2025
Increasing Omission of Race and Ethnicity in a National Surgical Database.
Hu K, Ihnat J, Zhao K, Oh S, Goss J, Parikh N, Kammien A, Fereydooni S, Butler P, Alperovich M. Increasing Omission of Race and Ethnicity in a National Surgical Database. Journal Of The American College Of Surgeons 2025 PMID: 40035446, DOI: 10.1097/xcs.0000000000001372.Peer-Reviewed Original ResearchBM patientsNSQIP-PHospital lengths-of-stayNational surgical databaseLengths-of-stayNon-BM patientsEthnicity dataCochran-Armitage testOdds of readmissionSurgical databaseSurgical outcomesPatient demographicsSurgery typeNSQIP-P.Multivariate analysisIncreased omissionsPatientsSurgical disparitiesCochran-ArmitageMissing raceSurgical careLinear mixed-effects modelsAccurate data collectionComplicationsMixed-effects models[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original ResearchSpecificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities.
Connors K, Guertin E, Nichol M, Bosson-Heenan J, Gruen J, Frijters J. Specificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities. Journal Of Learning Disabilities 2025, 222194241312189. PMID: 39924773, DOI: 10.1177/00222194241312189.Peer-Reviewed Original ResearchLearning disabilitiesMath disabilitiesReading disabilityCo-occurring disabilitiesDomain-specificReading skills of childrenGrade 1 childrenCo-occurrenceGroup-level differencesSkills of childrenTrajectories of childrenMath deficitsMath difficultiesGrowth trajectories of childrenMath interventionReading skillsReading trajectoriesSkill growthPatterns of childrenImpairment levelMathDisabilityImpairmentLinear mixed-effects modelsElementary schoolPregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic functionAir Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Zhu Q, Lyu Y, Huang K, Zhou J, Wang W, Steenland K, Chang H, Ebelt S, Shi X, Liu Y. Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). GeoHealth 2025, 9: e2024gh001023. PMID: 39776607, PMCID: PMC11705411, DOI: 10.1029/2024gh001023.Peer-Reviewed Original ResearchChinese Longitudinal Health Longevity SurveyWarm-season O<sub>3</sub>Chinese elderly populationAssociated with cognitive impairmentLongevity SurveyCognitive impairmentLinear mixed-effects modelsChinese Longitudinal Healthy Longevity SurveyAir pollutionAssociation of air pollutionMixed-effects modelsAverage NO<sub>2</sub>Average PM<sub>2.5</sub>Elderly populationSingle-pollutant modelsMulti-pollutant modelsLogistic regression modelsCMMSE scoresControl Action PlanAir pollution preventionStudy participantsGaseous air pollutantsFollow-up visitRandom interceptPositive association
2024
Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine
Machavariani E, Bromberg D, Dumchev K, Esserman D, Earnshaw V, Pykalo I, Filippovich M, Ivasiy R, Ahmad B, Long J, Haddad M, Madden L, Oliveros D, Dvoriak S, Altice F. Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine. International Journal Of Drug Policy 2024, 136: 104682. PMID: 39705875, PMCID: PMC11821433, DOI: 10.1016/j.drugpo.2024.104682.Peer-Reviewed Original ResearchConceptsPrimary care centersQuality health indicatorsProvider stigmaEvidence-based practiceGuideline-concordantPatient outcomesHealth indicatorsReduce provider stigmaCare centerInfluence healthcare utilizationSpecialty health servicesPatient-level outcomesTele-educationImprove patient outcomesProvider fearsImplementation trialHealthcare utilizationPreventive careHealth servicesPoor healthLinear mixed-effects modelsImprove attitudesStigmaIncrease accessMixed-effects modelsDehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study
