2025
Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient age
2024
Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis
Sayeed S, Theriault B, Hengartner A, Serrato P, Sadeghzadeh S, Belkasim S, Ahsan N, Elsamadicy E, DiLuna M, Elsamadicy A. Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. Child's Nervous System 2024, 40: 3571-3580. PMID: 38955900, DOI: 10.1007/s00381-024-06514-5.Peer-Reviewed Original ResearchNational Inpatient SampleIntraoperative variablesLong-term neurodevelopmental outcomesLow gestational ageMultivariate logistic regression analysisPermanent CSF shuntNational database analysisLow birth weightPercentage of patientsRetrospective cohort studyAssociated with decreased oddsImpact of insurance statusAssociated with reduced oddsMedian total costAssociated with mortalityLogistic regression analysisBackgroundIntraventricular hemorrhageNeonatal IVHGestational ageIntraventricular hemorrhageNeurodevelopmental outcomesCSF diversionCSF shuntingCost of admissionBirth weightInsurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage
Sayeed S, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Insurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage. World Neurosurgery 2024, 189: e46-e54. PMID: 38815926, DOI: 10.1016/j.wneu.2024.05.136.Peer-Reviewed Original ResearchIntraventricular hemorrhagePI patientsInsurance statusAssociated with surgical delayDiagnosis of intraventricular hemorrhageMultivariate logistic regression analysisNeonatal intraventricular hemorrhageAssociated with increased healthcare utilizationNational Inpatient Sample databaseRetrospective cohort studyImpact of insurance statusTime to referralAssociated with increased oddsInpatient Sample databaseAssociation of insurance statusLogistic regression analysisLength of stayMyelomeningocele repairSurgical delayCost of admissionAdverse eventsPrivate insuranceCohort studyMedicaid patientsPI cohortReduced racial disparities among newborns with intraventricular hemorrhage
Sayeed S, Reeves B, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Reduced racial disparities among newborns with intraventricular hemorrhage. Child's Nervous System 2024, 40: 2051-2059. PMID: 38526575, DOI: 10.1007/s00381-024-06369-w.Peer-Reviewed Original ResearchLength of stayIntroductionIntraventricular hemorrhageAdverse eventsMultivariate logistic regression analysisRate of adverse eventsPermanent neurological dysfunctionProlonged length of stayNational Inpatient Sample databaseRates of NECInpatient Sample databaseLogistic regression analysisIntraventricular hemorrhageAA patientsImpact of raceCost of admissionIndependent predictorsRate of mortalityPatient characteristicsMultivariate analysisPercentage of AAWhite patientsNeurological dysfunctionNewbornsPatient genderPatients
2023
In Situ Simulation and Clinical Outcomes in Infants Born Preterm
Chitkara R, Bennett M, Bohnert J, Yamada N, Fuerch J, Halamek L, Quinn J, Padua K, Gould J, Profit J, Xu X, Lee H. In Situ Simulation and Clinical Outcomes in Infants Born Preterm. The Journal Of Pediatrics 2023, 263: 113715. PMID: 37659586, PMCID: PMC10841094, DOI: 10.1016/j.jpeds.2023.113715.Peer-Reviewed Original ResearchConceptsChronic lung diseaseClinical outcomesNeonatal resuscitationDelivery room continuous positive airway pressureVery low birth weight birthsNeonatal intensive care unit admissionCalifornia Perinatal Quality Care CollaborativeContinuous positive airway pressureVery low birth weightSecondary outcomesNeonatal intensive care unitInfants born pretermLow birth weight birthsSevere intraventricular hemorrhageIntensive care unit admissionPositive airway pressureLow birth weightInfant born pretermEvaluate clinical outcomesIntensive care unitParticipating sitesIntraventricular hemorrhageWeeks gestationBorn pretermCollaborative quality improvement projectA 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit
Berson E, Mozayan A, Peterec S, Taylor S, Bamford N, Ment L, Rowe E, Lisse S, Ehrlich L, Silva C, Goodman T, Payabvash S. A 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit. Frontiers In Neuroscience 2023, 17: 1132173. PMID: 36845429, PMCID: PMC9951115, DOI: 10.3389/fnins.2023.1132173.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitIntraventricular hemorrhageCare unitHypoxic injuryIntracranial pathologyAverage gestational ageParenchymal injuryPreterm neonatesCommon indicationIschemic lesionsNICU patientsGestational ageClinical findingsPatient weightInfantsTranscranial ultrasoundMRIInjuryCareMicrohemorrhagesScansLesionsFollowPathology467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants
Weaver L, Gentle S, Shukla V, Nakhmani A, Rahman F, Ambalavanan N, Askenazi D, Travers C. 467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants. The American Journal Of The Medical Sciences 2023, 365: s252. DOI: 10.1016/s0002-9629(23)00474-3.Peer-Reviewed Original ResearchSevere intraventricular hemorrhagePreterm infantsIntraventricular hemorrhageFluid statusPretermHemorrhageInfants
2022
One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability
Shah VA, Thompson RE, Yenokyan G, Acosta JN, Avadhani R, Dlugash R, McBee N, Li Y, Hansen BM, Ullman N, Falcone G, Awad IA, Hanley DF, Ziai WC. One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability. JAMA Neurology 2022, 79: 856-868. PMID: 35877105, PMCID: PMC9316056, DOI: 10.1001/jamaneurol.2022.1991.Peer-Reviewed Original ResearchConceptsSevere intracerebral hemorrhagePhase 3 trialIntracerebral hemorrhageIntraventricular hemorrhagePoor functional outcomeHospital eventsBetter outcomesDay 30Functional recoveryPoor outcomeFunctional outcomeLong-term functional recoverySevere disabilityMultivariable logistic regression modelHealth Stroke ScaleAcute ischemic strokeCerebral perfusion pressureRankin Scale scoreStandard medical careIndividual patient dataOverall mean ageIntracranial pressure monitoringLogistic regression modelsIntraventricular alteplaseMISTIE IIIDoes Antenatal Progesterone Administration Modify the Risk of Neonatal Intraventricular Hemorrhage?
Leon-Martinez D, Bank TC, Lundsberg LS, Culhane J, Silasi M, Son M, Partridge C, Reddy UM, Hoffman MK, Merriam A. Does Antenatal Progesterone Administration Modify the Risk of Neonatal Intraventricular Hemorrhage? American Journal Of Perinatology 2022, 41: e46-e52. PMID: 35436803, DOI: 10.1055/a-1827-6712.Peer-Reviewed Original ResearchNeonatal intraventricular hemorrhageIntraventricular hemorrhageBrain injuryOdds ratioDiagnosis of IVHRisk of IVHImproved neurological outcomeNeonatal brain injuryLarge academic medical centerConfidence intervalsRoute of deliveryEffect of progesteroneTraumatic brain injuryAcademic medical centerHospitalization encountersNeurological outcomePreterm neonatesSingleton deliveriesMaternal administrationProgesterone administrationRetrospective studyAntepartum periodLow birthweightPotential confoundersDiagnosis codesAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
