2025
Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)
Soleimani N, Iraji A, Pearlson G, Preda A, Calhoun V. Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs). Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40222638, DOI: 10.1016/j.bpsc.2025.03.015.Peer-Reviewed Original ResearchAutism spectrum disorderFunctional network connectivityBipolar disorderPsychiatric conditionsMental disordersMental illnessResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingConnectivity patternsBrain network alterationsFunctional connectivity patternsNeurobiological underpinningsDepressive disorderEmotion regulationNeural signaturesPsychiatric diagnosisConnectivity alterationsBrain regionsSpectrum disorderCognitive functionNeural landscapeCerebellar connectivitySocial behaviorNetwork alterationsSchizophreniaMovies reveal the fine-grained organization of infant visual cortex
Ellis C, Yates T, Arcaro M, Turk-Browne N. Movies reveal the fine-grained organization of infant visual cortex. ELife 2025, 12 DOI: 10.7554/elife.92119.4.Peer-Reviewed Original ResearchBrain activityInfant visual systemMagnetic resonance imagingFunctional magnetic resonance imagingInfants' visual processingAdults' brain activityVentral visual cortexInfant brain activityShort attention spanAdult brainVisual cortexInfants' perceptionCognitive tasksBrain organizationBrain structuresInfant scansInfant mindFMRI dataInfant brain structureSensory processingNeurodevelopmental conditionsVisual processingAttention spanHomotopic areasInfant brainConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyTransdiagnostic study of dynamic brain activity and connectivity among people with gambling and internet gaming disorders DYNAMIC BRAIN ACTIVITY IN GD AND IGD
Zhou H, He Y, Liu L, Yin J, Xiong A, Leong K, Wu A, Potenza M. Transdiagnostic study of dynamic brain activity and connectivity among people with gambling and internet gaming disorders DYNAMIC BRAIN ACTIVITY IN GD AND IGD. International Journal Of Clinical And Health Psychology 2025, 25: 100547. PMID: 39944189, PMCID: PMC11815891, DOI: 10.1016/j.ijchp.2025.100547.Peer-Reviewed Original ResearchInternet gaming disorder groupInternet gaming disorderIGD participantsFunctional magnetic resonance imagingDynamic brain activityGambling disorderHC participantsBrain activityTransdiagnostic studiesFrontal gyrusLeft triangular inferior frontal gyrusFeatures of behavioral addictionsResting-state functional magnetic resonance imagingTriangular inferior frontal gyrusInferior frontal gyrusCombination of self-reportHealthy controlsPositive playBehavioral addictionsSelf-reported indicatorsNeural measuresGaming disorderDiagnostic groupsBrain connectivitySelf-reportNeural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Scholl J, Panchal P, Nelissen N, Atkinson L, Kolling N, Saunders K, Geddes J, Rushworth M, Nobre A, Harrison P, Harmer C. Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment. Molecular Psychiatry 2025, 1-11. PMID: 39880901, DOI: 10.1038/s41380-025-02900-w.Peer-Reviewed Original ResearchBipolar disorderDecision-making taskReward-guided decision-making taskFunctional magnetic resonance imagingWeeks of lithiumSymptoms of maniaDorsolateral prefrontal cortexMood Disorder QuestionnaireRisk-takingReward outcomesReward processingPrefrontal cortexMood ratingsNeural signaturesNeural mechanismsRisk-related behaviorsLithium treatmentMoodDiagnosed BDBD studiesFunction of riskDisordersOutcome historyMagnetic resonance imagingMDQSelf-reports map the landscape of task states derived from brain imaging
Mckeown B, Goodall-Halliwell I, Wallace R, Chitiz L, Mulholland B, Karapanagiotidis T, Hardikar S, Strawson W, Turnbull A, Vanderwal T, Ho N, Wang H, Xu T, Milham M, Wang X, Zhang M, Gonzalez Alam T, Vos de Wael R, Bernhardt B, Margulies D, Wammes J, Jefferies E, Leech R, Smallwood J. Self-reports map the landscape of task states derived from brain imaging. Communications Psychology 2025, 3: 8. PMID: 39843761, PMCID: PMC11754446, DOI: 10.1038/s44271-025-00184-y.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBrain activityFunctional magnetic resonance imaging studyBrain functionPsychological statePatterns of brain activitySelf-reportTask statesDescription of brain functionIndicator of cognitionSelf-reported descriptionsBrain systemsTask performanceObject representationsIntrospective descriptionsIntrospective reportsBrain imagingMagnetic resonance imagingBrainDescription of experimentsSelf-reports of experienceTaskResonance imagingCognitionLearningInfants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025 PMID: 39760730, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor network
2024
Cognitive Control Network and Language Reorganization in Patients with Brain Tumors
