2025
Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsStandard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound
Halim D, Kelly A, Hayes J, Bennett K, Tzouvelekis A, Ampazis D, Sampsonas F. Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound. Medicina 2025, 61: 313. PMID: 40005430, PMCID: PMC11857366, DOI: 10.3390/medicina61020313.Peer-Reviewed Original ResearchConceptsLevels of experienceNon-inferiorityPortable ultrasound deviceOverall image qualityLung pathologyUltrasound deviceInterquartile rangeRespiratory departmentThoracic ultrasoundAnatomical visualizationHandheld ultrasound devicePatient careImprove healthcareOperator's level of experienceNo significant differenceLikert scaleTrainee levelStatistically significant variablesDiagnostic accuracyClinical decisionsOverall perceptionOnline questionnaireClinical utilityMedian rateClinical settingRadiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.
Zaree O, Nguyen J, de Oliveira Santo I, Kertam A, Rahmani S, Johnson J, Tu L. Radiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations. American Journal Of Neuroradiology 2025, ajnr.a8660. PMID: 39832953, DOI: 10.3174/ajnr.a8660.Peer-Reviewed Original ResearchStroke code activationAttending radiologistsTimeliness of reportingEmergency department settingRadiologist characteristicsCare settingsMultivariate regression modelImprove workflow efficiencyDepartment settingStroke codeModifiable factorsDescriptive statisticsSecondary analysisCoding activitiesReport factorsPatient ageObservational studyWorkflow efficiencyShift typeMedian TATMultivariate regressionInterquartile rangeRegression modelsCTA reportsLogistical factorsNeural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis
Gunes I, Bernstein E, Cowper S, Panse G, Pradhan N, Camacho L, Page N, Bundschuh E, Williams A, Carns M, Aren K, Fantus S, Volkmann E, Bukiri H, Correia C, Kolachalama V, Wilson F, Mawe S, Mahoney J, Hinchcliff M. Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis. Arthritis Research & Therapy 2025, 27: 85. PMID: 40217251, DOI: 10.1186/s13075-025-03508-9.Peer-Reviewed Original ResearchConceptsModified Rodnan skin scoreSystemic sclerosisFibrosis scoreHistological parametersDiffuse cutaneous systemic sclerosisInterquartile rangeSystemic sclerosis skin biopsiesRodnan skin scoreCutaneous systemic sclerosisOpen-label trialSkin scorePathological parametersSkin biopsiesBiopsySkin outcomesStudy terminationFibrosisHistological analysisBlinded dermatopathologistStained sectionsSpearman correlationBelumosudilPatientsSkin featuresScores
2024
Comparison of EEG Signal Characteristics of Subdural and Depth Electrodes.
Alkawadri C, Yan Q, Kocuglu Kinal A, Spencer D, Alkawadri R. Comparison of EEG Signal Characteristics of Subdural and Depth Electrodes. Journal Of Clinical Neurophysiology 2024 PMID: 39787440, DOI: 10.1097/wnp.0000000000001139.Peer-Reviewed Original ResearchStereo-EEGHigh gamma bandSurgical epilepsy centersDrug-resistant epilepsyIntracranial EEG evaluationElectrode contact pairsImpact of electrode sizeElectrode sizeEffects of electrode sizeEEG evaluationCompare signal characteristicsHigh-frequency signalsEpilepsy centersSignal-to-noise ratioInterquartile rangeMedian correlation coefficientIntracranial EEGPower spectral densitySubdural electrodesPower ratioElectrode designFast-Fourier transformHigh gammaMedian distanceContact pairsLong-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study
Liao M, Zhang S, Wolf K, Bolte G, Laxy M, Schwettmann L, Peters A, Schneider A, Kraus U. Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study. International Journal Of Hygiene And Environmental Health 2024, 264: 114513. PMID: 39719813, DOI: 10.1016/j.ijheh.2024.114513.Peer-Reviewed Original ResearchConceptsSelf-perceived healthLong-term air pollution exposureSelf-perceived health statusAir pollution exposurePoor SRHHealth statusAssociated with poor self-perceived healthPoor self-perceived healthPollution exposureInterquartile rangeLand-use regression modelsLogistic regressionGeocoded residential addressesParticle number concentrationFace-to-face interviewsCooperative Health ResearchEQ-5D index valueSelf-perceived stressAmbient air pollutionEQ-VAS scoresIQR increaseAir pollutionCross-sectional studyBody mass indexMultinomial logistic regressionRelative Citation Ratio Among Pediatric Orthopaedic Surgeons: Examining the Factors Associated With Higher Scores.
