2025
Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy
Ezzeldin M, Hukamdad M, Kasem R, Ezzeldin R, Maier I, T A, Jabbour P, Kim J, Howard B, Alawieh A, Wolfe S, Starke R, Psychogios M, Shaban A, Goyal N, Dye J, Alaraj A, Yoshimura S, Fiorella D, Tanweer O, Romano D, Navia P, Cuellar H, Fragata I, Polifka A, Mascitelli J, Osbun J, Siddiqui F, Moss M, Limaye K, Mokin M, Matouk C, Park M, Brinjikji W, Daglioglu E, Williamson R, Altschul D, Ogilvy C, Crosa R, Levitt M, Gory B, Grandhi R, Paul A, Kan P, Casagrande W, Chowdhry S, Stiefel M, Chaubal V, Spiotta A. Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy. Journal Of NeuroInterventional Surgery 2025, jnis-2024-022781. PMID: 39884851, DOI: 10.1136/jnis-2024-022781.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageTrevo stent retrieverContact aspirationStent retrieverAcute ischemic strokeEndovascular thrombectomyRecanalization rateFunctional outcomesAssociated with higher recanalization ratesOdds of symptomatic intracranial hemorrhageHigher recanalization ratesAssociated with higher oddsEndovascular thrombectomy patientsContact aspiration techniqueIntracranial hemorrhageMulticenter registryRecanalizationReduced oddsStroke thrombectomyHigher oddsIschemic strokeThrombectomyAspiration techniqueBailout strategyOddsEmergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study
Sousa J, Rodrigo-Gisbert M, Shu L, Luo A, Xiao H, Mahmoud N, Shah A, Santos A, Moore M, Mandel D, Heldner M, Barata V, Bernardo-Castro S, Henninger N, Muppa J, Arnold M, Nehme A, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Metanis I, Leker R, Nolte C, Ghannam M, Samaniego E, Almajali M, Poppe A, Romoli M, Frontera J, Zedde M, Kam W, Mac Grory B, Velez F, Ranasinghe T, Siegler J, Zubair A, Marto J, Klein P, Nguyen T, Abdalkader M, Mantovani G, Simpkins A, Sen S, Elnazeir M, Yaghi S, Sargento-Freitas J, Requena M. Emergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study. Stroke 2025, 56: 808-817. PMID: 39882629, DOI: 10.1161/strokeaha.124.048295.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageCarotid artery dissectionEmergent carotid stentingIntracranial recanalizationAcute ischemic strokeCervical carotid artery dissectionEndovascular treatmentIntracranial hemorrhageTandem occlusionEmergency stentingArtery dissectionCarotid stentingIschemic strokeAnterior circulation acute ischemic strokePatients treated with endovascular treatmentIncreased symptomatic intracranial hemorrhageAlberta Stroke Program Early CT ScoreCervical carotid dissectionInverse probability of treatment weightingFunctional independenceProbability of treatment weightingNational Institutes of Health Stroke ScaleSecondary to dissectionHealth Stroke ScaleMixed-effects logistic regressionMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, jnis-2024-022677. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsEfficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
Prolonged intracranial catheter dwell time exacerbates penumbral stress and worsens stroke thrombectomy outcomes
Alawieh A, Elawady S, Zohdy Y, Chalhoub R, Cunningham C, Howard B, Cawley C, Barrow D, Akbik F, Pabaney A, Tong F, Al Kasab S, Jabbour P, Goyal N, Arthur A, Siddiqui F, Yoshimura S, Park M, Brinjikji W, Matouk C, Romano D, Altschul D, Williamson R, Moss M, De Leacy R, Ezzeldin M, Kan P, Levitt M, Grandhi R, Mascitelli J, Grossberg J, Spiotta A. Prolonged intracranial catheter dwell time exacerbates penumbral stress and worsens stroke thrombectomy outcomes. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022271. PMID: 39542713, DOI: 10.1136/jnis-2024-022271.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageAcute ischemic strokeModified Rankin ScaleMechanical thrombectomyRecanalization successIncreasing SICHDuration of catheter useBlood flowCatheter dwell timeNegative predictors of outcomeAnalysis of patientsMulticenter international registryPropensity scorePredictors of outcomeInternal carotid arteryCerebral artery blood flowMiddle cerebral arteryArtery blood flowIn vitro modelIntracranial hemorrhageCatheter placementCatheter useCaliber catheterProcedure timeAIS patientsEndovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score
