2025
Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms
Aminorroaya A, Dhingra L, Pedroso A, Shankar S, Coppi A, Khunte A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms. European Heart Journal - Digital Health 2025, ztaf034. DOI: 10.1093/ehjdh/ztaf034.Peer-Reviewed Original ResearchDetectable structural heart diseaseStructural heart diseaseCommunity-based screeningLeft-sided valvular diseaseHeart diseaseELSA-BrasilYale-New Haven HospitalAI-ECG algorithmDeep learning algorithmsPopulation-based cohortSevere LVHEchocardiographic dataPredictive biomarkersHospital-based sitesNew Haven HospitalRisk stratificationValvular diseaseEnsemble deep learning algorithmUK BiobankCommunity hospitalLead I ECGHarnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care
Aminorroaya A, Biswas D, Pedroso A, Khera R. Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102562. PMID: 40230673, PMCID: PMC11993883, DOI: 10.1016/j.jscai.2025.102562.Peer-Reviewed Original ResearchClinical careCommunity-based screening programCare quality outcomesPatient outcomesPatient-focused careHarness artificial intelligenceArtificial intelligencePotential of AIImprove patient outcomesIndividualized clinical careTransform careTransform clinical practiceCardiovascular careScreening programHealth dataQuality outcomesCareClinical workflowClinical tasksAcute coronary syndromeClinical practiceHeart diseaseAI-driven technologiesInterventionAI-enabledThe burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study
Alhuneafat L, Al Ta'ani O, Arriola-Montenegro J, Al-Ajloun Y, Naser A, Chaponan-Lavalle A, Ordaya-Gonzales K, Pertuz G, Maaita A, Jabri A, Altibi A, Al-Abdouh A, Van't Hof J, Gutierrez Bernal A. The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study. International Journal Of Cardiology 2025, 428: 133143. PMID: 40064205, DOI: 10.1016/j.ijcard.2025.133143.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal Burden of DiseaseBurden of cardiovascular diseaseCardiovascular diseaseRisk factorsMortality-to-incidence ratioGlobal burdenIschemic heart diseaseAge-standardized disability-adjusted life yearsGlobal Burden of Disease StudyDisability-adjusted life year ratesBurden of Disease StudyAge-standardized prevalenceComparative risk assessment frameworkCardiovascular disease prevalenceCardiovascular disease burdenBurden of diseaseLeading risk factorHeart diseaseTailored interventionsCountry-specific variationsElevated BMIRate of strokeHealthcare infrastructureSocio-economic factorsRecessive genetic contribution to congenital heart disease in 5,424 probands
Dong W, Jin S, Sierant M, Lu Z, Li B, Lu Q, Morton S, Zhang J, López-Giráldez F, Nelson-Williams C, Knight J, Zhao H, Cao J, Mane S, Gruber P, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor J, Cnota J, Wagner M, Srivastava D, Bernstein D, Porter G, Newburger J, Roberts A, Yandell M, Yost H, Tristani-Firouzi M, Kim R, Seidman J, Chung W, Gelb B, Seidman C, Lifton R, Brueckner M. Recessive genetic contribution to congenital heart disease in 5,424 probands. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419992122. PMID: 40030011, PMCID: PMC11912448, DOI: 10.1073/pnas.2419992122.Peer-Reviewed Original ResearchConceptsRecessive genotypeCHD probandsCongenital heart diseaseAssociated with laterality defectsGene-based analysisAnalyzed whole-exome sequencingLeft-sided congenital heart diseaseWhole-exome sequencingCongenital heart disease phenotypeAshkenazi Jewish probandsOffspring of consanguineous unionsSingle-cell transcriptomicsCHD geneExome sequencingMouse notochordSecreted proteinsConsanguineous familyFounder variantGenesSignificant enrichmentLaterality phenotypesHeart diseaseProbandsAbnormal contractile functionConsanguineous unionsRisk of late sudden death after surgery for congenital heart disease.