Halperin S, Gilson A, Dhodapkar M, Prenner M, Tuason D, Grauer J. Relative Citation Ratio Among Pediatric Orthopaedic Surgeons: Examining the Factors Associated With Higher Scores. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39693538, DOI: 10.5435/jaaos-d-24-00756.Peer-Reviewed Original ResearchPediatric orthopaedic surgeonsNational Provider IdentifierOrthopaedic surgeonsProvider IdentifierGeographic region of practiceMultivariate ordinary least squares regressionRelative Citation RatioPediatric Orthopaedic Society of North AmericaRegion of practicePediatric Orthopaedic SocietyNational Institutes of HealthPhysician sexInstitutes of HealthOrthopaedic physiciansDO degreeAuthor’s publication historiesOrdinary least squares regressionCareer lengthPhysiciansMale sexInterquartile rangeCitation ratioResearch metricsWeighted relative citation ratioNational InstituteFeasibility of Multi-Modal Physical Function Data Collection to Assess Treatment Tolerability in Patients with Lymphoma
Paludo J, Dueck A, Bhatnagar V, Brown A, Cathcart-Rake E, Copley D, Diamond M, Faust L, Fiero M, Huntington S, Jeffery M, Jones L, Noble B, Power B, Ritchie J, Ross J, Ruddy K, Schellhorn S, Tarver M, Torre L, Wood W, Gross C, Kluetz P, Thanarajasingam G. Feasibility of Multi-Modal Physical Function Data Collection to Assess Treatment Tolerability in Patients with Lymphoma. Blood 2024, 144: 387-387. DOI: 10.1182/blood-2024-194607.Peer-Reviewed Original ResearchEastern Cooperative Oncology GroupPhysical functionPatient reportsTreatment toleranceCompletion ratesBaseline 6MWTExit surveyInterquartile rangeAssess treatment tolerancePost-treatment follow-upAssessment of PFCooperative Oncology GroupMedian wear timeUnique implementation challengesWearable sensor dataWalk testCytotoxic chemotherapyNon-Hispanic/LatinoNo standard approachOncology GroupAlaska NativesPerformance statusPF measuresFull-time employmentMedian timeAssociation between Body Mass Index and Outcomes in Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Hypomethylating Agents and Venetoclax
Weiss J, Yates S, Badar T, Patel A, Winer E, Litzow M, Cheng W, Lin C, Shallis R. Association between Body Mass Index and Outcomes in Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Hypomethylating Agents and Venetoclax. Blood 2024, 144: 1489-1489. DOI: 10.1182/blood-2024-206670.Peer-Reviewed Original ResearchAcute myeloid leukemiaBody mass indexOverall response rateBody mass index groupsSecondary AMLObese ptsHypomethylating agentsEuropean LeukemiaNetMulti-centerOverall survivalMyeloid leukemiaRetrospective studyMass indexNewly diagnosed acute myeloid leukemiaVariable volume of distributionSecondary acute myeloid leukemiaAssociated with higher 90-day mortalityTreatment of acute myeloid leukemiaHigher 30-day mortalityMultivariate Cox regression modelInterquartile rangeComposite remission rateExtensive protein bindingKaplan-Meier methodRisk of early mortalityThe impact of exposure assessment on associations between air pollution and cardiovascular mortality risks in the city of Rio de Janeiro, Brazil
Heo S, Schuch D, Junger W, Zhang Y, de Fatima Andrade M, Bell M. The impact of exposure assessment on associations between air pollution and cardiovascular mortality risks in the city of Rio de Janeiro, Brazil. Environmental Research 2024, 263: 120150. PMID: 39414104, DOI: 10.1016/j.envres.2024.120150.Peer-Reviewed Original ResearchAir pollutionCardiovascular mortality riskExposure assessmentMortality riskExposure methodHealth risk estimatesAir pollution risksAir quality modelsExposure levelsOdds ratioHealth impact assessmentAssociated with mortality riskPollution riskConfidence intervalsCardiovascular mortality dataComplex air quality modelRio de JaneiroCase-crossover studyEstimate mortality riskWRF-ChemCity of Rio de JaneiroMonitoring networkInterquartile rangeMultiple logistic regressionImpact assessmentPhysical space of thirty pediatric intensive care units in the United States of America: a national survey
Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.Peer-Reviewed Original ResearchRoom sizePediatric intensive care unitPhysical spaceConstruction of hospitalsIntensive care unitBuilding yearDesign practiceCare unitBuildings dateRoom designPrivate bathroomsOccupancy rateDouble roomRenovationBathroomCompliant unitsRoom characteristicsAmenitiesDesignConstructionIntermediate care unitCardiac ICUClinical outcomesInterquartile rangeUnit typesMDS-166 Clinical Benefit of Luspatercept Treatment in Transfusion-Dependent (TD), Erythropoiesis-Stimulating Agent (ESA)-Naive Patients With Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) in the COMMANDS Trial
