2025
Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased riskA comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
Pradella M, Elbaz M, Lee D, Hong K, Passman R, Kholmovski E, Peters D, Baraboo J, Herzka D, Nezafat R, Edelman R, Kim D. A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101852. PMID: 39920924, PMCID: PMC11889362, DOI: 10.1016/j.jocmr.2025.101852.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceLeft atriumCardiac imaging modalitiesLeft atrial appendageContext of atrial fibrillationAtrial fibrillationAtrial appendageHeart failureAtrial diseaseAtrial myopathyImaging modalitiesMagnetic resonanceCardiovascular medicineClinical applicationImaging parametersAtriumMyopathyTissue characterizationState of the Art in Left Atrial Appendage Occlusion
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang D, Saw J, Hahn R, Freeman J, Ellis C, Lakkireddy D. State of the Art in Left Atrial Appendage Occlusion. JACC Clinical Electrophysiology 2025, 11: 602-641. PMID: 39797854, DOI: 10.1016/j.jacep.2024.10.024.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAppendage occlusionStroke preventionLeft atrial appendage occlusion devicesNonvalvular atrial fibrillationOptimal patient selectionDevice-related thrombusLeft atrial appendagePericardial effusionPostprocedural complicationsPatient selectionAtrial fibrillationAtrial appendageArrhythmia therapyDevice leakTherapeutic targetClinical needOcclusionPreventionStroke
2024
Unforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus
Sethi S, Stolear A, Dulgher M, Nwokeocha N, Mejia V, Shkolnik E. Unforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus. Cureus 2024, 16: e63442. PMID: 39077225, PMCID: PMC11284824, DOI: 10.7759/cureus.63442.Peer-Reviewed Original ResearchDevice-related thrombusLeft atrial appendageOral anticoagulantsLAA occlusionLong-term oral anticoagulationAssociated with increased morbidityLeft atrial appendage occlusionHeparin dripPeriprocedural managementPrompt diagnosisThrombus resolutionSafety profileRare caseWatchman deviceArterial thromboembolismAtrial fibrillationAtrial appendageLeft atriumPersistent AFibAtrial sideRisk factorsBlood clot formationThrombusPatientsTherapeutic interventions
2023
The Left Atrial Appendage and Atrial Fibrillation—A Contemporary Review
Sulague R, Whitham T, Danganan L, Effiom V, Candelario K, Latif N, Hameed I. The Left Atrial Appendage and Atrial Fibrillation—A Contemporary Review. Journal Of Clinical Medicine 2023, 12: 6909. PMID: 37959374, PMCID: PMC10650862, DOI: 10.3390/jcm12216909.Peer-Reviewed Original ResearchLeft atrial appendageAtrial appendageAtrial fibrillationClinical utilityThrombus formationAtrial appendage occlusionGood alternative treatmentProcedure's clinical utilityThromboembolism prophylaxisThromboembolic eventsAppendage occlusionAlternative treatmentPatientsFibrillationContemporary reviewProphylaxisSCAI/HRS expert consensus statement on transcatheter left atrial appendage closure
Saw J, Holmes D, Cavalcante J, Freeman J, Goldsweig A, Kavinsky C, Moussa I, Munger T, Price M, Reisman M, Sherwood M, Turi Z, Wang D, Whisenant B. SCAI/HRS expert consensus statement on transcatheter left atrial appendage closure. Heart Rhythm 2023, 20: e1-e16. PMID: 36990925, DOI: 10.1016/j.hrthm.2023.01.007.Peer-Reviewed Original ResearchSCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Saw J, Holmes D, Cavalcante J, Freeman J, Goldsweig A, Kavinsky C, Moussa I, Munger T, Price M, Reisman M, Sherwood M, Turi Z, Wang D, Whisenant B. SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure. JACC Cardiovascular Interventions 2023, 16: 1384-1400. PMID: 36990858, DOI: 10.1016/j.jcin.2023.01.011.Peer-Reviewed Original ResearchSCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Saw J, Holmes D, Cavalcante J, Freeman J, Goldsweig A, Kavinsky C, Moussa I, Munger T, Price M, Reisman M, Sherwood M, Turi Z, Wang D, Whisenant B. SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100577. PMID: 39130704, PMCID: PMC11307869, DOI: 10.1016/j.jscai.2022.100577.Peer-Reviewed Original ResearchAtrial appendage closureAppendage closureConsensus statementTranscatheter Left Atrial Appendage ClosureLeft atrial appendage closureImportant clinical trialsExpert consensus statementLeft atrial appendageCardiovascular Computed TomographyDrug Administration approvalEvidence-based best practicesThromboembolic riskWatchman deviceLAAC procedureAtrial fibrillationAtrial appendageAdministration approvalClinical trialsCardiovascular AngiographyAmerican CollegeComputed tomographyClinical developmentClinical practiceEndovascular devices