Needleman J, Whitehill R, Claxton J, McCracken C, Zmora R, Vinocur J, Oster M, Kochilas L. Risk of late sudden death after surgery for congenital heart disease. Cardiology In The Young 2025, 1-7. PMID: 40012309, DOI: 10.1017/s1047951125000277.Peer-Reviewed Original ResearchCongenital heart diseaseSudden cardiac deathSingle-ventricle physiologyCongenital heart surgerySudden cardiac death riskCardiac deathCardiac death riskHeart surgerySingle-ventricleHeart failurePediatric Cardiac Care Consortium RegistryRisk of late sudden deathLeft-to-right shunt lesionsLeft-to-right shuntCongenital heart disease typeMild congenital heart diseaseHeart diseaseLong-term follow-upDeath riskLate sudden deathGeneral populationCardiac death patientsSudden cardiac death patientsYears of ageMortality ratioNovel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve densityCACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis
Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseCACNA1GLow-voltage-activated calcium channelsExpression of Cacna1gCalcium channelsPatient cohortCardiac functionLR patterningHeterotaxyLR organizerChannel familyCACNA1SHeart diseaseLeft-rightG expressionXenopus tropicalisAbnormal expressionProcess of cilia formationCardiac loopingMultiple organsSignaling cascadesLR asymmetryPatientsT-typeEmbryonic developmentExamining multimorbidity contributors to dementia over time
Klee M, Markwardt S, Elman M, Han L, Leist A, Allore H, Quiñones A. Examining multimorbidity contributors to dementia over time. Alzheimer's & Dementia 2025, 21: e14589. PMID: 39988573, PMCID: PMC11847647, DOI: 10.1002/alz.14589.Peer-Reviewed Original ResearchConceptsAverage attributable fractionDementia incidenceDementia riskAttributable fractionChronic conditionsAssociated with increased risk of dementiaHealth and Retirement Study participantsMedicare fee-for-service beneficiariesAcute myocardial infarctionFee-for-service beneficiariesRetirement Study participantsRisk of dementiaPatterns of comorbiditiesAssociated with increased riskDementia casesMyocardial infarctionClaims algorithmIncident casesADRDStudy participantsIschemic heart diseaseDementiaConfidence intervalsMultimorbidityHeart diseaseCharacteristics and Outcomes of Patients with Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network
Carnicelli A, Miller P, Berg D, Aliyev N, Alviar C, Bohula E, Chaudhry S, Chonde M, Chow C, Cooper H, Daniels L, Fordyce C, Ghafghazi S, Goldfarb M, Gorder K, Hamilton M, Keane R, Kontos M, Kusner J, Leibner E, Loriaux D, Menon V, Nair R, Newby L, Oduah M, Palazzolo M, Patolia H, Pierce J, Pierce M, Potter B, Proudfoot A, Roswel R, Schnell G, Shaw J, Sidhu K, Sinha S, Varshney A, Katz J, Diepen S, Morrow D. Characteristics and Outcomes of Patients with Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network. Journal Of Cardiac Failure 2025 PMID: 39970998, DOI: 10.1016/j.cardfail.2025.01.019.Peer-Reviewed Original ResearchValvular heart diseaseCardiac intensive care unitCritical Care Cardiology Trials NetworkCardiogenic shockIn-hospital mortalityClinically significant valvular heart diseaseSignificant valvular heart diseaseSevere valvular heart diseaseHeart diseaseHigher in-hospital mortality ratesAssociated with higher in-hospital mortality ratesIn-hospital mortality rateTrials NetworkOutcomes of patientsTertiary cardiac intensive care unitUnadjusted in-hospital mortalityIntensive care unitMitral regurgitationValve interventionAortic stenosisCICU admissionCS admissionsOdds ratioCare unitConsecutive admissionsUnderrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials
Ali T, Grimshaw A, Thomas A, Solomon M, Ross J, Miller P. Underrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials. European Heart Journal Acute Cardiovascular Care 2025, zuaf023. PMID: 39950988, DOI: 10.1093/ehjacc/zuaf023.Peer-Reviewed Original ResearchContemporary cardiac intensive care unitsRandomized controlled trialsIschemic heart diseaseCardiovascular diseaseHeart failureDisciplines of critical care medicineHistory of heart failureProspective randomized controlled trialsHeart diseaseControlled trialsExclusion criteriaMultivariate logistic regression analysisCardiac intensive care unitProportion of patientsExclusion of patientsComorbid cardiovascular diseaseCardiovascular disease historyIntensive care unitLogistic regression analysisApplication of randomized controlled trialsComplex patient populationGeneral internal medicineCardiovascular disease comorbiditiesMulticenter trialIndependent predictorsPrenatal Diagnosis of Congenital Heart Disease in Liveborn Infants in the New England Region
