2024
Incidental Detection of Previously Unknown Strokes on Head CT Examinations: An Untapped Opportunity for Secondary Prevention
Kenny-Howell C, Dixe de Oliveira Santo I, Wira C, de Havenon A, Tu L. Incidental Detection of Previously Unknown Strokes on Head CT Examinations: An Untapped Opportunity for Secondary Prevention. Journal Of The American College Of Radiology 2024 PMID: 39571646, DOI: 10.1016/j.jacr.2024.11.010.Peer-Reviewed Original ResearchHead CT imagesEmergency departmentOld strokeSecondary preventionHead CTCT imagesRetrospective study of adult patientsImplement secondary preventionStudy of adult patientsAssociated with greater ageHead CT examinationsED careRisk of recurrent strokeED encountersUnivariate regressionCerebellar locationCT examinationsRetrospective studyAdult patientsIncidental detectionUnivariate analysisIncidental discoveryGreater ageMultivariate regressionPatientsClinically relevant findings on 24-h head CT after acute stroke therapy: The 24-h CT score
Zhang B, King A, Voetsch B, Silverman S, Schwamm L, Ji X, Singhal A. Clinically relevant findings on 24-h head CT after acute stroke therapy: The 24-h CT score. International Journal Of Stroke 2024, 20: 226-234. PMID: 39324561, DOI: 10.1177/17474930241289992.Peer-Reviewed Original ResearchCT scoreCT findingsHead CTClinically relevant findingsFollow-up head CTRoutine head computed tomographyHead CT findingsHead computed tomographyConsecutive acute ischemic stroke patientsBlood pressure goalsAcute ischemic stroke patientsLow-risk groupMedium-risk groupAdministration of mannitolHigh-risk groupMultivariate logistic regressionAcute stroke therapyComprehensive stroke centerIschemic stroke patientsBlood glucose levelsCT abnormalitiesAntithrombotic treatmentRelevant findingsHypertonic salineRetrospective studyUncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan
Tran A, Zeevi T, Haider S, Abou Karam G, Berson E, Tharmaseelan H, Qureshi A, Sanelli P, Werring D, Malhotra A, Petersen N, de Havenon A, Falcone G, Sheth K, Payabvash S. Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan. Npj Digital Medicine 2024, 7: 26. PMID: 38321131, PMCID: PMC10847454, DOI: 10.1038/s41746-024-01007-w.Peer-Reviewed Original ResearchDeep learning modelsHematoma expansionIntracerebral hemorrhageICH expansionComputed tomographyNon-contrast head CTNon-contrast head computed tomographyHigh risk of HEHead computed tomographyHigh-confidence predictionsRisk of HENon-contrast headReceiver operating characteristic areaModifiable risk factorsMonte Carlo dropoutOperating characteristics areaPotential treatment targetHead CTVisual markersIdentified patientsAutomated deep learning modelDataset of patientsRisk factorsHigh riskPatientsTime-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome
Karam G, Chen M, Zeevi D, Harms B, Torres-Lopez V, Rivier C, Malhotra A, de Havenon A, Falcone G, Sheth K, Payabvash S. Time-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome. Diagnostics 2024, 14: 308. PMID: 38337824, PMCID: PMC10855868, DOI: 10.3390/diagnostics14030308.Peer-Reviewed Original ResearchPredictors of NDSupratentorial intracerebral hemorrhageHematoma expansionIntracerebral hemorrhageNeurological deteriorationPoor outcomeNIH Stroke ScalePost-ICHFunctional outcomesMild symptomsHematoma expansion ratesIntracerebral hemorrhage onsetAssociation of HEModifiable risk factorsGlasgow Coma ScaleBaseline CTHematoma growthConsecutive patientsHead CTSCAN-3Follow-upRate of HEComa ScaleRisk factorsHematoma
2023
Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers
Haider S, Qureshi A, Jain A, Tharmaseelan H, Berson E, Zeevi T, Werring D, Gross M, Mak A, Malhotra A, Sansing L, Falcone G, Sheth K, Payabvash S. Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers. Frontiers In Neuroscience 2023, 17: 1225342. PMID: 37655013, PMCID: PMC10467422, DOI: 10.3389/fnins.2023.1225342.Peer-Reviewed Original ResearchIndependent validation cohortIntracerebral hemorrhageRadiomic featuresValidation cohortClinical variablesHematoma expansionSpontaneous supratentorial intracerebral hemorrhageNon-contrast head CTSupratentorial intracerebral hemorrhageTomography (CT) of patientsNon-contrast headFuture clinical trialsNon-contrast CTIntracerebral Hemorrhage ExpansionHigh predictive valueBAT scoreHypertensive patientsClinical predictorsPrognostic relevanceFunctional outcomeClinical trialsHead CTHemorrhage expansionClinical trial datasetDiscovery cohortCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsEarly VTE prophylaxis in severe traumatic brain injury: A propensity score weighted EAST multicenter study
Ratnasekera A, Kim D, Seng S, Jacovides C, Kaufman E, Sadek H, Perea L, Monaco C, Shnaydman I, Lee A, Sharp V, Miciura A, Trevizo E, Rosenthal M, Lottenberg L, Zhao W, Keininger A, Hunt M, Cull J, Balentine C, Egodage T, Mohamed A, Kincaid M, Doris S, Cotterman R, Seegert S, Jacobson L, Williams J, Whitmill M, Palmer B, Mentzer C, Tackett N, Hranjec T, Dougherty T, Morrissey S, Donatelli-Seyler L, Rushing A, Tatebe L, Nevill T, Aboutanos M, Hamilton D, Redmond D, Cullinane D, Falank C, McMellen M, Duran C, Daniels J, Ballow S, Schuster K, Ferrada P. Early VTE prophylaxis in severe traumatic brain injury: A propensity score weighted EAST multicenter study. Journal Of Trauma And Acute Care Surgery 2023, 95: 94-104. PMID: 37017458, DOI: 10.1097/ta.0000000000003985.Peer-Reviewed Original ResearchConceptsVenous thromboembolism eventsIntracranial hemorrhage expansionSevere traumatic brain injuryTraumatic brain injuryVTE prophylaxisPropensity scoreBrain injuryHead CTHigh riskHigh incidenceAdult patients 18 yearsLevel II trauma centerEarly VTE prophylaxisEAST multicenter studyPatients 18 yearsUnivariate logistic regression modelMulti-center analysisLogistic regression modelsTiming of initiationProphylaxis initiationThromboembolism eventsPredictors of interestClinical characteristicsPrimary outcomeRetrospective reviewImaging Findings on Head Computed Tomography Scans in Victims of Intimate Partner Violence
Watane G, Tang A, Thomas R, Park H, Gujrathi R, Gosangi B, Khurana B. Imaging Findings on Head Computed Tomography Scans in Victims of Intimate Partner Violence. Journal Of Computer Assisted Tomography 2023, 47: 307-314. PMID: 36790916, DOI: 10.1097/rct.0000000000001427.Peer-Reviewed Original ResearchConceptsSoft tissue injuriesHead CTInjury visitsIntimate partner violenceTissue injurySubsequent injuryHead computed tomography (CT) scanLeft-sided injuriesInstitutional review board-approved retrospective analysisTime of injurySoft-tissue swellingComputed tomography scanConcomitant injuriesBilateral injuryRadiological findingsImaging findingsStudy cohortSubdural hematomaUnique patientsInjury patternsMean ageCommon manifestationHead injuryInjury typePrior injury
2022
Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports
Torres-Lopez VM, Rovenolt GE, Olcese AJ, Garcia GE, Chacko SM, Robinson A, Gaiser E, Acosta J, Herman AL, Kuohn LR, Leary M, Soto AL, Zhang Q, Fatima S, Falcone GJ, Payabvash MS, Sharma R, Struck AF, Sheth KN, Westover MB, Kim JA. Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports. JAMA Network Open 2022, 5: e2227109. PMID: 35972739, PMCID: PMC9382443, DOI: 10.1001/jamanetworkopen.2022.27109.Peer-Reviewed Original ResearchConceptsNatural language processingF-scoreTest data setsLanguage processingIndependent test data setsData setsBidirectional Encoder RepresentationsAcute brain injuryLarge data setsHead CTBrain injuryNLP toolsF1 scoreNER modelTransformer architectureClinical textEncoder RepresentationsNLP algorithmNLP modelsCT reportsCustom dictionaryTraining setCross-validation performancePerformance metricsAvailable new tools
2021
Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.Peer-Reviewed Original ResearchConceptsGray-white matter ratioHCT findingsArrest patientsInter-rater reliabilityPost-cardiac arrest patientsTertiary care academic medical centerEarly head CTPost-CA carePost-CA patientsCardiac arrest patientsHalf of casesAcademic medical centerElectronic medical recordsWithdrawal of lifeNeurophysiologic testingSpontaneous circulationInjury burdenMedical recordsHead CTTherapeutic decisionsMedical CenterPatientsNeurointensivistsHctTemperature managementBasal Ganglia Calcification in Hypoparathyroidism Is Associated With Low Serum Calcium/Phosphate Ratio
Zavatta G, Tebben P, Clarke B. Basal Ganglia Calcification in Hypoparathyroidism Is Associated With Low Serum Calcium/Phosphate Ratio. Journal Of The Endocrine Society 2021, 5: a255-a256. PMCID: PMC8091468, DOI: 10.1210/jendso/bvab048.519.Peer-Reviewed Original ResearchHead CT scanBasal ganglia calcificationNon-surgical hypoparathyroidismCT scanPrevalence of basal ganglia calcificationsHead CTSerum calciumAssociated with lower serum calciumCalcium x phosphate productRisk factorsAverage serum calciumComplications of hypoparathyroidismDuration of hypoparathyroidismHead CT-Scan imageLow serum calciumPost-surgical hypoparathyroidismCohort of patientsIncreased serum phosphateCardiovascular risk factorsDiagnosis of hypoparathyroidismMedical record reviewCalcium/phosphate ratioSerum phosphateCase seriesCase report
2020
Vascular Neuroanatomy
Amin H, Schindler J. Vascular Neuroanatomy. 2020, 11-29. DOI: 10.1007/978-3-030-52552-1_3.ChaptersDevelopment of an Operative Trauma Course in Uganda—A Report of a Three-Year Experience
Ullrich SJ, DeWane MP, Cheung M, Fleming M, Namugga MM, Fu W, Kurigamba G, Kabuye R, Mabweijano J, Galukande M, Ozgediz D, Pei KY. Development of an Operative Trauma Course in Uganda—A Report of a Three-Year Experience. Journal Of Surgical Research 2020, 256: 520-527. PMID: 32799000, DOI: 10.1016/j.jss.2020.07.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild, PreschoolClinical CompetenceCurriculumFemaleHealth ResourcesHumansInjury Severity ScoreInterdisciplinary PlacementInternship and ResidencyMaleMiddle AgedSurgeonsSurgical Procedures, OperativeSurveys and QuestionnairesTraumatologyTreatment OutcomeUgandaWounds and InjuriesYoung AdultConceptsOperative techniqueTrauma courseInitial patient evaluationThree-year experienceLow-resource settingsHealth care systemBedside interventionsRoad traffic crashesPatient demographicsClinical outcomesPatient evaluationLiver repairHead CTLeading causePractice patternsDiagnostic imagingLow-income countriesSecond-year surgical residentsStudy periodCare systemResident practiceSurgical residentsLaparotomySignificant differencesPatients
2018
ADHERENCE TO THE PECARN PEDIATRIC HEAD INJURY RULE IN TWO CANADIAN EMERGENCY SETTINGS
Gariepy M, Gravel J, Turcotte S, Légaré F, Melnick E, Hess E, Witteman H, Lelaidier-Hould L, Truchon C, Sauvé L, Plante P, Lesage N, Archambault P. ADHERENCE TO THE PECARN PEDIATRIC HEAD INJURY RULE IN TWO CANADIAN EMERGENCY SETTINGS. Paediatrics & Child Health 2018, 23: e9-e10. PMCID: PMC5961350, DOI: 10.1093/pch/pxy054.024.Peer-Reviewed Original ResearchTraumatic brain injuryLevel II trauma centerEmergency departmentHead CTPECARN rulesHead traumaTrauma centerImportant traumatic brain injuryMinor traumatic brain injuryMandatory inclusion criteriaRetrospective chart reviewPediatric level ICanadian emergency departmentsRisk of cancerYears of ageCT overuseEligible patientsChart reviewPediatric patientsRelated complicationsHead injuryMedical recordsBrain injuryInclusion criteriaLevel IF80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage
Sheikh Z, Stretz C, Maciel C, Dhakar M, Hirsch L, Gilmore E. F80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage. Clinical Neurophysiology 2018, 129: e96-e97. DOI: 10.1016/j.clinph.2018.04.243.Peer-Reviewed Original ResearchDeep intraparenchymal hemorrhageAnti-seizure drugsDecompressive hemicraniectomyIntraparenchymal hemorrhageThalamic involvementHematoma volumeContinuous EEGClinical seizuresSedative infusionsSurgical interventionInsular involvementPrior historyHigh riskMean hematoma volumeIncidence of seizuresRisk of seizuresRhythmic delta activitySpike-wave dischargesHigher hematoma volumeRetrospective reviewElectrographic seizuresSubdural hemorrhageHead CTHigh incidencePatients
