2025
Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study
Cristin L, Dixit S, Bibby D, Tang J, Fang Q, Tastet L, Rich A, Jhawar R, Nagata Y, Higuchi S, Levine R, Hsia H, Tseng Z, Schiller N, Delling F. Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study. Circulation Cardiovascular Imaging 2025, 18: e017051. PMID: 39764632, PMCID: PMC11753933, DOI: 10.1161/circimaging.124.017051.Peer-Reviewed Original ResearchConceptsMitral valve prolapseMitral annular disjunctionSudden cardiac arrestPostsystolic shortening indexAnnular disjunctionNormal mitral valveSudden cardiac deathValve prolapseMitral valveLongitudinal strainShortening indexArrhythmic mitral valve prolapseGlobal longitudinal strainExperience sudden cardiac arrestSpeckle-tracking echocardiographyFamilial mitral valve prolapsePeak longitudinal strainGlobal strain parametersBileaflet involvementGenetic myopathiesArrhythmic riskVentricular ectopyCardiac deathCardiac arrestHealthy controls
2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingArtificial Intelligence–Enhanced Risk Stratification of Cancer Therapeutics–Related Cardiac Dysfunction Using Electrocardiographic Images
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence–Enhanced Risk Stratification of Cancer Therapeutics–Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024, 18: e011504. PMID: 39221857, PMCID: PMC11745701, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost hoc analysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screenImpact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Hegde S, Claggett B, Wang X, Jering K, Prasad N, Roshanali F, Masri A, Nassif M, Barriales-Villa R, Abraham T, Cardim N, Coats C, Kramer C, Maron M, Michels M, Olivotto I, Saberi S, Jacoby D, Heitner S, Kupfer S, Meng L, Wohltman A, Malik F, Solomon S, Investigators S. Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2024, 84: 1789-1802. PMID: 39217556, DOI: 10.1016/j.jacc.2024.08.002.Peer-Reviewed Original ResearchLeft ventricular ejection fractionObstructive hypertrophic cardiomyopathySymptomatic obstructive hypertrophic cardiomyopathyLVOT gradientKCCQ-CSSNT-proBNPAssociated with improvementsHypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire Clinical Summary ScoreCardiac structureMeasures of LV diastolic functionLV global circumferential strainN-terminal pro-B-type natriuretic peptideLV global longitudinal strainLV end-systolic volumePro-B-type natriuretic peptideEchocardiographic measures of cardiac structureMeasures of cardiac structureLateral e' velocityLV diastolic functionAtrial volume indexGlobal longitudinal strainLV systolic functionPlacebo-controlled studyGlobal circumferential strain
2023
Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy
Frye R, Ittleman B, Shabanova V, Sugeng L, Steele J, Ferdman D, Karnik R. Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy. Progress In Pediatric Cardiology 2023, 69: 101636. DOI: 10.1016/j.ppedcard.2023.101636.Peer-Reviewed Original ResearchBicuspid aortic valveLeft ventricular strainVentricular strainGlobal longitudinal strainGlobal circumferential strainAortic valvePediatric patientsEjection fractionLeft ventricle global longitudinal strainLeft ventricular global longitudinal strainBackground Bicuspid aortic valveVentricle global longitudinal strainSingle-center retrospective studyVentricular global longitudinal strainCommon congenital cardiac defectLongitudinal strainCircumferential strainAortic valve replacementNormal ejection fractionPrior cardiac interventionCongenital cardiac defectsYears of agePotential early markerLeft ventricular myocardiumSignificant differencesQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin useImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strainIntramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial
Kaushal S, Hare J, Hoffman J, Boyd R, Ramdas K, Pietris N, Kutty S, Tweddell J, Husain S, Menon S, Lambert L, Danford D, Kligerman S, Hibino N, Korutla L, Vallabhajosyula P, Campbell M, Khan A, Naioti E, Yousefi K, Mehranfard D, McClain-Moss L, Oliva A, Davis M. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial. European Heart Journal Open 2023, 3: oead002. PMID: 36950450, PMCID: PMC10026620, DOI: 10.1093/ehjopen/oead002.Peer-Reviewed Original ResearchCardiac magnetic resonance imagingGlobal longitudinal strainMedicinal signaling cellsEjection fractionRight ventricleOpen-label multicentre trialMajor adverse cardiac eventsHypoplastic left heart syndromeAdverse cardiac eventsInvestigational cell therapyBidirectional cavopulmonary anastomosisPhase I trialRV ejection fractionRisk of deathMagnetic resonance imagingPrimary endpointCardiac eventsRV functionSurgical palliationI trialMulticentre trialCavopulmonary anastomosisCell-based therapiesHeart syndromeRibonucleic acid
2022
Cardioprotection Using Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy 3-Year Results of the SUCCOUR Trial
Negishi T, Thavendiranathan P, Penicka M, Lemieux J, Murbraech K, Miyazaki S, Shirazi M, Santoro C, Cho G, Popescu B, Kosmala W, Costello B, la Gerche A, Mottram P, Thomas L, Seldrum S, Hristova K, Bansal M, Kurosawa K, Fukuda N, Yamada H, Izumo M, Tajiri K, Sinski M, Vinereanu D, Shkolnik E, Banchs J, Kutty S, Negishi K, Marwick T. Cardioprotection Using Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy 3-Year Results of the SUCCOUR Trial. JACC Cardiovascular Imaging 2022, 16: 269-278. PMID: 36435732, DOI: 10.1016/j.jcmg.2022.10.010.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainCancer therapeutics-related cardiac dysfunctionCardiac dysfunctionCardiotoxic chemotherapyHeart failureMulticenter prospective randomized controlled trialPatients treated with anthracyclinesProspective randomized controlled trialsBaseline to 3 yearsLeft ventricular functionRandomized controlled trialsChemotherapy regimenLV dysfunctionVentricular functionBreast cancerFollow-upDiabetes mellitusChemotherapyLongitudinal strainPatientsRisk factorsCardioprotectionDysfunctionCancerAnthracyclines
2021
Understanding the role of left and right ventricular strain assessment in patients hospitalized with COVID-19
Park J, Kim Y, Pereira J, Hennessey KC, Faridi KF, McNamara RL, Velazquez EJ, Hur DJ, Sugeng L, Agarwal V. Understanding the role of left and right ventricular strain assessment in patients hospitalized with COVID-19. American Heart Journal Plus Cardiology Research And Practice 2021, 6: 100018. PMID: 34095889, PMCID: PMC8168299, DOI: 10.1016/j.ahjo.2021.100018.Peer-Reviewed Original ResearchLV global longitudinal strainGlobal longitudinal strainFree wall strainLV ejection fractionAbnormal LV global longitudinal strainRV free wall strainCardiac injuryWorse outcomesHigh riskCOVID-19Normal LV ejection fractionLV-GLS valuesSubclinical cardiac injuryRetrospective chart reviewCoronavirus disease 2019Abnormal rightGLS cutoffHospital mortalityChart reviewTransthoracic echocardiographyEjection fractionPrimary outcomeVentricular functionClinical variablesAbnormal LVAcute changes of left ventricular function during surgical revascularization by 3D speckle tracking
Chen W, Ortiz‐Leon X, Posada‐Martinez E, Pereira J, Dewar ML, Darr U, Geirsson A, Sugeng L, Zhu Q. Acute changes of left ventricular function during surgical revascularization by 3D speckle tracking. Echocardiography 2021, 38: 623-631. PMID: 33740279, DOI: 10.1111/echo.15040.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainLV ejection fractionTissue motion annular displacementGlobal circumferential strainLeft ventricular functionTransesophageal echocardiographyLongitudinal strainSurgical revascularizationVentricular functionAcute changesThree-dimensional speckle tracking echocardiographyTerritorial longitudinal strainCoronary artery bypassIntraoperative transesophageal echocardiographySpeckle tracking imagingLV longitudinal functionSpeckle tracking echocardiographyCoronary perfusion territoriesRegional longitudinal strainArtery bypassCABG surgeryEjection fractionClinical outcomesFunctional recoveryAbsence of changesLeft ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity
Higgins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity. PLOS ONE 2021, 16: e0246764. PMID: 33606757, PMCID: PMC7895343, DOI: 10.1371/journal.pone.0246764.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainImmune checkpoint inhibitorsLate gadolinium enhancementRecovery of LVEFLake Louise criteriaCheckpoint inhibitorsNormal LVEFAverage global longitudinal strainPresence of LGEAbnormal global longitudinal strainCardiac magnetic resonance imagingCorrect clinical contextEvaluation of myocarditisLeft ventricular dysfunctionVentricular ejection fractionDiagnosis of myocarditisLeft ventricular strainCardiac magnetic resonanceLeft ventricular myocardial strainOvert left ventricular dysfunctionVentricular myocardial strainMagnetic resonance imagingAtrial strainVentricular dysfunctionVentricular strain
2020
Role of myocardial strain imaging in surveillance and management of cancer therapeutics‐related cardiac dysfunction: A systematic review
McGregor P, Moura F, Banchs J, Aragam J. Role of myocardial strain imaging in surveillance and management of cancer therapeutics‐related cardiac dysfunction: A systematic review. Echocardiography 2020, 38: 314-328. PMID: 33277729, DOI: 10.1111/echo.14944.Peer-Reviewed Original ResearchConceptsCancer therapeutics-related cardiac dysfunctionLeft ventricular ejection fractionManagement of Cancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainSpeckle-tracking echocardiographyMyocardial strain imagingCardiac dysfunctionPeak systolic global longitudinal strainLeft ventricular ejection fraction assessmentSystolic global longitudinal strainVentricular ejection fractionCardiac imaging modalitiesAdverse cardiac eventsMyocardial deformation imagingTransthoracic echocardiographyEjection fractionCardiac eventsStrain imagingMyocardial changesCancer patientsMyocardial strainGLS measurementsLongitudinal strainImaging modalitiesPRISMA guidelinesExercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy
Fava A, Alashi A, Saijo Y, Mathias I, Popovic Z, Thamilarasan M, Lever H, Desai M. Exercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy. European Heart Journal 2020, 41: ehaa946.0081. DOI: 10.1093/ehjci/ehaa946.0081.Peer-Reviewed Original ResearchLV-GLSHypertrophic cardiomyopathyExercise capacityHCM patientsVentricular global longitudinal strainGlobal myocardial strainSymptomatic HCM patientsReduced exercise capacitySubclinical cardiac dysfunctionSubclinical myocardial dysfunctionGlobal longitudinal strainLVOT gradientCardiac deteriorationExercise impairmentCardiac dysfunctionMyocardial dysfunctionMaximal exerciseExercise testExercise variablesClinical utilityFunctional capacityPatientsMyocardial strainLogistic regressionLongitudinal strainAssessment of right ventricular function following left ventricular assist device (LVAD) implantation—The role of speckle‐tracking echocardiography: A meta‐analysis