Pasquini L, Napolitano A, Spitoni L, Schmid M, Dellepiane F, Jenabi M, Peck K, Holodny A. Cognitive Control Network and Language Reorganization in Patients with Brain Tumors. American Journal Of Neuroradiology 2024, ajnr.a8638. PMID: 39730156, DOI: 10.3174/ajnr.a8638.Peer-Reviewed Original ResearchCognitive control networkLanguage reorganizationResting-state fMRIHealthy controlsFunctional magnetic resonance imagingControl networkTask-based fMRIResting state networksRight-handed patientsCognitive controlLanguage lateralizationReorganize languageEffect of lateralitySpeech deficitsLaterality indexFMRIAge-matched healthy controlsRight-handednessPatient's speechBrain tumorsTask-basedCognitive networksIndependent component analysisMagnetic resonance imagingBrainBrain networks and intelligence: A graph neural network based approach to resting state fMRI data
Thapaliya B, Akbas E, Chen J, Sapkota R, Ray B, Suresh P, Calhoun V, Liu J. Brain networks and intelligence: A graph neural network based approach to resting state fMRI data. Medical Image Analysis 2024, 101: 103433. PMID: 39708510, PMCID: PMC11877132, DOI: 10.1016/j.media.2024.103433.Peer-Reviewed Original ResearchConceptsGraph neural networksNeural networkGraph isomorphism networkGraph convolutional layersGraph convolutional networkMachine learning modelsNetwork connectivity matrixCognitive processesConvolutional layersConvolutional networkPrediction taskModel architectureGraph architectureAdolescent Brain Cognitive Development datasetResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingLearning modelsMiddle frontal gyrusPredicting individual differencesResting state fMRI dataPredictive intelligenceIntelligenceNetworkFunctional network connectivity matricesArchitectureChildhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments
Armbruster‐Genç D, Neil L, Valton V, Phillips H, Rankin G, Sharp M, Rapley J, Viding E, Roiser J, McCrory E. Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments. Journal Of Child Psychology And Psychiatry 2024 PMID: 39665511, DOI: 10.1111/jcpp.14095.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingReward learningOrbitofrontal cortexChildhood maltreatmentProbabilistic reinforcement learning taskDocumented history of maltreatmentAtypical reward processingOrbitofrontal cortex connectivityNon-maltreated individualsLower exploratory behaviorMid-cingulate cortexDisrupt neural processingHistory of maltreatmentImpact of maltreatmentReinforcement learning taskPrefrontal activationReward processingReward contingenciesNeural indicesOutcome deliveryNeural signalsLatent vulnerabilityBehavioral measuresInternalising symptomsOutcome processingGPR-SCSANet: Unequal-Length Time Series Normalization with Split-Channel Residual Convolution and Self-Attention for Brain Age Prediction
Sun F, Liang C, Adali T, Zhang D, Jiang R, Calhoun V, Qi S. GPR-SCSANet: Unequal-Length Time Series Normalization with Split-Channel Residual Convolution and Self-Attention for Brain Age Prediction. 2024, 00: 5097-5103. DOI: 10.1109/bibm62325.2024.10822453.Peer-Reviewed Original ResearchSelf-attention mechanismResidual convolutionGaussian process regressionFunctional magnetic resonance imagingReal-world scenariosAge prediction taskSelf-attentionPrediction taskBrain age estimationAge predictionInherent informationBrain age predictionFMRI time coursesLength of time seriesProcess regressionVariables conflictBrain functional alterationsConvolutionPrediction accuracyUnequal-lengthTraditional methodsMotion artifactsDownstream applicationsTime series normalizationPrediction modelSelf-supervised Pre-training Tasks for an fMRI Time-Series Transformer in Autism Detection
Zhou Y, Duan P, Du Y, Dvornek N. Self-supervised Pre-training Tasks for an fMRI Time-Series Transformer in Autism Detection. Lecture Notes In Computer Science 2024, 15266: 145-154. DOI: 10.1007/978-3-031-78761-4_14.Peer-Reviewed Original ResearchSelf-supervised pre-training tasksPre-training tasksFunctional magnetic resonance imagingPre-training stepTransformer-based modelsTime-series fMRI dataTraining data availabilityAutism spectrum disorderTime series transformationsTransformation modelMachine learning methodsFunctional magnetic resonance imaging time-series dataClassification taskPublic datasetsTraining dataOver-fittingComputed functional connectivityLearning methodsModel performanceMasking strategyAutism detectionCross-validationTaskDatasetAverage improvementMinimal Variation in Functional Connectivity in Relation to Daily Affect
Godfrey K, Rai S, Graff K, Yin S, Merrikh D, Tansey R, Vanderwal T, Harris A, Bray S. Minimal Variation in Functional Connectivity in Relation to Daily Affect. ENeuro 2024, 11: eneuro.0209-24.2024. PMID: 39592226, PMCID: PMC11680495, DOI: 10.1523/eneuro.0209-24.2024.Peer-Reviewed Original ResearchAffective disorder symptomsFunctional connectivityBrain functional connectivityDaily affectDisorder symptomsEffect sizeDay-to-day affectFunctional magnetic resonance imagingNetwork-level functional connectivityBetween-network connectivityWithin-network connectivityNon-clinical cohortPassive viewing conditionsParticipants self-reportedDorsal attentionPANAS-XIndividual differencesSubcortical regionsMultiple sessionsVisual networkSelf-reportAffectResearchers planning studiesConnectivity patternsMagnetic resonance imagingAnxiety symptoms are differentially associated with facial expression processing in boys and girls
