2025
American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision
Notrica D, Tominaga G, Gross J, Southard R, McOmber M, Crandall M, Kozar R, Kaups K, Schuster K, Ball C. American Association for the Surgery of Trauma pancreatic organ injury scale: 2024 revision. Journal Of Trauma And Acute Care Surgery 2025, 98: 442-447. PMID: 39898876, DOI: 10.1097/ta.0000000000004522.Peer-Reviewed Original ResearchConceptsOrgan Injury ScaleDuctal injuryPancreatic headAmerican Association for the Surgery of Trauma-Organ Injury ScaleAmerican Association for the SurgeryAmerican Association for the Surgery of TraumaGrade V injuriesGrade IV injuriesSurgery of TraumaInjury ScaleV injuriesGrade IIIDuctal transectionGrade IIParenchymal injuryIV injuriesPathological findingsPortal veinInterventional gastroenterologyGrading systemIncreasing gradeInjury locationDuctal integrityClinical experienceIncreasing severity
2023
71. Integrated genomic analysis of hepatocellular carcinoma using WES and aCGH
Chong M, Chai H, Hu Q, Li P. 71. Integrated genomic analysis of hepatocellular carcinoma using WES and aCGH. Cancer Genetics 2023, 278: 22. DOI: 10.1016/j.cancergen.2023.08.079.Peer-Reviewed Original ResearchWhole-exome sequencingTumor mutation burdenHepatocellular carcinomaGrade IIICNA burdenCase seriesClinicopathologic associationsArray comparative genomic hybridizationBarcelona Clinic Liver Cancer stageCopy number alterationsBCLC stage CLiver Cancer stageEdmondson-Steiner gradingLarge case seriesGenetic defectsHigher CNA burdenAdjacent nontumor tissuesΒ-catenin pathwayIntegrated genomic analysisBetter prognosisClinicopathologic findingsPoor prognosisRetrospective studyClinicopathologic classificationCancer stagePoster 306: Examining Preoperative Magnetic Resonance Imaging for Medial Meniscal Ramp Lesions in Patients Surgically Treated for Acute Grade III Combined Posterolateral Corner Knee Injuries
Jimenez A, Katz L, Wang A, McLaughlin W, Gillinov S, Kunze K, Hewett T, Alaia M, LaPrade R, Medvecky M, Moran J. Poster 306: Examining Preoperative Magnetic Resonance Imaging for Medial Meniscal Ramp Lesions in Patients Surgically Treated for Acute Grade III Combined Posterolateral Corner Knee Injuries. Orthopaedic Journal Of Sports Medicine 2023, 11: 2325967123s00279. PMCID: PMC10392321, DOI: 10.1177/2325967123s00279.Peer-Reviewed Original ResearchPreoperative magnetic resonance imagingMedial meniscal ramp lesionsMulti-ligament knee injuriesAcute grade IIIMeniscal ramp lesionsMagnetic resonance imagingPosterolateral corner knee injuriesRamp lesionsIntra-class correlation coefficientPLC injuriesGrade IIIKnee injuriesBone bruisingBone bruiseResonance imagingAnterior cruciate ligament injuryMulti-ligament reconstructionCruciate ligament injuryDays of injuryMeniscocapsular tearsConsecutive patientsLigament injuryMeniscal injurySame patientLevel IIntegrated exome sequencing and microarray analyses detected genetic defects and underlying pathways of hepatocellular carcinoma
Chong M, Knight J, Peng G, Ji W, Chai H, Lu Y, Wu S, Li P, Hu Q. Integrated exome sequencing and microarray analyses detected genetic defects and underlying pathways of hepatocellular carcinoma. Cancer Genetics 2023, 276: 30-35. PMID: 37418972, DOI: 10.1016/j.cancergen.2023.06.002.Peer-Reviewed Original ResearchConceptsTumor mutation burdenWhole-exome sequencingGrade IIIHepatocellular carcinomaCNA burdenCase seriesBarcelona Clinic Liver Cancer stageExome sequencingBCLC stage CLiver Cancer stageEdmondson-Steiner gradingLarge case seriesGenetic defectsHigher CNA burdenAdjacent nontumor tissuesΒ-catenin pathwayBetter prognosisClinicopathologic findingsPoor prognosisClinicopathologic classificationCancer stageSurvival statusMutation burdenStage CPrognostic prediction
2021