Galecio-Castillo M, Farooqui M, Guerrero W, Ribo M, Hassan A, Jumaa M, Divani A, Abraham M, Petersen N, Fifi J, Malik A, Siegler J, Nguyen T, Sheth S, Linares G, Janjua N, Soomro J, Quispe-Orozco D, Olivé-Gadea M, Tekle W, Zaidi S, Sabbagh S, Barkley T, Prasad A, De Leacy R, Abdalkader M, Salazar-Marioni S, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal D, Yoo A, Sarraj A, Jovin T, Ortega-Gutierrez S. Endovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score. Journal Of The American Heart Association 2024, 13: e035977. PMID: 39508172, PMCID: PMC11681390, DOI: 10.1161/jaha.124.035977.Peer-Reviewed Original ResearchLower Alberta Stroke Program Early Computed Tomography ScoreAlberta Stroke Program Early Computed Tomography ScoreModified Rankin ScaleComputed Tomography ScoreSymptomatic intracranial hemorrhageEndovascular thrombectomyIntracranial hemorrhageTandem lesionsBaseline Alberta Stroke Program Early Computed Tomography ScoreAnterior circulation tandem lesionsModified Rankin Scale shiftModified Rankin Scale 0 to 2Score 0 to 2Safety of endovascular thrombectomySymptomatic intracranial hemorrhage riskOdds of symptomatic intracranial hemorrhageEndovascular treatment of patientsAcute large-vessel occlusionInternal carotid artery stenosis/occlusionIntracranial hemorrhage riskRetrospective analysis of dataProportion of patientsTreatment of patientsOrdinal modified Rankin ScaleAssociated with reduced oddsPreventing Long-Term Neurologic Disability in Hemophilia (A): Cost-Effectiveness of Emicizumab Prophylaxis for the Prevention of Intracranial Hemorrhage in Infants with Severe Hemophilia (A)
Glaeser-Khan S, Richmond R, Ito S, Bona R, Krumholz H, Cuker A, Goshua G. Preventing Long-Term Neurologic Disability in Hemophilia (A): Cost-Effectiveness of Emicizumab Prophylaxis for the Prevention of Intracranial Hemorrhage in Infants with Severe Hemophilia (A). Blood 2024, 144: 157-157. DOI: 10.1182/blood-2024-203690.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioStandard-of-careStandard half-lifeEmicizumab prophylaxisSevere hemophilia AIntracranial hemorrhageIntracranial hemorrhage incidenceSevere HAHemophilia AProbabilistic sensitivity analysesYears of agePrevention of intracranial hemorrhageNeurological disabilityPrevent intracranial hemorrhageIntracranial hemorrhage eventsIntracranial hemorrhage riskPhase III studyBase-casePersistent neurological disabilityAged 1 monthFactor VIII replacementStandard-of-care armUS societal perspectiveInfants aged 0Aged 0Acute Stroke Treatment: Thrombectomy
Veltri N, Elnazer S, De Havenon A. Acute Stroke Treatment: Thrombectomy. 2024, 93-102. DOI: 10.1007/978-3-031-66289-8_9.Peer-Reviewed Original ResearchIntravenous Thrombolysis in Patients With Cervical Artery Dissection
Shu L, Akpokiere F, Mandel D, Field T, Leon Guerrero C, Henninger N, Muppa J, Affan M, Haq Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, López-Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy Rivas R, Aziz Y, Mistry E, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Garcia J, Muddasani V, de Havenon A, Sanchez S, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Krupka D, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Tountopoulou A, Tentolouris-Piperas V, Martinez-Marino M, Carrasco Wall V, Indraswari F, El Jamal S, Liu S, Zhou M, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Wangqin R, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Intravenous Thrombolysis in Patients With Cervical Artery Dissection. Neurology 2024, 103: e209843. PMID: 39298709, PMCID: PMC11415265, DOI: 10.1212/wnl.0000000000209843.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke symptomsCervical artery dissectionFunctional independenceIntravenous thrombolysisIschemic stroke symptomsStroke symptomsArtery dissectionIncidence of symptomatic intracranial hemorrhageIschemic strokeSymptomatic intracranial hemorrhageSuspected ischemic strokeClass III evidenceMedian ageSymptomatic ICHIntracranial hemorrhageSecondary analysisGuideline recommendationsICH riskIII evidenceFunctional outcomesPatientsThrombolysisCeADYoung adultsDissectionThe effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy.
