2025
A telescopic independent component analysis on functional magnetic resonance imaging dataset
Mirzaeian S, Faghiri A, Calhoun V, Iraji A. A telescopic independent component analysis on functional magnetic resonance imaging dataset. Network Neuroscience 2025, 9: 61-76. PMCID: PMC11949590, DOI: 10.1162/netn_a_00421.Peer-Reviewed Original ResearchRight frontoparietal networkVisual networkIndependent component analysisBrain functionExtraction of informationFunctional magnetic resonance imaging datasetsImage datasetsFrontoparietal networkMagnetic resonance imaging datasetFMRI dataGroup differencesLeverage informationSmall networksDMNNetworkComponent analysisIncomplete viewAbstract Brain functionFunctional sourceConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyPreliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial
O’Malley S, Miranda R, Book S, Chun T, Liss T, Malcolm R, Muvvala S, Padovano H, Schacht J, Blackburn B, Diamond I, Ransom J, Ryan M, Falk D, Litten R. Preliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial. Alcohol And Alcoholism 2025, 60: agaf001. PMID: 39829301, PMCID: PMC11744046, DOI: 10.1093/alcalc/agaf001.Peer-Reviewed Original ResearchAlcohol use disorderAldehyde dehydrogenase 2 inhibitorUse disorderTreat alcohol use disorderCue reactivity sessionsCue-elicited cravingCue-induced cravingHuman laboratory studiesTreatment-seeking adultsAlcohol use disorder pharmacotherapiesAldehyde dehydrogenase 2Multisite clinical trialDose to placeboWeeks of medicationEffect size estimatesReactivation sessionDrinking outcomesGroup differencesCravingMeasured 1 weekEffect sizeCohen's dDouble-blindPreliminary effectivenessAlcohol consumptionPreserved but Un-Sustained Responses to Bids for Dyadic Engagement in School-Age Children with Autism
Wall C, Hudac C, Dommer K, Li B, Atyabi A, Foster C, Wang Q, Barney E, Ahn Y, Kim M, Mahony M, Bernier R, Ventola P, Shic F. Preserved but Un-Sustained Responses to Bids for Dyadic Engagement in School-Age Children with Autism. Journal Of Autism And Developmental Disorders 2025, 1-9. PMID: 39754656, DOI: 10.1007/s10803-024-06691-x.Peer-Reviewed Original ResearchNeurotypical childrenDyadic engagementEye-tracking paradigmEye-tracking taskNo significant group differencesSignificant group differencesSocial attention mechanismAutism groupAttentional responsesAttention shiftsAutism featuresReduced attentionSchool-aged ChildrenSocial cuesNeurotypical peersGroup differencesSocial attentionChildren's attentionAutistic childrenStudying social attentionAutismOverall attentionSchool-ageExploratory analysisInteraction contextPositron Emission Tomography Brain Imaging Methodologies
Hillmer A, Cosgrove K, Carson R. Positron Emission Tomography Brain Imaging Methodologies. 2025, 107-120. DOI: 10.1093/med/9780197640654.003.0009.Peer-Reviewed Original ResearchPositron emission tomographyBrain imaging studiesStudy of mental illnessDrug occupancyGroup differencesBinding potentialMental illnessSynaptic densityPET imaging dataBrain imagingPositron emission tomography imagingAbstract Positron emission tomographyMethodological considerationsNeurotransmitter synthesisEmission tomographyImaging studiesNeurotransmitter releaseVolume of distributionOutcome measuresClinical researchBPNDNeurotransmitterBrainIllnessImage data
2024
Mentalizing, epistemic trust and interpersonal problems in emotion regulation: A sequential path analysis across common mental health disorders and community control samples