Zeidan A, Platzbecker U, Della Porta M, Santini V, Garcia-Manero G, Li J, Kreitz S, Pozharskaya V, Rose S, Lai Y, Davidárcel D, Fenaux P, Shortt J, Komrokji R. MDS-166 Clinical Benefit of Luspatercept Treatment in Transfusion-Dependent (TD), Erythropoiesis-Stimulating Agent (ESA)-Naive Patients With Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) in the COMMANDS Trial. Clinical Lymphoma Myeloma & Leukemia 2024, 24: s387-s388. DOI: 10.1016/s2152-2650(24)01346-6.Peer-Reviewed Original ResearchEA patientsTransfusion-dependentRBC unitsLuspatercept treatmentRBC-TITransfusion burdenMyelodysplastic syndromeLR-MDSRBC transfusionIntermediate-risk myelodysplastic syndromesEA-treated patientsRBC transfusion independenceBone marrow blastsLowered riskTransfusion independenceMarrow blastsTreatment initiationCumulative medianLuspaterceptEpoetin alfaESA-naivePatients adultsEffective treatmentPatientsInterquartile rangeRisk of new‐onset diabetes and efficacy of pharmacological weight loss therapy
Moura F, Bellavia A, Berg D, Melloni G, Feinberg M, Leiter L, Bohula E, Morrow D, Scirica B, Wiviott S, Sabatine M. Risk of new‐onset diabetes and efficacy of pharmacological weight loss therapy. Diabetes Obesity And Metabolism 2024, 26: 4441-4449. PMID: 39056220, PMCID: PMC11410501, DOI: 10.1111/dom.15798.Peer-Reviewed Original ResearchNew-onset diabetesRisk of new-onset diabetesClinical risk modelWeight loss therapyRisk groupsWeight loss pharmacotherapyMultivariate Cox regressionStable cardiovascular patientsTherapeutic decision makingAbsolute risk reductionHigh-risk groupType 2 diabetesIndependent predictorsValidation cohortFollow-upPersonalized patient careCox regressionHazard ratioPrimary outcomeRisk modelHigh riskInterquartile rangePatientsDiabetesCardiovascular patientsTemperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Kim N, Nguyen C, McGinniss G, Deng Y, Kitlen E, Garcia G, Wira C, Khosla A, Johnson J, Miller P, Perman S, Sheth K, Greer D, Gilmore E. Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2024, 84: 549-559. PMID: 39033449, DOI: 10.1016/j.annemergmed.2024.06.007.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestNeurological outcomeDevice cohortCardiac arrestOut-of-hospital cardiac arrest patientsConsecutive out-of-hospital cardiac arrestPreinduction timeInterquartile rangeAssociated with improved outcomesCardiac arrest patientsProportion of patientsMultivariate logistic regression modelInverse probability of treatmentDevice timeInverse probability treatment weightsProbability of treatmentProspective trialsOHCA patientsArrest patientsClinical outcomesLogistic regression modelsCenter studyEarly initiationSecondary outcomesTreatment weightingEvaluating the Impact of Point-of-Care Electroencephalography on Length of Stay in the Intensive Care Unit: Subanalysis of the SAFER-EEG Trial
Desai M, Kalkach-Aparicio M, Sheikh I, Cormier J, Gallagher K, Hussein O, Cespedes J, Hirsch L, Westover B, Struck A. Evaluating the Impact of Point-of-Care Electroencephalography on Length of Stay in the Intensive Care Unit: Subanalysis of the SAFER-EEG Trial. Neurocritical Care 2024, 42: 108-117. PMID: 38981999, DOI: 10.1007/s12028-024-02039-6.Peer-Reviewed Original ResearchIntensive care unitIntensive care unit LOSNonconvulsive seizuresClinical outcomesFunctional outcomesCare unitDetection of nonconvulsive seizuresInterquartile rangeAssociated with neuronal injuryDiagnose nonconvulsive seizuresIntensive care unit patientsUnfavorable functional outcomeMann-Whitney U testProlonged nonconvulsive seizuresPropensity score matchingDeleterious clinical outcomesClinical characteristicsAdult patientsRandomized studyConventional EEGICU LOSNeuronal injuryFunctional/clinical outcomesAcademic centersClinical covariatesImprovement in Measures of Quality of Life and Symptoms of Anxiety and Depression in Patients with Severe Alopecia Areata Achieving Sustained Scalp Hair Regrowth with Baricitinib