2022
Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis
Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. AJP Heart And Circulatory Physiology 2022, 323: h559-h568. PMID: 35960632, PMCID: PMC9576173, DOI: 10.1152/ajpheart.00083.2022.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionLA stiffnessAppendage occlusionLA appendageLA mechanicsTransesophageal echocardiographyPressure-volume analysisPercutaneous left atrial appendage occlusionAdverse atrial remodelingAtrial appendage occlusionLeft atrial appendageLA volume measurementsAtrial cardiomyopathyBaseline characteristicsLA complianceAtrial remodelingClinical outcomesAtrial appendageAtrial mechanicsCardiac performancePathophysiological roleBaseline parametersMagnitude of increaseAppendage sizeOcclusionRegional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction
Stacy MR, Lin BA, Thorn SL, Lobb DC, Maxfield MW, Novack C, Zellars KN, Freeburg L, Akar JG, Sinusas AJ, Spinale FG. Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm 2022, 19: 847-855. PMID: 35066183, PMCID: PMC9064890, DOI: 10.1016/j.hrthm.2022.01.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationMyocardial infarctionRight atrial regionsAtrial regionsPost-MIMMP activityMatrix metalloproteinasesMMP/TIMP profilesNew-onset atrial fibrillationLeft atrial regionsMMP/TIMP expressionLeft atrial appendageMatrix remodelingElectrical stimulation protocolFibrillar collagen contentExtracellular matrix remodelingAF vulnerabilityTIMP profilesAtrial appendagePostmyocardial infarctionMyocardial substrateStimulation protocolNoninvasive molecular imagingTIMP expressionTissue inhibitorIntraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion
Santana J, Rosell F, Dave B, Manafi A. Intraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion. Annals Of Cardiac Anaesthesia 2022, 25: 77-80. PMID: 35075025, PMCID: PMC8865348, DOI: 10.4103/aca.aca_192_20.Peer-Reviewed Original Research
2020
Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return
Ong CS, D’Alessandro DA, Cameron DE, Melnitchouk S. Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 672-674. PMID: 32853065, DOI: 10.1177/2150135120918785.Peer-Reviewed Original ResearchConceptsPartial anomalous pulmonary venous returnAnomalous pulmonary venous returnPulmonary venous returnTube graftVenous returnLeft-sided partial anomalous pulmonary venous returnPolytetrafluoroethylene tube graftLeft atrial appendageTension-free anastomosisPulmonary veinsAtrial appendageVenoatrial connectionsVertical veinGraftVeinPatientsAnastomosis
2019
Interatrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study
Goparaju A, Morris A, Csecs I, Bhalodia R, Ditter T, Fuimaono K, Kholmovski E, Marrouche N, Cates J, Elhabian S. Interatrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study. 2016 Computing In Cardiology Conference (CinC) 2019, 46: 1-3. PMID: 32632372, PMCID: PMC7338039, DOI: 10.22489/cinc.2019.439.Peer-Reviewed Original ResearchLeft atrial appendageLeft atrial appendage closureAtrial fibrillationInteratrial septumAtrial fibrillation patientsFibrillation patientsPatient-specific implant selectionImage guidanceOstium planeAtrial appendagePopulation studiesImplant choiceImplant selectionPrevent strokeAppendage ostiumPatientsCatheter designSeptumOstiumOcclusionDifferentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help?
Posada‐Martinez E, Trejo‐Paredes C, Ortiz‐Leon X, Ivey‐Miranda J, Lin BA, McNamara RL, Arias‐Godinez J, Lombo B, Sugeng L. Differentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help? Echocardiography 2019, 36: 1413-1417. PMID: 31260135, DOI: 10.1111/echo.14405.Peer-Reviewed Original Research
2018
Periprocedural Use of Oral Anticoagulation Therapy in Patients Undergoing Atrial Fibrillation Ablation
Maraj I, Gonzalez MD, Naccarelli GV. Periprocedural Use of Oral Anticoagulation Therapy in Patients Undergoing Atrial Fibrillation Ablation. Journal Of Innovations In Cardiac Rhythm Management 2018, 9: 3274-3281. PMID: 32477818, PMCID: PMC7252752, DOI: 10.19102/icrm.2018.090801.Peer-Reviewed Original ResearchAtrial fibrillationStroke preventionCatheter ablationLeft atrial appendage occlusion devicesAtrial appendage occlusion devicesRhythm control strategyOral anticoagulation therapyImportant treatment strategyRisk of strokeAtrial fibrillation ablationCommon sustained arrhythmiaLeft atrial appendageClinical practice todayOral anticoagulationPeriprocedural useAnticoagulation therapySurgical exclusionFibrillation ablationSustained arrhythmiaDrug optionsAtrial appendageTreatment strategiesHigh riskOcclusion devicePatientsLeft Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study
