2025
Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesLow Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility
Mollon J, Schultz L, Knowles E, Jacquemont S, Glahn D, Almasy L. Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility. Biological Psychiatry 2025 PMID: 40113122, DOI: 10.1016/j.biopsych.2025.03.006.Peer-Reviewed Original ResearchAlcohol use disorderPolygenic risk scoresSchizophrenia polygenic risk scoresPercentage of individualsHigh riskDepressive disorderLack of clinical utilityUse disorderValidity of polygenic risk scoresSchizophreniaClinical utilityMDDRisk scoreEffect sizeSNP effect sizesWhite British individualsDisordersHigh-risk individualsUK BiobankType 2 diabetesBritish individualsPRS-CSIndividualsT2DPsychiatryTraining School-Based Health Clinicians in New Mexico Regarding Adverse Childhood Experiences
Katzman J, Tomedi L, Chari K, Pandey N, Del Fabbro A, Ramos M, Kazhe-Dominguez B. Training School-Based Health Clinicians in New Mexico Regarding Adverse Childhood Experiences. Healthcare 2025, 13: 638. PMID: 40150488, PMCID: PMC11942032, DOI: 10.3390/healthcare13060638.Peer-Reviewed Original ResearchSchool-based health centersAdverse childhood experiencesHealth professionalsHealth cliniciansTelementoring programRural stateChildhood experiencesPrevalence of adverse childhood experiencesPoor mental healthCapacity-building modelECHO programHealth centersMental healthPre/post surveyCase-based learningChronic painSubstance useHealthCliniciansHigh riskParticipantsProfessionalsTraumatic experiencesYouthProgramNicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective
Ameral V, Sofuoglu M, Kelly M. Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective. Expert Review Of Clinical Pharmacology 2025, ahead-of-print: 1-8. PMID: 40047379, DOI: 10.1080/17512433.2025.2472837.Peer-Reviewed Original ResearchSmoking cessationE-cigarettesEvidence-based clinical guidelinesEfficacy of e-cigarettesBenefits of e-cigarettesSmoking cessation treatmentHarm reduction optionsHarm reduction principlesNicotine replacement therapyNicotine e-cigarettesQuality of lifeIncreased life expectancyNicotine useCessation treatmentClinical guidelinesNicotineSmokingLife expectancyCigarette smokingClinical pharmacology perspectivePharmacological perspectiveClinical practiceHigh riskLong-term effectsReplacement therapyHigh-Risk Patient Refusals in the Prehospital Setting—Clinical and Legal Considerations
McNeilly B, Maggiore W, Goebel M, O’Brien M, Cozzi N, Ariyaprakai N, Lardaro T, Weinstock M. High-Risk Patient Refusals in the Prehospital Setting—Clinical and Legal Considerations. Journal Of The American College Of Emergency Physicians Open 2025, 6: 100083. PMID: 40125342, PMCID: PMC11927591, DOI: 10.1016/j.acepjo.2025.100083.Peer-Reviewed Original ResearchEmergency medical servicesEmergency medical services medical directorsMedical directorsEmergency Medical Services ProfessionsEmergency medical services systemIn-hospital physiciansDecline careQuality assessment effortsMedical oversightMedical servicesEmergency departmentQuality improvementRisk of morbidityLife-threatening emergencyHigh-risk procedureDeclined treatmentHigh riskPatient refusalDeliberate trainingLegal counselState statutesLegal considerationsLegal risksRiskStandard policyCarotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry
Lal B, Roubin G, Meschia J, Jones M, Heck D, Sternbergh W, Aronow H, Mena-Hurtado C, Howard G, Mayorga-Carlin M, Sorkin J, Brott T. Carotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry. Journal Of Vascular Surgery 2025 PMID: 40024381, DOI: 10.1016/j.jvs.2025.02.025.Peer-Reviewed Original ResearchCarotid artery stentingOpen-cell stentClosed-cell stentsFood and Drug Administration-approved deviceArtery stentingEmbolic protectionComparison of clinical outcomesStandardized procedure protocolsSymptomatic patientsPeri-proceduralAntiplatelet therapyPatient selectionClinical outcomesInstitutional experiencePatient characteristicsProcedural detailsCREST-2Lesion characteristicsLesion selectionHigh riskStentVascular anatomyPatient preferencesPatientsProcedure protocolPsychosocial Burden and Suicidality in Epilepsy: A Public Health Concern.
Kiriakopoulos E, Chu F, Salpekar J, Baslet G, Ghearing G, Altalib H, Sajatovic M. Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern. Epilepsy Currents 2025, 15357597251318577. PMID: 40028187, PMCID: PMC11869224, DOI: 10.1177/15357597251318577.Peer-Reviewed Original ResearchPsychosocial burdenSelf-harmPublic health concernEvidence-based suicide prevention strategiesHealth concernSuicide prevention strategiesSocial stressorsHigh riskGlobal public health concernMultidisciplinary cliniciansSuicide preventionPrevention strategiesGeneral populationAdjunctive supportSuicide riskIncreased riskIdentification of patientsEarly identificationSuicideBurdenRiskFunctional seizuresPeoplePatient subpopulationsPsychosocialExploring Perspectives and Challenges to Type 2 Diabetes Self-management in Haitian American Immigrants in the COVID-19 Era: An Emic View
Magny-Normilus C, Whittemore R, Schnipper J, Grey M. Exploring Perspectives and Challenges to Type 2 Diabetes Self-management in Haitian American Immigrants in the COVID-19 Era: An Emic View. Journal Of Racial And Ethnic Health Disparities 2025, 1-11. PMID: 39979694, DOI: 10.1007/s40615-025-02309-9.Peer-Reviewed Original ResearchT2D self-managementSelf-managementType 2 diabetes self-managementT2D managementCross-sectional studyAmerican immigrantsSocial supportDisproportionate burdenHealthcare systemType 2 diabetesParticipants' perspectivesPurposive samplingMultifaceted approachContent analysisEthnic minoritiesHigh riskEffects of COVID-19T2DFamily relationshipsFacilitationCOVID-19Unique challengesMacrovascular diseaseParticipantsFinancial constraintsOpioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review
Cance J, Hairgrove S, Saavedra L, Bonar E, Walton M, Patel S, Yule A, King C, Chavez L, Slesnick N, Fernandes C. Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review. Journal Of Adolescent Health 2025 PMID: 39945684, DOI: 10.1016/j.jadohealth.2024.10.026.Peer-Reviewed Original ResearchSuicide-related outcomesOpioid misuseSystematic reviewYoung adultsHigh risk of biasRisk of biasBoolean search strategyAdministrative dataConfounding biasInclusion criteriaReporting biasEligible publicationsObservational studyLongitudinal researchHigh riskAdultsOpioidAssociationSearch strategyOutcomesMisuseData studiesPotential mechanismsYouthConfoundingLow-Dose CT of the Chest: Is High-Risk Population Screening for Both Lung Cancer and Cardiovascular Disease Possible?
Fuss C. Low-Dose CT of the Chest: Is High-Risk Population Screening for Both Lung Cancer and Cardiovascular Disease Possible? Radiology 2025, 314: e250215. PMID: 39964272, DOI: 10.1148/radiol.250215.Peer-Reviewed Original ResearchEvidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional study
Marek K, Russell D, Concha-Marambio L, Choi S, Jennings D, Brumm M, Coffey C, Brown E, Seibyl J, Stern M, Soto C, Siderowf A. Evidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional study. EBioMedicine 2025, 112: 105567. PMID: 39893720, PMCID: PMC11835612, DOI: 10.1016/j.ebiom.2025.105567.Peer-Reviewed Original ResearchConceptsDementia with Lewy bodiesCross-sectional studyCognitive symptomsParkinson Associated Risk Syndrome StudyPrevention StudyYear follow-upOlder individualsDopamine transporter imagingHigh riskSyndrome studiesParticipantsParkinson's diseaseHyposmic individualsFollow-upSynuclein pathologySymptomsHyposmicsDepartment of DefenseU.S. Department of DefenseIndividualsRiskLewy bodiesClinical parkinsonismMichael J. Fox FoundationDementiaAssessing cardiovascular disease risk and social determinants of health: A comparative analysis of five risk estimation instruments using data from the Eastern Caribbean Health Outcomes Research Network
