2025
Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada
Wang Y, Pond G, Gafni A, Kong C, Ellis P. Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada. Current Oncology 2025, 32: 346. PMID: 40558289, PMCID: PMC12191781, DOI: 10.3390/curroncol32060346.Peer-Reviewed Original ResearchConceptsCancer-attributable costsPhase of careNon-small-cell lung cancerAdvanced non-small-cell lung cancerInstitute for Clinical Evaluative SciencesHealthcare costsEnd-of-lifePre-diagnosis costsCost disparityEnd-of-life phaseDiagnosis of advanced non-small-cell lung cancerStage IV non-small-cell lung cancerTreatment of advanced non-small-cell lung cancerIV non-small-cell lung cancerRetrospective cohort studyLung cancerEvaluative SciencesPre-diagnosisCancer diagnosisCohort studyOlder patientsDeceased patientsCareReceiving chemotherapyMedian ageDecreasing inappropriate MRCP with contrast exams: impact of an EMR-Embedded clinical care pathway
Asch D, Gunabushanam G, Cole K, Holland C, Pahade J. Decreasing inappropriate MRCP with contrast exams: impact of an EMR-Embedded clinical care pathway. Abdominal Radiology 2025, 1-8. PMID: 40439723, DOI: 10.1007/s00261-025-05022-7.Peer-Reviewed Original ResearchPlan-Do-Study-ActClinical care pathwayCare pathwaysClinical appropriatenessPlan-do-study-act cycle 1Clinical guidanceElectronic medical recordsReduce healthcare costsChi-square testHealthcare costsEmergency departmentMedical recordsResultsAt baselinePatient characteristicsAppropriate ordersStudy periodResource useProvidersStatistical significanceBaselineExamAppropriatenessIV contrastIntravenous contrastGadolinium exposureImproving adherence in hypertension management: digital tools, barriers, and innovations across Asia
Yang H, Sawano M, Lu Y. Improving adherence in hypertension management: digital tools, barriers, and innovations across Asia. Hypertension Research 2025, 1-4. PMID: 40374956, DOI: 10.1038/s41440-025-02227-7.Peer-Reviewed Original ResearchLong-term user engagementDigital health interventionsReduce cardiovascular disease riskLack of interoperabilityUser-centered designCardiovascular disease riskCultural dietary habitsPublic health resilienceHypertension careHealth interventionsHypertension prevalenceUnique barriersOlder adultsImprove adherenceCross-sector collaborationHealthcare systemUser engagementHealthcare costsHypertension managementData protocolDietary habitsHealth resilienceHealthcare infrastructureEquitable implementationMobile appsCommon Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications
Sailer A, Latich I, Levey A. Common Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications. Seminars In Interventional Radiology 2025, 42: 205-212. PMID: 40376212, PMCID: PMC12077947, DOI: 10.1055/s-0045-1804492.Peer-Reviewed Original ResearchQuality of lifePain managementCombination of therapiesImprove quality of lifeIncreased healthcare costsOpioid consumptionAdjunctive therapyHealthcare costsPatient's painUncontrolled painPhysical sufferingPainPotential complicationsAnatomical considerationsCryoneurolysisAbstract PainImprove qualityPatient outcomesPatientsClinical settingPerson's abilityCritical anatomyPatient pathologyTherapyPersonsTrends in Preventable Hospitalization Rates for Children With or Without Observation Stay Data
Tian Y, Macy M, Hockenberry J, Holl J, Sabbatini A, Ackermann R, Kan K, Huang L, Raval M. Trends in Preventable Hospitalization Rates for Children With or Without Observation Stay Data. JAMA Network Open 2025, 8: e251533. PMID: 40126481, PMCID: PMC11933988, DOI: 10.1001/jamanetworkopen.2025.1533.Peer-Reviewed Original ResearchConceptsAmbulatory care sensitive conditionsPediatric ambulatory care sensitive conditionsPreventable hospitalization ratesAnnual percentage changeHospitalization ratesPercentage changeCross-sectional studyRetrospective cross-sectional studyHospital stay dataAmbulatory careInpatient dataMain OutcomesHealthcare costsSensitive conditionsInpatient-onlyObservation staysPediatric hospitalPatients aged 6Aged 6Quality indicatorsPatient statusHospitalDisease surveillanceCounty levelImpact of policiesHigh-Value Care Education in the USA: Lessons from a National Value Curriculum for Resident and Fellow Physicians
