996, 80: 266-272. PMID: 8811046, DOI: 10.1006/clin.1996.0122.Peer-Reviewed Original ResearchConceptsGamma delta T cellsDelta T cellsGamma delta T-cell receptorDelta T-cell receptorPosttransplantation lymphoproliferative diseaseT cellsBrain lesionsT cell receptorLymphoproliferative diseaseCell receptorInflammatory brain lesionsPosttransplantation lymphoproliferative disorderEpstein-Barr virusCultured T cell linesCentral nervous systemT cell linesHuman brain tissueLymphoproliferative disordersAutoimmune diseasesInflammatory processVirus immunityNervous systemBrain tissueLesionsTarget cells
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