2025
The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study
Alhuneafat L, Al Ta'ani O, Arriola-Montenegro J, Al-Ajloun Y, Naser A, Chaponan-Lavalle A, Ordaya-Gonzales K, Pertuz G, Maaita A, Jabri A, Altibi A, Al-Abdouh A, Van't Hof J, Gutierrez Bernal A. The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study. International Journal Of Cardiology 2025, 428: 133143. PMID: 40064205, DOI: 10.1016/j.ijcard.2025.133143.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal Burden of DiseaseBurden of cardiovascular diseaseCardiovascular diseaseRisk factorsMortality-to-incidence ratioGlobal burdenIschemic heart diseaseAge-standardized disability-adjusted life yearsGlobal Burden of Disease StudyDisability-adjusted life year ratesBurden of Disease StudyAge-standardized prevalenceComparative risk assessment frameworkCardiovascular disease prevalenceCardiovascular disease burdenBurden of diseaseLeading risk factorHeart diseaseTailored interventionsCountry-specific variationsElevated BMIRate of strokeHealthcare infrastructureSocio-economic factorsNovel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve densityExamining multimorbidity contributors to dementia over time
Klee M, Markwardt S, Elman M, Han L, Leist A, Allore H, Quiñones A. Examining multimorbidity contributors to dementia over time. Alzheimer's & Dementia 2025, 21: e14589. PMID: 39988573, PMCID: PMC11847647, DOI: 10.1002/alz.14589.Peer-Reviewed Original ResearchConceptsAverage attributable fractionDementia incidenceDementia riskAttributable fractionChronic conditionsAssociated with increased risk of dementiaHealth and Retirement Study participantsMedicare fee-for-service beneficiariesAcute myocardial infarctionFee-for-service beneficiariesRetirement Study participantsRisk of dementiaPatterns of comorbiditiesAssociated with increased riskDementia casesMyocardial infarctionClaims algorithmIncident casesADRDStudy participantsIschemic heart diseaseDementiaConfidence intervalsMultimorbidityHeart diseaseUnderrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials
Ali T, Grimshaw A, Thomas A, Solomon M, Ross J, Miller P. Underrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials. European Heart Journal Acute Cardiovascular Care 2025, zuaf023. PMID: 39950988, DOI: 10.1093/ehjacc/zuaf023.Peer-Reviewed Original ResearchContemporary cardiac intensive care unitsRandomized controlled trialsIschemic heart diseaseCardiovascular diseaseHeart failureDisciplines of critical care medicineHistory of heart failureProspective randomized controlled trialsHeart diseaseControlled trialsExclusion criteriaMultivariate logistic regression analysisCardiac intensive care unitProportion of patientsExclusion of patientsComorbid cardiovascular diseaseCardiovascular disease historyIntensive care unitLogistic regression analysisApplication of randomized controlled trialsComplex patient populationGeneral internal medicineCardiovascular disease comorbiditiesMulticenter trialIndependent predictors
2024
HEALTH PROMOTION BEHAVIORS AMONG SPOUSAL CAREGIVERS WITH HIGH DAILY MANAGEMENT CHRONIC CONDITIONS
Cho J, Horstman M, Stevens A, Sands L, Allore H. HEALTH PROMOTION BEHAVIORS AMONG SPOUSAL CAREGIVERS WITH HIGH DAILY MANAGEMENT CHRONIC CONDITIONS. Innovation In Aging 2024, 8: 1060-1060. PMCID: PMC11693161, DOI: 10.1093/geroni/igae098.3409.Peer-Reviewed Original ResearchIntensity of caregivingHealth-promoting behaviorsSpousal caregiversPhysical activityChronic conditionsPromoting behaviorsManaging chronic conditionsDaily self-managementICD-10 codesFamily caregiversChronic obstructive pulmonary diseaseCaregiver distressCaregiving intensityCaregiving roleHealth behaviorsSelf-managementObstructive pulmonary diseaseDisease trajectoryCaregiversHealth responseStress managementIschemic heart diseaseICD-10Reduce burdenHealthIdentification of Gender Differences in Acute Myocardial Infarction Presentation and Management at Aga Khan University Hospital-Pakistan: Natural Language Processing Application in a Dataset of Patients With Cardiovascular Disease
Ngaruiya C, Samad Z, Tajuddin S, Nasim Z, Leff R, Farhad A, Pires K, Khan M, Hartz L, Safdar B. Identification of Gender Differences in Acute Myocardial Infarction Presentation and Management at Aga Khan University Hospital-Pakistan: Natural Language Processing Application in a Dataset of Patients With Cardiovascular Disease. JMIR Formative Research 2024, 8: e42774. PMID: 39705071, PMCID: PMC11699486, DOI: 10.2196/42774.Peer-Reviewed Original ResearchConceptsAMI symptomsAcute myocardial infarctionNatural language processingTertiary care hospitalAssess gender differencesCare hospitalAcute myocardial infarction presentationsMiddle-income countriesIdentification of gender differencesPrimary discharge diagnosisGender differencesMyocardial infarction presentationManagement of patientsNatural language processing applicationsDisproportionate burdenFuzzy matching techniqueHigher oddsLanguage processing applicationsDischarge summariesMedication prescriptionsClinical priorityIschemic heart diseaseDischarge diagnosisLMICsPrescribed statinsLong-Term Exposure to Arsenic in Community Water Supplies and Risk of Cardiovascular Disease among Women in the California Teachers Study