Preoperative Texture Analysis Using 11C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma
Manabe O, Yamaguchi S, Hirata K, Kobayashi K, Kobayashi H, Terasaka S, Toyonaga T, Magota K, Kuge Y, Tamaki N, Shiga T, Kudo K. Preoperative Texture Analysis Using 11C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma. Diagnostics 2021, 11: 189. PMID: 33525709, PMCID: PMC7911154, DOI: 10.3390/diagnostics11020189.Peer-Reviewed Original ResearchPositron emission tomographyOverall survivalEmission tomographyMET positron emission tomographyWorld Health Organization classificationMean standardized uptake valuePreoperative metabolic imagingPreoperative texture analysisMalignant brain tumorsStandardized uptake valueCause deathLow gray-level run emphasisContralateral cortexMET uptakeSingle centerPrognostic valueGrade IIIOrganization classificationTumor gradeUnivariate analysisGrade IIGrade IVBrain tumorsUptake valueSurvival curves
2020
A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma
Xu K, Ye Q, Han L, Zhong M. A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma. American Journal Of Clinical Pathology 2020, 154: s32-s33. DOI: 10.1093/ajcp/aqaa161.066.Peer-Reviewed Original ResearchEndometrial endometrioid carcinomaMetastatic carcinomaEndometrioid carcinomaNuclear beta-catenin stainingPrimary carcinomaImmunohistochemistry stainingBeta-catenin stainingEndometrioid carcinoma casesRetrospective institutional reviewMedian patient ageCommon metastatic siteBeta-catenin mutationsVariety of tumorsPatient ageMetastatic sitesPR expressionGrade IIIGrade IGrade IIImmunohistochemical profileCarcinoma casesIHC expressionINTRODUCTION/Cancer tumorigenesisCarcinomaThalamic tumors in children: case series from our institution and literature review
Renedo D, Ferraro F, Johnson A, Argañaraz R, Giovannini S, Zabala J, Zemma E, Mantese B. Thalamic tumors in children: case series from our institution and literature review. Child's Nervous System 2020, 37: 457-463. PMID: 32712861, DOI: 10.1007/s00381-020-04830-0.Peer-Reviewed Original ResearchConceptsThalamic tumorsCase seriesSurgical approachStereotactic-guided biopsyGross total resectionEndoscopic third ventriculostomyGrade IV tumorsHigh-grade tumorsInvasive surgical proceduresTime of treatmentSubtotal resectionMedian ageVentriculoperitoneal shuntMotor deficitsGrade IIIThird ventriculostomyGrade IGrade IIObservational studySurgical proceduresPatientsResultsFrom 2013TumorsCommon formResection
2019
The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions.
Keihani S, Rogers DM, Putbrese BE, Anderson RE, Stoddard GJ, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller BD, Santucci RA, Carrick MM, Allen L, Norwood S, Hewitt T, Burks FN, Heilbrun ME, Gross JA, Myers JB. The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions. Journal Of Trauma And Acute Care Surgery 2019, 88: 357-365. PMID: 31876692, DOI: 10.1097/ta.0000000000002572.Peer-Reviewed Original ResearchConceptsHigh-grade renal traumaAAST grading systemComputed tomography scanGrading systemAAST gradingTomography scanMixed-effects multivariable logistic regressionInitial computed tomography (CT) scanLevel 1 trauma centerGrade IV injuriesGrade V injuriesNon-operative managementMultivariable logistic regressionSurgery of TraumaImportant radiologic findingsAmerican AssociationRenal traumaRadiologic findingsTrauma centerGrade IIIInjury patternsGrade reclassificationEpidemiological studiesLevel IIIControl interventionsATIM-17. A PHASE I TRIAL OF HYPOFRACTIONATED STEREOTACTIC IRRADIATION (HFSRT) COMBINED WITH NIVOLUMAB (NIVO), IPILIMUMAB (IPI) AND BEVACIZUMAB (BEV) IN PATIENTS (PTS) WITH RECURRENT HIGH GRADE GLIOMAS
