2025
Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis
Zhang Z, Yildirim M, Keskinocak P, Dasthagirisaheb Y, Hinderstein S, Tran K, Crockett M, Burns M, Johnson H, Popstefanija M, Madoff L, Pelton S, Yildirim I. Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis. Vaccine 2025, 56: 127193. PMID: 40318350, DOI: 10.1016/j.vaccine.2025.127193.Peer-Reviewed Original ResearchIncidence rate ratiosInvasive pneumococcal diseaseSickle cell diseaseIncidence ratePost-PCV13 periodCalculated incidence ratesValency vaccinesVaccine effectivenessPneumococcal diseaseHealthy childrenRates of invasive pneumococcal diseasePopulation-basedCell diseaseHealth conditionsRate ratiosNon-PCV13 serotypesPneumococcal vaccine effectivenessVulnerable populationsBootstrapping resamplingIncreased riskHigher IRNon-PCV13Genetic hematological diseasesHematological diseasesVaccine formulationsSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsSociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study.
Goldstein D, Jimenez N, Faulk D, Jones J, Reece-Nguyen T, Gooden C, Markowitz D, Dalal P. Sociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study. Anesthesia & Analgesia 2025 PMID: 40036165, DOI: 10.1213/ane.0000000000007451.Peer-Reviewed Original ResearchCase-control studySystemic risk factorsRisk factorsNPO guidelinesRetrospective multicenter case-control studyMulticenter retrospective case-control studyRetrospective case-control studyMulticenter case-control studySingle-center studyDay of procedureMultivariate logistic regressionPublic health insuranceYears of ageLanguage of carePediatric patientsMulticenter studyAffected patientsNoncompliance eventsHealth insurance typeIncreased riskMultivariate analysisPrimary outcomeSecondary outcomesElective proceduresHealth insurancePsychosocial Burden and Suicidality in Epilepsy: A Public Health Concern.
Kiriakopoulos E, Chu F, Salpekar J, Baslet G, Ghearing G, Altalib H, Sajatovic M. Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern. Epilepsy Currents 2025, 15357597251318577. PMID: 40028187, PMCID: PMC11869224, DOI: 10.1177/15357597251318577.Peer-Reviewed Original ResearchPsychosocial burdenSelf-harmPublic health concernEvidence-based suicide prevention strategiesHealth concernSuicide prevention strategiesSocial stressorsHigh riskGlobal public health concernMultidisciplinary cliniciansSuicide preventionPrevention strategiesGeneral populationAdjunctive supportSuicide riskIncreased riskIdentification of patientsEarly identificationSuicideBurdenRiskFunctional seizuresPeoplePatient subpopulationsPsychosocialEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalAddressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased riskDocumented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients.
Pathak N, Ratnasamy P, Oghenesume O, Luo X, Grauer J, Halim A. Documented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients. Hand 2025, 15589447251317225. PMID: 39968879, PMCID: PMC11840816, DOI: 10.1177/15589447251317225.Peer-Reviewed Original ResearchDocumented cannabis useCannabis useNonunion surgeryScaphoid fracturesNonunion rateNon-user groupNonoperative managementMultivariate analysisTreated with nonoperative managementIncreased riskScaphoid nonunionNon-usersPotential associationElectronic medical recordsManagement of scaphoid fracturesAcute scaphoid fracturesIndex fractureTobacco useRetrospective reviewTobacco-onlyFracture patientsAdult patientsFracture diagnosisMatched cohortCannabis-onlyColorectal Neoplasia in Inflammatory Bowel Disease
Al Sulais E, AlAmeel T, Alenzi M, Shehab M, AlMutairdi A, Al-Bawardy B. Colorectal Neoplasia in Inflammatory Bowel Disease. Cancers 2025, 17: 665. PMID: 40002259, PMCID: PMC11853504, DOI: 10.3390/cancers17040665.Peer-Reviewed Original ResearchRisk of colonic neoplasiaColonic neoplasiaInflammatory bowel diseaseConcomitant primary sclerosing cholangitisRisk factorsMultiple risk factorsColorectal neoplasiaBowel diseaseHigh-risk featuresIncreased riskPrimary sclerosing cholangitisColonic Crohn's diseaseColonic dysplasiaDisease extentSclerosing cholangitisRiskCrohn's diseaseNeoplasiaUlcerative colitisDiseaseSurveillancePatientsColorectalEpidemiologyAssociation between isolated abnormal 1-hour glucose challenge test and adverse pregnancy outcomes: a retrospective review from an urban tertiary care center in the United States