Haxel C, Wang A, Levine J, Drucker N, Hart M, Glatz J, Ferdman D, Karnik R, Tsirka A, Arya P, Doherty M, Laraja K, Hagenbuch S, Rotondo K. Prenatal Diagnosis of Congenital Heart Disease in Liveborn Infants in the New England Region. Pediatric Cardiology 2025, 1-5. PMID: 39849107, DOI: 10.1007/s00246-025-03778-9.Peer-Reviewed Original ResearchCongenital heart diseasePediatric cardiology centersPrenatal diagnosis of congenital heart diseaseDiagnosis of congenital heart diseasePrenatal diagnosisCardiology centersHeart diseaseDetection of congenital heart diseaseDiagnostic rateRates of prenatal detectionPediatric cardiology carePrenatal diagnostic ratePrenatal detection ratePrenatal diagnosis rateEarly cardiac catheterizationDetection ratePrenatal diagnosis dataMonths of lifeFetal echocardiogramFetal evaluationIncrease appropriate referralsLiveborn infantsPrenatal detectionCardiac catheterizationFetal detectionTakotsubo Syndrome in a 47-Year-Old Woman With Repaired Tetralogy of Fallot
Kayani J, Bailey L, Hopkins K, Zaidi A, Love B. Takotsubo Syndrome in a 47-Year-Old Woman With Repaired Tetralogy of Fallot. JACC Case Reports 2025, 30: 102804. PMID: 39886417, PMCID: PMC11775812, DOI: 10.1016/j.jaccas.2024.102804.Peer-Reviewed Original ResearchCase of takotsubo syndromeCongenital heart diseaseTakotsubo syndromePremenopausal womenAdult congenital heart diseaseCongenital heart disease populationComplex congenital heart diseaseEvidence of coronary artery diseaseHeart diseaseHeart disease populationExtremely rare caseAcquired cardiac diseaseRegional systolic dysfunctionCoronary artery diseaseAcute plaque ruptureRepaired tetralogySystolic dysfunctionNonischemic cardiomyopathyBroken-heart syndromeRare formAcute onsetMyocardial contractilityArtery diseaseCardiac diseaseChest tightness
2024
Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact
Mondragon-Estrada E, Newburger J, DePalma S, Brueckner M, Cleveland J, Chung W, Gelb B, Goldmuntz E, Hagler D, Huang H, McQuillen P, Miller T, Panigrahy A, Porter G, Roberts A, Rollins C, Russell M, Tristani-Firouzi M, Grant P, Im K, Morton S. Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact. IScience 2024, 28: 111707. PMID: 39877905, PMCID: PMC11772982, DOI: 10.1016/j.isci.2024.111707.Peer-Reviewed Original ResearchNoncoding variantsCongenital heart diseaseFunctions related to neuronal developmentGene regulatory signalsH3K9me2 modificationRegulatory signalsCongenital heart disease cohortsDevelopmental pathwaysNeuronal developmentFolding patternHeart diseaseFunctional impactGenetic factorsGenesVariantsBrain developmentPredictive impactSulcal patternsChanges in Risk Tolerance for Ovarian Cancer Prevention Strategies during the COVID-19 Pandemic: Results of a Discrete Choice Experiment
Egleston B, Daly M, Lew K, Bealin L, Husband A, Stopfer J, Przybysz P, Tchuvatkina O, Wong Y, Garber J, Rebbeck T. Changes in Risk Tolerance for Ovarian Cancer Prevention Strategies during the COVID-19 Pandemic: Results of a Discrete Choice Experiment. Medical Decision Making 2024, 45: 168-176. PMID: 39722532, PMCID: PMC11881031, DOI: 10.1177/0272989x241302829.Peer-Reviewed Original ResearchConceptsHigher ovarian cancer riskRisk of ovarian cancerRisk-reducing surgeryOvarian cancer riskCancer prevention strategiesCancer riskPrevention strategiesOvarian cancerOvarian cancer prevention strategiesElevated risk of breastRisk of breastCOVID-19 pandemicPrevention scenariosInfluence patients' decisionsRisk-reducing strategiesMedical decision makingAge of menopauseDiscrete choice experimentPatient's decisionElevated riskGenetic testingCOVID-19Menopausal symptomsMedical CenterHeart diseasePATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study