Sahebjam S, Forsyth P, Tran N, Etame A, Arrington J, Jaglal M, Mokhtari S, MacAulay R, Wicklund M, Evernden B, Gatewood T, Robinson T, Raval R, Yu M. ATIM-17. A PHASE I TRIAL OF HYPOFRACTIONATED STEREOTACTIC IRRADIATION (HFSRT) COMBINED WITH NIVOLUMAB (NIVO), IPILIMUMAB (IPI) AND BEVACIZUMAB (BEV) IN PATIENTS (PTS) WITH RECURRENT HIGH GRADE GLIOMAS. Neuro-Oncology 2019, 21: vi5-vi5. PMCID: PMC6847102, DOI: 10.1093/neuonc/noz175.017.Peer-Reviewed Original ResearchGrade 1 elevationExpansion cohortSafety cohortPD-1/PDLStrong pre-clinical evidencesAnti-tumor immune responseRecurrent high-grade gliomaPhase IDose-expansion cohortsGrade 1 anorexiaGrade 1 diarrheaRT treatment fieldUse of corticosteroidsPre-clinical evidenceHigh-grade gliomasPrimary study objectiveCommon toxicitiesEligible ptsPrior RTSecondary endpointsFlat doseRecurrent tumorsGrade IIITumor regressionEfficacy dataImplantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timingEvaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor–positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials
Martín M, Loibl S, Hyslop T, De la Haba-Rodríguez J, Aktas B, Cirrincione CT, Mehta K, Barry WT, Morales S, Carey LA, Garcia-Saenz JA, Partridge A, Martinez-Jañez N, Hahn O, Winer E, Guerrero-Zotano A, Hudis C, Casas M, Rodriguez-Martin C, Furlanetto J, Carrasco E, Dickler MN, Group G, GBG, Oncology A. Evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor–positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials. European Journal Of Cancer 2019, 117: 91-98. PMID: 31276981, PMCID: PMC6718694, DOI: 10.1016/j.ejca.2019.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBone NeoplasmsBreast NeoplasmsEvaluation Studies as TopicFemaleFollow-Up StudiesFulvestrantHumansLetrozoleMiddle AgedNeoplasm Recurrence, LocalPrognosisReceptors, EstrogenReceptors, ProgesteroneSoft Tissue NeoplasmsSurvival RateTamoxifenConceptsProgression-free survivalClinical benefit rateObjective response rateEndocrine therapyMetastatic breast cancerOverall survivalGrade IIIBreast cancerHormone receptor-positive metastatic breast cancerMedian progression-free survivalAddition of BevSignificant additional toxicityStandard endocrine therapyDe novo diseaseAddition of bevacizumabFirst-line treatmentPredictors of efficacyNovo diseaseRecurrent diseaseLiver eventsEndocrine sensitivityBenefit rateAdditional toxicityPatientsResponse rateGRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia
Mehta RS, Holtan SG, Wang T, Hemmer MT, Spellman SR, Arora M, Couriel DR, Alousi AM, Pidala J, Abdel-Azim H, Ahmed I, Aljurf M, Askar M, Auletta JJ, Bhatt V, Bredeson C, Chhabra S, Gadalla S, Gajewski J, Gale RP, Gergis U, Hematti P, Hildebrandt GC, Inamoto Y, Kitko C, Khandelwal P, MacMillan ML, Majhail N, Marks DI, Mehta P, Nishihori T, Olsson RF, Pawarode A, Diaz MA, Prestidge T, Qayed M, Rangarajan H, Ringden O, Saad A, Savani BN, Seo S, Shah A, Shah N, Schultz KR, Solh M, Spitzer T, Szer J, Teshima T, Verdonck LF, Williams KM, Wirk B, Wagner J, Yared JA, Weisdorf DJ. GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia. Blood Advances 2019, 3: 1441-1449. PMID: 31053571, PMCID: PMC6517657, DOI: 10.1182/bloodadvances.2018030171.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlemtuzumabBone Marrow CellsChildChild, PreschoolDisease-Free SurvivalFemaleFetal BloodGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMalePrecursor Cell Lymphoblastic Leukemia-LymphomaProportional Hazards ModelsRecurrenceSurvival RateThyroglobulinTransplantation ConditioningWhole-Body IrradiationConceptsRelapse-free survivalPediatric patientsGrade IIIBM groupAcute leukemiaHigh riskAlternative donor hematopoietic cell transplantationTotal body irradiation-based conditioningMultivariate analysisDonor hematopoietic cell transplantationFree relapse-free survivalCox proportional hazards modelAnti-thymocyte globulinHematopoietic cell transplantationIrradiation-based conditioningAcute lymphoblastic leukemiaProportional hazards modelUmbilical cord bloodBM recipientsGraft variablesGVHD prophylaxisUCB groupHost diseaseMycophenolate mofetilClinical characteristics
