2025
Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver. NMR In Biomedicine 2025, 38: e70014. PMID: 39994887, DOI: 10.1002/nbm.70014.Peer-Reviewed Original ResearchConceptsH-MRSHepatic DNLMRS dataLiver tissueMeasurement of lipogenesisDietary interventionLiver lipidsHepatic de novo lipogenesisLow density lipoproteinDetection of deuteriumGold standard measureMetabolic diseasesIncreased hepatic DNLLiverDensity lipoproteinDrinking waterDeuterium labelingIn vivo measurementsNMR dataExcised liver tissueTissueDeuteriumMRSMethylene resonancesDeuterated water
2022
Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.Peer-Reviewed Original Research
2021
Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder
Batistuzzo M, Sottili B, Shavitt R, Lopes A, Cappi C, de Mathis M, Pastorello B, Diniz J, Silva R, Miguel E, Hoexter M, Otaduy M. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder. Frontiers In Psychiatry 2021, 12: 668304. PMID: 34168581, PMCID: PMC8218991, DOI: 10.3389/fpsyt.2021.668304.Peer-Reviewed Original ResearchGamma-aminobutyric acidObsessive-compulsive disorderClinical symptomsHealthy controlsExcitatory/inhibitory imbalancePathophysiology of OCDGlu/Gln ratioH-MRS studiesGray matter fractionGlu/CrCortico-striatal circuitsGlutamate levelsExcitatory neurotransmissionNeurochemical imbalanceInhibitory imbalanceStriatal regionsUnderlying neurochemistryN-acetylaspartatePatientsKey neurotransmitterH-MRSVentromedial prefrontal cortexSecondary analysisAbnormal levelsPrefrontal cortex
2020
Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations
Choi I, Andronesi O, Barker P, Bogner W, Edden R, Kaiser L, Lee P, Marjańska M, Terpstra M, de Graaf R. Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4411. PMID: 32946145, PMCID: PMC8557623, DOI: 10.1002/nbm.4411.Peer-Reviewed Original ResearchConceptsSpectral editingIn vivo<sup>1</sup>H MRS, paMulticenter clinical trialSpectral fittingExpert consensus recommendationsD-2-hydroxyglutarateJ-couplingG-aminobutyric acidH-MRSFrequency driftClinical trialsSignal overlapConsensus recommendationsMagnetic resonance spectroscopyMetabolite signalsResonance spectroscopyResonanceExpert recommendationsSequence parameters
2019
Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker
Swanberg KM, Landheer K, Pitt D, Juchem C. Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker. Frontiers In Neurology 2019, 10: 1173. PMID: 31803127, PMCID: PMC6876616, DOI: 10.3389/fneur.2019.01173.Peer-Reviewed Original ResearchMultiple sclerosisProton magnetic resonance spectroscopyDiagnostic biomarkersH-MRSStudy designVivo proton magnetic resonance spectroscopyCentral nervous system tissueNormal-appearing white matterNumerous metabolic alterationsPotential diagnostic biomarkersNervous system tissueMetabolic abnormalitiesH-MRS dataSpinal cordLesion compositionSclerosisMetabolic alterationsWhite matterGray matterMagnetic resonance spectroscopyMetabolic signaturesBiomarkersExperimental cohortLines of evidenceTechnical considerations
2017
Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing
Lindeboom L, de Graaf R. Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing. Magnetic Resonance In Medicine 2017, 79: 619-627. PMID: 28474367, DOI: 10.1002/mrm.26740.Peer-Reviewed Original ResearchConceptsAdipose tissueProton magnetic resonance spectroscopySkeletal muscleH-MRSAccumulation of triglyceridesInvasive biopsyMetabolic derangementsEctopic fatInsulin resistanceCardiovascular diseaseMetabolic diseasesMEGA-sLASER sequenceIn vivoNonadipose tissuesLipid resonancesSpectral editingPolyunsaturated fatty acidsHuman skeletal muscleMagnetic resonance spectroscopyLipid storesLipid compositionAdiposeSpectral resolutionTissuePhantom experiments
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