Jain P, King C, Johnson K, Fogerty R, Andukuri V, Thakur K, Popa R, Graves K. High-Value Care Education in the USA: Lessons from a National Value Curriculum for Resident and Fellow Physicians. Journal Of General Internal Medicine 2025, 40: 1776-1781. PMID: 39825179, PMCID: PMC12119410, DOI: 10.1007/s11606-024-09343-z.Peer-Reviewed Original ResearchHigh-value careQuality improvementBaseline self-assessmentHVC educationCost-conscious practicesCost-conscious careSelf-assessmentNational healthcare costsStructured educational activitiesWeb-based curriculumPaired sample t-testQI projectCare educationHealthcare valueCare teachingFellow physiciansHealthcare costsSample t-testPhysician's abilityPractice frequencySubscale scoresMentorship modelPhysiciansNational organizationsCare
2024
Evaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study
Morgante N, Bjørnelv G, Aasdahl L, Nguyen C, Fimland M, Kunst N, Burger E. Evaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study. Value In Health 2024, 28: 415-423. PMID: 39579934, DOI: 10.1016/j.jval.2024.10.3850.Peer-Reviewed Original ResearchQuality-adjusted life yearsReturn to workO-ACTReturn-to-work interventionsHealth-related quality of lifeDecision-analytic modelRates of sickness absenceHealth-related qualityCost-effectiveQuality of lifeRTW interventionsProductivity lossSickness absenceSick leaveCost-effectiveness thresholdRegistry dataHealthcare costsNorwegian guidelinesHealthcare perspectiveLife yearsSocietal perspectiveEconomic evaluationInterventionTrial outcomesPsychological disordersChronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost
McGeary D, Swan A, Kennedy E, Dismuke-Greer C, McGeary C, Sico J, Amuan M, Manhapra A, Bouldin E, Watson P, Kenney K, Myers M, Werner J, Mitchell J, Carlson K, Delgado R, Esmaeili A, Pugh M. Chronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost. NeuroRehabilitation An International Interdisciplinary Journal 2024, 55: 303-317. PMID: 39422976, PMCID: PMC11613006, DOI: 10.3233/nre-230277.Peer-Reviewed Original ResearchTraumatic brain injuryChronic headacheTraumatic brain injury diagnosisPost-9/11-era veteransPost-traumatic headacheAssociated with higher costsCare burdenBrain injuryHealthcare costsHeadache diagnosisEra veteransClinical characteristicsHeadache disordersHigher expendituresCareVeteransIndividual headachesHigh costHeadacheIntensive treatmentRefractory headacheOutcomesDiagnosisInjuryConfoundingImproving racial/ethnic health equity and naloxone access among people at risk for opioid overdose: A simulation modeling analysis of community‐based naloxone distribution strategies in Massachusetts, United States
Zang X, Skinner A, Li Z, Shaw L, Behrends C, Chatterjee A, Jalali A, Jordan A, Morgan J, Nolen S, Schackman B, Marshall B, Walley A. Improving racial/ethnic health equity and naloxone access among people at risk for opioid overdose: A simulation modeling analysis of community‐based naloxone distribution strategies in Massachusetts, United States. Addiction 2024, 120: 316-326. PMID: 39450522, PMCID: PMC11707306, DOI: 10.1111/add.16691.Peer-Reviewed Original ResearchRates of opioid overdose deathsOpioid overdose deathsEthnic disparitiesNaloxone availabilityHealth equityNaloxone distribution strategiesRacial/ethnic groupsHispanic/Latinx populationsHealthcare costsImprove overall population healthOverall population healthOverdose deathsRisk of opioid overdose deathCost per lifePopulation healthNaloxone kitsNaloxone accessSimulation model analysisOpioid overdoseDisparitiesIncremental costPopulation levelAnnual numberHealthcareEthnic groupsYoung adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Young adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021. Epidemiology And Psychiatric Sciences 2024, 33: e48. PMID: 39390846, PMCID: PMC11561524, DOI: 10.1017/s2045796024000404.Peer-Reviewed Original ResearchConceptsMental healthcare expenditureMental healthcare costsHealthcare expendituresGeneral practitionersMental distressHealthcare costsPublic mental health approachYounger ageYoung adultsMental healthcare utilisationMental health approachPostal code levelYoung womenHealthcare utilisationOlder adultsSpecialist costsHealth approachMedical specialistsHealth insuranceMedical systemAge groupsTime pointsAdultsYoung peopleLinear regressionReal-World Healthcare Costs Among Patients With Chronic Lymphocytic Leukemia Receiving First-Line Treatment With Venetoclax + Obinutuzumab Versus Bruton Tyrosine Kinase Inhibitors
