2025
The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINEPreoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications
Carr Z, Charchaflieh J, Brenes-Bastos A, He H, Lin H, Jankelovits A, Gu E, Zafar J, Ghali F, Tan W, Heerdt P. Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open 2025, 14: 100407. PMID: 40421445, PMCID: PMC12105740, DOI: 10.1016/j.bjao.2025.100407.Peer-Reviewed Original ResearchLength of staySubmaximal cardiopulmonary exercise testingInstitutional review board approvalPostoperative complication riskReview board approvalDuke Activity Status IndexCardiopulmonary exercise testingIncreased length of stayAdjusted multivariable regression modelsPostoperative complications predictionPulmonary capacitanceOpen-labelPeak oxygen uptakePerioperative surveillancePrimary endpointNoncardiac surgeryPostoperative complicationsSecondary endpointsSingle-centreComplication riskMET assessmentPeak VOBoard approvalMultivariate regression modelMetabolic equivalentsThirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis
Freund J, Gosalvez C, Rady A, Notarianni A, Carr Z. Thirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis. Anesthesiology And Perioperative Science 2025, 3: 9. DOI: 10.1007/s44254-025-00087-5.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsPostoperative cardiopulmonary complicationsLength of staySarcoidosis patientsSarcoidosis diagnosisCardiopulmonary complicationsCohort analysisAssociated with 30-day MACEIndependent of disease stageSystemic granulomatous disorderRetrospective matched cohort analysisMethodsThis retrospective studyAssociated with higher riskCongestive heart failure eventsComparative cohort analysisHeart failure eventsPreoperative chest radiographyAdverse cardiovascular eventsMatched cohort analysisCompared to controlsPulmonary complicationsSarcoidosis cohortGranulomatous disorderLung involvementThirty-dayFinding the optimal length of stay for veterans in substance use disorder residential treatment using generalized propensity score modeling
Dams G, Gross G, Ketchen B, Smith N, Burden J. Finding the optimal length of stay for veterans in substance use disorder residential treatment using generalized propensity score modeling. International Journal Of Drug Policy 2025, 137: 104715. PMID: 40024631, DOI: 10.1016/j.drugpo.2025.104715.Peer-Reviewed Original ResearchConceptsSubstance use disordersResidential treatmentSevere substance use disordersTreatment outcomesComplex clinical needsVeterans AffairsResidential programsLength of stayDepartment of Veterans AffairsOptimal length of stayResidential centersMethodological issuesVeteransEnhanced outcomesClinical assessmentIndividual patient needsGeneralized propensity score modelAssociation of malnutrition with surgical outcomes after spine surgery for spinal epidural abscess
Elsamadicy A, Serrato P, Ghanekar S, Mitre L, Khalid S, Lo S, Sciubba D. Association of malnutrition with surgical outcomes after spine surgery for spinal epidural abscess. Clinical Neurology And Neurosurgery 2025, 249: 108754. PMID: 39862535, DOI: 10.1016/j.clineuro.2025.108754.Peer-Reviewed Original ResearchConceptsSpinal epidural abscessNon-routine dischargeNational Surgical Quality Improvement ProgramLength of stayAdverse eventsMalnourished cohortEpidural abscessAmerican College of SurgeonsSurgical outcomesPredictors of poor surgical outcomeSpinal epidural abscess patientsNutritional statusSurgical Quality Improvement ProgramMultivariate logistic regression analysisPoor surgical outcomesExtended length of stayPost-operative outcomesAssociation of malnutritionRetrospective cohort studyIncreased LOSPost-surgical outcomesLogistic regression analysisQuality Improvement ProgramSEA patientsSpine surgeryImpact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study
Elsamadicy A, Serrato P, Belkasim S, Ghanekar S, Khalid S, Lo S, Sciubba D. Impact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study. Clinical Neurology And Neurosurgery 2025, 249: 108740. PMID: 39813756, DOI: 10.1016/j.clineuro.2025.108740.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAcute CSCI patientsLength of stayCSCI patientsTreatment modalitiesCervical SCIAcute traumatic cervical spinal cord injuryTraumatic cervical spinal cord injuryAssociated with increased morbidityImpact of patient ageAcute cervical SCICervical spinal cord injuryRetrospective cohort studyMultivariate logistic regressionPredictors of AEYears of ageSpinal cord injuryCervicothoracic fusionAssociated with AECervical fusionPatient ageIndependent predictorsInjury typePatient demographicsProgram databaseAnalgesic Quality Improvement in Paravertebral Blocks for Pediatric Nuss Procedure: An Exploratory Report on the Effects of Perineural Combined Glucocorticoids