Craiglow B, Lee Y, Vañó-Galván S, Egeberg A, Dutronc Y, Durand F, Pierce E, Yu G, Chen Y, Mostaghimi A. Improvement in Measures of Quality of Life and Symptoms of Anxiety and Depression in Patients with Severe Alopecia Areata Achieving Sustained Scalp Hair Regrowth with Baricitinib. Dermatology And Therapy 2024, 14: 1959-1968. PMID: 38904749, PMCID: PMC11265044, DOI: 10.1007/s13555-024-01208-x.Peer-Reviewed Original ResearchSymptoms of anxietyQuality of lifeDomain scoresHealth-related quality of lifeMeasures of quality of lifeMeasures of HRQoLHealth-related qualityBaricitinib 2 mgSALT scoreBaricitinib 4 mgPsychosocial distressAssociated with improvementsHair regrowthAA scaleMethodsThis post hoc analysisHRQoLDose of baricitinibInterquartile rangePhase III trialsResultsIn totalSevere alopecia areataPost hoc analysisDisease associated with high ratesDepressionScoresAssociation of infertility and recurrent pregnancy loss with the risk of dementia
Liang C, Dobson A, Chung H, van der Schouw Y, Sandin S, Weiderpass E, Mishra G. Association of infertility and recurrent pregnancy loss with the risk of dementia. European Journal Of Epidemiology 2024, 39: 785-793. PMID: 38888679, PMCID: PMC11343804, DOI: 10.1007/s10654-024-01135-3.Peer-Reviewed Original ResearchConceptsRisk of dementiaHigher risk of dementiaAssociation of infertilityInternational Collaboration for a Life Course ApproachRecurrent stillbirthHazard ratio of dementiaRisk factors of dementiaChronic disease eventsFactors of dementiaDeath registry dataAssessment of dementiaRisk factorsCause-specific Cox regression modelsInterquartile rangeHigh riskAged careWithin-study correlationsReproductive exposuresRegistry dataCox regression modelsSelf-reportDementiaCourse approachDisease eventsHazard ratioCharacterizing the authorship of phase 3 randomized clinical trials in oncology, 1960-2023.
Warner J, Bakow B, Brown A, Choe J, Fan E, Ganta T, Glover M, Hadfield M, Hilton C, Khaki A, Kothari S, Lythgoe M, Nagpal S, Nguyen R, Noyd D, Riaz I, Rooney M, Sethi T, Singhi E, Rubinstein S. Characterizing the authorship of phase 3 randomized clinical trials in oncology, 1960-2023. Journal Of Clinical Oncology 2024, 42: 11079-11079. DOI: 10.1200/jco.2024.42.16_suppl.11079.Peer-Reviewed Original ResearchPhase 3 randomized clinical trialPhase 3 RCTsPrimary endpointClinical trialsEligible publicationsProlific authorsSystemic anticancer therapySuccess rateMann-Whitney U testStandard of carePositive publication biasTrial sample sizePositive resultsYear of publicationPublication biasTherapeutic advancesPrimary outcomeAuthorship patternAnticancer therapyExperimental armAuthor's outputMann-WhitneyU testInterquartile rangeAuthor informationComparison for the effects of different components of temperature variability on mortality: A multi-country time-series study
Wen B, Wu Y, Guo Y, Gasparrini A, Tong S, Overcenco A, Urban A, Schneider A, Entezari A, Vicedo-Cabrera A, Zanobetti A, Analitis A, Zeka A, Tobias A, Nunes B, Alahmad B, Armstrong B, Forsberg B, Pan S, Íñiguez C, Ameling C, Valencia C, Åström C, Houthuijs D, Van Dung D, Royé D, Indermitte E, Lavigne E, Mayvaneh F, Acquaotta F, de'Donato F, Rao S, Sera F, Carrasco-Escobar G, Kan H, Orru H, Kim H, Holobaca I, Kyselý J, Madureira J, Schwartz J, Jaakkola J, Katsouyanni K, Diaz M, Ragettli M, Hashizume M, Pascal M, Coélho M, Ortega N, Ryti N, Scovronick N, Michelozzi P, Matus Correa P, Goodman P, Saldiva P, Raz R, Abrutzky R, Osorio S, Dang T, Colistro V, Huber V, Lee W, Seposo X, Honda Y, Kim Y, Guo Y, Bell M, Li S. Comparison for the effects of different components of temperature variability on mortality: A multi-country time-series study. Environment International 2024, 187: 108712. PMID: 38714028, DOI: 10.1016/j.envint.2024.108712.Peer-Reviewed Original ResearchInter-day TVRespiratory mortalityIQR increaseAll-cause mortalityMortality riskInterquartile rangeAssociated with increased mortality riskCardiovascular mortalityTime-series studyAll-causeMulti-level analysisMortalityRiskLag intervalStandard deviationHealthAverage SDTemperature variabilityComprehensive evaluationAssociationClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
Regan C, Scierka L, Dardik A, Tonnessen B, Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 33: 466-471. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectives
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