Hosier H, Lundsberg L, Culhane J, Partridge C, Son M. Association between isolated abnormal 1-hour glucose challenge test and adverse pregnancy outcomes: a retrospective review from an urban tertiary care center in the United States. BMC Pregnancy And Childbirth 2025, 25: 145. PMID: 39934722, PMCID: PMC11817534, DOI: 10.1186/s12884-025-07214-x.Peer-Reviewed Original ResearchConceptsAbnormal 1-hour glucose challenge testGlucose challenge testNeonatal intensive care unitAdverse pregnancy outcomesIncreased riskMorbidity outcomesWeeks gestationPregnancy outcomesNeonatal intensive care unit admissionTransient tachypnea of theHypertensive disorders of pregnancyAssociated with adverse outcomesChallenge testDisorders of pregnancyUrban tertiary care centerNormal screening resultsRespiratory distress syndromeTertiary care centerRetrospective cohort studyMultivariate logistic regression modelNormal screeningIntensive care unitScreening resultsMultiple secondary outcomesSingleton fetusesRisk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm
Levine A, Klug T, Cross J, Salameh M, Riedel M, Leslie M. Risk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm. Injury 2025, 56: 112205. PMID: 39954635, DOI: 10.1016/j.injury.2025.112205.Peer-Reviewed Original ResearchConceptsTip-apex distanceIntertrochanteric hip fracturesHip fractureRisk factorsAnterior-posteriorLevel 1 academic trauma centerSliding hip screwFracture reduction qualityNeck-shaft angleCut-out complicationsTrauma centerHip screwNeck-shaftIntramedullary nailingRetrospective reviewReduction qualityReduced riskIncreased riskFracture typeClinical outcomesRiskComplicationsCohortLateral viewFixation devicesDetection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data
Ramanand P, Indic P, Gentle S, Ambalavanan N. Detection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data. Pediatric Research 2025, 1-8. PMID: 39915610, DOI: 10.1038/s41390-025-03891-8.Peer-Reviewed Original ResearchDetection of pulmonary hypertensionBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionClinical risk factorsOxygen saturation dataBedside markersPresence of patent ductus arteriosusRisk factorsSignificant clinical risk factorsPatent ductus arteriosusIncreased risk of mortalityMultivariate logistic regression modelIdentification of PHPresence of PHRisk of mortalityOxygen saturation variabilityDuctus arteriosusClinical courseBackgroundPulmonary hypertensionClinical featuresPretermLogistic regression modelsAssociated PHIncreased riskRisk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
Janetzki J, Kim J, Minty E, Lee J, Morales D, Khera R, Kim C, Alshammari T, DuVall S, Matheny M, Falconer T, Kim S, Phan T, Nguyen P, Hsu M, Hsu J, Park R, Man K, Seager S, Van Zandt M, Gilbert J, Ryan P, Schuemie M, Suchard M, Hripcsak G, Pratt N, You S. Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study. EClinicalMedicine 2025, 81: 103096. PMID: 39975698, PMCID: PMC11836508, DOI: 10.1016/j.eclinm.2025.103096.Peer-Reviewed Original ResearchUrinary tract infectionRisk of aortic aneurysmTreat urinary tract infectionsOutpatient settingAortic aneurysmIndex dateCohort studyHazard ratioUrinary tract infection treatmentYonsei University College of MedicineRetrospective cohort studyPropensity scoreCox proportional hazards modelsPropensity-matched pairsRandom-effects meta-analysisProportional hazards modelNational Health and Medical Research Council (NHMRCUniversity College of MedicineSystemic fluoroquinolonesTract infectionsNo significant differenceBayesian random-effects meta-analysisFollow-upPrimary outcomeIncreased riskLong-term drought and risk of infant mortality in Africa: A cross-sectional study
Wang P, Rogne T, Warren J, Asare E, Akum R, Toure N, Ross J, Chen K. Long-term drought and risk of infant mortality in Africa: A cross-sectional study. PLOS Medicine 2025, 22: e1004516. PMID: 39888958, PMCID: PMC11785314, DOI: 10.1371/journal.pmed.1004516.Peer-Reviewed Original ResearchConceptsRisk of infant mortalityInfant mortality riskCross-sectional studyInfant mortalityMortality riskIncreased risk of infant mortalityIncreased risk of neonatal mortalityIncreased riskRisk of neonatal mortalityHealth Surveys ProgramPost-neonatal mortalityCox regression modelsStatistically significant associationChild healthGlobal burdenNon-casesNeonatal mortalitySignificant associationImpact mortalityNon-exposureSurvival periodRegression modelsPregnancyMortalityHealthA deep learning analysis for dual healthcare system users and risk of opioid use disorder
