2025
Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes
Johnson B, Allen M, Nader S, Sai K, Kumar A, Su Y, Singh S, Li S, Huang Y, Deep G, Nader M. Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes. Biological Psychiatry 2025 PMID: 40054763, DOI: 10.1016/j.biopsych.2025.02.900.Peer-Reviewed Original ResearchLong-term cocaine self-administrationKappa-opioid receptorsCocaine self-administrationSelf-administrationKappa opioid receptor availabilityPeripheral measuresSocially housed monkeysOpioid receptorsCocaine intakeCocaine SAIntravenous cocaineCocaine misuseBrain regionsCocainePET imagingCynomolgus monkeysSocial rankPET studiesPharmacological interventionsMonkeysPET scansBrainBlood samplesDominant femalesSocial
2023
Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors
Angarita G, Pittman B, Nararajan A, Mayerson T, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors. Drug And Alcohol Dependence 2023, 250: 110898. PMID: 37523916, PMCID: PMC10905422, DOI: 10.1016/j.drugalcdep.2023.110898.Peer-Reviewed Original Research
2010
Locomotion and Self-Administration Induced by Cocaine in 129/OlaHsd Mice Lacking Galanin
Brabant C, Kuschpel AS, Picciotto MR. Locomotion and Self-Administration Induced by Cocaine in 129/OlaHsd Mice Lacking Galanin. Behavioral Neuroscience 2010, 124: 828-838. PMID: 21038934, PMCID: PMC3058554, DOI: 10.1037/a0021221.Peer-Reviewed Original ResearchConceptsGal KO miceCocaine-induced hyperactivityGalanin receptor agonistCocaine-induced hyperlocomotionSpontaneous motor activityGalanin knockout miceEffects of cocaineDrug takersDoses of cocaineDrugs of abuseSelf-administer cocaineGalanin systemReceptor agonistLocomotor effectsKnockout miceGalaninIntravenous cocaineMotor activityFixed ratio scheduleSelf-AdministrationGenetic deletionMiceCocaineDifferent schedulesRatio schedule
2006
Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice
Steiner RC, Hsiung HM, Picciotto MR. Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice. Behavioural Brain Research 2006, 171: 56-62. PMID: 16621045, DOI: 10.1016/j.bbr.2006.03.022.Peer-Reviewed Original ResearchConceptsKnockout miceLocomotor sensitizationCocaine-induced locomotor sensitizationAmphetamine-regulated transcriptEffects of psychostimulantsRange of dosesAcute cocaineBone resorptionAmphetamine injectionsNucleus accumbensIntravenous cocaineIntact animalsMiceCocaineSchedule of reinforcementInsulin regulationCART geneSensitizationWild-type siblingsPhysiological functionsRegulatory roleStriatumAccumbensPsychostimulantsRats
2005
A paradigm to investigate the self-regulation of cocaine administration in humans
Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ, Self D, Jatlow P, Malison RT. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology 2005, 180: 436-446. PMID: 15726333, DOI: 10.1007/s00213-005-2192-8.Peer-Reviewed Original ResearchConceptsCocaine administrationCocaine infusionsEscalating-dose regimenSignificant adverse eventsEffective pharmacological treatmentFixed ratio 1Dose-response relationshipCocaine-taking behaviorAnalgesia methodsAdverse eventsMeasures of cocainePharmacological treatmentNarcotic analgesicsCocaine doseIntravenous cocaineCocaine addictionLess cocaineDrug accessCocaineCocaine usersTest daySignificant main effectInfusionAdministrationSession duration
2001
Intravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users
1993
Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study
Rosen M, Pearsall H, McDougle C, Price L, Woods S, Kosten T. Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 1993, 19: 451-464. PMID: 8273766, DOI: 10.3109/00952999309001634.Peer-Reviewed Original Research
1987
Marijuana and cocaine interactions in humans: Cardiovascular consequences
Foltin R, Fischman M, Pedroso J, Pearlson G. Marijuana and cocaine interactions in humans: Cardiovascular consequences. Pharmacology Biochemistry And Behavior 1987, 28: 459-464. PMID: 2829241, DOI: 10.1016/0091-3057(87)90506-5.Peer-Reviewed Original ResearchConceptsMean arterial pressureCombination of cocaineHeart rateArterial pressureBaseline cardiovascular indexesAdult male volunteersDose-dependent increaseDoses of cocaineCardiovascular consequencesResearch wardBlood levelsMale volunteersDaily experimental sessionsMarijuana smokingCocaine interactionsIntravenous cocaineCardiovascular indicesMarijuana cigarettesCocaineCocaine hydrochlorideDependent increaseSimilar increaseMarijuanaExperimental sessionsSmoking
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