Medgyesi D, Bangia K, Spielfogel E, Fisher J, Madrigal J, Jones R, Ward M, Lacey J, Sanchez T. Long-Term Exposure to Arsenic in Community Water Supplies and Risk of Cardiovascular Disease among Women in the California Teachers Study. Environmental Health Perspectives 2024, 132: 107006. PMID: 39440943, PMCID: PMC11498017, DOI: 10.1289/ehp14410.Peer-Reviewed Original ResearchConceptsBody mass indexIschemic heart diseaseHazard ratioCardiovascular diseaseHealth care administrative recordsSmoking statusCalifornia Teachers Study cohortIschemic heart disease casesRisk of ischemic heart diseaseParticipant's residential addressNeighborhood socioeconomic statusCalifornia Teachers StudyCardiovascular disease casesCases of ischemic heart diseaseCardiovascular disease riskRisk of cardiovascular diseaseIncreased cardiovascular disease riskResidential addressesFollow-upSocioeconomic statusYears of ageStratified analysisBaseline ageTeachers StudyCommunity water suppliesAssociation between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm
Kano M, Nishibe T, Dardik A, Iwahashi T, Nakano Y, Shimahara Y. Association between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm. Annals Of Vascular Surgery 2024, 110: 255-264. PMID: 39341560, DOI: 10.1016/j.avsg.2024.07.110.Peer-Reviewed Original ResearchThoracic endovascular aortic repairPatients treated with thoracic endovascular aortic repairDegenerative thoracic aortic aneurysmsPreoperative neutrophil-lymphocyte ratioNeutrophil-lymphocyte ratioThoracic aortic aneurysmAll-cause mortalityEndovascular aortic repairAortic repairAortic aneurysmCut-off values of neutrophil-lymphocyte ratioOptimal cut-off values of neutrophil-lymphocyte ratioElevated preoperative neutrophil-lymphocyte ratioOverall mortalityValue of neutrophil-lymphocyte ratioOptimal cut-off valueAbsolute lymphocyte countAbsolute neutrophil countRisk of overall mortalityLikelihood of all-cause mortalityReceiver operating characteristic curveIschemic heart diseaseLymphocyte countStratify patientsNeutrophil countDiagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, PMCID: PMC11681466, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategiesQuality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial
Park D, Jamil Y, Moumneh M, Batchelor B W, Nanna M, Damluji A. Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial. The American Journal Of Cardiology 2024, 223: 58-69. PMID: 38797195, PMCID: PMC11214881, DOI: 10.1016/j.amjcard.2024.05.016.Peer-Reviewed Original ResearchDuke Activity Status IndexOlder adultsYears of follow-upStable ischemic heart diseaseIntensive medical therapyQoL measuresStatus indexIschemic heart diseaseDistress ratingsOlder adult populationOlder adult patientsBARI 2D trialDiabetes mellitusQuality of lifeQuality-of-lifeHeart diseaseMultivariate linear regressionFollow-upMedical therapyAdult populationQoLCognitive impairmentOlder patientsPost hoc analysisChronic total occlusionDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresAssociation between gestational diabetes and cardiovascular disease within 24 months postpartum
Ackerman-Banks C, Palmsten K, Lipkind H, Ahrens K. Association between gestational diabetes and cardiovascular disease within 24 months postpartum. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101366. PMID: 38580094, DOI: 10.1016/j.ajogmf.2024.101366.Peer-Reviewed Original ResearchGestational diabetes mellitusShort-term risks of cardiovascular diseaseRisk of cardiovascular diseaseGestational diabetesChronic hypertensionDiabetes mellitusMonths postpartumIschemic heart diseaseCardiovascular diseaseShort-term riskHeart failureEffect of gestational diabetes mellitusPre-gestational diabetes mellitusIncreased riskEffects of gestational diabetesDecreased risk of heart failureHeart diseaseCerebrovascular disease/strokePre-pregnancy diagnosisGestational age <Pregestational diabetes mellitusRisk of heart failurePremature cardiovascular morbidityLongitudinal population-based studyDevelopment of diabetes mellitusDietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study