Yin Y, Workman E, Ma P, Cheng Y, Shao Y, Goulet J, Sandbrink F, Brandt C, Spevak C, Kean J, Becker W, Libin A, Shara N, Sheriff H, Butler J, Agrawal R, Kupersmith J, Zeng-Trietler Q. A deep learning analysis for dual healthcare system users and risk of opioid use disorder. Scientific Reports 2025, 15: 3648. PMID: 39881142, PMCID: PMC11779826, DOI: 10.1038/s41598-024-77602-4.Peer-Reviewed Original ResearchConceptsRisk of opioid use disorderOpioid use disorderDeep neural networksUse disorderClinical factorsIncreased risk of opioid use disorderOpioid use disorder riskOpioid prescribing guidelinesNatural language processing of clinical notesDeep neural network modelU.S. veteransSubstance useOpioid useNatural language processingRetrospective studyBaltimore VA Medical CenterVA Medical CenterIncreased riskPrescribing guidelinesDrug useRisk factorsOpioidMedical CenterVeteransVeterans Health AdministrationEmulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk
Miranda O, Qi X, Brannock M, Whitworth R, Kosten T, Ryan N, Haas G, Kirisci L, Wang L. Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk. Frontiers In Psychiatry 2025, 15: 1526488. PMID: 39935628, PMCID: PMC11811752, DOI: 10.3389/fpsyt.2024.1526488.Peer-Reviewed Original ResearchPost-traumatic stress disorderSuicide-related eventsPost-traumatic stress disorder patientsPost-traumatic stress disorder populationEffects of antidepressant useIncreased risk of suicideInitiation of antidepressantsRisk of suicideStress disorderSuicide riskAntidepressant useAntidepressantsBehavioral changesSuicideLoss to follow-upRandomized clinical trialsMultiple comparisonsTreatment cessationFollow-upClinical trialsIncreased riskElevated riskPatientsCitalopramVenlafaxineDrug interactions in people with HIV treated with antivirals for other viral illnesses
Okoli A, Ogbuagu O. Drug interactions in people with HIV treated with antivirals for other viral illnesses. Expert Opinion On Drug Metabolism & Toxicology 2025, ahead-of-print: 1-15. PMID: 39836520, DOI: 10.1080/17425255.2025.2455401.Peer-Reviewed Original ResearchDrug-drug interactionsDrug interactionsManagement of drug interactionsTreatment of HIVViral coinfectionAntiviral therapyHepatitis CViral illnessHIV treatmentIncreased riskPrescribing informationEffective treatmentViral infectionHIVAntiviral agentsConference abstractsPWHPatient outcomesARVDrug prescribing informationTreatmentCoinfectionGoogle ScholarDrugMetabolic pathwaysAnti-Amyloid Therapies for Alzheimer’s Disease and Amyloid-Related Imaging Abnormalities: Implications for the Emergency Medicine Clinician
Rech M, Carpenter C, Aggarwal N, Hwang U. Anti-Amyloid Therapies for Alzheimer’s Disease and Amyloid-Related Imaging Abnormalities: Implications for the Emergency Medicine Clinician. Annals Of Emergency Medicine 2025 PMID: 39818674, DOI: 10.1016/j.annemergmed.2024.12.002.Peer-Reviewed Original ResearchEmergency medicine cliniciansAnti-amyloid therapiesCases of dementiaEmergency department visitsAlzheimer's diseaseDepartment visitsIschemic stroke patientsStroke patientsIncreased riskAlzheimer's disease progressionCliniciansRisk of adverse effectsAnti-amyloidDisease-modifying treatmentsAmyloid-relatedNeurodegenerative disordersImaging abnormalitiesAlzheimerAdverse effectsEmergencyDementiaAmyloid-related imaging abnormalitiesGestational weight gain and increased risk of cesarean delivery across body mass index categories
MCELFISH P, AYERS B, HAWLEY N, CALDWELL A, PORTER A, MACECHKO M, WATSON D, CALLAGHAN-KORU J, SELIG J, ANDERSEN J, MANNING N, WHITE L, GOMEZ-POMAR E, BROWN C. Gestational weight gain and increased risk of cesarean delivery across body mass index categories. AJOG Global Reports 2025, 5: 100445. PMID: 40027475, PMCID: PMC11869019, DOI: 10.1016/j.xagr.2025.100445.Peer-Reviewed Original ResearchRisk of cesarean deliveryGestational weight gainRate of gestational weight gainHealthy pre-pregnancy BMIIncreased risk of cesarean deliveryPre-pregnancy BMIExcessive rate of gestational weight gainExcessive gestational weight gainCesarean deliveryBMI categoriesAssociated with increased risk of cesarean deliveryCesarean delivery riskPre-pregnancy BMI categoriesLow-risk birthsAmerican College of Obstetricians and GynecologistsReduce cesarean deliveryIncreased GWGVital records dataIncreased riskObstetricians and GynecologistsStudy design analysisAssociated with increased riskProportion of womenMaternal healthExcess rateAssociation of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards modelThe bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey population
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply