2025
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsCongenital hydrocephalusCSF dynamicsIncreased CSF productionDe novo mutationsFrequent monogenic causeEverolimus treatmentCSF shuntingNonsurgical treatmentPTEN mutationsAqueductal stenosisInhibitory interneuronsVentriculomegalyProgenitor cellsChoroid plexusMonogenic causeCortical networksIncreased survivalBrain ventriclesCortical deficitsNeural progenitorsGene PTENCSF productionNkx2.1PTEN
2024
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 101: 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementiaMolecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo
Goodchild S, Shuart N, Williams A, Ye W, Parrish R, Soriano M, Thouta S, Mezeyova J, Waldbrook M, Dean R, Focken T, Ghovanloo M, Ruben P, Scott F, Cohen C, Empfield J, Johnson J. Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo. ACS Chemical Neuroscience 2024, 15: 1169-1184. PMID: 38359277, PMCID: PMC10958515, DOI: 10.1021/acschemneuro.3c00757.Peer-Reviewed Original ResearchExcitatory pyramidal neuronsPyramidal neuronsNeuronal action potential firingSeizure modelsActivity of excitatory neuronsInhibition of firingAction potential firingVoltage-gated sodium channelsSuppress epileptiform activityTherapeutic safety marginActivity ex vivoNeuronal hyperexcitabilityInhibitory interneuronsChannel inhibitorsEpileptiform activityInhibitory neuronsPotential firingExcitatory neuronsAntiseizure medicationsExcitatory circuitsBrain slicesReduced excitabilityPharmacological dissectionAntiseizure medication carbamazepineSodium channels
2023
Laminar mechanisms of saccadic suppression in primate visual cortex
Denagamage S, Morton M, Hudson N, Reynolds J, Jadi M, Nandy A. Laminar mechanisms of saccadic suppression in primate visual cortex. Cell Reports 2023, 42: 112720. PMID: 37392385, PMCID: PMC10528056, DOI: 10.1016/j.celrep.2023.112720.Peer-Reviewed Original ResearchConceptsSaccadic suppressionFiring rateInter-neuronal correlationsLocal inhibitory activityCortical firing ratesEye movementsSaccadic eye movementsPutative inhibitory interneuronsDistinct neural subpopulationsVisual cortical networkPrimate visual cortexVisual area V4Inhibitory interneuronsCortical circuitryVisual cortexSaccade onsetArea V4Single neuronsCortical networksNeural subpopulationsVisual stabilityNeuronsInhibitory activityTemporary reductionVisual sensitivity
2021
Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model
Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.Peer-Reviewed Original ResearchConceptsCortical circuitsCognitive deficitsCortical circuit modelAltered excitation-inhibition balanceExcitatory pyramidal neuronsNMDA receptor hypofunctionCerebral cortical circuitsExcitation-inhibition balancePyramidal neuronsReceptor hypofunctionDistinct time coursesSynaptic excitationInhibitory interneuronsMultiple neuropsychiatric disordersBehavioral deficitsSynaptic balanceSynaptic levelLatest evidenceNeuropsychiatric disordersCognitive functionCircuit mechanismsBehavioral effectsPsychometric performanceBehavioral levelTask paradigm
2020
Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior
Mossner JM, Batista-Brito R, Pant R, Cardin JA. Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior. ELife 2020, 9: e55639. PMID: 32343226, PMCID: PMC7213975, DOI: 10.7554/elife.55639.Peer-Reviewed Original ResearchConceptsVIP interneuronsRett syndromeVasoactive intestinal peptide-expressing (VIP) interneuronsLoss of MeCP2Neurodevelopmental disordersGABAergic cell typesDevastating neurodevelopmental disorderBehavioral phenotypesInhibitory interneuronsPathophysiological roleCortical functionMouse modelCortical circuitsLoss of functionInterneuronsSyndromeDevelopmental lossCell typesDisordersCritical rolePotential key pointsMeCP2PhenotypeMutationsProper development
2018
Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2017
VGF function in depression and antidepressant efficacy
Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Molecular Psychiatry 2017, 23: 1632-1642. PMID: 29158577, PMCID: PMC5962361, DOI: 10.1038/mp.2017.233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressionDepressive DisorderDown-RegulationFemaleHippocampusHumansKetamineMaleMiceMice, Inbred C57BLMiddle AgedNerve Growth FactorsNeuronsNeuropeptidesNucleus AccumbensReceptors, AMPASex FactorsSignal TransductionStress, PsychologicalTOR Serine-Threonine KinasesUp-RegulationConceptsChronic social defeat stressDepression-like behaviorBrain-derived neurotrophic factorSocial defeat stressNucleus accumbensAntidepressant efficacyAntidepressant responseDefeat stressFloxed micePro-depressant effectsRapid antidepressant efficacyBDNF/TrkBIsoxazolepropionic acid (AMPA) receptorsWild-type miceDepressed human subjectsBDNF translationTLQP-62VGF levelsAAV-CreAntidepressant behaviorNeurotrophic factorSwim testDorsal hippocampusInhibitory interneuronsVGF expression
2016
Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.
Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Cerebral Cortex 2016, 27: 3186-3207. PMID: 27269961, PMCID: PMC6059165, DOI: 10.1093/cercor/bhw143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiophysicsCell CountCluster AnalysisDNA-Binding ProteinsElectric StimulationEntorhinal CortexGreen Fluorescent ProteinsIn Vitro TechniquesInterneuronsIntracellular Signaling Peptides and ProteinsMembrane PotentialsMiceMice, TransgenicNeuropeptide YParvalbuminsPatch-Clamp TechniquesProteinsReceptors, Serotonin, 5-HT3Transcription FactorsVasoactive Intestinal PeptideStriatal-enriched protein tyrosine phosphatase modulates nociception
Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. Striatal-enriched protein tyrosine phosphatase modulates nociception. Pain 2016, 157: 377-386. PMID: 26270590, PMCID: PMC4809206, DOI: 10.1097/j.pain.0000000000000329.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzothiepinsDisease Models, AnimalEnzyme InhibitorsEvoked PotentialsFemaleGene Expression RegulationHyperalgesiaInflammationMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, TransgenicNerve Fibers, UnmyelinatedNociceptionPainPain ThresholdProtein Tyrosine Phosphatases, Non-ReceptorRatsRats, Sprague-DawleySignal TransductionConceptsLumbar spinal cordSpinal cordThermal hyperalgesiaStriatal-enriched protein tyrosine phosphataseInflammatory painAdjuvant injectionC fibre-evoked spinal field potentialsKnockout miceComplete Freund's adjuvant injectionModulation of nociceptionFreund's adjuvant injectionProtein levelsSpinal field potentialsSTEP knockout miceGender-related differencesMechanical allodyniaCentral sensitizationInactivation of ERK1/2Dorsal hornFemale miceFemale genderInhibitory interneuronsPharmacological approachesHyperalgesiaBehavioral tests
2015
Function and Circuitry of VIP+ Interneurons in the Mouse Retina
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB. Function and Circuitry of VIP+ Interneurons in the Mouse Retina. Journal Of Neuroscience 2015, 35: 10685-10700. PMID: 26224854, PMCID: PMC4518048, DOI: 10.1523/jneurosci.0222-15.2015.Peer-Reviewed Original ResearchConceptsGanglion cell layerAmacrine cell typesInner nuclear layerAmacrine cellsGanglion cellsINL cellsON pathwayGanglion cell dendritesGanglion cell typesBipolar cell terminalsWhole-cell recordingsCell typesNervous system functionSpatial tuningBipolar cell pathwaysTransgenic mouse lineGCL cellsOptic nerveGABAergic interneuronsRetinal functionCell dendritesRetinal circuitryInhibitory interneuronsNuclear layerBipolar interneurons
2013
Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Komitova M, Xenos D, Salmaso N, Tran KM, Brand T, Schwartz ML, Ment L, Vaccarino FM. Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain. Journal Of Neuroscience 2013, 33: 13375-13387. PMID: 23946395, PMCID: PMC3742925, DOI: 10.1523/jneurosci.5286-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion Molecules, NeuronalCerebral CortexChromatography, High Pressure LiquidDisease Models, AnimalExtracellular Matrix ProteinsGene Knock-In TechniquesHousing, AnimalHypoxiaImmunohistochemistryInterneuronsMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsParvalbuminsProsencephalonReelin ProteinSerine EndopeptidasesSomatostatinConceptsCortical interneuronsNormoxic controlsMarker expressionPostnatal cortical developmentVasoactive intestinal peptidePostnatal day 3Central nervous systemTotal GABA contentImpact of hypoxicPostnatal mouse forebrainEnvironmental enrichmentIntestinal peptideGABAergic interneuronsFrontal neocortexInhibitory interneuronsCortical developmentMouse modelReelin expressionInterneuron numbersNervous systemDay 3Cognitive impairmentInterneuronsHousing miceRLN expression
2012
Center-surround vs. distance-independent lateral connectivity in the olfactory bulb
Kim D, Chang A, McTavish T, Patel H, Willhite D. Center-surround vs. distance-independent lateral connectivity in the olfactory bulb. Frontiers In Neural Circuits 2012, 6: 34. PMID: 22666190, PMCID: PMC3364486, DOI: 10.3389/fncir.2012.00034.Peer-Reviewed Original ResearchGranule cellsOlfactory bulbSynaptic connectionsM/T cellsGlomerular layerInhibitory interneuronsSensory information processingProjection neuronsPseudorabies virusOlfactory systemLateral connectionsNeuronal interactionsSomatosensory systemCenter-surround modelCellsNovel methodInterneuronsDistribution of labelNeuronsHigh temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus
Kim JA, Connors BW. High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus. Frontiers In Cellular Neuroscience 2012, 6: 27. PMID: 22783167, PMCID: PMC3390787, DOI: 10.3389/fncel.2012.00027.Peer-Reviewed Original ResearchO-LM interneuronsPyramidal cellsPyramidal neuronsArea CA3Oriens-lacunosum moleculare (O-LM) interneuronsSpontaneous synaptic activityMost pyramidal cellsMammalian central neuronsSpontaneous action potentialsFast synaptic transmissionIntrinsic membrane propertiesEffect of hyperthermiaHippocampal excitabilityImmature hippocampusFebrile seizuresCentral neuronsMoleculare interneuronsInhibitory interneuronsNeuronal excitabilitySynaptic transmissionAcute hyperthermiaArea CA1Synaptic activityInterneuronsAction potentials
2011
Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites
Casale A, McCormick D. Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites. Journal Of Neuroscience 2011, 31: 18289-18302. PMID: 22171033, PMCID: PMC3269759, DOI: 10.1523/jneurosci.4417-11.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusSomatic current injectionAction potentialsDendritic arborsGeniculate nucleusSynaptic stimulationThalamic interneuronsMouse dorsal lateral geniculate nucleusDendritic neurotransmitter releaseEntire dendritic arborSingle action potentialAxon initial segmentVoltage-gated sodiumProximal dendritesDendritic appendagesInhibitory neurotransmitterExcitatory inputsInhibitory interneuronsVoltage-sensitive dyeSynaptic inputsThalamocortical cellsCalcium transientsCalcium imagingNeurotransmitter release
2010
Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons
Cardin JA, Kumbhani RD, Contreras D, Palmer LA. Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons. Journal Of Neuroscience 2010, 30: 3652-3662. PMID: 20219999, PMCID: PMC2880457, DOI: 10.1523/jneurosci.5279-09.2010.Peer-Reviewed Original ResearchConceptsLayer 4 neuronsCortical neuronsSensory-evoked synaptic inputsVisual cortex neuronsCellular mechanismsPrimary visual cortexCortex neuronsInhibitory interneuronsCortical functionExcitatory neuronsSynaptic inputsMembrane potential responsesSpike precisionVisual cortexCortical layersExcitatory conductanceNeuronsCoincident inputsInput integrationSynchronous inputsCortexNonlinear summationTemporal sensitivityAcuityInterneuronsTargeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2
Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nature Protocols 2010, 5: 247-254. PMID: 20134425, PMCID: PMC3655719, DOI: 10.1038/nprot.2009.228.Peer-Reviewed Original ResearchConceptsOptical interferenceMajor long-term goalViral vectorsCell-type selectivityRecording of neuronsOptogenetic stimulationChannelrhodopsin-2Cre-dependent expressionBrain circuit functionSelective cell typesInhibitory interneuronsIntracellular recordingsVivo electrophysiologyExcitatory neuronsIntact brainType selectivityNeural subtypesOptogenetic techniquesSpecific populationsNeural activityCircuit functionNeuronsInterferenceCell typesStimulation
2009
Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing Interneurons
Morozov YM, Torii M, Rakic P. Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing Interneurons. Cerebral Cortex 2009, 19: i78-i89. PMID: 19346272, PMCID: PMC3584650, DOI: 10.1093/cercor/bhp028.Peer-Reviewed Original ResearchConceptsGanglionic eminenceInhibitory interneuronsGamma-aminobutyric acidCaudal ganglionic eminencePositive interneuronsCerebral cortexElectron microscopic levelProjection neuronsGABAergic interneuronsHippocampal interneuronsDentate gyrusVariety of markersPallial-subpallial boundaryForebrain interneuronsInterneuronsUtero electroporationMedial directionDorsal telencephalonEmbryonic dayMarginal zoneRecent studiesLast cell divisionHippocampusCortexTreatment of stiff-person syndrome with botulinum toxin
Jabbari B, Richardson D. Treatment of stiff-person syndrome with botulinum toxin. 2009, 189-194. DOI: 10.1017/cbo9780511575761.024.Peer-Reviewed Original ResearchStiff-person syndromeGlutamic acid decarboxylaseIslet cell antibodiesMuscle spasmTypical stiff-person syndromePainful muscle spasmsStiff-man syndromeLevels of antibodiesGamma-amino butyric acidEpisodic spasmsCell antibodiesProximal musclesAutoimmune disordersMuscle rigidityIdiopathic formLimb rigiditySpontaneous firingBotulinum toxinSpinal cordLower extremitiesMuscular rigidityInhibitory interneuronsLumbar spineAbdominal wallHigh incidence
2008
30 Towards a Dynamics of Seizure Mechanics
Schiff S, Cressman J, Barreto E, Žiburkus J. 30 Towards a Dynamics of Seizure Mechanics. 2008, 496-xviii. DOI: 10.1016/b978-012373649-9.50033-8.Peer-Reviewed Original ResearchDepolarization blockRelevant neuronal subtypesExcitatory principal cellsHippocampal seizuresGap junction connectivityPyramidal cellsHuman epilepsyInhibitory interneuronsIntracellular recordingsSynaptic currentsNeuronal subtypesHuman seizuresSeizuresInterneuronsPrincipal cellsSeizure dynamicsTime courseSynchrony featuresNeuronal dynamicsCellsEpilepsy
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