Donham R, Jin E, Caty M, Thomas D, Yuan C, Hollingsworth K, Zhang X, Yanez N, Li J. Analgesic Quality Improvement in Paravertebral Blocks for Pediatric Nuss Procedure: An Exploratory Report on the Effects of Perineural Combined Glucocorticoids. Journal Of Pain Research 2025, 18: 489-496. PMID: 39895814, PMCID: PMC11784254, DOI: 10.2147/jpr.s502600.Peer-Reviewed Original ResearchPostoperative opioid consumptionContinuous thoracic paravertebral blockMorphine milligram equivalentsThoracic paravertebral blockParavertebral blockOpioid consumptionNuss procedureDexamethasone sodium phosphateCombined glucocorticoidPain scoresDecreased postoperative opioid consumptionOral morphine milligram equivalentsMethylprednisolone acetateContinuous paravertebral blockPostoperative opioid usagePectus excavatum repairReview of patientsHospital length of stayAcademic children's hospitalLength of stayOpioid usageMilligram equivalentsElectronic health record reviewPlain ropivacaineWound dehiscence
2024
HEALTH CARE UTILIZATION AND COSTS FOR HOSPITALIZED DEMENTIA PATIENTS IN CHINA
Lin Z, Ba F, Allore H, Chen X. HEALTH CARE UTILIZATION AND COSTS FOR HOSPITALIZED DEMENTIA PATIENTS IN CHINA. Innovation In Aging 2024, 8: 954-955. PMCID: PMC11691564, DOI: 10.1093/geroni/igae098.3077.Peer-Reviewed Original ResearchLength of stayInsurance coverageCare utilizationDementia patientsPrimary diagnosis of dementiaInsurance typeTertiary hospitalTertiary hospital admissionChronic disease managementChinese older adultsHealth care utilizationInpatient care utilizationDiagnosis of dementiaEmergency roomOlder patientsLower-level hospitalsIncreased adjusted oddsLow insurance coverageDeterminants of length of stayMultivariate logistic regressionDementia careHealthcare utilizationHospital levelOlder adultsAdjusted oddsHEALTH CARE UTILIZATION AND COSTS FOR HOSPITALIZED DEMENTIA PATIENTS IN CHINA
Lin Z, Ba F, Allore H, Chen X. HEALTH CARE UTILIZATION AND COSTS FOR HOSPITALIZED DEMENTIA PATIENTS IN CHINA. Innovation In Aging 2024, 8: 1124-1124. PMCID: PMC11693179, DOI: 10.1093/geroni/igae098.3607.Peer-Reviewed Original ResearchLength of stayInsurance coverageCare utilizationDementia patientsPrimary diagnosis of dementiaInsurance typeTertiary hospitalTertiary hospital admissionChronic disease managementChinese older adultsHealth care utilizationInpatient care utilizationDiagnosis of dementiaEmergency roomOlder patientsLower-level hospitalsIncreased adjusted oddsLow insurance coverageDeterminants of length of stayMultivariate logistic regressionDementia careHealthcare utilizationHospital levelOlder adultsAdjusted oddsComplications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center
Fram B, Chintalapudi N, Davis J, Yu Z, Seymour R, Karunakar M, Collective E, Hsu J, Kempton L, Phelps K, Sims S, Medda S, Odum S, Wally M, Sweeney J, Hickson K, Young C, Kamath P. Complications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center. OTA International The Open Access Journal Of Orthopaedic Trauma 2024, 8: e353. PMID: 39703728, PMCID: PMC11654790, DOI: 10.1097/oi9.0000000000000353.Peer-Reviewed Original ResearchRisk of complicationsComplication rateFemur fracturesProphylactic antibioticsDuration of prophylactic antibioticsAssociated with increased risk of complicationsRisk factors of complicationsDeep surgical site infectionAssociated with increased complicationsIncreased risk of complicationsPatients aged 18+ yearsCase of compartment syndromeAcademic level I trauma centerAll-cause complicationsAssociated with increased riskFactors of complicationsHospital length of staySurgical site infectionRate of complicationsLevel I trauma centerLevel 1 trauma centerRate of vascular complicationsStandard of careAged 18+ yearsLength of stayUnnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries
Rivero R, Curran I, Hellmann Z, Carroll M, Hornick M, Solomon D, DiLuna M, Morrell P, Christison-Lagay E. Unnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries. Journal Of Pediatric Surgery 2024, 60: 162097. PMID: 39693726, DOI: 10.1016/j.jpedsurg.2024.162097.Peer-Reviewed Original ResearchPediatric Emergency Care Applied Research NetworkPECARN guidelinesPediatric Emergency Care Applied Research Network criteriaClinically important traumatic brain injuryComputed tomographyRisk patientsCross-sectional imagingIntermediate risk group patientsHead traumaIntracranial injuryIntermediate risk patientsRisk group patientsLow-risk injuriesLow-risk patientsRetrospective cohort studyClinically significant progressionEvaluate clinical managementIncreased hospital costsMild head traumaPenetrating head traumaLength of stayTraumatic brain injuryNon-accidental traumaBrain injuryRetrospective reviewPerioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: Risk factors associated with this “never event”
Seddio A, Jabbouri S, Gouzoulis M, Vasudevan R, Halperin S, Varthi A, Rubio D, Grauer J. Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: Risk factors associated with this “never event”. The Spine Journal 2024 PMID: 39631462, DOI: 10.1016/j.spinee.2024.11.018.Peer-Reviewed Original ResearchInpatient fallsLength of stayMultivariate logistic regressionAnterior cervical discectomyInpatient ACDFElixhauser Comorbidity IndexMultidisciplinary fall prevention programAnnual incidenceRisk factorsInpatient fall preventionFall prevention programsLogistic regressionNational sample of patientsCervical discectomyNational Quality ForumSocioeconomically disadvantaged patientsHistory of dementiaUnderweight body mass indexACDF patientsObese BMI >Posterior cervical proceduresBody mass indexMulti-level ACDFAdult patientsQuality ForumTrends in Total Hip Arthroplasty Length of Stay and Coding Status From 2018 to 2021: Two-Year Impact of the Removal From the Inpatient-Only List
Sanchez J, Dhodapkar M, Halperin S, Jiang W, Grauer J, Rubin L. Trends in Total Hip Arthroplasty Length of Stay and Coding Status From 2018 to 2021: Two-Year Impact of the Removal From the Inpatient-Only List. Arthroplasty Today 2024, 30: 101568. PMID: 39634104, PMCID: PMC11615875, DOI: 10.1016/j.artd.2024.101568.Peer-Reviewed Original ResearchLength of stayInpatient-onlyCode statusCenters for MedicareAverage length of stayPearson chi-square testOutpatient total hip arthroplastyCurrent Procedural Terminology codesChi-square testTotal hip arthroplasty patientsSmoking statusMethods DataTotal hip arthroplastyTwo-year impactProcedural Terminology codesNational Surgical Quality Improvement Program databaseAmerican Society of Anesthesiologists classificationAnalysis of variance testQuality Improvement Program databaseOutpatient statusOutpatient casesAge groupsYear of surgeryCategorical variablesTerminology codesThe Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study
Mark J, Colombo R, Alfonso C, Llanos A, Collado E, Larned J, Giese G, Dyal M, Nanna M, Damluji A. The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study. JACC Advances 2024, 3: 101358. PMID: 39600986, PMCID: PMC11588852, DOI: 10.1016/j.jacadv.2024.101358.Peer-Reviewed Original ResearchAdverse cardiovascular eventsCatheter ablationAtrial fibrillationCardiovascular eventsHeart failureFrail patientsHospital lengthNonfrail patientsReducing major adverse cardiovascular eventsAssociated with worse outcomesMajor adverse cardiovascular eventsReduced ejection fractionHospital length of stayIn-hospital mortalityLonger hospital lengthAssociated with increased oddsDischarge dispositionInfluence of frailtyMultivariate regression analysisNationwide Inpatient SampleImpact of frailtyLength of stayPrevalence of frailtyEjection fractionJohns Hopkins Adjusted Clinical GroupsPre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients
Hardenberg J, Kunz J, Rubarth K, Mittermaier M, Pigorsch M, Balzer F, Witzenrath M, Hinz R, Körner R, Eckardt K, Knauf F, Hinrichs C, Enghard P. Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients. Clinical Kidney Journal 2024, 17: sfae328. PMID: 39582778, PMCID: PMC11584513, DOI: 10.1093/ckj/sfae328.Peer-Reviewed Original ResearchGlucose 5% solutionGlucose 5%Severe hypernatremiaDrug diluentDrug solventSodium concentrationAssociated with increased mortalityResults Baseline characteristicsAdult COVID-19 patientsRetrospective before-and-after studyCritically ill patientsIntensive care unitPre-emptive usePrevalence of hypernatremiaStudy intensive care unitVenous blood gasesLength of stayCOVID-19 patientsBaseline characteristicsClinical outcomesICU admissionHypernatremiaMedical ICUCare unitBlood gasesIs Frailty Discouraging Surgeons from Performing Thoracolumbar Fusion? A Retrospective Study.