2018
Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma
Ookawa S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Ohtaki S, Noshiro S, Komatsu K, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma. World Neurosurgery 2018, 111: e783-e789. PMID: 29309973, DOI: 10.1016/j.wneu.2017.12.166.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasExpression of SERPINA1Polymerase chain reactionDigital polymerase chain reactionExpression groupMedian overall survivalAnti-inflammatory roleHigh expression groupMessenger RNA expressionCell linesGlioblastoma multiforme cell linesHuman glioblastoma cell linesParaffin-embedded tissuesPredict PrognosisOverall survivalPoor prognosisGrade IIIPolymerase chain reaction quantificationSERPINA1 expressionSurgical samplesGrade IVImmunohistochemical analysisGlioblastoma cell linesGlioma tissuesPrognosis
2017
Nivolumab combined with hypofractionated stereotactic irradiation (HFSRT) for patients with recurrent high grade gliomas: A phase I trial (NCT02829931).
Sahebjam S, Forsyth P, Arrington J, Tran N, Jaglal M, Mokhtari S, Long W, Macaulay R, Wicklund M, Drury-Sibiga A, Gatewood T, Robinson T, Raval R, Yu M. Nivolumab combined with hypofractionated stereotactic irradiation (HFSRT) for patients with recurrent high grade gliomas: A phase I trial (NCT02829931). Journal Of Clinical Oncology 2017, 35: tps2084-tps2084. DOI: 10.1200/jco.2017.35.15_suppl.tps2084.Peer-Reviewed Original ResearchHigh-grade gliomasPhase I trialGrade gliomasI trialPD-1PD-L1Grade IIIAnti-PD-1/PD-L1 blockadePD-1/PD-L1 blockadeRecurrent high-grade gliomaOngoing phase I trialDose-expansion cohortsPD-L1 blockadePrior radiation therapyTolerability of nivolumabGroup of patientsImmune checkpoint pathwaysLimited treatment optionsPreliminary antitumor activityOrthotopic murine modelLong-term survivalPrimary study objectiveIgG4 monoclonal antibodyNivolumab monotherapySafety cohort
2016
ACTC1 as an invasion and prognosis marker in glioma.
Ohtaki S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Noshiro S, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. ACTC1 as an invasion and prognosis marker in glioma. Journal Of Neurosurgery 2016, 126: 467-475. PMID: 27081897, DOI: 10.3171/2016.1.jns152075.Peer-Reviewed Original ResearchConceptsMedian overall survivalKarnofsky Performance Scale statusTime of diagnosisMIB-1 indexGBM patientsHazard ratioPatient ageRadiological findingsKaplan-Meier methodHigh-grade gliomasReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionRemote recurrenceDistant recurrenceOverall survivalClinical featuresIndependent prognosticRecurrence rateWHO criteriaGrade IIIPolymerase chain reactionSurgical removalContralateral cerebralGrade IGrade II
2015
The use of basiliximab–infliximab combination for the treatment of severe gastrointestinal acute GvHD
Nadeau M, Perreault S, Seropian S, Foss F, Isufi I, Cooper DL. The use of basiliximab–infliximab combination for the treatment of severe gastrointestinal acute GvHD. Bone Marrow Transplantation 2015, 51: 273-276. PMID: 26479982, DOI: 10.1038/bmt.2015.247.Peer-Reviewed Original ResearchConceptsGastrointestinal acute GVHDAcute GVHDGrade IIIAllogeneic stem cell transplantCombination of basiliximabSevere GI GvHDSevere grade IIISteroid-refractory diseaseLong-term survivorsStem cell transplantOverall response rateCurrent retrospective studyChronic GVHDGI GVHDSalvage therapySteroid therapyPrimary diseaseCell transplantMedian timeSignificant morbidityPoor outcomeRetrospective studyGVHDMost deathsNew agentsTherapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis
Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis. Liver Transplantation 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAnalgesics, Non-NarcoticBrain EdemaChemical and Drug Induced Liver InjuryChi-Square DistributionFemaleHumansHypothermia, InducedLiver Failure, AcuteLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute liver failureNon-APAP patientsALF patientsTherapeutic hypothermiaAPAP patientsLiver failureUS Acute Liver Failure Study GroupAcute Liver Failure Study GroupImpact of THMulticenter retrospective cohort analysisTransplant-free survival rateEnd-stage liver diseaseAPAP-ALF patientsRetrospective cohort studyRetrospective cohort analysisAcetaminophen patientsSpontaneous survivalCerebral edemaCohort studyProspective trialHepatic encephalopathyLiver diseaseTracheal infectionGrade IIIWorse outcomes
2014
Transarterial chemoembolization in soft-tissue sarcoma metastases to the liver – The use of imaging biomarkers as predictors of patient survival
Chapiro J, Duran R, Lin M, Mungo B, Schlachter T, Schernthaner R, Gorodetski B, Wang Z, Geschwind JF. Transarterial chemoembolization in soft-tissue sarcoma metastases to the liver – The use of imaging biomarkers as predictors of patient survival. European Journal Of Radiology 2014, 84: 424-430. PMID: 25542065, PMCID: PMC4315698, DOI: 10.1016/j.ejrad.2014.11.034.Peer-Reviewed Original ResearchConceptsMetastatic soft tissue sarcomaProgression-free survivalConventional transarterial chemoembolizationSoft tissue sarcomasOverall survivalTumor responseTransarterial chemoembolizationPatient survivalSafety profileCox proportional hazard ratio analysisProportional hazard ratio analysisSoft tissue sarcoma metastasisMedian overall survivalSalvage therapy optionsHazard ratio analysisReliable clinical dataSize-based criteriaEASL guidelinesModified RECISTIntraarterial therapySarcoma metastasisSurvival outcomesGrade IIIKaplan-MeierTherapy optionsClinical course and progression-free survival of adult intracranial and spinal ependymoma patients
Vera-Bolanos E, Aldape K, Yuan Y, Wu J, Wani K, Necesito-Reyes MJ, Colman H, Dhall G, Lieberman FS, Metellus P, Mikkelsen T, Omuro A, Partap S, Prados M, Robins HI, Soffietti R, Wu J, Gilbert MR, Armstrong TS. Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. Neuro-Oncology 2014, 17: 440-447. PMID: 25121770, PMCID: PMC4483095, DOI: 10.1093/neuonc/nou162.Peer-Reviewed Original ResearchConceptsProgression-free survivalClinical courseEpendymoma patientsMultivariate Cox proportional hazards modelMultivariate Cox proportional hazardsCox proportional hazards modelRare CNS tumorsTime of diagnosisPrognostic clinical factorsCox proportional hazardsProportional hazards modelSubtotal resectionClinical factorsMedian timeCNS tumorsCentral reviewGrade IIIMean ageTumor recurrenceEarly progressionTumor locationGrade IITumor gradeUnivariate analysisSupratentorial location
2013
Assessment and management of cerebral edema and intracranial hypertension in acute liver failure
Mohsenin V. Assessment and management of cerebral edema and intracranial hypertension in acute liver failure. Journal Of Critical Care 2013, 28: 783-791. PMID: 23683564, DOI: 10.1016/j.jcrc.2013.04.002.Peer-Reviewed Original ResearchConceptsAcute liver failureLiver failureIntracranial pressureMultiorgan failureCerebral edemaIntracranial hypertensionLiver injuryBrain edemaIngestion of acetaminophenJugular venous oximetryLife-threatening complicationsBrain stem herniationIntracranial pressure monitoringLiver transplantationNeurologic deficitsRare complicationTherapeutic hypothermiaOsmotic therapyVenous oximetryTranscranial DopplerClinical symptomsPrimary insultGrade IIIHypertonic salinePropofol sedation
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