2024
Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma
Santana J, Shewarega A, Nam D, Duncan J, Madoff D, Hyder F, Coman D, Chapiro J. Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma. JHEP Reports 2024, 7: 101294. PMID: 40028344, PMCID: PMC11870164, DOI: 10.1016/j.jhepr.2024.101294.Peer-Reviewed Original ResearchT cell infiltrationHepatocellular carcinomaRadiological-pathological correlationImaging mass cytometryImmune responseT1-weighted MRITumor-infiltrating CD8+ T lymphocytesAnti-tumor immune responseCD8+ T lymphocytesIncreased T lymphocyte infiltrationImaging biomarkersNon-immunogenic tumorsSystemic lymph nodesT lymphocyte infiltrationMurine tumor modelsImmune cell typesLocal tumor therapyPrimary liver cancerNon-invasive imaging biomarkerTesla MRI scannerInduce liver cirrhosisImmunogenic tumorsLocoregional therapySystemic immunotherapyHCC lesions
2021
Deep learning–assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver
Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Deep learning–assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver. European Radiology 2021, 31: 4981-4990. PMID: 33409782, PMCID: PMC8222094, DOI: 10.1007/s00330-020-07559-1.Peer-Reviewed Original ResearchConceptsNon-HCC lesionsHepatocellular carcinomaHCC lesionsAtypical imagingGrading systemLI-RADS criteriaAtypical imaging featuresPrimary liver cancerTypical hepatocellular carcinomaAtypical hepatocellular carcinomaContrast-enhanced MRISensitivity/specificityLiver transplantMethodsThis IRBRetrospective studyLiver malignanciesImaging featuresLiver cancerAtypical featuresConclusionThis studyLesionsMRIClinical applicationCarcinomaImage-based diagnosis
2018
Dynamic contrast enhanced perfusion CT imaging: A diagnostic biomarker tool for survival prediction of tumour response to antiangiogenetic treatment in patients with advanced HCC lesions
Ippolito D, Querques G, Okolicsanyi S, Franzesi C, Pecorelli A, Lombardi S, Orsini E, Strazzabosco M, Sironi S. Dynamic contrast enhanced perfusion CT imaging: A diagnostic biomarker tool for survival prediction of tumour response to antiangiogenetic treatment in patients with advanced HCC lesions. European Journal Of Radiology 2018, 106: 62-68. PMID: 30150052, DOI: 10.1016/j.ejrad.2018.07.012.Peer-Reviewed Original ResearchConceptsAdvanced hepatocellular carcinomaAnti-angiogenic therapyPerfusion CT imagingHepatocellular carcinomaPerfusion parametersProgressor groupSurvival rateNon-progressor groupOverall survival rateKaplan-Meier analysisAssessment of responseAntiangiogenetic treatmentCirrhotic patientsSorafenib administrationPrognostic indicatorTumor responseTarget lesionsHCC lesionsIndividualized treatmentTumor neoangiogenesisPatientsOverall populationHigher survival rateCT imagingSurvival predictionSensitivity and Reproducibility of Automated Feeding Artery Detection Software during Transarterial Chemoembolization of Hepatocellular Carcinoma
Chiaradia M, Izamis ML, Radaelli A, Prevoo W, Maleux G, Schlachter T, Mayer J, Luciani A, Kobeiter H, Tacher V. Sensitivity and Reproducibility of Automated Feeding Artery Detection Software during Transarterial Chemoembolization of Hepatocellular Carcinoma. Journal Of Vascular And Interventional Radiology 2018, 29: 425-431. PMID: 29402612, DOI: 10.1016/j.jvir.2017.10.025.Peer-Reviewed Original ResearchPrediction of post-TACE necrosis of hepatocellular carcinoma usingvolumetric enhancement on MRI and volumetric oil deposition on CT, with pathological correlation
Najmi Varzaneh F, Pandey A, Aliyari Ghasabeh M, Shao N, Khoshpouri P, Pandey P, Zarghampour M, Fouladi D, Liddell R, Anders R, Kamel I. Prediction of post-TACE necrosis of hepatocellular carcinoma usingvolumetric enhancement on MRI and volumetric oil deposition on CT, with pathological correlation. European Radiology 2018, 28: 3032-3040. PMID: 29383518, PMCID: PMC6435275, DOI: 10.1007/s00330-017-5198-9.Peer-Reviewed Original ResearchConceptsPercentage tumor necrosisTumor necrosisLiver transplantHCC patientsTherapeutic decisionsLT groupMean percentage necrosisPost-TACE CTPost-treatment MRIImaging modalitiesFurther therapeutic decisionsPathological necrosisLipiodol retentionWhole cohortBaseline MRINecrosis biomarkersPathological correlationTumor responseHCC necrosisTarget lesionsHCC lesionsUnenhanced CTPercentage necrosisNecrosisDual imaging modalities