Yaghi S, Chang AD, Hung P, Mac Grory B, Collins S, Gupta A, Reynolds J, Finn CB, Hemendinger M, Cutting SM, McTaggart RA, Jayaraman M, Leasure A, Sansing L, Panda N, Song C, Chu A, Merkler A, Gialdini G, Sheth KN, Kamel H, Elkind MSV, Greer D, Furie K, Atalay M. Left Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 1497-1501. PMID: 29398537, DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.036.Peer-Reviewed Original ResearchConceptsLeft atrial appendageNoncardioembolic strokeLAA morphologyIschemic strokeEmbolic strokeStroke subtypesChest CTUndetermined sourcePilot studyComprehensive stroke centerMulticenter pilot studyNon-chicken wing LAA morphologyRetrospective pilot studyAtrial appendage morphologyInpatient diagnostic evaluationESUS criteriaClinical chest CTCardioembolic strokeCE strokeStroke centersConsecutive patientsAtrial fibrillationMean ageAtrial appendageDiagnostic evaluation
2017
Ablation of Advanced Subtypes of Atrial Fibrillation: Highlighting the Art of When and When Not to Perform Additional Ablation
Romero J, Avendano R, Natale A, Di Biase L. Ablation of Advanced Subtypes of Atrial Fibrillation: Highlighting the Art of When and When Not to Perform Additional Ablation. Current Cardiovascular Risk Reports 2017, 11: 19. DOI: 10.1007/s12170-017-0544-7.Peer-Reviewed Original ResearchPersistent atrial fibrillationLeft atrial appendageSuperior vena cavaNon-PV triggersAtrial fibrillationPV isolationCoronary sinusVena cavaDetailed activation mappingLAA electrical isolationLeft atrial septumPulmonary vein triggersObstructive sleep apneaPulmonary vein isolationParoxysmal atrial fibrillationAblation of sitesEctopic atrial activityPosterior LA wallEntire posterior wallTreatable causeVein isolationEsophageal damageSleep apneaAdvanced subtypesSinus rhythm
2016
Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL
Freeman JV, Hutton DW, Barnes GD, Zhu RP, Owens DK, Garber AM, Go AS, Hlatky MA, Heidenreich PA, Wang PJ, Al-Ahmad A, Turakhia MP. Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL. Circulation Arrhythmia And Electrophysiology 2016, 9: e003407. PMID: 27307517, PMCID: PMC4911813, DOI: 10.1161/circep.115.003407.Peer-Reviewed Original ResearchConceptsLAA closureLeft atrial appendageQuality-adjusted life yearsPROTECT AFAtrial fibrillationPercutaneous closureWatchman deviceAtrial appendageLife yearsTrial dataWATCHMAN LAA closure devicePROTECT AF trialIncremental cost-effectiveness ratioMajor adverse eventsPrevention of strokeAtrial appendage closureProspective Randomized EvaluationLAA closure deviceLong-term trial resultsQuality-adjusted survivalCost-effectiveness ratioCost-effectiveness resultsMedical anticoagulationAF trialAdverse events
2015
Combined percutaneous treatment of structural and congenital heart defects
Chamié F, Chamié D, do Nascimento Simões L, Mattos R. Combined percutaneous treatment of structural and congenital heart defects. Journal Of Transcatheter Interventions 2015, 23: 61-65. DOI: 10.1016/j.rbciev.2015.01.005.Peer-Reviewed Original ResearchPatent foramen ovaleSeptal defectOstium secundum atrial septal defectPulmonary valve stenosisCongenital heart defectsVentricular septal defectPatent ductus arteriosusAtrial septal defectLeft atrial appendageAortic coarctationResultsTen patientsAortopulmonary fistulaDuctus arteriosusHeart defectsValve stenosisTherapeutic optionsAtrial appendageCongenital defectsPercutaneous treatmentFollow-upForamen ovaleSpecialized centersConclusionsThe small numberCombined proceduresAged 1
2012
Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation
Solomon MD, Ullal AJ, Hoang DD, Freeman JV, Heidenreich P, Turakhia MP. Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation. Journal Of Cardiovascular Medicine 2012, 13: 86-96. PMID: 22193838, DOI: 10.2459/jcm.0b013e32834f23cf.Peer-Reviewed Original ResearchConceptsCost-effectiveness analysisAtrial fibrillationNonpharmacologic therapiesAtrial fibrillation-related strokeVitamin K antagonistsNew pharmacologic therapiesDirect thrombin inhibitorDevice-based therapiesLeft atrial appendageStroke Risk ProfileHealth policy recommendationsPercutaneous ligationStroke prophylaxisK antagonistsStroke preventionPharmacologic therapySurgical ligationAbnormal heart rhythmAntiplatelet agentsProphylaxis strategiesAtrial appendageRight atriumEndovascular implantationInvasive therapySystemic circulation
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