Kuramatsu JB, Gerner ST, Ziai W, Bardutzky J, Sembill JA, Sprügel MI, Mrochen A, Kölbl K, Ram M, Avadhani R, Falcone GJ, Selim MH, Lioutas VA, Endres M, Zweynert S, Vajkoczy P, Ringleb PA, Purrucker JC, Volkmann J, Neugebauer H, Erbguth F, Schellinger PD, Knappe UJ, Fink GR, Dohmen C, Minnerup J, Reichmann H, Schneider H, Röther J, Reimann G, Schwarz M, Bäzner H, Claßen J, Michalski D, Witte OW, Günther A, Hamann GF, Lücking H, Dörfler A, Ishfaq MF, Chang JJ, Testai FD, Woo D, Alexandrov AV, Staykov D, Goyal N, Tsivgoulis G, Sheth KN, Awad IA, Schwab S, Hanley DF, Huttner HB, Sansing L, Matouk C, Leasure A, Sobesky J, Bauer M, Schurig J, Rizos T, Haeusler K, Müllges W, Kraft P, Schubert A, Stösser S, Ludolph A, Nueckel M, Glahn J, Stetefeld H, Rahmig J, Fisse A, Michels P, Schwert H, Hagemann G, Rakers F, Wöhrle J, Alshammari F, Horn M, Bahner D, Urbanek C, Palm F, Grau A. Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis. Stroke 2022, 53: 2876-2886. PMID: 35521958, PMCID: PMC9398945, DOI: 10.1161/strokeaha.121.038455.Peer-Reviewed Original ResearchConceptsAbsolute treatment effectStandard of careIntraventricular fibrinolysisIntracerebral hemorrhageIntraventricular hemorrhagePrimary outcomeAcute hydrocephalusAdverse eventsFunctional disabilityIVF treatmentFunctional outcomeOdds ratioOrdinal shift analysisIndividual Participant Data Meta-AnalysisModified Rankin ScaleExternal ventricular drainageImproved functional outcomesData Meta-AnalysisPromising therapeutic targetTreatment effectsIndividual participant dataCause mortalityRankin ScaleSecondary outcomesSymptom onset7 The Genetics of Disorders Affecting the Premature Newborn
Prosnitz A, Gruen J, Bhandari V. 7 The Genetics of Disorders Affecting the Premature Newborn. 2022, 149-185. DOI: 10.1016/b978-0-12-815236-2.00006-0.Peer-Reviewed Original ResearchCommon disorderPatent ductus arteriosusRespiratory distress syndromeRetinopathy of prematurityMultiple gene-environment interactionsPathogenesis of disordersBronchopulmonary dysplasiaPreterm infantsDistress syndromeIntraventricular hemorrhageNecrotizing enterocolitisDuctus arteriosusIL-10Premature birthPremature newbornsIL-1βIL-6IGF-1RIL-4RαGene-environment interactionsPrematurityGenetics of disordersReactive oxygen speciesDisordersSurfactant proteins
2021
Idiopathic primary intraventricular hemorrhage and cerebral small vessel disease
Das A, Regenhardt R, Gokcal E, Horn M, Daoud N, Schwab K, Rost N, Viswanathan A, Kimberly W, Goldstein J, Biffi A, Schwamm L, Rosand J, Greenberg S, Gurol M. Idiopathic primary intraventricular hemorrhage and cerebral small vessel disease. International Journal Of Stroke 2021, 17: 645-653. PMID: 34427471, PMCID: PMC10947797, DOI: 10.1177/17474930211043957.Peer-Reviewed Original ResearchConceptsCerebral small vessel diseaseCerebral amyloid angiopathyPrimary intraventricular hemorrhageIdiopathic primary intraventricular hemorrhageProbable cerebral amyloid angiopathyAmyloid angiopathySmall vessel diseaseIntraventricular hemorrhageVessel diseaseMean initial blood pressureNon-traumatic intracerebral hemorrhageBrain magnetic resonance imagingInitial blood pressurePrimary intraparenchymal hemorrhageSingle referral centerBrain magnetic resonanceMagnetic resonance imagingCSVD subtypesBoston criteriaReferral centerBlood pressureConsecutive patientsCerebral amyloidIntracerebral hemorrhageIntraparenchymal hemorrhageEarly Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage
Ziai WC, Parry-Jones AR, Thompson CB, Sansing LH, Mullen MT, Murthy SB, Mould A, Nekoovaght-Tak S, Hanley DF. Early Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage. Biomolecules 2021, 11: 1123. PMID: 34439789, PMCID: PMC8394793, DOI: 10.3390/biom11081123.Peer-Reviewed Original ResearchConceptsIL-10IL-6IL-1βIL-8Cerebrospinal fluidIntraventricular hemorrhageDay 1IVH volumeCerebral inflammatory responsePerihematomal edema volumePro-inflammatory markersExternal ventricular drainageInflammatory cytokine expressionSpontaneous intraventricular hemorrhageChemokine ligands CCL2Tumor necrosis factorEnzyme-linked immunosorbentCSF cytokinesRelative PHELigand CCL2Obstructive hydrocephalusVentricular drainageEdema volumeCytokine expressionICH volumeNovel Score for Stratifying Risk of Critical Care Needs in Patients With Intracerebral Hemorrhage