Li M, Xiao H, Amaerjiang N, Thapa B, Shu W, Asihaer Y, Guan M, Vermund S, Zou Z, Huang D, Hu Y. Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study. Nutrients 2024, 16: 3472. PMID: 39458467, PMCID: PMC11510355, DOI: 10.3390/nu16203472.Peer-Reviewed Original ResearchConceptsTransient renal impairmentRenal impairmentSystolic blood pressure z-scoreBody mass index z-scoreLong sleepBlood pressure z-scoreZ-scoreEarly renal impairmentOptimal sleepAssessment of sleep durationHealthy primary school childrenShort sleepMediterranean diet adherenceHydration statusAssociation of sleep durationSleep durationKidney healthMixed-effects modelsLinear mixed-effects modelsAssess longitudinal associationsMicroalbumin excretionGlomerular impairmentCohort studyDiet adherenceScreen timeMediation analysis in longitudinal study with high-dimensional methylation mediators
Cui Y, Lin Q, Yuan X, Jiang F, Ma S, Yu Z. Mediation analysis in longitudinal study with high-dimensional methylation mediators. Briefings In Bioinformatics 2024, 25: bbae496. PMID: 39406521, PMCID: PMC11479716, DOI: 10.1093/bib/bbae496.Peer-Reviewed Original ResearchConceptsBody mass indexMediation analysisPaternal body mass indexGeneralized estimating equationsLinear mixed-effects modelsCohort dataMass indexMixed-effects modelsDNA methylation sitesHigh-dimensional mediation analysisLongitudinal studyBonferroni correctionAccurate parameter estimatesSobel testVariable selectionLongitudinal dataSimulation studyIndependence screeningMethylation sitesCpG sitesIndirect effectsParameter estimationLinearization methodHypothesis testingMaternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach
Euclydes V, Braga C, Gouveia G, Martinez R, Camilo C, Simões S, Martins-Jr D, Fracolli L, Argeu A, Ferraro A, Matijasevich A, Fatori D, Miguel E, Polanczyk G, Brentani H. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. Brain Behavior & Immunity - Health 2024, 40: 100832. PMID: 39193418, PMCID: PMC11347843, DOI: 10.1016/j.bbih.2024.100832.Peer-Reviewed Original ResearchMaternal immune responseTrimester of pregnancyImmune responseNeurodevelopmental outcomesImmunological markersImmunological biomarkersMaternal childhood traumaNeurodevelopmental trajectoriesMother's immune responseEarly stages of pregnancyWeeks of pregnancyMaternal psychosocial stressStages of pregnancyStages of gestationRandomized clinical trialsAnti-inflammatory stateMaternal stress experienceNeurodevelopmental scoresImmune system responseInflammatory biomarkersClinical trialsPregnancyPsychosocial stress conditionBlood samplesLinear mixed-effects modelsPrenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study
Siwakoti R, Park S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study. Chemosphere 2024, 360: 142363. PMID: 38768789, PMCID: PMC11487489, DOI: 10.1016/j.chemosphere.2024.142363.Peer-Reviewed Original ResearchFetal sexMaternal raceEffect modificationOS biomarkersOxidative stressPre-pregnancy BMIAdverse pregnancy outcomesNo significant effect modificationMaternal oxidative stressPlasma PFASsSignificant effect modificationInterquartile range increasePositive associationExposure to OSPre-pregnancyPregnancy outcomesMaternal ageMultivariate linear regressionSex-specific effectsLinear mixed-effects modelsPotential confoundersInsurance statusRange increaseEndocrine functionEducation levelCross-continental environmental and genome-wide association study on children and adolescent anxiety and depression
Thapaliya B, Ray B, Farahdel B, Suresh P, Sapkota R, Holla B, Mahadevan J, Chen J, Vaidya N, Perrone-Bizzozero N, Benegal V, Schumann G, Calhoun V, Liu J. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. Frontiers In Psychiatry 2024, 15: 1384298. PMID: 38827440, PMCID: PMC11141390, DOI: 10.3389/fpsyt.2024.1384298.Peer-Reviewed Original ResearchEarly life stressAdolescent anxietyLife stressMega-analysisCognitive Development StudyHypothalamic-pituitary-adrenal axisSupport IndexAssociated with anxietyRisk of anxietyExternalizing disordersAdolescent brainGenome-wide association studiesGenetic vulnerabilityAnxietyGenome-wide association analysisPublic health concernDepressionMental healthLinear mixed-effects modelsEnvironmental factorsMixed-effects modelsAssociation studiesTissue enrichment analysisGenetic associationGenomic significanceAssociations of environmental cadmium exposure with kidney damage: Exploring mediating DNA methylation sites in Chinese adults
