2024
Impact of Inpatient Percutaneous Coronary Intervention Volume on 30-Day Readmissions After Acute Myocardial Infarction-Cardiogenic Shock
Bansal K, Gupta M, Garg M, Patel N, Truesdell A, Babar Basir M, Rab S, Ahmad T, Kapur N, Desai N, Vallabhajosyula S. Impact of Inpatient Percutaneous Coronary Intervention Volume on 30-Day Readmissions After Acute Myocardial Infarction-Cardiogenic Shock. JACC Heart Failure 2024, 12: 2087-2097. PMID: 39243243, DOI: 10.1016/j.jchf.2024.07.014.Peer-Reviewed Original ResearchPercutaneous coronary interventionCardiogenic shockAcute myocardial infarctionAnnual PCI volumesHeart failureAll-causeHigh-volume PCI centersHigh-volume centersAMI-CSNationwide Readmissions DatabaseMedian annual PCI volumesVolume-outcome relationshipAMI-CS admissionsHospital PCI volumePercutaneous coronary intervention volumeVolume centersOrgan dysfunctionPCI centerMultivariable adjustmentHF readmissionSupportive therapyHighest quartilesQ1 hospitalsNoncardiac readmissionComorbidity burdenMechanical versus Biological Mitral Valve Replacement: Insights from Propensity Score Matching on Survival and Reoperation Rates
Feirer N, Buchner A, Weber M, Lang M, Dzilic E, Amabile A, Geirsson A, Trenkwalder T, Krane M, Vitanova K. Mechanical versus Biological Mitral Valve Replacement: Insights from Propensity Score Matching on Survival and Reoperation Rates. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39067811, DOI: 10.1016/j.jtcvs.2024.07.038.Peer-Reviewed Original ResearchMitral valve replacementBiological mitral valve replacementPropensity-score matchingValve replacementReoperation rateCumulative incidenceFollow-upMechanical mitral valve replacementMedian follow-up timeCumulative incidence of reoperationSurgical mitral valve replacementSymptomatic mitral valve diseaseIncidence of reoperationThirty-day mortalityHigh-volume centersMitral valve diseaseHistory of neurological disordersPropensity score matchingAnalyzed time pointsConcomitant proceduresPeriprocedural complicationsSingle-centerThirty-dayRetrospective studyReoperationEarly-onset appendiceal adenocarcinoma (EOAA): 10-year experience from a single center.
Gujarathi R, Belmont E, Rodman C, Bansal V, Setia N, Alpert L, Hart J, Moller M, Eng O, Lee G, Chin J, Amin M, Polite B, Liao C, Turaga K, Shergill A. Early-onset appendiceal adenocarcinoma (EOAA): 10-year experience from a single center. Journal Of Clinical Oncology 2024, 42: 4178-4178. DOI: 10.1200/jco.2024.42.16_suppl.4178.Peer-Reviewed Original ResearchOutcomes of overall survivalAppendiceal adenocarcinomaEarly-onset diseasePerineural invasionCytoreductive surgeryUnivariate Cox proportional hazards regression analysisCox proportional hazards regression analysisIncidence of early-onsetAssociated with poor outcomesGrade 3 diseaseProportional hazards regression analysisTargetable genomic alterationsHigh-volume centersLymph node metastasisRecords of patientsHazards regression analysisGermline mutation testingLate-onset diseaseCHEK2 mutationsMedian OSVulnerable patient populationCancer ptsOverall survivalLocalized diseaseMetastatic/recurrent diseaseOverall Volume of Upper Gastrointestinal Surgery Positively Impacts Gastric Cancer Outcomes at Centers with Low Gastrectomy Volume
Romatoski K, de Geus S, Miriyam B, Chung S, Kenzik K, Papageorge M, Rasic G, Ng S, Tseng J, Sachs T. Overall Volume of Upper Gastrointestinal Surgery Positively Impacts Gastric Cancer Outcomes at Centers with Low Gastrectomy Volume. Annals Of Surgical Oncology 2024, 31: 5293-5303. PMID: 38777899, DOI: 10.1245/s10434-024-15381-y.Peer-Reviewed Original ResearchLow-volume hospitalsUpper gastrointestinal operationsGastric adenocarcinomaGastrointestinal operationsMethodsNational Cancer DatabasePathological stage 1Centralization of surgical careKaplan-Meier methodGastric cancer outcomesHigh-volume centersQuality cancer careUpper gastrointestinal surgeryUpper gastrointestinal cancer surgeryGastrointestinal cancer surgeryStage of diseaseAdequate lymphadenectomyChi-square testWorse survivalSurgical mortalitySurgical outcomesCancer DatabasePostoperative outcomesVolume centersMargin statusCancer careImmunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US
Kerekes D, Frey A, Prsic E, Tran T, Clune J, Sznol M, Kluger H, Forman H, Becher R, Olino K, Khan S. Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. JAMA Oncology 2024, 10: 342-351. PMID: 38175659, PMCID: PMC10767643, DOI: 10.1001/jamaoncol.2023.6025.Peer-Reviewed Original ResearchNon-small cell lung cancerEnd of lifeMonth of deathImmunotherapy initiationCohort studyMAIN OUTCOMEStage IV non-small cell lung cancerCharlson-Deyo comorbidity indexHigh metastatic burdenInitiation of immunotherapyNational prescribing patternsRisk-adjusted patientsImmune checkpoint inhibitorsRetrospective cohort studyStage IV melanomaPercentage of patientsHigh-volume centersLocation of metastasesLow-volume centersOdds of deathCell lung cancerNational Clinical DatabaseLow-volume facilitiesDrug Administration approvalCheckpoint inhibitorsImmunotherapy utilization in stage IIIA melanoma: less may be more
Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.Peer-Reviewed Original ResearchStage IIIA melanomaHigh-volume centersRisk-adjusted survivalLow-volume centersImmunotherapy utilizationAdjuvant immunotherapyStage IIIATreatment of stage III melanomaAcademic centersMultivariable Cox proportional hazards regressionStage III melanomaNational Cancer DatabaseStage III diseaseFactors associated with receiptCox proportional hazards regressionCompare patient outcomesProportional hazards regressionIII melanomaImmunotherapy receiptReceiving immunotherapyIII diseaseImmunotherapy agentsOverall survivalSurvival benefitAdjuvant treatment
2023
Predictors for Early Liver Cancer Survival After Ablation and Surgical Resection: A Surveillance, Epidemiology, and End Results Program-Medicare Study
Charalel R, Mushlin A, Zheng X, Mao J, Carlos R, Brown R, Fortune B, Talenfeld A, Madoff D, Ibrahim S, Johnson M, Sedrakyan A. Predictors for Early Liver Cancer Survival After Ablation and Surgical Resection: A Surveillance, Epidemiology, and End Results Program-Medicare Study. Journal Of The American College Of Radiology 2023, 21: 295-308. PMID: 37922972, DOI: 10.1016/j.jacr.2023.10.017.Peer-Reviewed Original ResearchCancer-specific mortalityCancer-specific deathSurgical resectionSocial determinantsPortal hypertensionTumor sizeTreatment characteristicsSmall HCCAsian raceDisease factorsMultivariable Cox regression modelsSEER-Medicare studyChronic kidney diseaseHigh-volume centersLarger tumor sizeCox regression modelSignificant protective factorCause mortalityClinical factorsEsophageal varicesIndependent predictorsSEER-MedicareKidney diseaseVolume centersProcedure yearFragmentation of Care in Patients with Peritoneal Metastases Undergoing Cytoreductive Surgery
Vierra M, Bansal V, Morgan R, Witmer H, Reddy B, Dhiman A, Godley F, Ong C, Belmont E, Polite B, Shergill A, Turaga K, Eng O. Fragmentation of Care in Patients with Peritoneal Metastases Undergoing Cytoreductive Surgery. Annals Of Surgical Oncology 2023, 31: 645-654. PMID: 37737968, DOI: 10.1245/s10434-023-14318-1.Peer-Reviewed Original ResearchConceptsCytoreductive surgeryHigh-volume centersOverall survivalSystemic therapyPeritoneal metastasisTherapy-related serious adverse eventsSerious adverse eventsCare patientsColorectal primaryAppendiceal adenocarcinomaMultimodal treatmentGastrointestinal malignanciesAdverse eventsPatientsTherapy deliveryTherapyGreater travel distanceFragmented careMetastasisSurgeryColorectalOutcomesEducational statusSurvivalTherapeutic careMulti-institutional study evaluating the role of circulating tumor DNA (ctDNA) in management of appendiceal cancers (AC).
Belmont E, Bansal V, Zeineddine M, White M, Polite B, Liao C, Eng O, Turaga K, Shen J, Shergill A. Multi-institutional study evaluating the role of circulating tumor DNA (ctDNA) in management of appendiceal cancers (AC). Journal Of Clinical Oncology 2023, 41: 4170-4170. DOI: 10.1200/jco.2023.41.16_suppl.4170.Peer-Reviewed Original ResearchCirculating tumor DNACirculating tumour DNA assaysAppendiceal cancerDisease free survivalPeritoneal metastasisCytoreductive surgeryAssociated with lower disease free survivalPost-operative ctDNASensitivity of ctDNAPositive ctDNALower disease free survivalCohort of surgical patientsGrade 3 tumorsSerum tumor markersHigh-volume centersTime of surgeryMulti-institutional studyCtDNA measurementsCox proportional hazardsCtDNA assaysFree survivalTumor DNATherapy responseTumor markersVolume centersThe use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair
Bhatt H, Lisann‐Goldman L, Baron E, Salter B, Lin H, Itagaki S, Anyanwu A, Adams D, Fischer G, El‐Eshmawi A. The use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair. Echocardiography 2023, 40: 562-567. PMID: 37212377, DOI: 10.1111/echo.15597.Peer-Reviewed Original ResearchConceptsSurgical scoreMV repairMitral valveDegenerative mitral valve repairMcNemar testSurgical complexity scoreSurgical MV repairMitral valve repairHigh-volume centersSevere mitral valveExamination of patientsCommissural prolapseComplex scoring systemsValve repairTEE examinationTransesophageal echocardiographyPreoperative stratificationSurgical repairVolume centersCardiac anesthesiologistsProlapsePosteromedial commissureGold standardScoring systemImaging modalitiesDiscrepant Volume-cost Relationship Of Septal Reduction Therapies For The Treatment Of Obstructive Hypertrophic Cardiomyopathy
Altibi A, Ghanem F, Masri A. Discrepant Volume-cost Relationship Of Septal Reduction Therapies For The Treatment Of Obstructive Hypertrophic Cardiomyopathy. Journal Of Cardiac Failure 2023, 29: 639-640. DOI: 10.1016/j.cardfail.2022.10.228.Peer-Reviewed Original ResearchAlcohol septal ablationSeptal reduction therapyObstructive hypertrophic cardiomyopathyHigh-volume centersSeptal myectomyTertile of hospital volumeLow-volume centersNational Readmission DatabaseSeptal ablationHypertrophic cardiomyopathyTreatment of obstructive hypertrophic cardiomyopathyReduction therapyAlcohol septal ablation proceduresInverse volume-cost relationshipHospital volumeProcedure volumeHospital procedure volumeMedical therapyAnnual procedure volumeReadmissions DatabaseAverage annual chargesInflation-adjusted chargesVolume-cost relationshipHospital costsTherapyMutational profiles and prognostic impact in colorectal and high‐grade appendiceal adenocarcinoma with peritoneal metastases
Morgan R, Dhiman A, Sood D, Ong C, Wu X, Shergill A, Polite B, Turaga K, Eng O. Mutational profiles and prognostic impact in colorectal and high‐grade appendiceal adenocarcinoma with peritoneal metastases. Journal Of Surgical Oncology 2023, 127: 831-840. PMID: 36636792, DOI: 10.1002/jso.27203.Peer-Reviewed Original ResearchConceptsHigh-grade appendiceal adenocarcinomaPeritoneal metastasisColorectal cancerAppendiceal adenocarcinomaTP53 mutationsMutation profilesHazard ratioIncreased peritoneal cancer indexPeritoneal cancer indexHyperthermic intraperitoneal chemotherapyHigh-volume centersIncreased HRAssociated with survivalIncreased hazard ratioCytoreductive surgeryIntraperitoneal chemotherapyPeritoneal spreadPrognostic impactOverall survivalCancer indexPIK3CA mutationsRetrospective reviewMucinous diseaseNGS testingAnalyzed outcomes
2022
Hospital procedural volume and clinical outcomes for transcatheter aortic valve replacement – US nationwide readmission database, 2016–2019
Altibi A, Ghanem F, Patel J, Al-Taweel O, Chadderdon S, Song H, Lantz G, Zahr F, Golwala H. Hospital procedural volume and clinical outcomes for transcatheter aortic valve replacement – US nationwide readmission database, 2016–2019. European Heart Journal 2022, 43: ehac544.2097. DOI: 10.1093/eurheartj/ehac544.2097.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementHigh-volume centersTransfemoral transcatheter aortic valve replacementNational Readmission DatabaseUS Nationwide Readmission DatabaseClinical outcomesHigh-volume hospitalsHospital procedure volumeProcedure volumePost-TAVRTAVR proceduresReadmission ratesReadmissions DatabaseHospital volumeTranscatheter aortic valve replacement outcomesCompare overall outcomesMultivariate logistic regression analysisHigh-volume TAVR centersDays post-TAVRTranscatheter aortic valve replacement casesAdverse in-hospital eventsAortic valve replacementHospital length of stayIn-hospital cardiac arrestAcute kidney injuryAssociation of Lymph Node Sampling and Clinical Volume in Lobectomy for Non–Small Cell Lung Cancer
Udelsman BV, Chang DC, Boffa DJ, Gaissert HA. Association of Lymph Node Sampling and Clinical Volume in Lobectomy for Non–Small Cell Lung Cancer. The Annals Of Thoracic Surgery 2022, 115: 166-173. PMID: 35752354, DOI: 10.1016/j.athoracsur.2022.05.051.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerHigh-volume centersThoracic Surgeons General Thoracic Surgery DatabaseGeneral Thoracic Surgery DatabaseMedium-volume centersLow-volume centersCell lung cancerThoracic Surgery DatabaseNodal harvestParticipant centersLymph nodesLung cancerSurgery DatabaseLymph node samplingMultivariable logistic regressionHigher center volumeLong-term survivalPotential quality metricElective lobectomyAdjuvant therapyNodal yieldGuideline adherencePrimary outcomeUnivariable analysisMultivariable analysisRadiation therapy in the definitive management of medically inoperable endometrial cancer
Chin C, Damast S. Radiation therapy in the definitive management of medically inoperable endometrial cancer. International Journal Of Gynecological Cancer 2022, 32: 323-331. PMID: 35256419, DOI: 10.1136/ijgc-2021-002532.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingInoperable patientsEndometrial cancerImage-guided brachytherapyRadiation therapySystemic anti-tumor immune responseAnti-tumor immune responseThree-dimensional image-guided brachytherapyInoperable endometrial cancerDefinitive radiation therapyPoor surgical candidatesNovel systemic agentsRecent consensus guidelinesHigh-volume centersExtent of tumorRates of obesityMagnetic resonance imagingMedical inoperabilityLate morbiditySurgical candidatesSystemic agentsClinical stagingDefinitive managementOngoing trialsUterine sizePeripheral access size evaluation in transfemoral transcatheter aortic valve replacement
Hameed I, Oakley CT, Hameed NUF, Jiang Y, Naeem N, Morsi M, Ahmed A, Amabile A, Hirji S, Truong QA, Gaudino M, Kaneko T, Salemi A. Peripheral access size evaluation in transfemoral transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2022, 37: 801-807. PMID: 35137971, DOI: 10.1111/jocs.16293.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMinimal luminal diameterBody mass indexAortic valve replacementPeripheral vascular diseaseAccess vessel sizeFemoral arteryValve replacementInguinal ligamentVascular diseaseOutcomes of TAVRTransfemoral transcatheter aortic valve replacementPatient's individual risk factorsMean body mass indexContrast-enhanced CTATomography Angiography AssessmentSymptomatic aortic stenosisChronic kidney diseaseCommon iliac arteryCoronary artery diseaseHigh-volume centersDeep femoral arteryTranscatheter heart valveGeneral patient populationIndividual risk factorsGrading Pancreatic Neuroendocrine Tumors Via Endoscopic Ultrasound-guided Fine Needle Aspiration
Javed A, Pulvirenti A, Razi S, Zheng J, Michelakos T, Sekigami Y, Thompson E, Klimstra D, Deshpande V, Singhi A, Weiss M, Wolfgang C, Cameron J, Wei A, Zureikat A, Ferrone C, He J, Alliance P. Grading Pancreatic Neuroendocrine Tumors Via Endoscopic Ultrasound-guided Fine Needle Aspiration. Annals Of Surgery 2022, 277: e1284-e1290. PMID: 35081574, PMCID: PMC9364076, DOI: 10.1097/sla.0000000000005390.Peer-Reviewed Original ResearchConceptsAccuracy of EUS-FNAEUS-FNAWHO-gradeWorld Health OrganizationFactors associated with concordanceDiagnostic accuracy of EUS-FNAWorld Health Organization grading systemMulticenter retrospective studyAssociated with tumor sizeHigh-volume centersC gradeRate of concordanceImproving diagnostic accuracyNeoadjuvant therapyTumor sizeSurgical specimensSmall tumorsH-gradeRetrospective studyPanNETsHistopathological analysisTumorPatientsGrading systemModerate concordance
2021
Favorable Outcomes of Revision Hip Arthroscopy Irrespective of Whether Index Surgery was Performed by the Same Surgeon or a Different Surgeon
Ankem HK, Diulus SC, Kyin C, Jimenez AE, Maldonado DR, Sabetian PW, Saks BR, Lall AC, Domb BG. Favorable Outcomes of Revision Hip Arthroscopy Irrespective of Whether Index Surgery was Performed by the Same Surgeon or a Different Surgeon. JAAOS Global Research And Reviews 2021, 5: e21.00107. PMID: 34882583, PMCID: PMC8667977, DOI: 10.5435/jaaosglobal-d-21-00107.Peer-Reviewed Original ResearchConceptsModified Harris Hip ScorePatient-reported outcomesNonarthritic Hip ScoreRevision hip arthroscopySame surgeonHOS-SSSHip scoreHip arthroscopyDifferent surgeonsIntraoperative findingsDS patientsMultiple patient-reported outcomesComparable improvementResidual bony deformityHarris hip scorePrimary hip arthroscopyHigh-volume centersBody mass indexDifferent patient cohortsIndex surgeryClinical outcomesMass indexPatient cohortSS patientsRevision surgeryPerforming Multiple Posterior Spinal Fusions in 1 Day: A Comparison of Perioperative Outcomes Between Morning and Afternoon Cases
O’Neill N, Hedequist D, Glotzbecker M, Cook D, Yang T, McCann M, Chacko S, Cravero J, Hresko M. Performing Multiple Posterior Spinal Fusions in 1 Day: A Comparison of Perioperative Outcomes Between Morning and Afternoon Cases. Journal Of Pediatric Orthopaedics 2021, 41: e722-e726. PMID: 34334697, DOI: 10.1097/bpo.0000000000001893.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionPerioperative outcomesIdiopathic scoliosisSame surgeonPSF casesCurve correctionSpinal fusionScoliosis Research Society-30 scoresMean age 15.6 yearsScoliosis Research Society-30Initial curve correctionInpatient opioid consumptionRate of complicationsHigh-volume centersPatient-reported outcomesLength of stayOperating room availabilityOpioid consumptionPostoperative outcomesBlood lossComplication ratePain outcomesRetrospective reviewPatient weightSurgical durationThe association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidence
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