Faigle R, Chen BJ, Krieger R, Marsh EB, Alkhachroum A, Xiong W, Urrutia VC, Gottesman RF. Novel Score for Stratifying Risk of Critical Care Needs in Patients With Intracerebral Hemorrhage. Neurology 2021, 96: e2458-e2468. PMID: 33790039, PMCID: PMC8205477, DOI: 10.1212/wnl.0000000000011927.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood PressureCerebral HemorrhageCerebral Intraventricular HemorrhageCritical CareFemaleGlasgow Coma ScaleHumansIntensive Care UnitsLength of StayLogistic ModelsMaleMiddle AgedNeeds AssessmentRetrospective StudiesRisk AssessmentRisk FactorsTomography, X-Ray ComputedTriageConceptsCritical care needsSystolic blood pressureIntensive care unitCritical care interventionsIntracerebral hemorrhageIntraventricular hemorrhageValidation cohortCare needsLower riskIndependent predictorsICH volumeCare interventionsCritical careRisk scorePresence of IVHGlasgow Coma Scale scoreEmergency department stayClass II evidenceExternal validation cohortIntracerebral Hemorrhage ScoreRisk prediction scoreGCS 8SBP 160Stratifying RiskStrength of associationIntracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset
Witsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset. Neurocritical Care 2021, 35: 418-427. PMID: 33479920, PMCID: PMC8578176, DOI: 10.1007/s12028-020-01180-2.Peer-Reviewed Original ResearchConceptsLoss of consciousnessIntraventricular hemorrhageIntracerebral hemorrhageSymptom onsetICH onsetUnfavorable outcomeAdmission Glasgow Coma ScoreAdmission systolic blood pressureOnset of ICHGlasgow Coma ScoreSystolic blood pressureSpontaneous intracerebral hemorrhageAdmission serum glucoseThousand seven hundredVolumetric CT measurementsBackgroundIn patientsComa ScoreBlood pressureMedical chartsICH volumeMental statusSerum glucoseICH casesInclusion criteriaPatients
2020
Pediatric Hemovigilance and Adverse Transfusion Reactions
Sostin N, Hendrickson JE. Pediatric Hemovigilance and Adverse Transfusion Reactions. Clinics In Laboratory Medicine 2020, 41: 51-67. PMID: 33494885, DOI: 10.1016/j.cll.2020.10.004.Peer-Reviewed Original ResearchConceptsTransfusion reactionsBronchopulmonary dysplasia/chronic lung diseaseChronic lung diseaseNonhemolytic transfusion reactionsAdverse transfusion reactionsIntraventricular hemorrhagePediatric populationLung diseasePulmonary reactionsAllergic reactionsPreventive strategiesHemovigilance systemMale childrenAdult populationChildrenTransfusionHemorrhageNeonatesPathophysiologyPopulationHemovigilancePediatricsDisease
2019
Resource utilisation among patients transferred for intracerebral haemorrhage
Zachrison K, Aaronson E, Mahmood S, Rosand J, Viswanathan A, Schwamm L, Goldstein J. Resource utilisation among patients transferred for intracerebral haemorrhage. Stroke And Vascular Neurology 2019, 4: 223. PMID: 32030206, PMCID: PMC6979870, DOI: 10.1136/svn-2019-000255.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAge FactorsAgedAged, 80 and overCerebral HemorrhageCritical CareFemaleGlasgow Coma ScaleHumansIntensive Care UnitsMaleMiddle AgedNeurosurgical ProceduresPatient AdmissionPatient TransferProspective StudiesRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsGlasgow Coma ScoreIntracerebral hemorrhageSurgical interventionICH scoreAcademic hospitalBaseline Glasgow Coma ScoreIntensive care unit admissionCare unit admissionSingle academic hospitalPrimary intracerebral hemorrhageUrban academic hospitalLess frequent useCollected registryICU stayUnit admissionComa ScoreConsecutive patientsIntraventricular hemorrhagePrimary outcomePrimary patientsPatientsHospitalLogistic regressionHemorrhageResource utilisation
2018
Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial.
