2025
Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis.
Manning A, Letchuman V, Martin M, Gombos E, Robert-Fitzgerald T, Cao Q, Raza P, O'Donnell C, Renner B, Daboul L, Rodrigues P, Ramos M, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Suthiphosuwan S, Schindler M, Bilello M, Song J, Sotirchos E, Sicotte N, Al-Louzi O, Solomon A, Reich D, Ontaneda D, Sati P, Shinohara R. Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis. American Journal Of Neuroradiology 2025, 46: 620-626. PMID: 39332906, DOI: 10.3174/ajnr.a8510.Peer-Reviewed Original ResearchCentral vein signCVS+ lesionsWhite matter lesionsMultiple sclerosisMulticenter studyProportions of white matter lesionsSuspicion of MSReceiver-operating characteristic curveFluid-attenuated inversion recoveryDiagnosis of multiple sclerosisDiagnosis of MSMagnetic resonance imagingAtypical clinical syndromeRadiological mimicsClinical syndromeDiagnostic imaging biomarkersManual assessmentT MRIClinical implementationImaging biomarkersLesionsInversion recoveryResonance imagingCharacteristic curveInter-rater reliabilityParadoxical control of multifocal mammary oncogenesis by radiation therapy
Galluzzi L, Buqué A. Paradoxical control of multifocal mammary oncogenesis by radiation therapy. OncoImmunology 2025, 14: 2458886. PMID: 39873285, PMCID: PMC11776481, DOI: 10.1080/2162402x.2025.2458886.Peer-Reviewed Original ResearchNon-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis
Balter D, Cao Y, Garritano J, Micevic G, Sanchez A. Non-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis. Clinical Nephrology - Case Studies 2025, 13: 8-12. PMID: 39949516, PMCID: PMC11823000, DOI: 10.5414/cncs111578.Peer-Reviewed Original ResearchNon-uremic calciphylaxisDermatological complicationsAlcohol-associated cirrhosisPainful skin lesionsAcute kidney injurySodium thiosulfate therapyInfectious complicationsKidney injuryTreatment optionsSkin biopsiesHepatic encephalopathyWork-upSkin lesionsCalciphylaxisCirrhosisComplicationsThiosulfate therapyAlcohol associationsPatientsTreatmentBiopsyPrognosisTherapyLesionsEncephalopathy
2024
Quantitative susceptibility mapping is more sensitive and specific than phase imaging in detecting chronic active multiple sclerosis lesion rims: pathological validation
Gillen K, Nguyen T, Dimov A, Kovanlikaya I, Luu H, Demmon E, Markowitz D, Bagnato F, Pitt D, Gauthier S, Wang Y. Quantitative susceptibility mapping is more sensitive and specific than phase imaging in detecting chronic active multiple sclerosis lesion rims: pathological validation. Brain Communications 2024, 7: fcaf011. PMID: 39916751, PMCID: PMC11800486, DOI: 10.1093/braincomms/fcaf011.Peer-Reviewed Original ResearchPhase imagesQuantitative susceptibility mappingPerls' stainPredictive valueLesion rimFrequency of clinical relapsesNegative predictive valuePositive predictive valuePathological validationDecreased brain volumeProgression to disabilityQuantitative susceptibility mapping imagesClinical relapseBrain volumeMicroglial markersGold standardLesionsMultiple sclerosis lesionsParamagnetic rimMap imagesIncorporation of the central vein sign into the McDonald criteria
Amin M, Nakamura K, Daboul L, O'Donnell C, Cao Q, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prčkovska V, Raza P, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Incorporation of the central vein sign into the McDonald criteria. Multiple Sclerosis And Related Disorders 2024, 93: 106182. PMID: 39622133, PMCID: PMC11779579, DOI: 10.1016/j.msard.2024.106182.Peer-Reviewed Original ResearchCentral vein signDIS criteriaDiagnostic performanceMultiple sclerosisDeep white matter lesionsDiagnosis of multiple sclerosisMulti-center studyInternational multi-center studyWhite matter lesionsNorth American ImagingMcDonald CriteriaProspective studyDiagnostic accuracyMRI disseminationDemyelinating diseaseBackground DiagnosisMS diagnosisDiagnostic biomarkersCompare sensitivityLesionsBrain locationsMethods DataBrain imagingBrainSignsEarly Detection of Macular Atrophy Automated Through 2D and 3D Unet Deep Learning
