2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allelePrevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia E, Egan M, Emmenegger M, Leeds S. Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis. Annals Of Allergy Asthma & Immunology 2025 PMID: 40550267, DOI: 10.1016/j.anai.2025.06.024.Peer-Reviewed Original ResearchCystic fibrosisCF patientsFood allergyUS pediatric populationElectronic medical recordsPediatric populationPhenotypes of food allergyRetrospective pediatric cohort studyPrevalence of FAFA prevalenceCystic Fibrosis Foundation RegistryMale CF patientsUnited StatesPediatric CF patientsPancreatic enzyme replacementPediatric cohort studyIgE-mediated FACohort studyEstimated prevalenceInclusion criteriaMedical informationDevelopment of FAMedical recordsFA diagnosisPrevalenceRevitalizing reproductive health: innovations and future frontiers in restorative medicine
Bulletti F, Giacomucci E, Guido M, Palagiano A, Coccia M, Bulletti C. Revitalizing reproductive health: innovations and future frontiers in restorative medicine. Therapeutic Advances In Reproductive Health 2025, 19: 26334941251345844. PMID: 40546415, PMCID: PMC12182620, DOI: 10.1177/26334941251345844.Peer-Reviewed Original ResearchFertility careThyroid dysfunctionReproductive medicineFactors affecting infertilityLive birth rateMedically assisted reproductionNewcastle-Ottawa ScaleCochrane risk of bias toolAssisted reproductive technologyRisk of bias toolMulticenter trialPublic health challengeSurgical correctionReproductive-aged individualsEmbryo transferFertility outcomesART successSystem abnormalitiesBirth ratePregnancy rateAssisted reproductionNewcastle-OttawaWeb of ScienceReproductive technologyInclusion criteriaRefugee and Asylum Seeker Child and Adolescent Mental Health: A Systematic Review of Racial, Ethnic, and Contextual Disparities
Ali D, Olstein B, Vargas L, Hale E, Adi A, Savin D, Epperson C. Refugee and Asylum Seeker Child and Adolescent Mental Health: A Systematic Review of Racial, Ethnic, and Contextual Disparities. American Journal Of Orthopsychiatry 2025 PMID: 40504633, DOI: 10.1037/ort0000858.Peer-Reviewed Original ResearchSystematic reviewMental healthUnderuse of careMental health outcomesAdolescent mental health outcomesPreferred Reporting ItemsCare accessAPA PsycInfoHealth outcomesWeb of Science databasesAsylum-seeking populationReporting ItemsSociostructural factorsContextual disparitiesCareInclusion criteriaDisparitiesHealthAdolescent populationScience databasesAcculturative stressEthnic groupsInvestigated childrenAccess of refugeesOutcomesConsideration of Sociodemographics in Machine Learning-Driven Sepsis Risk Prediction.
Hauschildt K, Pan A, Bernstein T, Admon A, Mukherjee B, Iwashyna T, Rountree L. Consideration of Sociodemographics in Machine Learning-Driven Sepsis Risk Prediction. Critical Care Medicine 2025 PMID: 40488579, DOI: 10.1097/ccm.0000000000006741.Peer-Reviewed Original ResearchSociodemographic dataNarrative reviewRisk predictionStratified analysisSociodemographicsSociodemographic biasesSystematic reviewInclusion criteriaAdult populationGoogle ScholarStudy typeReview studiesPubMedOutcomesGeographic heterogeneityReview articleSepsis-related outcomesInclusionRace/ethnicityReviewAdvancing Precision Medicine in PDAC: An Ethical Scoping Review and Call to Action for IHC Implementation
Delgado-Coka L, Roa-Peña L, Flescher A, Escobar-Hoyos L, Shroyer K. Advancing Precision Medicine in PDAC: An Ethical Scoping Review and Call to Action for IHC Implementation. Cancers 2025, 17: 1899. PMID: 40563550, PMCID: PMC12191404, DOI: 10.3390/cancers17121899.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaMolecular subtypesMolecular subtypes of pancreatic ductal adenocarcinomaSubtype of pancreatic ductal adenocarcinomaBasal-like tumorsMolecular subtyping methodsSystematic literature searchAnalysis of gene expressionPredictive biomarkersPreoperative settingAggressive subtypeGoogle Scholar databasesTherapy selectionDuctal adenocarcinomaLevel of transcriptionClinical managementTreatment strategiesGene expression profilesImmunohistochemistryBiomarker assessmentToxic treatmentMRNA analysisPrecision oncologyInclusion criteriaSubtyping methodsThe landscape and effectiveness of patient retention strategies in cancer clinical trials.
