2025
Connectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyMachine learning for identifying caregiving adversities associated with greatest risk for mental health problems in children
Vannucci A, Fields A, Heleniak C, Bloom P, Harmon C, Nikolaidis A, Douglas I, Gibson L, Camacho N, Choy T, Hadis S, VanTieghem M, Dozier M, Milham M, Tottenham N. Machine learning for identifying caregiving adversities associated with greatest risk for mental health problems in children. Nature Mental Health 2025, 3: 71-82. DOI: 10.1038/s44220-024-00355-6.Peer-Reviewed Original Research
2024
Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample.
Carlisi C, Fielder J, Knodt A, Romer A, Hariri A, Viding E. Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample. Journal Of Personality Disorders 2024, 38: 535-558. PMID: 39705101, DOI: 10.1521/pedi.2024.38.6.535.Peer-Reviewed Original ResearchConceptsPsychopathic traitsAntisocial facet of psychopathyBehavioral features of psychopathyFacets of psychopathyFeatures of psychopathySample of young adultsYoung adult sampleMental health problemsU.S. undergraduate studentsAntisocial facetPersonality disorderLifestyle facetGeneral psychopathologyAffective facetsAntisocial behaviorExternalizing behaviorsAdult samplesPsychopathologyPsychopathyInternalizing behaviorsBehavioral featuresUndergraduate studentsYoung adultsLifestyle traitsDifferential mappingSpanish Validation of the Brief Pornography Screen Within a Clinical Sample of Individuals with Gambling Disorder
Tarragón E, Testa G, Granero R, Potenza M, Kraus S, Uríszar J, Chiclana Actis C, Fernández-Aranda F, Jiménez-Murcia S, Mestre-Bach G. Spanish Validation of the Brief Pornography Screen Within a Clinical Sample of Individuals with Gambling Disorder. Archives Of Sexual Behavior 2024, 53: 3759-3768. PMID: 39358592, DOI: 10.1007/s10508-024-02986-3.Peer-Reviewed Original ResearchBrief Pornography ScreenProblematic pornography useClinical sample of individualsConfirmatory factor analysisGambling disorderSample of individualsPsychometric propertiesLow self-directednessOne-factor solutionAdequate psychometric propertiesClinical samplesGeneral psychopathologySelf-directednessBehavioral addictionsImpulsive tendenciesConvergent validityPornography usePsychological distressScreening instrumentSpanish versionSpanish validationFactor analysisBriefDisordersIndividuals
2022
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructureEstimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study
Pries L, Moore T, Visoki E, Sotelo I, Barzilay R, Guloksuz S. Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study. Biological Psychiatry Global Open Science 2022, 2: 283-291. PMID: 36325038, PMCID: PMC9616253, DOI: 10.1016/j.bpsgos.2022.05.005.Peer-Reviewed Original ResearchPregnancy/birth complicationsExposome factorsGeneral psychopathologyBirth complicationsCognitive Development StudyGeneral psychopathology factorAdolescent Brain Cognitive Development (ABCD) studyClinical symptomsAdjusted modelMultiple comparison correctionExposome approachLinear regression analysisMental disordersNeurodevelopmental psychopathologyChildhood adversityPsychosisEnvironmental exposuresABCD studyNongenetic factorsComplicationsRegression analysisPsychopathology factorNeighborhood environmentPsychopathologyExposomeThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2020
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markersGene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
Ota V, Santoro M, Spindola L, Pan P, Simabucuro A, Xavier G, Vieira-Fonseca T, Zanardo E, dos Santos F, Schäfer J, Kulikowski L, Galante P, Asprino P, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Gadelha A, Mari J, Bressan R, Salum G, Belangero S. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents. Translational Psychiatry 2020, 10: 99. PMID: 32184383, PMCID: PMC7078305, DOI: 10.1038/s41398-020-0772-3.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsMental disordersChild Behavior Checklist total scoresTrajectories of psychopathologyBlood gene expression profilesHigh Risk Cohort StudyGeneral psychiatric symptomsBlood gene expression patternsPsychopathological trajectoriesCohort studyLow-low groupLongitudinal cohortPostmortem brainsGeneral psychopathologySpecific disordersTotal scoreGene expressionCBCL scoresGene expression changesGene expression profilesDisordersSymptoms
2018
Prediction of prodromal symptoms and schizophrenia-spectrum personality disorder traits by positive and negative schizotypy: A 3-year prospective study
Racioppi A, Sheinbaum T, Gross G, Ballespí S, Kwapil T, Barrantes-Vidal N. Prediction of prodromal symptoms and schizophrenia-spectrum personality disorder traits by positive and negative schizotypy: A 3-year prospective study. PLOS ONE 2018, 13: e0207150. PMID: 30408119, PMCID: PMC6224105, DOI: 10.1371/journal.pone.0207150.Peer-Reviewed Original ResearchConceptsNegative schizotypyPersonality traitsYoung adult samplePrevious cross-sectional findingsSchizophrenia-spectrum psychopathologyAvoidant personality traitsPsychotic-like symptomsPsychometric high-risk strategyMental health treatmentCross-sectional findingsPositive schizotypyPersonality disorder traitsSchizotypy dimensionsResilience factorsSchizotypyLongitudinal findingsAdult samplesNegative dimensionsDisorder traitsEmotional disturbancePredictive validityGeneral psychopathologyMultidimensional modelHealth treatmentMultidimensional structureA transdiagnostic neuroanatomical signature of psychiatric illness