Linden B, Willging A, Chainani M, Koch K, Galet C, McGonagill P. Is Frailty Discouraging Surgeons from Performing Thoracolumbar Fusion? A Retrospective Study. Spine 2024 PMID: 39482285, DOI: 10.1097/brs.0000000000005203.Peer-Reviewed Original ResearchThoracolumbar fracturesPre-frailtyPre-frailCSHA-CFSTrauma patientsFrail patientsFrailty scoreCanadian Study of Health and Aging Clinical Frailty ScaleThoracolumbar fusionSkilled nursing facilityAssociated with increased risk of pneumoniaOlder trauma patientsManagement of thoracolumbar fracturesAssociated with adverse outcomesAssociated with lower mortalityAssociated with poor outcomesAssociated with increased riskHospital length of stayClinical Frailty ScaleAdult trauma patientsRisk of pneumoniaIn-hospital mortalityNursing facilitiesLength of stayCanadian studyLong-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database
Satam K, Brahmandam A, Zheng X, Mao J, Goodney P, Ochoa Chaar C. Long-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database. Journal Of Vascular Surgery 2024, 81: 672-681.e2. PMID: 39454844, DOI: 10.1016/j.jvs.2024.10.026.Peer-Reviewed Original ResearchPopliteal artery aneurysm repairGreat saphenous veinLong-term outcomesVascular Quality InitiativeAneurysm repairAssociated with increased survivalShort hospital length of stayGreat saphenous vein bypassHospital length of stayRandomized multicenter studyCox proportional hazards regressionKaplan-Meier curvesAssociated with lower mortalityPopliteal aneurysm repairPopliteal artery aneurysmPeripheral vascular interventionsProportional hazards regressionLength of stayP2Y12 inhibitorsBaseline characteristicsMulticenter studyEndovascular therapyArtery aneurysmPropensity-matchedSubgroup analysisUtility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity
Elsamadicy A, Sadeghzadeh S, Serrato P, Sayeed S, Hengartner A, Belkasim S, Khalid S, Lo S, Sciubba D. Utility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity. World Neurosurgery 2024, 192: e292-e305. PMID: 39321916, DOI: 10.1016/j.wneu.2024.09.089.Peer-Reviewed Original ResearchPosterior spinal fusionAdult spinal deformityRisk Analysis IndexLength of stayMFI-5Spinal fusionReceiver operating characteristicSpinal deformityFrail patientsMultivariate analysisModified 5-item frailty indexACS NSQIP databasePreoperative surgical planningRetrospective cohort studyNSQIP databasePatient ageAssess morbidityComplication riskPredicting 30-day readmissionCohort studySurgical planningNormal patientsAdvanced ageComplicationsPatientsHigh inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis
Sandhu M, Craft S, Reeves B, Sayeed S, Hengartner A, Tuason D, DiLuna M, Elsamadicy A. High inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis. Spine Deformity 2024, 13: 111-121. PMID: 39320702, DOI: 10.1007/s43390-024-00960-6.Peer-Reviewed Original ResearchLength of hospital stayPosterior spinal fusionAdolescent idiopathic scoliosisProportion of patientsAdverse eventsCost of admissionHospital stayIdiopathic scoliosisSpinal fusionMethodsA retrospective cohort studyLogistic multivariate regression analysisIncreased 30-day readmission ratePost-operative adverse eventsExtended length of hospital stayHospital length of stayReadmission ratesPost-operative analgesiaRetrospective cohort studyPremier Healthcare DatabaseHigh cohortPerioperative adverse eventsMultivariate regression analysisIncreased cost of admissionLength of staySpine surgeryAssessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors
Elsamadicy A, Serrato P, Sadeghzadeh S, Sayeed S, Hengartner A, Khalid S, Lo S, Shin J, Mendel E, Sciubba D. Assessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors. Journal Of Neuro-Oncology 2024, 171: 213-228. PMID: 39320656, DOI: 10.1007/s11060-024-04830-z.Peer-Reviewed Original ResearchModified frailty index-5Length of stayRAI-revMetastatic spinal tumorsPredicting 30-day mortalityReceiver operating characteristicArea under the curveSpine surgeryFrail patientsSpinal tumorsNo significant differenceSpinal pathologyMultivariate analysisMethodsA retrospective cohort studySignificant differenceExtended length of stayReceiver operating characteristic analysisACS NSQIP databasePredictors of extended length of stayRetrospective cohort studyMultidisciplinary decision makingMetastatic diseaseNSQIP databasePatient ageSpinal surgery
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