Wei W, Patel R, Laponogov I, Cordeiro M, Veselkov K. Early Detection of Macular Atrophy Automated Through 2D and 3D Unet Deep Learning. Bioengineering 2024, 11: 1191. PMID: 39768009, PMCID: PMC11726850, DOI: 10.3390/bioengineering11121191.Peer-Reviewed Original ResearchAge-related macular degenerationOptical coherence tomographyMacular atrophyEarly detectionVolumetric optical coherence tomographyDice similarity coefficient scoreMacular degenerationCoherence tomographyFollow-upMonitoring patientsPatientsDetection of MAClinical decisionsAtrophyHuman gradersScoresLesionsTomographyEndpointDegenerationEyesDiscordances Between Radiology and Pathology
Harigopal M, Verma A, Andrejeva L, Lewin J. Discordances Between Radiology and Pathology. 2024, 375-391. DOI: 10.1007/978-3-031-65711-5_14.Peer-Reviewed Original ResearchPathological findingsImaging characteristicsMRI-guided biopsyFalse-negative diagnosesRadiology-pathology correlationH&E levelsPreoperative biopsyStereotactic biopsySurgical excisionPercutaneous biopsyDiscordant casesSonographic guidanceBreast biopsyAncillary stainsHistopathological findingsBiopsyMammographic lesionsLesionsIndividual pathologistsPathologistsPotential causesUltrasoundWeekly conferencesImage featuresDiscordanceMRI Breast Findings
Narasimhamurthy M, O’Brien S, Andrejeva L, Nayak A. MRI Breast Findings. 2024, 235-267. DOI: 10.1007/978-3-031-65711-5_9.Peer-Reviewed Original ResearchMagnetic resonance imagingNon-mass enhancementBreast lesionsBreast magnetic resonance imagingPracticing pathologistsMagnetic resonance imaging findingsRadiologic-pathologic correlationBreast core biopsiesMalignant breast lesionsDiagnosing breast lesionsCore biopsyMRI findingsBreast biopsyImaging examinationsFalse-positive rateBiopsyResonance imagingLesionsBreastImaging techniquesPathologistsImage patternsMulticenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis
Chen L, Ren Z, Clark K, Lou C, Liu F, Cao Q, Manning A, Martin M, Luskin E, O'Donnell C, Azevedo C, Calabresi P, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Bilello M, Song J, Kaisey M, Sicotte N, Reich D, Solomon A, Ontaneda D, Sati P, Absinta M, Schindler M, Shinohara R, Cooperative T. Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis. Journal Of Neuroimaging 2024, 34: 750-757. PMID: 39410780, DOI: 10.1111/jon.13242.Peer-Reviewed Original ResearchParamagnetic rim lesionsArea under the curveRim lesionsMultiple sclerosisPrognosis of MSBiomarkers of chronic inflammationWhite matter lesionsMulticenter settingMulticenter studyMulticenter validationChronic inflammationBrain MRIClinical trialsIdentified lesionsMulticenterMS diagnosisLesionsParamagnetic rimAutomated segmentation methodMRIMRI biomarkersMulticenter datasetDiagnosisSclerosisTeam of trained ratersDuctal hamartoma of the pancreas: A clinicopathologic study
Das D, Gonzalez I, Yeh M, Wu T, Jain D. Ductal hamartoma of the pancreas: A clinicopathologic study. Human Pathology 2024, 153: 105669. PMID: 39362530, DOI: 10.1016/j.humpath.2024.105669.Peer-Reviewed Original ResearchConceptsPancreatectomy specimensPancreatic mucinous cystic neoplasmsConsecutive pancreatic resectionsVariable cystic changesCyst fluid CEAHigh-grade dysplasiaMucinous cystic neoplasmsClinical suspicionPancreatic resectionAbdominal symptomsPancreatic carcinomaPatient ageClinicopathological featuresCystic changesLow columnar epitheliumSquamous metaplasiaCystic neoplasmsCystic lesionsProliferative lesionsClinicopathological studyDuctal structuresColumnar epitheliumPancreatectomyLesionsLuminal secretionsEarly Tibial Vessel Recoil Following Treatment With the Bare Temporary Spur Stent System: Results From the DEEPER OUS Vessel Recoil Substudy.