Barssoum K, Altibi A, Rai D, Kharsa A, Kumar A, Chowdhury M, Elkaryoni A, Abuzaid A, Baibhav B, Parikh V, Masri A, Amsallem M, Nanda N. Assessment of right ventricular function following left ventricular assist device (LVAD) implantation—The role of speckle‐tracking echocardiography: A meta‐analysis. Echocardiography 2020, 37: 2048-2060. PMID: 33084128, DOI: 10.1111/echo.14884.Peer-Reviewed Original ResearchConceptsRight ventricle free wall strainRight ventricle global longitudinal strainRight ventricular failureSpeckle-tracking echocardiographyRight ventricular failure patientsLeft ventricular assist deviceStandardized mean differenceTransthoracic echocardiographyPrediction of right ventricular failureSubgroup analysisAssessment of right ventricular functionVentricular assist deviceOdds ratioAssociated with worse outcomesFree wall strainGlobal longitudinal strainRight ventricular functionLeft ventricular assist device recipientsMeta-analysisMeta-analysis of published literaturePooled odds ratioRandom-effects modelNo significant differenceVentricular failureVentricular functionSpeckle tracking echocardiography can predict subclinical myocardial involvement in patients with sarcoidosis: A meta‐analysis
Barssoum K, Altibi A, Rai D, Kumar A, Kharsa A, Chowdhury M, Thakkar S, Shahid S, Abdelazeem M, Abuzaid A, Baibhav B, Parikh V, Feitell S, Balmer‐Swain M, Rao M, Amsallem M, Nanda N. Speckle tracking echocardiography can predict subclinical myocardial involvement in patients with sarcoidosis: A meta‐analysis. Echocardiography 2020, 37: 2061-2070. PMID: 33058271, DOI: 10.1111/echo.14886.Peer-Reviewed Original ResearchConceptsLeft ventricular global longitudinal strainGlobal circumferential strainSpeckle tracking echocardiographyStandardized mean differenceCardiac sarcoidosisCardiac magnetic resonanceSarcoidosis groupTracking echocardiographyHealthy controlsConfidence intervalsExtra-cardiac sarcoidosisGlobal longitudinal strainSubclinical myocardial involvementMeta-analysisScreening of CSAdvanced imaging modalitiesRandom-effects modelEnglish-language articlesPositron emission tomographyMyocardial involvementSarcoidosis patientsCardiac symptomsFDG-PETLongitudinal strainEchocardiographyAssociation Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burdenCharacteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic functionComputed Tomographic Angiography Assessment of Epicardial Coronary Vasoreactivity for Early Detection of Doxorubicin-Induced Cardiotoxicity
Feher A, Boutagy NE, Stendahl JC, Hawley C, Guerrera N, Booth CJ, Romito E, Wilson S, Liu C, Sinusas AJ. Computed Tomographic Angiography Assessment of Epicardial Coronary Vasoreactivity for Early Detection of Doxorubicin-Induced Cardiotoxicity. JACC CardioOncology 2020, 2: 207-219. PMID: 34396230, PMCID: PMC8352292, DOI: 10.1016/j.jaccao.2020.05.007.Peer-Reviewed Original ResearchComputed tomography angiographyEpicardial coronary diameterGlobal longitudinal strainCoronary diameterCoronary vasoreactivityLeft ventricular ejection fraction reductionVentricular ejection fraction reductionLongitudinal strainCoronary Computed Tomography AngiographyEjection fraction reductionEpicardial coronary arteriesVentricular ejection fractionDoxorubicin-Induced CardiotoxicityChronic canine modelPrevention of doxorubicinEpicardial vasodilationVasodilator responseAngiography assessmentEjection fractionCumulative dosesCoronary arteryTomography angiographyPharmacological stressorVascular toxicityVascular endotheliumFetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system
Ozawa K, Davey M, Tian Z, Hornick M, Mejaddam A, McGovern P, Flake A, Rychik J. Fetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system. Ultrasound In Obstetrics And Gynecology 2020, 55: 516-522. PMID: 30989734, PMCID: PMC7187205, DOI: 10.1002/uog.20295.Peer-Reviewed Original ResearchConceptsMean arterial pressureMiddle cerebral arteryPulsatility indexCardiac outputFetal sheepUmbilical arteryCardiac functionExtrauterine environmentHeart rateFetal middle cerebral arteryStudy periodMedian gestational ageGlobal longitudinal strainExtend systemUtero stateMCA-PIUA-PIArterial pressureCerebral arteryGestational agePlacental circulationProspective studyDiastolic flowDepressed contractilityFetal growth
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