2025
Low-Dose CT of the Chest: Is High-Risk Population Screening for Both Lung Cancer and Cardiovascular Disease Possible?
Fuss C. Low-Dose CT of the Chest: Is High-Risk Population Screening for Both Lung Cancer and Cardiovascular Disease Possible? Radiology 2025, 314: e250215. PMID: 39964272, DOI: 10.1148/radiol.250215.Peer-Reviewed Original Research
2024
Editorial: Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban or the combination: Secondary analysis of the COMPASS randomised controlled trial
Sehgal K, Shung D. Editorial: Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban or the combination: Secondary analysis of the COMPASS randomised controlled trial. Alimentary Pharmacology & Therapeutics 2024, 60: 961-962. PMID: 39219413, DOI: 10.1111/apt.18195.Commentaries, Editorials and LettersCorrelation Between AI-Measured Coronary Artery Calcium on Low-Dose Attenuation Correction CT and Myocardial Blood Flow
Cho S, Lee J, Cho K, Park K, Kim J, Moon J, Song H. Correlation Between AI-Measured Coronary Artery Calcium on Low-Dose Attenuation Correction CT and Myocardial Blood Flow. Journal Of Nuclear Cardiology 2024, 38: 101975. DOI: 10.1016/j.nuclcard.2024.101975.Peer-Reviewed Original ResearchA phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes
Bender C, Wiedeman A, Hu A, Ylescupidez A, Sietsema W, Herold K, Griffin K, Gitelman S, Long S, Gottlieb P, Strock R, Chesshir L, Redondo M, Williams C, Clements M, Moore W, DiMeglio L, Legge M, Mullen M, Sanchez J, Spall M, Woerner S, Gaglia J, Resnick B, Bryant N, Krishfield S, Turley J, Koshy N, Mackey M, Guttmann-Bauman I, Fitch R, Bartholow L, Shelso J, Al Nofal A, Hanisch K, Casas L, Thurlow B, Gottschalk M, Hashiguchi M, Paglia L, Lam A, Sanda S, Torok C, Wesch R, Moore D, Russell W, Smith T, Brown A, Brendle F, Haller M, Cintron M, Baidal D, Matheson D, Blaschke C, Moran A, Pappensus E, Leschyshyn J, Street A. A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes. Science Translational Medicine 2024, 16: eadn2404. PMID: 38718135, DOI: 10.1126/scitranslmed.adn2404.Peer-Reviewed Original ResearchConceptsRegulatory T cellsType 1 diabetesT cellsC-peptideFoxp3<sup>+</sup> regulatory T cellsNew-onset type 1 diabetesResidual B-cell functionPhase 1 clinical trialAutoimmune type 1 diabetesC-peptide preservationHigh-dose cohortPhase 2 randomized trialYears compared to placeboNew-onset T1DBaseline C-peptidePeripheral blood samplesSuppression in vitroDetected 1 weekMatching placeboAdoptive transferDouble-blindHigh-dosePrevent autoimmunityLow-doseFold expansionAI-derived epicardial fat measurements improve cardiovascular risk prediction from myocardial perfusion imaging
Miller R, Shanbhag A, Killekar A, Lemley M, Bednarski B, Van Kriekinge S, Kavanagh P, Feher A, Miller E, Einstein A, Ruddy T, Liang J, Builoff V, Berman D, Dey D, Slomka P. AI-derived epicardial fat measurements improve cardiovascular risk prediction from myocardial perfusion imaging. Npj Digital Medicine 2024, 7: 24. PMID: 38310123, PMCID: PMC10838293, DOI: 10.1038/s41746-024-01020-z.Peer-Reviewed Original ResearchEpicardial adipose tissueMyocardial infarctionPerfusion imagingEpicardial adipose tissue measurementsEpicardial adipose tissue volumeEAT attenuationMedian follow-upIncreased risk of deathEpicardial fat measurementMyocardial perfusion imagingAssociated with cardiovascular riskCoronary artery diseaseAssociated with deathEating measuresRisk of deathEAT volumeLow-dosePrognostic insightsFollow-upCardiovascular riskCardiovascular risk predictionUngated CTArtery diseaseIncreased riskCardiac silhouetteA Review on Low-Dose Emission Tomography Post-Reconstruction Denoising With Neural Network Approaches
Bousse A, Kandarpa V, Shi K, Gong K, Lee J, Liu C, Visvikis D. A Review on Low-Dose Emission Tomography Post-Reconstruction Denoising With Neural Network Approaches. IEEE Transactions On Radiation And Plasma Medical Sciences 2024, 8: 333-347. PMID: 39429805, PMCID: PMC11486494, DOI: 10.1109/trpms.2023.3349194.Peer-Reviewed Original Research
2023
Cross-Domain Iterative Network for Simultaneous Denoising, Limited-Angle Reconstruction, and Attenuation Correction of Cardiac SPECT
Chen X, Zhou B, Xie H, Guo X, Liu Q, Sinusas A, Liu C. Cross-Domain Iterative Network for Simultaneous Denoising, Limited-Angle Reconstruction, and Attenuation Correction of Cardiac SPECT. Lecture Notes In Computer Science 2023, 14348: 12-22. DOI: 10.1007/978-3-031-45673-2_2.Peer-Reviewed Original ResearchSimultaneous denoisingAttenuation correctionCardiac single-photon emission computed tomographySingle-photon emission computed tomographyLimited-angleCross-domainIterative networkLow reconstruction accuracyDeep learning methodsEnd-to-endReduce hardware costIncreased image noiseAblation studiesReconstruction performanceInput featuresSingle-photonHardware costLearning methodsAttenuation mapLow-doseReconstruction accuracyLimited-angle reconstructionRadiation exposureExtra radiation exposureMultiple iterations
2019
Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases.
Tahvildari M, Dana R. Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases. The Journal Of Immunology 2019, 203: 2749-2755. PMID: 31740549, PMCID: PMC6986328, DOI: 10.4049/jimmunol.1900733.Peer-Reviewed Original ResearchConceptsLow-dose IL-2 therapyLow-dose IL-2IL-2 therapyIL-2Administration of low-dose IL-2Low-dose IL-2 regimensLow-dose IL-2 treatmentGraft-versus-host diseaseInflammatory conditionsProduction of immunoregulatory cytokinesCombination of IL-2Receptors to IL-2IL-2 regimensIL-2 treatmentTreg suppressive functionRegulatory T cellsMaintenance of immune homeostasisSystemic lupus erythematosusType 1 diabetesCorneal allograftsTreg frequencyFoxp3 expressionAllograft rejectionLow-doseT cells
2016
Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer
Wong A, Sundar R, Wang T, Ng T, Zhang B, Tan S, Soh T, Pang A, Tan C, Ow S, Wang L, Mogro J, Ho J, Jeyasekharan A, Huang Y, Thng C, Chan C, Hartman M, Iau P, Buhari S, Goh B, Lee S. Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer. Oncotarget 2016, 7: 64089-64099. PMID: 27577069, PMCID: PMC5325427, DOI: 10.18632/oncotarget.11596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnthracyclinesAntineoplastic AgentsBiomarkers, TumorBreast NeoplasmsContrast MediaCyclophosphamideDisease-Free SurvivalDoxorubicinDrug Administration ScheduleFemaleHumansImmunohistochemistryIndolesMagnetic Resonance ImagingMiddle AgedNeoadjuvant TherapyPreoperative PeriodPyrrolesSunitinibTreatment OutcomeConceptsPathological complete responseVascular normalization indexChemotherapy dose delaysLow-doseDose delaysDCE-MRIPhase IbDecreased lymphatic vessel densityIntra-tumoral drug deliveryPathologic complete response rateRecommended phase II dosePhase II doseDose of sunitinibTreatment of breast cancerDCE-MRI parametersPre-operative treatmentAnthracycline-based chemotherapyOpen-label studyRandomized to chemotherapyTumor vessel normalizationLymphatic vessel densityEnhance chemotherapy efficacyBreast cancer patientsFunctional imaging biomarkersPharmacodynamic evidence
2014
Effect of low-dose, short-course sunitinib (Su) on tumor vasculature and tumor blood flow for enhancement of chemotherapy efficacy in breast cancer.
Wong A, Sundar R, Ow S, Wang T, Ng T, Chan C, Hartman M, Iau P, Tan S, Zhang B, Thng C, Mogro M, Voon P, Buhari S, Soh I, Goh B, Lee S. Effect of low-dose, short-course sunitinib (Su) on tumor vasculature and tumor blood flow for enhancement of chemotherapy efficacy in breast cancer. Journal Of Clinical Oncology 2014, 32: 1060-1060. DOI: 10.1200/jco.2014.32.15_suppl.1060.Peer-Reviewed Original Research
2013
SU‐E‐T‐118: Small Dynamic Field Dosimetry by Gfachromic Film (EBT3) and 2D‐Array Diode
Chu A, Feng W, Lincoln H, Su F, Nath R. SU‐E‐T‐118: Small Dynamic Field Dosimetry by Gfachromic Film (EBT3) and 2D‐Array Diode. Medical Physics 2013, 40: 230-231. DOI: 10.1118/1.4814553.Peer-Reviewed Original ResearchFilm dosimetryField dosimetryChamber measurementsCentral axisAbsolute dose comparisonDynamic MLC fieldsVarian iX linacDiode arraySAD setupMLC fieldsSun NuclearIntrinsic buildupAbsolute doseFilm measurementsDose pointsDose comparisonDose valuesDosimetryDosimetersLow-doseEnergy-dependentSystematic noiseDose accuracyMapCHECKDiode performance
2009
Stents liberadores de sirolimus com e sem cobertura polimérica: análise seriada com angiografia e ultrassom intracoronariano tridimensional
Chamié D, Costa J, Abizaid A, da Silva J, Feres F, Mattos L, Staico R, Costa R, Siqueira D, Tanajura L, Sousa A, Sousa J. Stents liberadores de sirolimus com e sem cobertura polimérica: análise seriada com angiografia e ultrassom intracoronariano tridimensional. Journal Of Transcatheter Interventions 2009, 17: 20-30. DOI: 10.1590/s2179-83972009000100007.Peer-Reviewed Original ResearchIn-stent late luminal lossLate luminal lossLuminal lossDrug doseIntravascular ultrasoundCohort of patientsCases of binary restenosisSirolimus-eluting stentsPrimary endpointHigh-doseLow-doseClinical characteristicsPost-procedureSafety profileFollow-upBinary restenosisInflammatory responseDrug delivery kineticsPatientsEfficacy issuesObstructionStentHyperplasia formationEfficacyDrug
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