Zeller T, Zhang Z, Parise H, Mascho C, Holden A, Schmidt A, Thieme M, Piorkowski M, Hertting K, Wissgott C, Andrassy M, Noory E, Weinberg I, Kolluri R. Early Tibial Vessel Recoil Following Treatment With the Bare Temporary Spur Stent System: Results From the DEEPER OUS Vessel Recoil Substudy. Journal Of Endovascular Therapy 2024, 15266028241280685. PMID: 39305087, DOI: 10.1177/15266028241280685.Peer-Reviewed Original ResearchMinimal lumen diameterMinutes post-treatmentBalloon angioplastyTreated lesion lengthVessel recoilLumen diameterLesion lengthVessel preparation strategyNo significant differenceStatistically significant correlationDuplex ultrasoundPost-treatmentLesion characteristicsTherapy supplementsPatencyLesionsPatientsVessel preparationStent systemSignificant differenceTibial diseaseAntiproliferative drugsMonthsTherapyAngioplastyEarly Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis
Zeydan B, Azevedo C, Makhani N, Cohen M, Tutuncu M, Thouvenot E, Siva A, Okuda D, Kantarci O, Lebrun-Frenay C. Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis. CNS Drugs 2024, 38: 973-983. PMID: 39285136, PMCID: PMC11560559, DOI: 10.1007/s40263-024-01117-9.Peer-Reviewed Original ResearchRadiologically isolated syndromeRisk factorsLaboratory biomarkersMultiple sclerosisDisease-modifying treatmentsSpinal cordGadolinium-enhancing lesionsEfficacy of disease-modifying treatmentsRandomized clinical trialsIncrease diagnostic accuracyLack of clinical guidelinesSymptomatic MSNeurofilament-light chainCSF abnormalitiesPresymptomatic individualsAdverse eventsMale sexMS criteriaClinical eventsDiagnostic accuracyClinical trialsDisease outcomeClinical guidelinesYounger ageLesionsComprehensive management and classification of first branchial cleft anomalies: An International Pediatric Otolaryngology Group (IPOG) consensus statement
Heilingoetter A, See G, Brookes J, Campisi P, Cervantes S, Chadha N, Chelius D, Chen D, Chun B, Cunningham M, D'Souza J, Din T, Dzongodza T, Francom C, Gallagher T, Gerber M, Gorelik M, Goudy S, Graham M, Hartley B, Hazkani I, Hong P, Hsu W, Isaac A, Jatana K, Johnston D, Kabagenyi F, Kazahaya K, Koempel J, Leboulanger N, Luscan R, Maurrasse S, Mercier E, Peer S, Preciado D, Rahbar R, Rastatter J, Richter G, Rosenblatt S, Shay S, Sheyn A, Tassew Y, Walz P, Whigham A, Wiedermann J, Yeung J, Maddalozzo J. Comprehensive management and classification of first branchial cleft anomalies: An International Pediatric Otolaryngology Group (IPOG) consensus statement. International Journal Of Pediatric Otorhinolaryngology 2024, 186: 112095. PMID: 39278130, DOI: 10.1016/j.ijporl.2024.112095.Peer-Reviewed Original ResearchInternational Pediatric Otolaryngology GroupBranchial cleft anomaliesCleft anomaliesOtolaryngology GroupConsensus recommendationsHead and neck lesionsParotid gland involvementManagement of childrenGland involvementComprehensive managementNeck lesionsSurgical managementSurgical treatmentOtolaryngologic disordersComprehensive management of childrenDiagnostic considerationsConsensus statementLesionsGerm layersExpert consensusImprove care of childrenClassification systemCare of childrenDelphi method surveyChildrenNIRL-12 UNDERSTANDING LESION RESPONSE ON MRI AFTER LASER INTERSTITIAL THERMAL THERAPY (LITT) IN METASTATIC BRAIN TUMOR PATIENTS