Kumpasoğlu G, Saunders R, Campbell C, Nolte T, Montague R, Pilling S, Leibowitz J, Fonagy P. Mentalizing, epistemic trust and interpersonal problems in emotion regulation: A sequential path analysis across common mental health disorders and community control samples. Journal Of Affective Disorders 2024, 372: 502-511. PMID: 39694336, DOI: 10.1016/j.jad.2024.12.050.Peer-Reviewed Original ResearchInterpersonal problemsEmotion regulationEmotion dysregulationSequential mediation analysisMental health disordersEpistemic trustMediation analysisCross-sectional design prevents causal inferencesAssociated with emotion dysregulationMultiple mental health disordersHealth disordersCommunity control sampleEffective emotion regulationNon-clinical populationsModerated mediation analysisSample recruitment methodPsychological functioningSocial-communicative aspectsGroup differencesEmotionsMentalPath analysisStudy limitationsSequential path analysisDisordersA spatially constrained independent component analysis jointly informed by structural and functional network connectivity
Fouladivanda M, Iraji A, Wu L, van Erp T, Belger A, Hawamdeh F, Pearlson G, Calhoun V. A spatially constrained independent component analysis jointly informed by structural and functional network connectivity. Network Neuroscience 2024, 8: 1212-1242. PMID: 39735500, PMCID: PMC11674407, DOI: 10.1162/netn_a_00398.Peer-Reviewed Original ResearchIntrinsic connectivity networksFunctional brain connectivityBrain connectivityStructural connectivityFunctional connectivityIndependent component analysisResting-state functional MRIAnalysis of group differencesBrain functional organizationFunctional network connectivityStructural-functional connectivityNeuroimaging studiesFunctional MRIWhole-brain tractographyGroup differencesRs-fMRIBrain disordersFunctional couplingSchizophreniaStatistical analysis of group differencesSubject levelFunctional organizationConnectivity networksBrainDiffusion-weighted MRIEffect of brain network scale on Persistence Cycles: An ADNI comparative study
Garai S, Liu M, Xu F, Goñi J, Duong‐Tran D, Zhao Y, Shen L, for the ADNI. Effect of brain network scale on Persistence Cycles: An ADNI comparative study. Alzheimer's & Dementia 2024, 20: e092343. PMCID: PMC11716291, DOI: 10.1002/alz.092343.Peer-Reviewed Original ResearchStructural connectomeFunctional connectomeBOLD signal fluctuationsBrain networksHomologation cycleAlzheimer's diseaseDiffusion tensor imagingStages of AD progressionAverage persistenceFMRI neuroimagingTopological featuresAlzheimer's Disease Neuroimaging InitiativeStages of disease progressionSignal fluctuationsConnectomeGroup differencesResolution scaleAD progressionImage resolutionResolution imagesTopological pointIncrease image resolutionDeath timeRegion-of-interestBarcodingA Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies
Silva R, Damaraju E, Li X, Kochunov P, Ford J, Mathalon D, Turner J, van Erp T, Adali T, Calhoun V. A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies. Human Brain Mapping 2024, 45: e70037. PMID: 39560198, PMCID: PMC11574741, DOI: 10.1002/hbm.70037.Peer-Reviewed Original ResearchConceptsMultimodal neuroimaging datasetSchizophrenia patientsNeuroimaging studiesCognitive performanceGroup differencesSchizophreniaSex effectsNeuroimaging datasetsMagnetic resonance imagingCognitionAge-associated declineControl subjectsMarkers of agingResonance imagingNon-imaging variablesSubject profilesSexNeuroimagingUK Biobank datasetFusion of Novel FMRI Features Using Independent Vector Analysis for a Multifaceted Characterization of Schizophrenia
Jia C, Abu Baker Siddique Akhonda M, Yang H, Calhoun V, Adali T. Fusion of Novel FMRI Features Using Independent Vector Analysis for a Multifaceted Characterization of Schizophrenia. 2015 23rd European Signal Processing Conference (EUSIPCO) 2024, 1112-1116. DOI: 10.23919/eusipco63174.2024.10715096.Peer-Reviewed Original ResearchFractional amplitude of low-frequency fluctuationAmplitude of low-frequency fluctuationResting-state functional magnetic resonanceCharacterization of schizophreniaFunctional magnetic resonanceBrain activity changesLow-frequency fluctuationsVisual cortexSchizophrenia patientsSchizophrenia NetworkBrain alterationsPsychiatric conditionsBrain regionsSchizophrenia biomarkersSchizophreniaFMRI featuresFractional amplitudeGroup differencesFMRI dataNeuroimaging analysisIndependent vector analysisActivity changesHealthy controlsBrainHigher-order statistical informationDelays in bipolar depression treatment in primary care vs. integrated behavioral health and specialty care