2017
Diagnostic value of dynamic contrast-enhanced CT with perfusion imaging in the quantitative assessment of tumor response to sorafenib in patients with advanced hepatocellular carcinoma: A feasibility study
Ippolito D, Querques G, Okolicsanyi S, Franzesi CT, Strazzabosco M, Sironi S. Diagnostic value of dynamic contrast-enhanced CT with perfusion imaging in the quantitative assessment of tumor response to sorafenib in patients with advanced hepatocellular carcinoma: A feasibility study. European Journal Of Radiology 2017, 90: 34-41. PMID: 28583645, DOI: 10.1016/j.ejrad.2017.02.027.Peer-Reviewed Original ResearchConceptsHepatic perfusion indexAdvanced hepatocellular carcinomaArterial perfusionHepatic perfusionHepatocellular carcinomaTarget lesionsHCC lesionsBlood volumeCirrhotic parenchymaPerfusion valuesTarget liver lesionsFollow-up scanSelection of patientsNon-responder groupDynamic contrast-enhanced CTContrast-enhanced CTAnti-angiogenic therapyPerfusion CT measurementsDedicated perfusion softwareStable diseaseSorafenib administrationPartial responseComplete responsePortal perfusionHemodynamic changes
2012
Intraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma?
Loffroy R, Lin M, Yenokyan G, Rao PP, Bhagat N, Noordhoek N, Radaelli A, Blijd J, Liapi E, Geschwind JF. Intraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma? Radiology 2012, 266: 636-648. PMID: 23143027, PMCID: PMC3558876, DOI: 10.1148/radiol.12112316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArea Under CurveCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyDoxorubicinFemaleHumansLeast-Squares AnalysisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiation DosageROC CurveSwineTreatment OutcomeConceptsDual-phase cone-beam CTTranscatheter arterial chemoembolizationPartial tumor responseDrug-eluting beadsTumor responseTumor enhancementCone-beam CT scansHepatocellular carcinomaLogistic regression modelsCone-beam CTVenous phaseCT scanMR findingsMultivariate logistic regression modelMR imagingHCC tumor responseRadiation doseDoxorubicin-eluting beadsMagnetic resonance imagingInstitutional review boardArterial chemoembolizationLiver (EASL) guidelinesRegression modelsProspective studyHCC lesions
2011
Comparing the Detectability of Hepatocellular Carcinoma by C-Arm Dual-Phase Cone-Beam Computed Tomography During Hepatic Arteriography With Conventional Contrast-Enhanced Magnetic Resonance Imaging
Loffroy R, Lin M, Rao P, Bhagat N, Noordhoek N, Radaelli A, Blijd J, Geschwind J. Comparing the Detectability of Hepatocellular Carcinoma by C-Arm Dual-Phase Cone-Beam Computed Tomography During Hepatic Arteriography With Conventional Contrast-Enhanced Magnetic Resonance Imaging. CardioVascular And Interventional Radiology 2011, 35: 97-104. PMID: 21328023, DOI: 10.1007/s00270-011-0118-x.Peer-Reviewed Original ResearchConceptsHCC lesionsMagnetic resonance imagingHepatocellular carcinomaHepatic arteriographyVenous phaseArterial phaseDrug-Eluting Beads Transarterial ChemoembolizationCE-MRIResonance imagingContrast-enhanced magnetic resonance imagingGold standardResultsSeventy-sevenTransarterial chemoembolizationHCC nodulesTerms of conspicuitySufficient image qualityTumorsDiagnostic imagingLesionsArteriographyCE-MR imagesCarcinomaLiverTomographyImagingAccuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation
Addley H, Griffin N, Shaw A, Mannelli L, Parker R, Aitken S, Wood H, Davies S, Alexander G, Lomas D. Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation. Clinical Radiology 2011, 66: 349-356. PMID: 21295772, DOI: 10.1016/j.crad.2010.11.012.Peer-Reviewed Original ResearchConceptsDetection of HCC lesionsMultidetector computed tomographyHepatocellular carcinomaMDCT examinationsHCC lesionsLiver transplantationDiagnostic confidenceDiagnostic accuracyDiagnostic accuracy of multidetector computed tomographyAccuracy of multidetector computed tomographySize of hepatocellular carcinomaLesion sizeDetection of hepatocellular carcinomaFive-point confidence scaleHepatocellular carcinoma detectionHelical CT imagesEffect of radiologist experienceLiver populationMultidetector CTCirrhotic patientsHistopathological correlationHistopathological resultsComputed tomographyCarcinoma detectionRadiologist experience
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