Weintraub L, Karol A, Paredes R, Argulian A, Oguntuyo K, Miller J, Fujiwara Y, Joshi H, Doroshow D, Galsky M. The landscape and effectiveness of patient retention strategies in cancer clinical trials. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e23005.Peer-Reviewed Original ResearchTherapeutic cancer clinical trialsCancer clinical trialsRetention strategiesRate ratiosSupportive care trialsConfidence intervalsPatient education materialsEfficacy of current practicesBenefits of participationRandomized controlled trialsCare trialsClinical trialsPatient retentionReduced generalizabilityContact patientsUnivariate linear regressionInclusion criteriaPersonalized interventionsEducational materialsControlled trialsIncreased likelihoodMulti-siteProtocol documentsSupportive careCurrent practicesFactors influencing withdrawal without a defined reason in oncology trials.
Paredes R, Karol A, Argulian A, Oguntuyo K, Weintraub L, Miller J, Fujiwara Y, Joshi H, Doroshow D, Galsky M. Factors influencing withdrawal without a defined reason in oncology trials. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e23014.Peer-Reviewed Original ResearchRate ratiosImprove participant retentionSupportive care trialsPatient-level factorsCombination therapyParticipant flow diagramEnrollment sizeCare trialsSolid tumorsInterpretation of clinical trial resultsParticipant retentionIndustry-sponsored trialsPatient interactionsAssociated with significantly higher ratesInclusion criteriaMedian follow-upTrial enrollmentIncreased likelihoodSignificantly higher ratesMultivariate regressionClinical trial resultsMulti-siteTrial designPatient enrollmentDefinitive RT0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea
Ahsan M, Yaggi H, Anwar A, Chen H, Chen C, Zinchuk A, Wu H. 0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea. Sleep 2025, 48: a316-a317. DOI: 10.1093/sleep/zsaf090.0728.Peer-Reviewed Original ResearchObstructive sleep apneaApnea-hypopnea indexBody mass indexNegative predictive valuePositive predictive valueResidual apnea-hypopnea indexSleep apneaObstructive sleep apnea patientsPredictive valuePositive airway pressureSleep stateFirst-line treatmentFlow signalsCPAP effectsCPAP titrationCPAP adherenceCPAP devicesCPAP levelAirway pressureSleep centerCPAPPolysomnography recordingsMass indexInclusion criteriaRespiratory rate variabilityValidity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsEarly Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury
Veerapaneni D, Sakthiyendran N, Du Y, Mallinger L, Reinert A, Kim S, Nguyen C, Daneshmand A, Abdalkader M, Mohammed S, Dupuis J, Sheth K, Gilmore E, Greer D, Ong C. Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury. Critical Care Explorations 2025, 7: e1257. PMID: 40299976, PMCID: PMC12043342, DOI: 10.1097/cce.0000000000001257.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryNeurological Pupil indexUnfavorable discharge dispositionPrimary diagnosis of traumatic brain injuryDischarge dispositionPupil abnormalitiesAcute care settingInternational Mission for PrognosisDiagnosis of traumatic brain injuryQuantitative pupillometryTraumatic brain injury severityBrain injuryMultivariate logistic regressionAnalysis of clinical trialsCare settingsAssociated with unfavorable discharge outcomesTraumatic brain injury prognostic modelsClinical trialsDischarge outcomesUnfavorable discharge outcomesPrognostic modelPupillary assessmentAssociated with unfavorable outcomesDynamic prognostic informationInclusion criteriaThe Utility of a Critical Antibody Titer in Anti-K Alloimmunized Pregnancies: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy
Jacobs J, Sugrue R, Federspiel J, Funaro M, Adkins B, Booth G, de Haas M, Ding J, Drndarevic D, Kabre S, Liu S, Slootweg Y, Tiblad E, Moise K, Abels E. The Utility of a Critical Antibody Titer in Anti-K Alloimmunized Pregnancies: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy. Transfusion Medicine Reviews 2025, 39: 150895. PMID: 40253764, DOI: 10.1016/j.tmrv.2025.150895.Peer-Reviewed Original ResearchConceptsDiagnostic test accuracySevere HDFNMeta-analysisCases of severe HDFNInclusion criteriaAntibody titersTiter thresholdSevere hemolytic diseaseSystematic reviewMeta-analysis of diagnostic test accuracyAlloantibody levelsAlloimmunized pregnanciesFetal outcomesAlloimmunized patientsAntenatal surveillanceHemolytic diseaseAnti-KellClinical managementDiagnostic accuracyFetusesHDFNMaternal antibody titersSevere diseaseClinical guidelinesTitersPredictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review
Sarkar S, Choa E, Manzo L, Richman I, Batten J, Raziani Y, Poghosyan H. Predictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review. Lung Cancer 2025, 203: 108529. PMID: 40253942, DOI: 10.1016/j.lungcan.2025.108529.Peer-Reviewed Original ResearchConceptsLung cancer screeningCancer screeningUptake of lung cancer screeningLung cancer screening utilizationLung cancer mortalityOrganizational-level policiesIntegrative literature reviewUS-based studiesCancer mortalityUninsured individualsDecision-making resourcesOvid MEDLINEInclusion criteriaOvid EmbaseMedical librariansExclusion criteriaDisparitiesOvidEarly detectionLiterature reviewCINAHLScreeningLung cancerMEDLINEEmbasePopulation‐level impact of semaglutide 2.4 mg in patients with obesity or overweight and cardiovascular disease: A modelling study based on the SELECT trial
Nanna M, Doan Q, Fabricatore A, Faurby M, Henry A, Houshmand‐Oeregaard A, Levine A, Navar A, Sforzolini T, Toliver J. Population‐level impact of semaglutide 2.4 mg in patients with obesity or overweight and cardiovascular disease: A modelling study based on the SELECT trial. Diabetes Obesity And Metabolism 2025, 27: 3442-3452. PMID: 40183412, PMCID: PMC12046440, DOI: 10.1111/dom.16370.Peer-Reviewed Original ResearchConceptsHeart disease eventsRisk of heart diseaseUS adultsDisease eventsFood and Drug AdministrationImpact of semaglutideMedical careNational Health and Nutrition Examination Survey dataHeart diseaseNutrition Examination Survey dataPopulation-based prediction modelSurvey of US adultsCardiovascular diseaseRisk of heart attackFood and Drug Administration indicationsUnited StatesPopulation-level impactUS Food and Drug AdministrationRecurrent CV eventsTrial of patientsAdverse cardiovascular eventsType 2 diabetesAtherosclerotic cardiovascular diseaseHazard ratioInclusion criteriaModifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome
Senff J, Tack R, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball T, Tan B, Chemali Z, Newhouse A, Kourkoulis C, Rivier C, Falcone G, Sheth K, Lazar R, Ibrahim S, Pikula A, Tanzi R, Fricchione G, Brouwers H, Rinkel G, Yechoor N, Rosand J, Anderson C, Singh S. Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome. Journal Of Neurology Neurosurgery & Psychiatry 2025, 96: 515-527. PMID: 40180437, DOI: 10.1136/jnnp-2024-334925.Peer-Reviewed Original ResearchConceptsModifiable risk factorsLate-life depressionDisability-adjusted life yearsMeta-analysesRisk factorsComposite outcomeRelevant meta-analysesBody mass indexPhysical activityIdentified risk factorsComposite outcome of strokeHearing lossIncidence of strokeDepressive symptomsPrevention strategiesLife yearsOutcome of strokeSystematic reviewInclusion criteriaMass indexDementiaFasting plasma glucoseEffect sizeSystematic literature reviewSocial engagementLateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis
Surucu S, Okutan A, Lee M, MacLeod J, Kodra J, Fong S, Moran J, Donohue K, Graf A, Jimenez A. Lateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. JSES International 2025 DOI: 10.1016/j.jseint.2025.04.004.Peer-Reviewed Original ResearchDistalization shoulder anglesLateralization shoulder angleRange of motionReverse total shoulder arthroplastyRandom-effects modelSystematic reviewMeta-analysisShoulder angleInclusion criteriaTotal shoulder arthroplastyPreferred Reporting ItemsClinical outcomesRetrospective cohort designFollow-upShoulder arthroplastyCohort designReporting ItemsStudy qualityCochrane CenterNon-randomized studiesCorrelation coefficientMeta-analysesOutcome scoresControlled trialsQ testThe role of hinged external fixation in the treatment of knee dislocation, subluxation and fracture‐dislocation: A systematic review of indications