Ravelo A, Patel A, To T, Li S, Huntington S. Real-World Healthcare Costs Among Patients With Chronic Lymphocytic Leukemia Receiving First-Line Treatment With Venetoclax + Obinutuzumab Versus Bruton Tyrosine Kinase Inhibitors. Clinical Lymphoma Myeloma & Leukemia 2024, 24: s180. DOI: 10.1016/s2152-2650(24)00569-x.Peer-Reviewed Original ResearchCLL-144 Real-World Healthcare Costs Among Patients With Chronic Lymphocytic Leukemia Receiving First-Line Treatment With Venetoclax + Obinutuzumab Versus Bruton Tyrosine Kinase Inhibitors
Ravelo A, Patel A, To T, Li S, Huntington S. CLL-144 Real-World Healthcare Costs Among Patients With Chronic Lymphocytic Leukemia Receiving First-Line Treatment With Venetoclax + Obinutuzumab Versus Bruton Tyrosine Kinase Inhibitors. Clinical Lymphoma Myeloma & Leukemia 2024, 24: s345. DOI: 10.1016/s2152-2650(24)01263-1.Peer-Reviewed Original ResearchPer-patient per-monthPer-patient per-month costsChronic lymphocytic leukemiaBruton tyrosine kinase inhibitorFirst-line treatmentTyrosine kinase inhibitorsLymphocytic leukemiaMonths 0Kinase inhibitorsHealthcare costsCLL/small lymphocytic lymphomaFixed-duration treatmentFirst-line therapyOff-treatment periodMonths post-indexMonths pre-indexRetrospective observational studyClinical trial enrollmentUS health planCommercially insured patientsLymphocytic lymphomaPrimary cancerFirst-linePost-indexIbrutinibFor whom the bell tolls: assessing the incremental costs associated with failure to rescue after elective colorectal surgery
Schultz K, Moore M, Pantel H, Mongiu A, Reddy V, Schneider E, Leeds I. For whom the bell tolls: assessing the incremental costs associated with failure to rescue after elective colorectal surgery. Journal Of Gastrointestinal Surgery 2024, 28: 1812-1818. PMID: 39181234, DOI: 10.1016/j.gassur.2024.08.019.Peer-Reviewed Original ResearchFailure-to-rescueMedian total hospital costTotal hospital costsColorectal surgeryNational Inpatient SampleUneventful recoveryRetrospective study of adult patientsFailure-to-rescue patientsAssociated with increased healthcare costsStudy of adult patientsElective colorectal resectionHospital costsElective colorectal surgeryNationally representative cohortColorectal resectionElective colectomyPostoperative complicationsRetrospective studyAdult patientsRescue attemptsMedical futilityElective surgeryRepresentative cohortHealthcare costsPrimary outcomeA Nationwide Analysis on Major Upper Extremity Amputations and Replantations.
Stögner V, Hauc S, Hosseini H, Williams M, Boroumand S, Huelsboemer L, Kauke-Navarro M, Pomahac B, Colen D. A Nationwide Analysis on Major Upper Extremity Amputations and Replantations. Hand 2024, 15589447241259189. PMID: 38907654, PMCID: PMC11571424, DOI: 10.1177/15589447241259189.Peer-Reviewed Original ResearchUpper extremity amputationExtremity amputationTraumatic upper extremity amputationsUtilization Project's National Inpatient SampleProportion of amputationsUrban teaching hospitalLevel of injuryNational Inpatient SampleNontraumatic amputationsUnited StatesHospital typeLength of stayInternational ClassificationTraumatic amputationHealthcare costsHighest burdenUpper extremityAlcohol useTeaching hospitalInpatient SamplePool of casesAmputationNational trendsNationwide analysisLow likelihoodExperiences of Women Receiving Trauma-Informed Care: A Qualitative Systematic Review
Liu V, Nelson L, Shorey S. Experiences of Women Receiving Trauma-Informed Care: A Qualitative Systematic Review. Trauma Violence & Abuse 2024, 25: 3054-3065. PMID: 38804687, DOI: 10.1177/15248380241234346.Peer-Reviewed Original ResearchTrauma-informed careQualitative systematic reviewBarroso's two-step approachSystematic reviewEnhance patient engagementTrauma-informed care approachAdult heterosexual womenNon-peer-reviewed studiesIncreased healthcare costsExperiences of womenQualitative research synthesisPatient engagementRisk of illnessHistory of psychological traumaCare approachHealthcare providersPsychosocial interventionsWomen's recoveryGroup sessionsSynthesize evidenceWomen's comfortElectronic databasesExposure to traumaHealthcare costsTrauma-informedACO leakage among gynecologic cancer patients: Incidence, predictors, and impact on annual Medicare expenditure
