2025
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsCongenital hydrocephalusCSF dynamicsIncreased CSF productionDe novo mutationsFrequent monogenic causeEverolimus treatmentCSF shuntingNonsurgical treatmentPTEN mutationsAqueductal stenosisInhibitory interneuronsVentriculomegalyProgenitor cellsChoroid plexusMonogenic causeCortical networksIncreased survivalBrain ventriclesCortical deficitsNeural progenitorsGene PTENCSF productionNkx2.1PTEN
2019
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan Z, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho R, Otsuka T, Fuccillo M, Liston C, Pisapia D, Cossart R, De Marco García N. GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Neuron 2019, 105: 75-92.e5. PMID: 31780329, PMCID: PMC6982374, DOI: 10.1016/j.neuron.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell SurvivalExcitatory Postsynaptic PotentialsFemaleGABAergic Neuronsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsInterneuronsMaleMedian EminenceMembrane PotentialsMiceMice, TransgenicNeural PathwaysNeurogenesisParvalbuminsPyramidal CellsSomatosensory CortexSomatostatinSynaptic PotentialsConceptsPyramidal cellsGanglionic eminenceReduction of GABA releaseIncreased network synchronyAssembly of neuronal circuitsEffects of GABAMedial ganglionic eminenceCaudal ganglionic eminenceSpontaneous activity patternsGABA releaseInterneuron survivalPostnatal daySomatostatin interneuronsNeonatal developmentMouse pupsSynaptic inputsCalcium imagingInterneuronsDeveloping cortexIncreased survivalNeuronal circuitsSomatosensory cortexAberrant patternsNetwork synchronySensory cortex
2018
Temporal and geographic variation in the systemic treatment of advanced prostate cancer
Caram M, Estes J, Griggs J, Lin P, Mukherjee B. Temporal and geographic variation in the systemic treatment of advanced prostate cancer. BMC Cancer 2018, 18: 258. PMID: 29510667, PMCID: PMC5840834, DOI: 10.1186/s12885-018-4166-3.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerFirst-line therapyProstate cancerSystemic treatmentFirst-lineSystemic treatment of advanced prostate cancerTreatment of metastatic castration-resistant prostate cancerTreatment of advanced prostate cancerResultsOur final analysisAdvanced prostate cancerFirst line therapyFood and Drug AdministrationNational insurance providerLine therapySequence of treatmentTreatment patternsDisease courseStudy cohortPrescription ratesPrescribed drugsDrug AdministrationIncreased survivalCancerTherapy
2016
mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Driscoll D, Karim S, Sano M, Gay D, Jacob W, Yu J, Mizukami Y, Gopinathan A, Jodrell D, Evans T, Bardeesy N, Hall M, Quattrochi B, Klimstra D, Barry S, Sansom O, Lewis B, Morton J. mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer. Cancer Research 2016, 76: 6911-6923. PMID: 27758884, PMCID: PMC5135633, DOI: 10.1158/0008-5472.can-16-0810.Peer-Reviewed Original ResearchConceptsPancreatic cancerTumor-bearing miceMTORC2 signalingProgression of pancreatic cancerPI3K inhibitionPotential therapeutic strategyPancreatic tumorsDelayed tumorigenesisMTORC1/2 inhibitorsClinical trialsTherapeutic strategiesTherapeutic approachesIncreased survivalMTORC1 inhibitorsCancerTargeting mTORSuppress tumorigenesisRictor deletionMTOR signalingTumorigenesisMTORC1/2MTORC2 subunit RictorInhibitorsMTORRictor
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