Ayhan E, Levitt S, Abrams G, Stannard J, Medvecky M. The role of hinged external fixation in the treatment of knee dislocation, subluxation and fracture‐dislocation: A systematic review of indications. Journal Of Experimental Orthopaedics 2025, 12: e70275. PMID: 40390855, PMCID: PMC12086806, DOI: 10.1002/jeo2.70275.Peer-Reviewed Original ResearchKnee fracture-dislocationsHinged external fixatorComplex knee injuriesFracture-dislocationKnee injuriesKnee dislocationKnee-spanning external fixationTibiofemoral subluxationChronic KDTreatment of knee dislocationsExternal fixationSoft tissue injuriesEvaluation of patientsSystematic reviewInclusion criteriaKneeLigament deficiencyLevel IVReview of indicationsSubluxationClinical indicationsCapsular releaseNon-comparative evaluationExtensor mechanism disruptionChronic knee dislocationA systematic review of implant materials for facial reconstructive and aesthetic surgery
Kauke-Navarro M, Knoedler L, Baecher H, Sherwani K, Knoedler S, Allam O, Diatta F, Alperovich M, Safi A. A systematic review of implant materials for facial reconstructive and aesthetic surgery. Frontiers In Surgery 2025, 12: 1548597. PMID: 40225117, PMCID: PMC11985522, DOI: 10.3389/fsurg.2025.1548597.Peer-Reviewed Original ResearchPatient-specific implantsFacial implantsBone resorption ratePlastic surgery techniquesStandardized outcome reportingSystematic reviewPatient ageImplant displacementNerve injurySafety profileSurgery techniquesPostoperative recoveryFollow-upAlloplastic materialsReduce complicationsPotential complicationsWeb of SciencePatient anatomyInclusion criteriaResorption rateLong-term effectsAesthetic surgeryClinical practicePRISMA guidelinesOutcome reportingEngagement in Digital Self-management Interventions for Chronic Pain
MacLean R, Shor R, Reilly E, Reuman L, Solar C, Halat A, Higgins D. Engagement in Digital Self-management Interventions for Chronic Pain. The Clinical Journal Of Pain 2025, 41: e1289. PMID: 40145149, PMCID: PMC12150219, DOI: 10.1097/ajp.0000000000001289.Peer-Reviewed Original ResearchConceptsSelf-management interventionsDigital self-management interventionsDigital interventionsPain self-management interventionEngagement dataNon-pharmacological pain treatmentsPain treatmentChronic painChronic pain interventionsIndividuals seeking careNon-Hispanic whitesIdentified gapsSelf-reported useBoolean search termsImprovement of interventionsRemoval of duplicatesChronic pain treatmentClinician supportChronic conditionsSelf-reported engagementPain interventionsReduce burdenSystematic reviewInclusion criteriaIncrease accessImproving peer review of systematic reviews and related review types by involving librarians and information specialists as methodological peer reviewers: a randomised controlled trial
Rethlefsen M, Schroter S, Bouter L, Kirkham J, Moher D, Ayala A, Blanco D, Brigham T, Nardini H, Kirtley S, Nyhan K, Townsend W, Zeegers M. Improving peer review of systematic reviews and related review types by involving librarians and information specialists as methodological peer reviewers: a randomised controlled trial. BMJ Evidence-Based Medicine 2025, bmjebm-2024-113527. PMID: 40074237, DOI: 10.1136/bmjebm-2024-113527.Peer-Reviewed Original ResearchRisk of biasQuality of reportingIntervention groupSystematic reviewPeer reviewMonths post-studyRandomised controlled trialsSystematic review searchControl groupReview typesPRISMA itemsInformation specialistsPost-peer reviewImprove peer reviewGroup allocationReview searchPost-studyInclusion criteriaStudy enrollmentSecondary outcomesJournal peer review processControlled trialsPrimary outcomePeer review processAdequate reporting
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