Zheng J, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw Y, Tong T, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm C, Heath A, Ibsen D, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze M, Sieri S, Wareham N, Danesh J, Butterworth A, Forouhi N. Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study. American Journal Of Clinical Nutrition 2024, 119: 1164-1174. PMID: 38479550, PMCID: PMC11130694, DOI: 10.1016/j.ajcnut.2024.03.006.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseDietary protein intakeProtein intakeCase-cohort studyCardiovascular diseaseIncident cardiovascular diseaseFatal strokeAssociated with lower incidenceIncidence of fatal strokeRisk of cardiovascular diseaseEuropean Prospective InvestigationPrentice-weighted Cox regressionAssociated with incident cardiovascular diseaseOverall CVDIncident CVD casesIntake of plantMacronutrient intakeStroke incidenceProtein consumptionSubcohort membersIsocaloric substitutionDietary patternsDietary intakeNever smokersProspective InvestigationPsychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Gaffey A, Spatz E. Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan. Current Atherosclerosis Reports 2024, 26: 45-58. PMID: 38240928, PMCID: PMC11219074, DOI: 10.1007/s11883-023-01185-0.Peer-Reviewed Original ResearchConceptsIschemic heart disease riskPsychological healthIschemic heart diseasePsychosocial stressRisk of ischemic heart diseaseIschemic heart disease diagnosisPsychological factorsStudy of psychological factorsPositive psychological factorsOptimal psychological healthHeart diseaseSignificant life eventsIHD riskPsychosocial factorsSense of purposeWoman's riskPsychological screeningPsychological assessmentPsychological interventionsLife eventsSex-specific factorsSocial isolationHealthVulnerable groupsNarrative reviewBurden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019
Aminorroaya A, Moghaddam S, Tavolinejad H, Aryan Z, Heidari B, Ebrahimi H, Naderian M, Shobeiri P, Ghanbari A, Rezaei N, Malekpour M, Haghshenas R, Rezaei N, Larijani B, Farzadfar F. Burden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019. Journal Of The American Heart Association 2024, 13: e030165. PMID: 37956220, PMCID: PMC10926818, DOI: 10.1161/jaha.123.030165.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsBurden of ischemic heart diseaseDisability-adjusted life year ratesRates of ischemic heart diseaseIschemic heart diseaseRisk factorsMortality of ischemic heart diseaseEpidemiology of ischemic heart diseaseIschemic heart disease burdenHigh low-density lipoprotein cholesterolDietary risk factorsLost disability-adjusted life yearsYears of lifeHeart diseaseGBD studyPremature mortalityLow-density lipoprotein cholesterolSystolic blood pressureHighest burdenMetabolic riskBehavioral risksLife yearsPremature deathContemporary epidemiologyLipoprotein cholesterol
2023
Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial
Jamil Y, Park D, Verde L, Sherwood M, Tehrani B, Batchelor W, Frampton J, Damluji A, Nanna M. Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial. The American Journal Of Cardiology 2023, 214: 66-76. PMID: 38160927, PMCID: PMC10923116, DOI: 10.1016/j.amjcard.2023.12.045.Peer-Reviewed Original ResearchStable ischemic heart diseaseAnti-anginal agentIntensive medical therapyIschemic heart diseaseMedical therapyQOL metricsHeart diseaseFindings merit further researchMajor adverse cardiovascular eventsAnti-anginal treatmentBARI 2D trialGreater QoL improvementAdverse cardiovascular eventsMyocardial jeopardy indexCardiovascular eventsCause mortalityCardiovascular endpointsClinical confoundersPatient characteristicsDiabetes mellitusHeart failureTherapy intensityClinical outcomesQOL improvementMyocardial infarctionBeyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease
Kalra K, Moumneh M, Nanna M, Damluji A. Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease. Frontiers In Cardiovascular Medicine 2023, 10: 1276370. PMID: 38045910, PMCID: PMC10690830, DOI: 10.3389/fcvm.2023.1276370.Peer-Reviewed Original ResearchStable ischemic heart diseaseIschemic heart diseaseClinical trialsOlder adult populationOlder adultsHeart diseaseHealth outcomesAdult populationMajor adverse cardiovascular outcomesHigh cardiovascular riskAdverse cardiovascular outcomesMultiple chronic diseasesPatient-centered approachCardiovascular clinical trialsPoor health outcomesMore effective careQuality of lifeHolistic health outcomesCardiovascular outcomesCardiovascular riskGeriatric syndromesRandomized trialsPatient populationPatient preferencesChronic diseasesCurrent Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review
Chuy K, Velazquez E, Lansky A, Jamil Y, Ahmad Y. Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101197. PMID: 39131064, PMCID: PMC11307589, DOI: 10.1016/j.jscai.2023.101197.Peer-Reviewed Original ResearchIschemic systolic heart failureSystolic heart failurePercutaneous coronary interventionHeart failureMedical therapyCoronary revascularizationBenefits of PCITrials of PCILeft ventricular systolic dysfunctionPrevalence of HFBenefit of CABGContemporary medical therapyIschemic ventricular dysfunctionCoronary artery bypassVentricular systolic dysfunctionCoronary artery diseaseIschemic heart diseaseAcute cardiac careComparative clinical effectivenessUnmet clinical needRecent revascularizationArtery bypassSystolic dysfunctionVentricular dysfunctionCoronary interventionSGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injury
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