Park J, Breitinger S, Savitz S, Gardea-Resendez M, Singh B, Williams M, Frye M. Delays in bipolar depression treatment in primary care vs. integrated behavioral health and specialty care. Journal Of Affective Disorders 2024, 369: 404-410. PMID: 39389118, DOI: 10.1016/j.jad.2024.10.011.Peer-Reviewed Original ResearchIntegrated behavioral healthBipolar depression treatmentBipolar depressionBipolar disorderCollaborative care modelPrimary careCare modelSpecialty clinicsDepression treatmentEpisodes of bipolar depressionBehavioral healthDSM-5 criteriaSwitching to monotherapyPharmacological treatment patternsRetrospective study of adultsDepressive episodeDSM-5Mood stabilizersCompare treatment recommendationsStudy of adultsAntidepressant useGroup differencesDepression careEvidence of delayRetrospective study designObjective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA
Danese A, Widom C. Objective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA. The Lancet Psychiatry 2024, 11: 720-730. PMID: 39147460, DOI: 10.1016/s2215-0366(24)00224-4.Peer-Reviewed Original ResearchConceptsMeasures of childhood maltreatmentExperiences of childhood maltreatmentMeasures of maltreatmentChildhood maltreatmentCognitive deficitsRetrospective reports of childhood maltreatmentReports of childhood maltreatmentSelf-reportNational Institute of Mental HealthInstitute of Mental HealthPervasive cognitive deficitsNon-verbal intelligenceMeasures of neglectRetrospective self-reportsVerbal intelligenceAutobiographical memoryExecutive functionMaltreated childrenCognitive abilitiesPsychopathologyCognitive testsCognitive functionGroup differencesProcessing speedRetrospective reportsMaternal adverse childhood experiences and infant visual-limbic white matter development
Demers C, Hankin B, Haase M, Todd E, Hoffman M, Epperson C, Styner M, Davis E. Maternal adverse childhood experiences and infant visual-limbic white matter development. Journal Of Affective Disorders 2024, 367: 49-57. PMID: 39191307, DOI: 10.1016/j.jad.2024.08.146.Peer-Reviewed Original ResearchMaternal adverse childhood experiencesAdverse childhood experiencesInferior longitudinal fasciculusFractional anisotropyLongitudinal fasciculusChildhood experiencesLeft inferior longitudinal fasciculusStructural magnetic resonance imagingPredictors of mental healthVisual processing networksNo group differencesExploratory analysisChildhood questionnaireEarly life adversity exposuresWhite matter microstructureMother-infant dyadsFollow-up analysisCognitive circuitsPreliminary supportNeural circuit developmentInfant brain developmentMagnetic resonance imagingGroup differencesSensory processingIntergenerational riskAre They Prepared? Comparing Intern Milestone Performance of Accelerated 3-Year and 4-Year Medical Graduates
Santen S, Yingling S, Hogan S, Vitto C, Traba C, Strano-Paul L, Robinson A, Reboli A, Leong S, Jones B, Gonzalez-Flores A, Grinnell M, Dodson L, Coe C, Cangiarella J, Bruce E, Richardson J, Hunsaker M, Holmboe E, Park Y. Are They Prepared? Comparing Intern Milestone Performance of Accelerated 3-Year and 4-Year Medical Graduates. Academic Medicine 2024, 99: 1267-1277. PMID: 39178363, DOI: 10.1097/acm.0000000000005855.Peer-Reviewed Original ResearchMedical schoolsFamily medicineAccreditation Council for Graduate Medical Education MilestonesMS ratesU.S. medical schoolsNo significant differenceEstimate group differencesSignificant differenceMedical graduatesEmergency medicineInternal medicineRandom effects regressionEducational milestonesMedical studentsStudy designResident performanceProgram effectivenessNoninferiority study designMilestone performanceStatistically significant differenceStudy cohortControl cohortGroup differencesGeneral surgerySpecialtyMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaA new transfer entropy method for measuring directed connectivity from complex-valued fMRI data