2017
Use of early head CT following out-of-hospital cardiopulmonary arrest
Reynolds AS, Matthews E, Magid-Bernstein J, Rodriguez A, Park S, Claassen J, Agarwal S. Use of early head CT following out-of-hospital cardiopulmonary arrest. Resuscitation 2017, 113: 124-127. PMID: 28057527, PMCID: PMC5548415, DOI: 10.1016/j.resuscitation.2016.12.018.Peer-Reviewed Original ResearchConceptsEarly head CTHead CTAcute abnormalitiesCardiac arrestPremorbid statusCerebral Performance CategoryPatient's premorbid statusHospital cardiopulmonary arrestHospital cardiac arrestPost-arrest patientsPost-resuscitation managementDuration of arrestAbnormal scansCardiopulmonary arrestNeurological emergencyRetrospective studyFunctional statusNeurological abnormalitiesPatient managementPatientsAbnormalitiesPerformance categoriesFirst 24hOHCAArrest
2016
Determination of a Testing Threshold for Lumbar Puncture in the Diagnosis of Subarachnoid Hemorrhage after a Negative Head Computed Tomography: A Decision Analysis
Taylor RA, Gill H, Marcolini EG, Meyers HP, Faust JS, Newman DH. Determination of a Testing Threshold for Lumbar Puncture in the Diagnosis of Subarachnoid Hemorrhage after a Negative Head Computed Tomography: A Decision Analysis. Academic Emergency Medicine 2016, 23: 1119-1127. PMID: 27378053, DOI: 10.1111/acem.13042.Peer-Reviewed Original ResearchConceptsProbabilistic sensitivity analysesNegative head CTAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageLumbar punctureNegative CTTesting thresholdHead CTNormal neurologic findingsContrast-induced nephropathyNonaneurysmal subarachnoid hemorrhageLong-term morbidityHead Computed TomographyTwo-way sensitivity analysesDecision analytic modelProbability of deathNeurologic findingsRenal failureClinical variablesCurrent guidelinesPretest probabilityComputed tomographySecondary aimCTHemorrhageVascular Neuroanatomy
Amin H, Schindler J. Vascular Neuroanatomy. 2016, 9-21. DOI: 10.1007/978-3-319-39605-7_3.ChaptersThe Association Between Physician Empathy and Variation in Imaging Use
Melnick ER, O'Brien EG, Kovalerchik O, Fleischman W, Venkatesh AK, Taylor RA. The Association Between Physician Empathy and Variation in Imaging Use. Academic Emergency Medicine 2016, 23: 895-904. PMID: 27343485, PMCID: PMC5884096, DOI: 10.1111/acem.13017.Peer-Reviewed Original ResearchConceptsCT utilizationEmergency physician performanceEmergency physiciansPhysician performanceCT utilization ratesEmergency Department CTPhysician survey respondentsPatient-level variablesCross-sectional studyCohort of physiciansPhysician empathyLarge health systemPsychometric testsMixed effects regression modelsPhysician-based factorsPsychometric scalesSurvey response rateAcademic EDSubset analysisPhysician demographicsHead CTInterphysician variationResponse rateImaging useRTS score
2009
Disparities in use of computed tomography for patients presenting with headache
Harris B, Hwang U, Lee WS, Richardson LD. Disparities in use of computed tomography for patients presenting with headache. The American Journal Of Emergency Medicine 2009, 27: 333-336. PMID: 19328379, PMCID: PMC2757437, DOI: 10.1016/j.ajem.2008.03.041.Peer-Reviewed Original ResearchConceptsHead CTEmergency departmentPatient characteristics influencesPercent of patientsCommon presenting complaintRetrospective cohort reviewED medical recordsPatient demographic factorsHistory of migraineUrban emergency departmentCause of headacheDemographic factorsCharlson scoreAdult patientsCohort reviewED evaluationPresenting complaintChief complaintMultivariable analysisCT evaluationMean ageStudy eligibilityFinal diagnosisInsurance statusClinical evaluation
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