Osazuwa-Peters O, Greiner M, Kaufman B, Zambrano Guevara L, Dinan M, Havrilesky L, Moss H. ACO leakage among gynecologic cancer patients: Incidence, predictors, and impact on annual Medicare expenditure. Gynecologic Oncology 2024, 187: 184-191. PMID: 38788516, DOI: 10.1016/j.ygyno.2024.05.020.Peer-Reviewed Original ResearchAccountable care organizationsGynecologic cancer patientsACO sizeYear of cancer diagnosisReceipt of healthcareLog-binomial regression modelsCancer patientsNon-ACO providersPatients seeking careAdjusted risk ratiosHealth care costsAnnual Medicare expendituresMedian household incomeAssociated with useCare organizationsOutpatient careMedicare expendituresCare costsHealthcare costsMedicare spendingCancer diagnosisOutpatient settingHousehold incomeRisk ratioMultivariable adjusted risk ratiosImpact of sex differences on patients with neuroendocrine neoplasms during hospital admission
Tan W, Cramer L, Vijayvergia N, Lustberg M, Kunz P. Impact of sex differences on patients with neuroendocrine neoplasms during hospital admission. Therapeutic Advances In Medical Oncology 2024, 16: 17588359241292271. PMID: 39687054, PMCID: PMC11648047, DOI: 10.1177/17588359241292271.Peer-Reviewed Original ResearchNational Inpatient SampleHospital admissionPayer typeU.S. community hospitalsModifiers of healthTreatment-related side effectsHospital discharge sampleSelf-pay groupMetastatic neuroendocrine neoplasmsNeuroendocrine neoplasmsNative American raceSex differencesCommunity hospitalHispanic ethnicityHealthcare costsUtilization ProjectSex disparitiesInpatient SamplePrivate insuranceAmerican raceSex-based differencesDistribution of raceDescriptive analysisChronic pulmonary diseaseHospital
2023
Real-World Comparison of Healthcare Costs of Venetoclax-Obinutuzumab Vs. Btki Use Among Elderly U.S. Medicare Beneficiaries with Chronic Lymphocytic Leukemia in the Front-Line (1L) Setting
Manzoor B, Huntington S, Jawaid D, Puckett J, Emechebe N, Ravelo A, Kamal-Bahl S, Doshi J. Real-World Comparison of Healthcare Costs of Venetoclax-Obinutuzumab Vs. Btki Use Among Elderly U.S. Medicare Beneficiaries with Chronic Lymphocytic Leukemia in the Front-Line (1L) Setting. Blood 2023, 142: 5085. DOI: 10.1182/blood-2023-177939.Peer-Reviewed Original ResearchChronic lymphocytic leukemiaPost-index periodU.S. Medicare beneficiariesBTK inhibitorsHealth care costsMedicare beneficiariesTreatment periodIndex dateMonth 13Months 0Prescription coverageLymphocytic leukemiaHealthcare costsCare costsMonths post-index periodDiagnosis of CLLMonthly health care costsMonthly costCause total costsFixed-duration treatmentPre-index periodPrior CLL treatmentTreatment-free remissionBCL-2 inhibitor venetoclaxFront-line settingMore problems, more money: Identifying and predicting high-cost rescue after colorectal surgery
Leeds I, Moore M, Schultz K, Canner J, Pantel H, Mongiu A, Reddy V, Schneider E. More problems, more money: Identifying and predicting high-cost rescue after colorectal surgery. Surgery Open Science 2023, 16: 148-154. PMID: 38026825, PMCID: PMC10656212, DOI: 10.1016/j.sopen.2023.10.007.Peer-Reviewed Original ResearchColorectal surgeryElective surgeryMedian total inpatient costsAdditional major proceduresElective colorectal surgeryPreoperative clinical predictorsCongestive heart failureGreater healthcare utilizationMultivariable Poisson regressionNational Inpatient SampleTotal inpatient costsElective colectomyCost-conscious careAdult patientsUneventful recoveryClinical predictorsHeart failureHealthcare utilizationInpatient costsSecondary proceduresInpatient SampleHealthcare costsMedian increaseSurgeryPatientsManaging the Chronically Ventilated Critically Ill Population
Chichra A, Tickoo M, Honiden S. Managing the Chronically Ventilated Critically Ill Population. Journal Of Intensive Care Medicine 2023, 39: 703-714. PMID: 37787184, DOI: 10.1177/08850666231203601.Peer-Reviewed Original ResearchCritical illnessMechanical ventilationAcute critical illnessCritically Ill PopulationIntensive care therapyPopulation of patientsCare therapyAcute periodHigh morbidityIntensive carePalliative careDisease burdenIll populationNeuroendocrine disordersPsychiatric effectsHealthcare costsPsychiatric issuesNutritional deficienciesChances of survivalPatientsWeaning strategiesSignificant increaseIllnessCareVentilation
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