2025
Using Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation ratePositron Emission Tomography Brain Imaging Methodologies
Hillmer A, Cosgrove K, Carson R. Positron Emission Tomography Brain Imaging Methodologies. 2025, 107-120. DOI: 10.1093/med/9780197640654.003.0009.Peer-Reviewed Original ResearchPositron emission tomographyBrain imaging studiesStudy of mental illnessDrug occupancyGroup differencesBinding potentialMental illnessSynaptic densityPET imaging dataBrain imagingPositron emission tomography imagingAbstract Positron emission tomographyMethodological considerationsNeurotransmitter synthesisEmission tomographyImaging studiesNeurotransmitter releaseVolume of distributionOutcome measuresClinical researchBPNDNeurotransmitterBrainIllnessImage data
2024
Gut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingDevelopment of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain
Fernandes E, Palner M, Raval N, Jeppesen T, Danková D, Bærentzen S, Werner C, Eilts J, Maric H, Doose S, Aripaka S, Kaalund S, Aznar S, Kjaer A, Schlosser A, Haugaard-Kedström L, Knudsen G, Herth M, Stro̷mgaard K. Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain. Journal Of Medicinal Chemistry 2024, 67: 11975-11988. PMID: 38981131, DOI: 10.1021/acs.jmedchem.4c00615.Peer-Reviewed Original ResearchPostsynaptic densityBrain slicesPSD-95Tracer bindingPostsynaptic density protein 95Rat brain slicesMolecular imagingPost-mortem Parkinson's diseaseScaffold proteinQuantitative autoradiographyAbundant proteinsSynaptic transmissionPostsynaptic impairmentHigh-affinity inhibitorsSignaling moleculesImaging studiesFluorescent tagsCell imaging studiesIdentification of hepatic steatosis among persons with and without HIV using natural language processing
Torgersen J, Skanderson M, Kidwai-Khan F, Carbonari D, Tate J, Park L, Bhattacharya D, Lim J, Taddei T, Justice A, Re V. Identification of hepatic steatosis among persons with and without HIV using natural language processing. Hepatology Communications 2024, 8: e0468. PMID: 38896066, PMCID: PMC11186806, DOI: 10.1097/hc9.0000000000000468.Peer-Reviewed Original ResearchConceptsImaging ReportingSteatotic liver diseaseHIV statusHepatic steatosisPrevalence of metabolic comorbiditiesImaging studiesVeterans Aging Cohort StudyCompare patient characteristicsPositive predictive valueAlcohol use disorderAging Cohort StudyIdentification of hepatic steatosisHIV infectionHepatitis BMetabolic comorbiditiesNatural language processing algorithmsRadiological studiesCohort studyPatient characteristicsClinical reviewLiver diseaseHIVPredictive valueUse disorderClinical image reportsMulti-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice
Callegari S, Feher A, Smolderen K, Mena-Hurtado C, Sinusas A. Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice. American Heart Journal Plus Cardiology Research And Practice 2024, 42: 100400. PMID: 38779485, PMCID: PMC11108852, DOI: 10.1016/j.ahjo.2024.100400.Peer-Reviewed Original ResearchPeripheral arterial diseaseMicrovascular diseasePeripheral microcirculationArtery diseaseEvaluation of response to therapyResponse to therapyManagement of peripheral arterial diseaseImprove risk stratificationOutcomes of peripheral artery diseaseAssessment of perfusionPathophysiology of peripheral arterial diseaseRisk of mortalityMolecular imaging studiesMulti-modal imagesPredictors of amputationRisk stratificationPre-clinicalImaging studiesClinical perfusionProcedural treatmentsClinical practicePersonalized managementMicrocirculationDiseasePerfusionImaging Utilization and Cost of Substance Use in an Urban Academic Medical Center During the Contemporary Opioid Epidemic
Blinick R, Felsen A, Ye K, Lewis A, Kargoli F, Bellin E, Naji L, Haramati L. Imaging Utilization and Cost of Substance Use in an Urban Academic Medical Center During the Contemporary Opioid Epidemic. Academic Radiology 2024, 31: 5217-5225. PMID: 38582686, DOI: 10.1016/j.acra.2024.02.023.Peer-Reviewed Original ResearchPositive urine toxicologyUrine toxicologyComparison cohortInstitutional review boardAcademic medical centerNegative urine toxicologyEmergency departmentMedical CenterImaging utilizationGroup of ED patientsIn-hospital mortalityCharlson Comorbidity IndexSubstance useICD codesRetrospective studyUrban academic medical centerUnderserved urban populationIllicit substance useComorbidity indexContemporary opioid epidemicED patientsOpioid epidemicImaging studiesPatientsED populationKidney Stones Account for Increased Imaging Studies in Autosomal Dominant Polycystic Kidney Disease
Simmons K, Ullman L, Dahl N. Kidney Stones Account for Increased Imaging Studies in Autosomal Dominant Polycystic Kidney Disease. Kidney360 2024, 5: 707-714. PMID: 38526140, PMCID: PMC11146651, DOI: 10.34067/kid.0000000000000424.Peer-Reviewed Original ResearchAbdominal imaging studiesChronic kidney diseaseADPKD patientsImaging studiesKidney stonesChronic kidney disease controlKidney diseaseChronic kidney disease groupIncreased incidence of kidney stonesChronic kidney disease populationChronic kidney disease stagePreserved renal functionRetrospectively reviewed patientsAutosomal dominant polycystic kidney diseaseIncidence of kidney stonesDominant polycystic kidney diseaseChi-square and t-testsCoronary artery diseasePolycystic kidney diseaseCompared to controlsCyst complicationsRenal functionChart reviewLower BMIManual chart reviewMarkov Spatial Flows in Bold FMRI: A Novel Lens on the Bold Signal Applied To an Imaging Study of Schizophrenia
Miller R, Vergara V, Calhoun V. Markov Spatial Flows in Bold FMRI: A Novel Lens on the Bold Signal Applied To an Imaging Study of Schizophrenia. 2024, 00: 13-16. DOI: 10.1109/ssiai59505.2024.10508684.Peer-Reviewed Original ResearchNeurovascular effects of cocaine: relevance to addiction
Clare K, Park K, Pan Y, Lejuez C, Volkow N, Du C. Neurovascular effects of cocaine: relevance to addiction. Frontiers In Pharmacology 2024, 15: 1357422. PMID: 38455961, PMCID: PMC10917943, DOI: 10.3389/fphar.2024.1357422.Peer-Reviewed Original ResearchBrain functionAssociated with adverse medical consequencesCerebral blood flowRelevant to addictionHealthy non-drugBrain imaging studiesCerebral blood flow deficitsCocaine addictionAddictive drugsCocaine misuseCocaine useTargeted pharmacological interventionsCocaineNon-drugAdverse medical consequencesNeuronal activityDebilitating neurological complicationsPharmacological interventionsAddictionCBF changesBrainImaging studiesMedical consequencesNeurological complicationsCerebrovascular accidentEffects of electroconvulsive therapy on cortical thickness in depression: a systematic review
Toffanin T, Cattarinussi G, Ghiotto N, Lussignoli M, Pavan C, Pieri L, Schiff S, Finatti F, Romagnolo F, Folesani F, Nanni M, Caruso R, Zerbinati L, Murri M, Ferrara M, Pigato G, Grassi L, Sambataro F. Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review. Acta Neuropsychiatrica 2024, 37: e44. PMID: 38343196, DOI: 10.1017/neu.2024.6.Peer-Reviewed Original ResearchElectroconvulsive therapyCortical thicknessBipolar depressionStructural magnetic resonance imaging studiesEffects of electroconvulsive therapyEfficacy of electroconvulsive therapyTreatment-resistant depressionECT protocolsLongitudinal cortical thicknessClinical efficacy of electroconvulsive therapyElectroconvulsive therapy treatmentsMagnetic resonance imaging studiesClinical responseDepressed patientsBiomarkers of clinical responseNeural mechanismsBrain areasFrontal regionsDepressionSystematic reviewClinical efficacyFollow-upIncreased CTImaging studiesPatientsHigh-Plex Assessment of Biomarkers in Tumors
Aung T, Bates K, Rimm D. High-Plex Assessment of Biomarkers in Tumors. Modern Pathology 2024, 37: 100425. PMID: 38219953, DOI: 10.1016/j.modpat.2024.100425.Peer-Reviewed Original ResearchAssociations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study
Liang M, Chen P, Tang Y, Liang Y, Li S, Hu G, Sun Z, Yu Y, Molassiotis A, Knobf M, Ye Z. Associations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study. Depression And Anxiety 2024, 2024 PMCID: PMC11919035, DOI: 10.1155/2024/5595912.Peer-Reviewed Original ResearchInferior fronto-occipital fasciculusBreast cancerIntegrated discrimination improvementDiagnosed breast cancerIncremental predictive valueDiffusion tensor imagingQuantitative anisotropyPredictive valueDiffusion tensor imaging studiesDemoralization Scale-IIFronto-occipital fasciculusWhite matter tractsSelf-reported dataImaging studiesDiscrimination improvementLongitudinal diffusion tensor imaging studyCancerPatientsCorrelational tractographyNeural pathwaysBrain structural connectivityTensor imagingLongitudinal programBreastScale IIQuantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study
Bini J, Strober J, Kapinos M, Zheng M, Li S, Ropchan J, Nabulsi N, Huang Y, Perry R, Vatner D, Carson R. Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study. Molecular Imaging 2024, 23: 15353508241301584. DOI: 10.1177/15353508241301584.Peer-Reviewed Original ResearchImage-derived input functionTime-activity curvesRat modelIntracellular glucocorticoid actionZucker fatty (ZFZucker fatty rat modelFatty acid metabolismInactive 11-dehydrocorticosteroneMetabolic disease statusFatty (ZFPET imaging studiesAcid metabolismObesity pathophysiologyPreclinical modelsLevels in vivoZF ratsGlucocorticoid actionRadioligand bindingRodent modelsImaging studiesObesityProtein expressionPET imagingMeasurement of glucoseDisease status
2023
Cerebral embolic protection during transcatheter heart interventions.