Li W, Lin Q, Zhang C, Han Y, Calhoun V. A new transfer entropy method for measuring directed connectivity from complex-valued fMRI data. Frontiers In Neuroscience 2024, 18: 1423014. PMID: 39050665, PMCID: PMC11266018, DOI: 10.3389/fnins.2024.1423014.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFMRI dataBrain regionsAnatomical Automatic LabelingTransfer entropyFunctional magnetic resonance imaging dataConnectivity of brain regionsFrontal-parietal regionsConsistent with previous findingsSignificant group differencesRight frontal-parietal regionPartial transfer entropyPredicting mental disordersMental disordersParietal regionsGroup differencesMagnitude effectExperimental fMRI dataDirectional connectivityComplex-valued fMRI dataSchizophreniaMagnetic resonance imagingComplex-valued approachEntropyMagnitude dataContext-dependent reduction in corticomuscular coupling for balance control in chronic stroke survivors
Kukkar K, Rao N, Huynh D, Shah S, Contreras-Vidal J, Parikh P. Context-dependent reduction in corticomuscular coupling for balance control in chronic stroke survivors. Experimental Brain Research 2024, 242: 2093-2112. PMID: 38963559, DOI: 10.1007/s00221-024-06884-x.Peer-Reviewed Original ResearchChronic stroke survivorsMuscle groupsBalance controlStroke survivorsBalance tasksLeg musclesLaboratory-based testsActivities of daily livingAssess balance performanceLeg muscle groupsProximal muscle groupsStroke participantsSway-referencingDaily livingIndicators of mobilitySway referenceBalance performanceDelta-band coherenceBalance maintenanceSupport surfaceCorticomuscular coherenceSomatosensory modulationParticipantsGroup differencesStrokeBrain community detection in the general children population
Farahdel B, Thapaliya B, Suresh P, Ray B, Calhoun V, Liu J. Brain community detection in the general children population. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-6. PMID: 40040186, DOI: 10.1109/embc53108.2024.10782157.Peer-Reviewed Original ResearchParallel Multilink Joint ICA for Multimodal Fusion of Gray Matter and Multiple Resting fMRI Networks
Khalilullah K, Agcaoglu O, Duda M, Calhoun V. Parallel Multilink Joint ICA for Multimodal Fusion of Gray Matter and Multiple Resting fMRI Networks. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039683, DOI: 10.1109/embc53108.2024.10782528.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingJoint independent component analysisAssociated with Alzheimer's diseaseFalse discovery rateMultimodal fusion approachGray matterAssess group differencesHealthy controlsMultimodal fusionIndependent component analysisFusion approachSensorimotor domainBrain regionsSMRI dataGroup differencesParacentral lobuleBrain functionAD pathologyConnectivity patternsDiscovery rateJoint ICAJoint relationshipAlzheimer's diseaseActivity patternsMagnetic resonance imagingRevealing Alzheimer's Disease Dementia Patterns in [18F]Florbetapir PET with Independent Component Analysis
Khasayeva N, Eierud C, Jensen K, Premi E, Borroni B, Calhoun V, Iraji A. Revealing Alzheimer's Disease Dementia Patterns in [18F]Florbetapir PET with Independent Component Analysis. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039485, DOI: 10.1109/embc53108.2024.10782873.Peer-Reviewed Original ResearchConceptsPositron emission tomographyFrontal componentIndependent component analysisAlzheimer's Disease Neuroimaging InitiativeInteraction effects of diagnosisPositron emission tomography brain imagingEffect of diagnosisSignificant group effectAlzheimer's diseasePotential of independent component analysisAD dementia groupsSignificant interaction effectEvaluate group differencesGroup differencesDementia groupGeneralized linear modelGroup effectBrain imagingSalienceIC weightsEmission tomographyAD dementiaDementiaDementia patternsNeurobiology
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