Schwartz J, Howitt C, Raman S, Nair S, Hassan S, Oladele C, Hambleton I, Sarpong D, Adams O, Maharaj R, Nazario C, Nunez M, Nunez-Smith M. Assessing cardiovascular disease risk and social determinants of health: A comparative analysis of five risk estimation instruments using data from the Eastern Caribbean Health Outcomes Research Network. PLOS ONE 2025, 20: e0316577. PMID: 39854547, PMCID: PMC11760610, DOI: 10.1371/journal.pone.0316577.Peer-Reviewed Original ResearchConceptsCardiovascular disease riskSocial determinants of healthDeterminants of healthSocial determinantsRisk estimation toolsCardiovascular diseaseEstimate 10-year CVD riskCVD riskEastern Caribbean Health Outcomes Research NetworkCardiovascular disease risk estimatesHigh riskHigher level of educationHistory of cardiovascular diseaseHigher CVD riskMultivariate logistic regression modelEthnically diverse populationsResource-constrained settingsLogistic regression modelsNon-professional occupationsSDoH variablesLevel of educationSDoHPerceived social statusRisk toolFraminghamEfficacy of a Clinical Decision Support Tool to Promote Guideline-Concordant Evaluations in Patients With High-Risk Microscopic Hematuria: A Cluster Randomized Quality Improvement Project.
Matulewicz R, Tsuruo S, King W, Nagler A, Feuer Z, Szerencsy A, Makarov D, Wong C, Dapkins I, Horwitz L, Blecker S. Efficacy of a Clinical Decision Support Tool to Promote Guideline-Concordant Evaluations in Patients With High-Risk Microscopic Hematuria: A Cluster Randomized Quality Improvement Project. Journal Of Urology 2025, 101097ju0000000000004436. PMID: 39854625, DOI: 10.1097/ju.0000000000004436.Peer-Reviewed Original ResearchClinical decision supportQuality improvement projectIntervention armImprovement projectImplementation of clinical decision supportClinical decision support alertsMultisite academic medical centerClinical decision support toolPrimary outcomeElectronic health recordsBarriers to evaluationAcademic medical centerHigh riskCDS alertsCDS toolsUsual careHealth recordsHealth systemPatient completionGuideline-concordantAmbulatory sitesImaging ordersCompletion of imagingControl armPromotion evaluationNeoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial
Loi S, Salgado R, Curigliano G, Romero Díaz R, Delaloge S, Rojas García C, Kok M, Saura C, Harbeck N, Mittendorf E, Yardley D, Suárez Zaizar A, Caminos F, Ungureanu A, Reinoso-Toledo J, Guarneri V, Egle D, Ades F, Pacius M, Chhibber A, Chandra R, Nathani R, Spires T, Wu J, Pusztai L, McArthur H. Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial. Nature Medicine 2025, 31: 433-441. PMID: 39838118, PMCID: PMC11835735, DOI: 10.1038/s41591-024-03414-8.Peer-Reviewed Original ResearchPathological complete responseIncreased pCR ratePhase 3 trialNeoadjuvant chemotherapyBreast cancerER+/HER2- BCNivolumab armPCR rateAnti-programmed death 1 agentsDouble-blind phase 3 trialEndpoint of pathologic complete responseStromal tumor-infiltrating lymphocyte levelsProgrammed death-ligand 1 expressionEstrogen receptor-positive breast cancerLower pathologic complete responseTumor-infiltrating lymphocyte levelsRandomized phase 3 trialReceptor-positive breast cancerHigh riskLigand 1 expressionEstrogen receptor-positivePrimary breast cancerTaxane-based chemotherapyDense lymphocytic infiltrateT cell immunosurveillanceChimerism testing in myeloid malignancies: techniques, considerations, and connections to post-transplant outcomes
Puzo C, Siddon A. Chimerism testing in myeloid malignancies: techniques, considerations, and connections to post-transplant outcomes. Pathology 2025, 57: 267-275. PMID: 39934013, DOI: 10.1016/j.pathol.2024.12.632.Peer-Reviewed Original ResearchLineage specific chimerismChimerism testingMyeloid malignanciesCell burdenHematopoietic cellsPost allogeneic stem cell transplantationHost hematopoietic cellsMalignant cell burdenLeukemic cell burdenStem cell transplantationRisk of relapseRecipient hematopoietic cellsPost-transplant outcomesCell transplantationRelapse detectionRecipient chimerismTherapy decisionsRelapsePercentage of donorsChimerismHigh riskConcurrent useChimerism percentageEarly identificationMalignancyRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder AdultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analysesCommunity-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda
Ediriweera D, Hakizimana D, Diggle P, Schurer J. Community-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, 119: 310-316. PMID: 39749566, DOI: 10.1093/trstmh/trae069.Peer-Reviewed Original ResearchConceptsSnakebite incidenceHealth worker trainingResource prioritisationEvidence-based decisionsEastern ProvinceResource-poor countriesHousehold visitsSnakebite preventionSnakebite eventsSurveillance of peopleSnakebite riskWorker trainingWell-trained personnelMedical emergencyHigh riskLow riskRisk mapsSnakebite envenomingRiskPrediction mapsSnakebitePrioritisationGeostatistical modelSpatial variationLow incidenceLiving From Test to Test: A Concept Analysis of CA-125 Preoccupation in Ovarian Cancer Survivorship
Gormley M, Dunnack Yackel H, Redeker N. Living From Test to Test: A Concept Analysis of CA-125 Preoccupation in Ovarian Cancer Survivorship. Cancer Care Research Online 2025, 5: e064. DOI: 10.1097/cr9.0000000000000064.Peer-Reviewed Original ResearchPsychosocial symptomsImprove survivorship careCINAHL electronic databasesEvolutionary concept analysisConcept analysisSymptoms of anxietySurvivorship careCancer survivorshipCare preferencesIllness intrusivenessPatient experienceCA-125 levelsCA-125Diagnosis of ovarian cancerElectronic databasesOvarian cancerHigh riskSurvey measuresHigh risk of recurrencePrompt actionDisease statusRisk of recurrenceAnxietySymptomsNursesThe Buford Complex: A Review of Embryology, Imaging, Technical Considerations, and Clinical Significance
Moran J, Joo P, Vasavada K, Cheng R, Levitt S, Manzi J, Patel S, Cecere R, Porrino J, Katz L, Jimenez A, Medvecky M. The Buford Complex: A Review of Embryology, Imaging, Technical Considerations, and Clinical Significance. JSES Reviews Reports And Techniques 2025 DOI: 10.1016/j.xrrt.2024.12.005.Peer-Reviewed Original ResearchSuperior labrum anterior-posteriorBuford complexMiddle glenohumeral ligamentClinical significanceCord-like middle glenohumeral ligamentBenign anatomical variantAnterosuperior labral tearReview of embryologyCongenital variantPreoperative imagingGeneral adult populationTechnical considerationsAnatomical variantsLabral tearsShoulder instabilityHigh riskLabral variantsAnterosuperior labrumExternal rotationAdult populationAnterior-posteriorGlenohumeral ligamentEarly childhoodTearsBuford
2024
Müllerian anomalies and endometriosis: associations and phenotypic variations
Bhamidipaty-Pelosi S, Kyei-Barffour I, Volpert M, O’Neill N, Grimshaw A, Eriksson L, Vash-Margita A, Pelosi E. Müllerian anomalies and endometriosis: associations and phenotypic variations. Reproductive Biology And Endocrinology 2024, 22: 157. PMID: 39702195, PMCID: PMC11656925, DOI: 10.1186/s12958-024-01336-1.Peer-Reviewed Original ResearchConceptsMullerian anomaliesObstructive Mullerian anomaliesAdverse pregnancy outcomesDevelopment of endometriosisAbsence of obstructionFemale reproductive tractHeterogeneity of phenotypesPregnancy outcomesRetrograde menstruationSurgical correctionCongenital conditionEndometriosisAnatomical variationsHigh riskReproductive tractCardiovascular systemVariable comorbiditiesClinical researchIncomplete developmentLack of genetic informationMalformationsComorbiditiesObstructionInfertilityMenstruation
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