Wei Y, Wang X, Sun Q, Shi W, Zhang W, Gao X, Li Y, Hao R, Dong X, Chen C, Cao K, Jiang W, Yang Z, Zhu Y, Lv Y, Xv D, Li J, Shi X. Associations of environmental cadmium exposure with kidney damage: Exploring mediating DNA methylation sites in Chinese adults. Environmental Research 2024, 251: 118667. PMID: 38462081, DOI: 10.1016/j.envres.2024.118667.Peer-Reviewed Original ResearchDifferentially methylated positionsUrinary CdDNA methylationAssociated with urinary CdSource of cadmiumExposure to CdEnvironmental Cd exposureNon-smoking adultsCd-induced kidney damageCd exposureEnvironmental CdDNA methylation sitesDNA methylation changesIllumina Infinium MethylationEPIC BeadChip arrayDNA methylation profilesEpigenome-wide associationInfinium MethylationEPIC BeadChip arrayLinear mixed-effects modelsMethylationEPIC BeadChip arrayEnvironmental pollutionPerspective of environmental pollutionMethylation sitesMethylation changesBeadChip arrayMethylation profilesIntegrating methadone into primary care settings in Ukraine: effects on provider stigma and knowledge
Bromberg D, Machavariani E, Madden L, Dumchev K, LaMonaca K, Earnshaw V, Pykalo I, Filippovych M, Haddad M, Dvoriak S, Altice F. Integrating methadone into primary care settings in Ukraine: effects on provider stigma and knowledge. Journal Of The International AIDS Society 2024, 27: e26202. PMID: 38379179, PMCID: PMC10879646, DOI: 10.1002/jia2.26202.Peer-Reviewed Original ResearchConceptsPrimary care clinicsStigma reduction interventionsOpioid agonist therapyClinicians' attitudesStigma constructsHIV preventionReduction interventionsEvidence-based HIV preventionCluster randomized controlled trialEvidence-based carePrimary care settingIntegrated care sitesDirect providersRandomized controlled trialsProvider stigmaCare clinicsCare sitesHIV careCare settingsHealth outcomesClinical staffSubstance use disordersLinear mixed-effects modelsTreatment continuumImprove attitudes
2023
Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis
Zhao Y, Nogueira M, Chen Q, Dai Q, Cai Q, Wen W, Lan Q, Rothman N, Gao Y, Shu X, Zheng W, Milne G, Yang G. Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis. Gerontology 2023, 70: 134-142. PMID: 37967546, PMCID: PMC10922451, DOI: 10.1159/000534258.Peer-Reviewed Original ResearchConceptsF2-IsoP-MAssociated with subsequent weight lossOlder womenMeasures of anthropometryWeight changeF2-IsoPsIncreased all-cause mortalityF2-isoprostanesWeight lossFollow-upLowest quartile groupProspective cohort studyAll-cause mortalityPhysical activityDetermination of body weightProlonged follow-upTime-varying covariatesLinear mixed-effects modelsFollow-up periodInverse associationLongitudinal associationsPercentage of weight changeHealth issuesCohort studyMiddle-agedThe efficacy of an online family-based cognitive behavioral therapy on psychological distress, family cohesion, and adaptability of divorced head-of-household women in Iran
Golboni F, Alimoradi Z, Potenza M, Pakpour A. The efficacy of an online family-based cognitive behavioral therapy on psychological distress, family cohesion, and adaptability of divorced head-of-household women in Iran. Asian Journal Of Social Health And Behavior 2023, 6: 133-140. DOI: 10.4103/shb.shb_262_23.Peer-Reviewed Original ResearchCognitive behavioral therapyIntervention groupFamily-based CBTFamily-based cognitive behavioral therapyPsychological distressState Welfare Organization of IranBreast self-examinationScores of anxietyBehavioral therapyState Welfare OrganizationActive control groupFamily cohesionRandomized controlled trialsSelf-examinationLinear mixed-effects modelsPsychological statusMeasures of anxietyControl groupRandom interceptFamily adaptationMixed-effects modelsCBT sessionsFunctioning of familiesPsychological problemsInterventionPortable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions.