Jimenez Diaz V, Kapadia S, Linke A, Mylotte D, Lansky A, Grube E, Settergren M, Puri R. Cerebral embolic protection during transcatheter heart interventions. EuroIntervention 2023, 19: 549-570. PMID: 37720969, PMCID: PMC10495748, DOI: 10.4244/eij-d-23-00166.Peer-Reviewed Original ResearchConceptsCerebral embolic protection devicesTranscatheter aortic valve replacementNew cerebral lesionsMajority of patientsCerebral lesionsTransfemoral transcatheter aortic valve replacementHeart interventionsCerebral embolic protectionAortic valve replacementEmbolic protection devicesBrain imaging studiesPrimary endpointDevastating complicationPeriprocedural strokeValve replacementEmbolic protectionEmbolic showerApparent strokeCerebral embolisationTranscatheter proceduresSpecific trialsImaging studiesStrokePatientsLesionsImaging acute cholecystitis, one test is enough
Schuster K, Schroeppel T, O'Connor R, Enniss T, Cripps M, Cullinane D, Kaafarani H, Crandall M, Puri R, Tominaga G. Imaging acute cholecystitis, one test is enough. The American Journal Of Surgery 2023, 226: 99-103. PMID: 36882336, DOI: 10.1016/j.amjsurg.2023.02.018.Peer-Reviewed Original ResearchConceptsCommon bile duct diameterBile duct diameterAcute cholecystitisIntra-class correlation coefficientDuct diameterRight upper quadrant painUpper quadrant painSigns of inflammationSingle imaging studyChi-square testQuadrant painPericholecystic fluidWall thicknessMulticenter studyPatientsImaging studiesCholecystitisAbnormal valuesGold standardAdequate informationPainInflammationAdmissionStudyDiagnosisManagement of asymptomatic cutaneous lumbosacral findings in newborns: a neurosurgical perspective.
Aby J, Rocque B, Loyal J. Management of asymptomatic cutaneous lumbosacral findings in newborns: a neurosurgical perspective. Journal Of Neurosurgery Pediatrics 2023, 31: 484-487. PMID: 36840732, DOI: 10.3171/2023.1.peds22453.Peer-Reviewed Original ResearchConceptsLarge skin tagsAsymptomatic newbornsPediatric neurosurgeonsFaun tail nevusVascular marksWatchful waitingRoutine careSkin tagsSubcutaneous lipomaSubspecialty consultationLocal referral patternsComplete responseSkin findingsReferral patternsSpinal MRIClinical managementPediatrics SectionAppropriate managementAmerican AcademyNewbornsImaging studiesClinical casesNeurosurgical perspectiveNeurosurgeonsDemographic information
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interactionTwo-person multimodal imaging using functional near infrared spectroscopy reveals neural mechanisms for emotional contagion
Hirsch J. Two-person multimodal imaging using functional near infrared spectroscopy reveals neural mechanisms for emotional contagion. 2022, 00: 1-2. DOI: 10.1109/ipc53466.2022.9975753.Peer-Reviewed Original ResearchFacial mimicryNeural mechanismsRight temporal parietal junctionLive face-to-face interactionEmotional contagionTemporal parietal junctionInteractive social behaviorBehavioral findingsNeural resultsEmotion ratingsNeural systemsSocial behaviorEmotional meaningFacial expressionsHuman brainFace-to-face interactionImaging studiesFacial classificationEmotionsFNIRSHypothesisBrainParticipantsContagionIndividuals
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