Phelps D, Watterberg K, Nolen T, Cole C, Cotten C, Oh W, Poindexter B, Zaterka-Baxter K, Das A, Lacy C, Scorsone A, Walsh M, Bell E, Kennedy K, Schibler K, Sokol G, Laughon M, Lakshminrusimha S, Truog W, Garg M, Carlo W, Laptook A, Van Meurs K, Carlton D, Graf A, DeMauro S, Brion L, Shankaran S, Orge F, Olson R, Mintz-Hittner H, Yang M, Haider K, Wallace D, Chung M, Hug D, Tsui I, Cogen M, Donahue J, Gaynon M, Hutchinson A, Bremer D, Quinn G, He Y, Lucas W, Winter T, Kicklighter S, Kumar K, Chess P, Colaizy T, Hibbs A, Ambalavanan N, Harmon H, McGowan E, Higgins R. Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial. JAMA 2018, 320: 1649-1658. PMID: 30357297, DOI: 10.1001/jama.2018.14996.Peer-Reviewed Original ResearchConceptsType 1 ROPWeeks gestational ageMyo-inositol groupGestational ageRandomized clinical trialsIntraventricular hemorrhagePremature infantsPlacebo groupRespiratory distressType 1 retinopathy of prematuritySeverity of retinopathy of prematurityClinical trialsEfficacy of myo-inositolNeonatal intensive care centersPreterm infants <Retinopathy of prematurityWeeks postmenstrual ageMyo-inositolDose of myo-inositolAll-cause deathIntensive care centersEffect of myo-inositolROP outcomePostmenstrual agePreterm infantsSeizures, periodic and rhythmic patterns in primary intraventricular hemorrhage
Stretz C, Sheikh Z, Maciel CB, Hirsch LJ, Gilmore EJ. Seizures, periodic and rhythmic patterns in primary intraventricular hemorrhage. Annals Of Clinical And Translational Neurology 2018, 5: 1104-1111. PMID: 30250866, PMCID: PMC6144442, DOI: 10.1002/acn3.627.Peer-Reviewed Original ResearchPrimary intraventricular hemorrhageFrequency of seizuresIctal-interictal continuumAntiseizure medicationsIntraventricular hemorrhageCEEG monitoringExternal ventricular drain placementPresence of hydrocephalusRhythmic EEG patternsVentricular drain placementCEEG durationCEEG patternsMedian ageNeuronal injuryElectrographic seizuresDrain placementRisk factorsOnly significant differenceGraeb scoreContinuous electroencephalographyCEEG recordingsSeizuresPatientsPeriodic dischargesEEG patterns
2017
Intracerebral Hemorrhage with Intraventricular Extension—Getting the Prognosis Right Early
Stretz C, Gao C, Greer DM, Loomis C, Gilmore EJ, Kundishora AJ, Matouk CC, Hwang DY. Intracerebral Hemorrhage with Intraventricular Extension—Getting the Prognosis Right Early. Frontiers In Neurology 2017, 8: 418. PMID: 28861039, PMCID: PMC5562676, DOI: 10.3389/fneur.2017.00418.Peer-Reviewed Original ResearchIntraventricular hemorrhageIntracerebral hemorrhageClinical trajectoriesCerebrospinal fluidSupportive ICU careSignificant intraventricular hemorrhageLimitation of carePatient's clinical trajectoryInpatient neurologistsAcute hydrocephalusICU careConservative managementOutcome prognosticationSignificant morbidityICH patientsCSF diversionIntraventricular extensionCare existClinical examPatientsHemorrhagePrognosisCareExamMorbidity
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