Hong C, Lamsam L, Yadlapalli V, Parasuram N, Mazurek M, Chavva I, Lalwani D, Zabinska J, Schiff S, Manes R, Vining E, Rimmer R, Kimberly W, Sheth K, Omay S. Portable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions. Journal Of Neurosurgery 2023, 139: 1664-1670. PMID: 37347618, DOI: 10.3171/2023.5.jns23174.Peer-Reviewed Original ResearchConceptsEndoscopic endonasal surgeryOptic nerve decompressionEndonasal surgerySuprasellar lesionsNerve decompressionOptic chiasmThird ventricleConventional MRIOptic chiasm compressionEndoscopic endonasal resectionChiasm compressionPreoperative imagingSingle institutionEndonasal resectionMRI availabilityRoutine MRISignificant interrater reliabilitySuprasellar pathologiesSurgeryNeurosurgical oncologyLinear mixed-effects modelsPortable MRIPatientsMRIMixed-effects modelsBrain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort
Zhao Y, Paulus M, Potenza M. Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort. Journal Of Behavioral Addictions 2023, 12: 80-93. PMID: 36940096, PMCID: PMC10260217, DOI: 10.1556/2006.2023.00006.Peer-Reviewed Original ResearchConceptsScreen media activitiesGray matter volumeInternalizing problemsTwo yearsSymptoms two yearsTwo-year followInferior temporal regionsCortical thickness measuresHours/dayLongitudinal brain imagingInternalizing psychopathologyABCD cohortSmall effect sizesFuture internalizing problemsInternalizing behaviorsExternalizing psychopathologyInferior parietalMediation analysisBrain patternsBrain featuresGreater riskLinear mixed-effects modelsTemporal regionsAge 9Thickness measuresAssociations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sample
2021
How Total Performance Scores of Medicare Value-Based Purchasing Program Hospitals Change Over Time
Ramirez A, Marsh K, McMurry T, Turrentine F, Tracci M, Jones R. How Total Performance Scores of Medicare Value-Based Purchasing Program Hospitals Change Over Time. Journal For Healthcare Quality 2021, 44: 78-87. PMID: 34469925, DOI: 10.1097/jhq.0000000000000321.Peer-Reviewed Original ResearchConceptsPhysician-owned surgical hospitalsTotal performance scoreAccountable care organizationsValue-based purchasingHospital typeCenters for MedicareMedicare Value-Based PurchasingGeneral HospitalPerformance scoresPerformance-based financial incentivesSurgical hospitalsDisproportionate share hospital paymentsLongitudinal linear mixed-effects modelsCase mix indexIndividual domain scoresCare organizationsMedicare daysLinear mixed-effects modelsHospital changesInpatient daysPatient dischargeDomain scoresHospital paymentsPatient satisfactionKaiser hospitalsComparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease
Mayblyum D, Becker J, Jacobs H, Buckley R, Schultz A, Sepulcre J, Sanchez J, Rubinstein Z, Katz S, Moody K, Vannini P, Papp K, Rentz D, Price J, Sperling R, Johnson K, Hanseeuw B. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology 2021, 96: e2933-e2943. PMID: 33952655, PMCID: PMC8253562, DOI: 10.1212/wnl.0000000000012108.Peer-Reviewed Original ResearchPreclinical Alzheimer's diseaseCognitive declineHarvard Aging Brain StudyPreclinical Alzheimer Cognitive CompositePrevention trialsAlzheimer's diseaseAging Brain StudyClinically normal adultsPittsburgh compound B (PiB)-PETProspective cohort studyClass II evidenceCompound B (PiB)-PETCognitive compositeIsthmus cingulateIncrease of statistical powerStructural MRICognitive evaluationBackward stepwise regressionEntorhinal cortexHigher amyloidFDG-PETBrain studiesLinear mixed-effects modelsFollow-upCohort study
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