Gong Q, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vieira S, McCrory E, Ai Y, Yang C, Zhang F, Lui S, Mechelli A. A transdiagnostic neuroanatomical signature of psychiatric illness. Neuropsychopharmacology 2018, 44: 869-875. PMID: 30127342, PMCID: PMC6461829, DOI: 10.1038/s41386-018-0175-9.Peer-Reviewed Original ResearchConceptsHealthy controlsPsychiatric illnessFamilial vulnerabilityUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGray matter volumeGreater gray matter volumePost-traumatic stress disorderStructural magnetic resonanceDifferent diagnostic categoriesFamily-wise error correctionPutamen enlargementObsessive-compulsive disorderPsychiatric diagnosisMatter volumePutamen volumePsychiatric groupsGeneral psychopathologyNeuroanatomical signatureUnaffected relativesStress disorderTransdiagnostic alterationsDiagnostic categoriesMental healthS22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS
Qiyong G, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vreira S, McCrory E, Yang C, Zang F, Lui S, Mechelli A. S22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS. Schizophrenia Bulletin 2018, 44: s331-s331. PMCID: PMC5888883, DOI: 10.1093/schbul/sby018.809.Peer-Reviewed Original ResearchGray matter volumeHealthy controlsPsychiatric illnessMatter volumeMagnetic resonance imaging (MRI) scansHigher gray matter volumeFamilial vulnerabilityStructural magnetic resonance imaging (MRI) scansResonance imaging scansUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGreater gray matter volumePost-traumatic stress disorderDifferent diagnostic categoriesPutamen enlargementObsessive-compulsive disorderImaging scansBilateral putamenPsychiatric diagnosisPutamen volumeTrans-diagnostic approachPsychiatric groupsGeneral psychopathologyNeuroanatomical signature
2017
A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function
Martel M, Pan P, Hoffmann M, Gadelha A, do Rosário M, Mari J, Manfro G, Miguel E, Paus T, Bressan R, Rohde L, Salum G. A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function. Journal Of Psychopathology And Clinical Science 2017, 126: 137-148. PMID: 27748619, DOI: 10.1037/abn0000205.Peer-Reviewed Original ResearchConceptsChildren's executive functionExecutive functionGlobal executive functionGeneral p factorLittle residual varianceConfirmatory factor analysisChildren ages 6Specific factorsGeneral psychopathology factorFamily riskChild psychopathologyCommunity sampleDisorder diagnostic criteriaMental health researchParental factorsGeneral psychopathologyBest fitting modelPsychopathologyPsychopathology factorAge 6P-factorExternal validityFactor analysisStructured interviewsMental disorders
2015
Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Satterthwaite T, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents. Human Brain Mapping 2015, 36: 4926-4937. PMID: 26350757, PMCID: PMC6868942, DOI: 10.1002/hbm.22985.Peer-Reviewed Original ResearchConceptsDefault mode networkChild Behavior ChecklistDynamic functional connectivity patternsHigh Risk Cohort StudyBehavior ChecklistAbnormal connectivity patternsFunctional connectivity patternsResting-state fMRIPathological mental statesCohort studyConnectivity patternsPsychiatric disordersFunctional network dynamicsGeneral psychopathologyTotal scoreMode networkNetwork maturationBrain networksMaturation indexEmotional problemsChildrenAge effectsOverall presenceSpecific associationAdolescentsEvidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma
2012
Factor structure and clinical correlates of the Food Thought Suppression Inventory within treatment seeking obese women with binge eating disorder
Barnes RD, Sawaoka T, White MA, Masheb RM, Grilo CM. Factor structure and clinical correlates of the Food Thought Suppression Inventory within treatment seeking obese women with binge eating disorder. Eating Behaviors 2012, 14: 35-39. PMID: 23265399, PMCID: PMC3670144, DOI: 10.1016/j.eatbeh.2012.10.008.Peer-Reviewed Original Research
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptoms
2007
Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia
Zisook S, Montross L, Kasckow J, Mohamed S, Palmer BW, Patterson TL, Golshan S, Fellows I, Lehman D, Solorzano E. Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia. American Journal Of Geriatric Psychiatry 2007, 15: 1005-1014. PMID: 18056819, DOI: 10.1097/jgp.0b013e3180a725ec.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsChronic DiseaseCitalopramComorbidityDepressionDepressive Disorder, MajorDouble-Blind MethodFemaleFollow-Up StudiesHealth StatusHumansMaleMiddle AgedPlacebosPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologySelective Serotonin Reuptake InhibitorsSuicideTreatment OutcomeConceptsSubsyndromal depressive symptomsDepressive symptomsOlder patientsClinical featuresSchizoaffective disorderNegative symptomsHamilton Depression Rating ScaleImportant clinical dimensionGeneral medical conditionsDepression Rating ScaleSpecific depressive symptomsMental functioningSubstantial morbiditySevere akathisiaMovement abnormalitiesChronic schizophreniaMedical conditionsDepression groupOverall psychopathologyIntervention studiesDepressive symptomatologyPatientsSymptomsOlder personsGeneral psychopathology
2005
Cognitive training of verbal memory using a dichotic listening paradigm: impact on symptoms and cognition
Fiszdon JM, Whelahan H, Bryson GJ, Wexler BE, Bell MD. Cognitive training of verbal memory using a dichotic listening paradigm: impact on symptoms and cognition. Acta Psychiatrica Scandinavica 2005, 112: 187-193. PMID: 16095473, DOI: 10.1111/j.1600-0447.2005.00565.x.Peer-Reviewed Original ResearchConceptsVerbal memoryAuditory hallucinationsDichotic listeningDL taskMemory training taskCognitive remediation trainingCognitive remediation programVerbal episodic memoryVerbal memory taskDichotic listening paradigmRemediation trainingCognitive trainingEpisodic memoryMemory taskTraining tasksRemediation programGeneral psychopathologyControl conditionMemoryTaskCognitionPsychiatric symptomsTrainingHierarchical trainingCurrent investigation
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