Elawady S, Kasem R, Matsukawa H, Cunningham C, Sowlat M, Nawabi N, Orscelik A, Venegas J, Isidor J, Loulida H, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Al Kasab S. The effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy. Interventional Neuroradiology 2024, 15910199241279009. PMID: 39262342, PMCID: PMC11559907, DOI: 10.1177/15910199241279009.Peer-Reviewed Original ResearchAcute ischemic stroke patientsLarge vessel occlusionAcute ischemic strokeIntracranial hemorrhageBenefit of intravenous thrombolysisMechanical thrombectomyIntravenous thrombolysisMT alone groupAlone groupMT groupSecondary outcomesAnterior circulation large vessel occlusionSymptomatic intracranial hemorrhageEffect of intravenous thrombolysisIVT + MTIntravenous thrombolysis prior to MTPropensity score matchingMedian ageSymptomatic ICHMTICI scoreFailed recanalizationPrimary outcomeFunctional outcomesPatientsVessel occlusionAdjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanEndovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly. American Journal Of Neuroradiology 2024, 46: ajnr.a8473. PMID: 39181691, PMCID: PMC11878975, DOI: 10.3174/ajnr.a8473.Peer-Reviewed Original ResearchPropensity score matchingBasilar artery occlusionIntracranial hemorrhageAssociated with higher ratesIn-hospital mortalityEndovascular thrombectomyIntravenous thrombolysisMedical managementAssociated with increased risk of ICHTreated with medical managementPatients treated with endovascular thrombectomyRisk of intracranial hemorrhageSafety of endovascular thrombectomyBasilar artery occlusion strokeFavorable hospital outcomesTreated with intravenous thrombolysisHome dischargeAssociated with increased riskEndovascular thrombectomy groupArtery occlusion strokeNational Inpatient SampleNIH Stroke ScalePropensity score-matched controlsStroke patientsHigher ratesComparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis
Elawady S, Kasem R, Mulpur B, Cunningham C, Matsukawa H, Sowlat M, Orscelik A, Nawabi N, Isidor J, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Levitt M, Goyal N. Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis. Journal Of NeuroInterventional Surgery 2024, jnis-2024-021975. PMID: 39179373, DOI: 10.1136/jnis-2024-021975.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageAIS-LVO patientsIntracranial hemorrhageIntra-arteriallyModified Rankin ScaleNeurological improvementMechanical thrombectomyIAT groupFunctional outcomesIntra-arterial groupModified Rankin scale 0Long-term functional outcomeRate of recanalizationPropensity-matched analysisIntra-arterial thrombolysisLarge vessel occlusionStroke patientsAcute ischemic strokeSecondary outcomesPrimary outcomePropensity score matchingNo significant differencePropensity matchingAIS-LVOMT+IVT groupEndovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 271: 6247-6254. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-hospital mortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher ratesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeEarlier Endovascular Thrombectomy and Mortality in Patients with Anterior Circulation Large Vessel Occlusion: A Propensity-Matched Analysis of the Stroke Thrombectomy and Aneurysm Registry
Matsukawa H, Crosa R, Cunningham C, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Spiotta A, Collaborators S. Earlier Endovascular Thrombectomy and Mortality in Patients with Anterior Circulation Large Vessel Occlusion: A Propensity-Matched Analysis of the Stroke Thrombectomy and Aneurysm Registry. World Neurosurgery 2024, 189: e435-e441. PMID: 38908685, DOI: 10.1016/j.wneu.2024.06.082.Peer-Reviewed Original ResearchConceptsAIS-LVO patientsAnterior circulation large vessel occlusionLarge vessel occlusionEndovascular thrombectomyAcute ischemic strokePoor outcomeVessel occlusionReceiver operating characteristic curve analysisCharacteristic curve analysisPropensity-matched analysisScore matching analysisSecondary outcomesPrimary outcomeIntracranial hemorrhageNo significant differencePuncture timePatientsStroke thrombectomyCurve analysisIschemic strokeAneurysm RegistryMortalityThrombectomyOutcomesSignificant differenceRisk of Intracranial Hemorrhage in Persons with Hemophilia A in the United States: Real-World Retrospective Cohort Study Using the ATHNdataset
Hu J, Chandler M, Manuel C, Caicedo J, Denne M, Ewenstein B, Mokdad A, Xing S, Recht M. Risk of Intracranial Hemorrhage in Persons with Hemophilia A in the United States: Real-World Retrospective Cohort Study Using the ATHNdataset. Journal Of Blood Medicine 2024, 15: 191-205. PMID: 38699197, PMCID: PMC11063465, DOI: 10.2147/jbm.s443380.Peer-Reviewed Original ResearchIntracranial hemorrhageIncidence rateInhibitor statusHemophilia AEstimate hazard ratiosAssociated with intracranial hemorrhageIncidence of intracranial hemorrhageMedian follow-up timeRisk of intracranial hemorrhageCurrent treatment landscapeIntracranial hemorrhage riskFollow-up timeTime-to-event analysisYears of ageProphylaxis statusHazard ratioTreatment landscapeGreater riskHepatitis CProphylactic treatmentPWHARate of mortalityIncreased riskRisk factorsATHNdatasetDeviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization
Zhang Z, Pu Y, Yu L, Bai H, Duan W, Liu X, Nie X, Wen Z, Zheng L, Hu X, Leng X, Pan Y, Petersen N, Liu L. Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization. Journal Of The American Heart Association 2024, 13: e033633. PMID: 38533955, PMCID: PMC11179781, DOI: 10.1161/jaha.123.033633.Peer-Reviewed Original ResearchConceptsBlood pressure targetsBlood pressureAutoregulatory limitsWorse outcomesAssociated with symptomatic intracranial hemorrhageAssociated with unfavorable clinical outcomesPressure targetsAssociated with worse outcomesAssociated with poor outcomesSignificant infarction growthSymptomatic intracranial hemorrhageUnfavorable clinical outcomeLarge vessel occlusion strokeAcute ischemic strokeMean velocity indexIntracranial hemorrhageBP management strategiesNeurological deteriorationClinical outcomesInfarct growthPoor outcomeEndovascular thrombectomyOcclusion strokeRecanalizationIschemic strokeBrain AVM compactness score in children with hereditary hemorrhagic telangiectasia
Beslow L, Vossough A, Kim H, Nelson J, Lawton M, Pollak J, Lin D, Ratjen F, Hammill A, Hetts S, Gossage J, Whitehead K, Faughnan M, Krings T. Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia. Child's Nervous System 2024, 40: 2101-2108. PMID: 38517485, PMCID: PMC11179972, DOI: 10.1007/s00381-024-06366-z.Peer-Reviewed Original ResearchBrain arteriovenous malformationsSporadic brain arteriovenous malformationsHereditary hemorrhagic telangiectasiaHemorrhagic riskHemorrhagic telangiectasiaBrain arteriovenous malformation treatmentBrain vascular malformationsCompact nidusSurgical resectionArteriovenous malformationsIntracranial hemorrhageVascular malformationsRecurrence riskResultsForty-eightInterventional neuroradiologistsAngiographic measurementsHemorrhageNidusAngiogramMalformationsRecurrenceTelangiectasiaRiskChildrenBrainThrombolysis for Wake-Up Stroke Versus Non–Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis
Kamogawa N, Miwa K, Toyoda K, Jensen M, Inoue M, Yoshimura S, Fukuda-Doi M, Kitazono T, Boutitie F, Ma H, Ringleb P, Wu O, Schwamm L, Warach S, Hacke W, Davis S, Donnan G, Gerloff C, Thomalla G, Koga M, Cheng B, Bendszus M, Bladin C, Churilov L, Campbell B, Parsons M, Yassi N, Ebinger M, Endres M, Fiebach J, Kleinig T, Latour L, Lemmens R, Levi C, Leys D, Molina C, Muir K, Nighoghossian N, Pedraza S, Schellinger P, Schwab S, Simonsen C, Song S, Thijs V, Toni D, Hsu C, Wahlgren N. Thrombolysis for Wake-Up Stroke Versus Non–Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis. Stroke 2024, 55: 895-904. PMID: 38456303, PMCID: PMC10978262, DOI: 10.1161/strokeaha.123.043358.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageIntracranial hemorrhageIntravenous thrombolysisFavorable outcomeUnwitnessed strokeNon-WUSFrequency of favorable outcomesIndividual patient-data meta-analysisMultivariate logistic regression analysisModified Rankin Scale scoreSafety of intravenous thrombolysisRankin Scale scoreEffect of intravenous thrombolysisIntravenous thrombolysis groupLogistic regression analysisUnknown-onset strokeRandomized controlled trialsNo significant differencePatient-level dataData meta-analysisStandard treatmentInsufficient statistical powerPatientsSafety outcomesControlled trialsTrends in cerebral venous thrombosis before and during the COVID-19 pandemic: Analysis of the National Inpatient Sample
Klein P, Shu L, Qureshi M, Abdalkader M, Field T, Siegler J, Zhou L, Patel K, Al Kasab S, de Havenon A, Yaghi S, Qureshi A, Nguyen T. Trends in cerebral venous thrombosis before and during the COVID-19 pandemic: Analysis of the National Inpatient Sample. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107651. PMID: 38408574, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107651.Peer-Reviewed Original ResearchCerebral venous thrombosisIn-hospital mortalityAssociated with in-hospital mortalityCVT incidenceNational Inpatient SampleIntracranial hemorrhageVenous thrombosisAtrial fibrillationMale sexPredictors of in-hospital mortalityAll-cause in-hospital mortalityIncidence of cerebral venous thrombosisInpatient SampleIncreasing ageStroke diagnosisCOVID-19 pandemicNationally representative estimatesICD-10 codesQuartile of incomeCensus dataMedian NIHSSProthrombotic stateHematological conditionsJoinpoint regressionMultivariate analysis
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