Becker R, Harnett B, Wayne D, Mardis R, Meganathan K, Steen D. PATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study. Clinical Research In Cardiology 2024, 114: 497-506. PMID: 39527276, DOI: 10.1007/s00392-024-02572-6.Peer-Reviewed Original ResearchStable cardiovascular diseaseAmbulatory clinic visitsAmbulatory clinic settingCardiovascular diseaseS-ECGClinical research coordinatorsClinical indicationsClinic visitsResearch coordinatorsValvular heart diseaseCoronary artery diseaseMedical practiceParticipantsEssential hypertensionClinical settingLead placementAtrial fibrillationHeart diseaseHeart failureTreatment decisionsArtery diseaseST-TElectrocardiographyBaselineHeart rhythmExpanding artificial intelligence to understudied populations: congenital heart disease as the next frontier
Oikonomou E, Khera R. Expanding artificial intelligence to understudied populations: congenital heart disease as the next frontier. European Heart Journal 2024, 46: 869-871. PMID: 39523016, PMCID: PMC11879170, DOI: 10.1093/eurheartj/ehae737.Commentaries, Editorials and LettersCongenital heart diseaseHeart diseaseCT for Congenital Heart Disease
Fuss C. CT for Congenital Heart Disease. 2024, 277-293. DOI: 10.1007/978-981-97-6919-3_21.Peer-Reviewed Original ResearchCongenital heart diseaseHeart diseaseEvaluation of congenital heart diseaseManagement of congenital heart diseaseContrast doseAffected patientsBirth defectsStages of repairRadiation exposureAltered physiologySmall organ sizeCT roleDiseaseVariable stagesCongenitallyPatientsCTDoseSpatial image resolutionComplexity of defectsBirthCardiac Disease in Pregnancy
Cifuentes J, Fardelmann K. Cardiac Disease in Pregnancy. 2024, 41-53. DOI: 10.1007/978-3-031-62756-9_6.Peer-Reviewed Original ResearchCongenital heart diseaseCardiac diseaseHeart diseasePregnant patientsPrevalence of congenital heart diseaseMaternal-fetal medicine physiciansRegistry of pregnanciesHigh-risk pregnanciesPregnancy-related mortalityProportion of patientsIncreasing maternal ageValvular heart diseasePeripartum planFetal outcomesMaternal morbidityPostpartum managementAntepartum periodDelivery hospitalizationsChronic medical conditionsComplication rateMaternal ageProspective studyDiabetes mellitusCardiothoracic surgeonsPregnancySex Differences in Hypertension and Its Management Throughout Life
Yeo W, Abraham R, Surapaneni A, Schlosser P, Ballew S, Ozkan B, Flaherty C, Yu B, Bonventre J, Parikh C, Kimmel P, Vasan R, Coresh J, Grams M. Sex Differences in Hypertension and Its Management Throughout Life. Hypertension 2024, 81: 2263-2274. PMID: 39229711, PMCID: PMC11483212, DOI: 10.1161/hypertensionaha.124.22980.Peer-Reviewed Original ResearchPrevalence of hypertensionUncontrolled hypertensionChronic kidney disease progressionPrevalence of uncontrolled hypertensionKidney disease progressionBody mass indexClasses of medicationsSex differencesEstimate sex differencesCoronary heart diseaseHeart failureMass indexAntihypertensive medicationsDisease progressionStudy visitsAtherosclerosis RiskHypertensionHigh riskHypertensive individualsHeart diseaseLife courseCommunity studiesPrevalenceMedicationPeripheral Arterial Disease prevalence and risk factors in the Eastern Caribbean Health Outcomes Research Network (ECHORN) cohort
Adams O, Galusha D, Martinez-Brockman J, Morris E, Hassan S, Maharaj R, Nazario C, Nunez M, Nunez-Smith M. Peripheral Arterial Disease prevalence and risk factors in the Eastern Caribbean Health Outcomes Research Network (ECHORN) cohort. PLOS ONE 2024, 19: e0306918. PMID: 39186495, PMCID: PMC11346651, DOI: 10.1371/journal.pone.0306918.Peer-Reviewed Original ResearchConceptsEastern Caribbean Health Outcomes Research NetworkAnkle brachial indexPeripheral arterial disease prevalencePeripheral arterial diseasePotential risk factorsSample of community-dwelling peopleRisk factorsCommunity-dwelling peopleAssociation of potential risk factorsFemale sexLower educational attainmentHistory of heart diseaseRisk factors of peripheral arterial diseaseCohort Study participantsAssociated with peripheral arterial diseaseHigh school educationHeart diseaseBody mass indexMultivariate logistic regressionOscillometric deviceAssociation of increasing ageSmoking statusYears of ageStudy participantsHeart disease history
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