Robert S, Sirota M, Sotoudeh S, Kaur M, Merkaj S, Aboian M, Chiang V. NIRL-12 UNDERSTANDING LESION RESPONSE ON MRI AFTER LASER INTERSTITIAL THERMAL THERAPY (LITT) IN METASTATIC BRAIN TUMOR PATIENTS. Neuro-Oncology Advances 2024, 6: i22-i22. PMCID: PMC11296850, DOI: 10.1093/noajnl/vdae090.073.Peer-Reviewed Original ResearchLaser interstitial thermal therapyPost-LITTPercentage volume changeStereotactic radiosurgeryLesion volumeFLAIR signal abnormalityEnhancing lesion volumeContrast-enhancing lesionsThermal therapyTreatment factorsFLAIR changesImmunotherapy useBrain metastasesPerilesional edemaBiopsy pathologyFLAIR volumeSignal abnormalitiesPatientsLesion changesLesionsMonthsTreatment variablesTherapyFLAIRImaging changesOutcomes of repeat conventional transarterial chemoembolization in patients with liver metastases
Ghabili K, Windham-Herman A, Konstantinidis M, Murali N, Borde T, Adam L, Laage-Gaupp F, Lin M, Chapiro J, Georgiades C, Nezami N. Outcomes of repeat conventional transarterial chemoembolization in patients with liver metastases. Annals Of Hepatology 2024, 29: 101529. PMID: 39033928, PMCID: PMC11558520, DOI: 10.1016/j.aohep.2024.101529.Peer-Reviewed Original ResearchConventional transarterial chemoembolizationLiver metastasesNeuroendocrine tumorsColorectal carcinomaTransarterial chemoembolizationOverall survivalLung cancerAssociated with improved patient survivalManagement of liver metastasesMetastatic liver lesionsSingle-institution analysisNonresponding patientsSurvival outcomesPatient survivalResponse assessmentTarget lesionsMetastasisLiver lesionsPatientsResponse rateChemoembolizationSurvivalLiverLesionsCancerPenile Prosthetic Pump Reservoir Mimicking a Cecal Subepithelial Mass
Ameyaw A, Aslanian H. Penile Prosthetic Pump Reservoir Mimicking a Cecal Subepithelial Mass. ACG Case Reports Journal 2024, 11: e01413. PMID: 39006051, PMCID: PMC11245230, DOI: 10.14309/crj.0000000000001413.Peer-Reviewed Original ResearchMechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Huseman E, Lo A, Fedorova O, Elia J, Gueble S, Lin K, Sundaram R, Oh J, Liu J, Menges F, Rees M, Ronan M, Roth J, Batista V, Crawford J, Pyle A, Bindra R, Herzon S. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal Of The American Chemical Society 2024, 146: 18241-18252. PMID: 38815248, PMCID: PMC11409917, DOI: 10.1021/jacs.3c06483.Peer-Reviewed Original ResearchDNA repair capacityDifferential DNA repair capacityDNA interstrand cross-linksRepair capacityInterstrand cross-linksDisplacement of fluorideDNA repairCross-linkingAberrant DNA repairLesionsHealthy tissueBrain cancerRing openingHealthy cellsMGMTSelective chemotherapyGenotoxic agentsTumorChemical DNA modificationsCancerMultistep processRepairStem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus
Fraser E, Kennedy J, Gianakos A, Yasui Y. Stem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus. 2024, 47-56. DOI: 10.1201/9781003524205-7.Peer-Reviewed Original ResearchDeep Learning-Based Detect-Then-Track Pipeline for Treatment Outcome Assessments in Immunotherapy-Treated Liver Cancer
Zhou J, Xia Y, Xun X, Yu Z. Deep Learning-Based Detect-Then-Track Pipeline for Treatment Outcome Assessments in Immunotherapy-Treated Liver Cancer. Journal Of Imaging Informatics In Medicine 2024, 38: 380-393. PMID: 38740661, PMCID: PMC11811366, DOI: 10.1007/s10278-024-01132-8.Peer-Reviewed Original ResearchTargeting immunogenic cell stress and death for cancer therapy
Galluzzi L, Guilbaud E, Schmidt D, Kroemer G, Marincola F. Targeting immunogenic cell stress and death for cancer therapy. Nature Reviews Drug Discovery 2024, 23: 445-460. PMID: 38622310, PMCID: PMC11153000, DOI: 10.1038/s41573-024-00920-9.Peer-Reviewed Original ResearchImmunogenic cell deathTherapeutic strategiesImmunogenic cell death inducerImmunologically cold tumorsConventional therapeutic strategiesCell deathCancer cell biologyICD inducersCold tumorsAnticancer treatmentCancer therapyCancerCell stressDeathTreatmentCell biologyTranslational effortsImmunotherapyDiscovery platformTumorTherapyInducerLesionsImmunology
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