Doucet G, Kruse J, Keefe A, Rice D, Coutant A, Pulliam H, Smith O, Calhoun V, Stephen J, Wang Y, White S, Picci G, Taylor B, Wilson T. Anxiety symptoms are differentially associated with facial expression processing in boys and girls. Social Cognitive And Affective Neuroscience 2024, 19: nsae085. PMID: 39587034, PMCID: PMC11631531, DOI: 10.1093/scan/nsae085.Peer-Reviewed Original ResearchFacial expression processingAssociated with psychiatric disordersExpression processingFacial expressionsFunctional magnetic resonance imagingFace processing taskMedial temporal cortexTypically-developing youthLevels of anxietyEmotional facesNeutral contrastAnxiety symptomsPosterior networkPsychiatric disordersFacial emotionsBrain responsesTemporal cortexNeural mechanismsHigher anxietyFMRI dataAnxietySocial informationAnxiety levelsBehavioral changesMagnetic resonance imagingMultimodal predictive modeling: Scalable imaging informed approaches to predict future brain health
Ajith M, Spence J, Chapman S, Calhoun V. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. Journal Of Neuroscience Methods 2024, 414: 110322. PMID: 39608579, PMCID: PMC11687617, DOI: 10.1016/j.jneumeth.2024.110322.Peer-Reviewed Original ResearchStatic functional network connectivityHealth constructsNeuroimaging dataBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingSupport vector regressionFunctional network connectivityRandom forestCognitive performanceAssessment-onlyRs-fMRINeural patternsBehavioral outcomesBehavioral dataDiverse data sourcesNeural connectionsPsychological stateTraining stageMagnetic resonance imagingLongitudinal changesNetwork connectivityBrainPerformance evaluationVector regressionThe cell-type underpinnings of the human functional cortical connectome
Anderson K, Chopra S, Dhamala E, Emani P, Gerstein M, Margulies D, Holmes A. The cell-type underpinnings of the human functional cortical connectome. Nature Neuroscience 2024, 28: 150-160. PMID: 39572742, DOI: 10.1038/s41593-024-01812-2.Peer-Reviewed Original ResearchSingle-nucleus RNA sequencing dataCell-type distributionRNA sequencing dataMicroarray dataSingle-nucleusIn vivo organizationCortical sheetCortical connectomeAllen Human Brain AtlasCell typesFunctional magnetic resonance imagingCellular fingerprintsCortical tissue samplesHuman Brain AtlasOrganization of cortexFunctional organization of cortexCellular compositionBrain atlasesFunctional organizationCellsEnriched cellsAssociative territoryFunctional propertiesTissue samplesSpatial topographyRADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS
Gui C, Jenabi M, Daly J, Gillick C, Bradley T, Sze E, Maldonado R, Tiwari A, Stember J, Mankuzhy N, Yamada Y, Pike L, Pasquini L, Peck K, Ballangrud-Popovic Å, Holodny A, Imber B. RADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS. Neuro-Oncology 2024, 26: viii83-viii83. PMCID: PMC11554023, DOI: 10.1093/neuonc/noae165.0329.Peer-Reviewed Original ResearchStereotactic radiosurgerySymptomatic RNRadiation necrosisBrain metastasesNeurological symptomsDosimetric analysisTarget coverageComplications of stereotactic radiosurgeryMonths of SRSSacrificing target coverageSymptomatic radiation necrosisUnresectable brain metastasesMonths post-SRSEloquent cortical areasFunctional magnetic resonance imagingFocal neurological symptomsMagnetic resonance imagingRadiosurgery planningPost-SRSSRS plansPrimary motorEloquent areasNeurological functionPatientsResonance imagingChanges in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder
Knowles K, Stevens M, Levy H, Tolin D. Changes in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder. Journal Of Psychiatric Research 2024, 180: 473-481. PMID: 39547046, PMCID: PMC11606758, DOI: 10.1016/j.jpsychires.2024.11.017.Peer-Reviewed Original ResearchCognitive-behavioral therapyHoarding-related beliefsFunctional magnetic resonance imagingHoarding disorderNeural activityMaladaptive beliefsCourse of CBTGroup cognitive-behavioral therapyLeft anterior cingulate cortexLeft middle frontal gyrusAssociated with cognitive changesCognitive-behavioral treatmentAssociated with increased activityAnterior ventral insulaAnterior cingulate cortexMiddle frontal gyrusInferior temporal lobeLeft middle insulaCognitive-behavioralAssociated with specific changesFrontal gyrusCingulate cortexMiddle insulaNeural regionsVentral insulaNeighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma
Webb E, Stevens J, Ely T, Lebois L, van Rooij S, Bruce S, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Murty V, Hudak L, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Joormann J, Pizzagalli D, Harte S, Kessler R, Koenen K, Ressler K, McLean S, Harnett N. Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma. JAMA Psychiatry 2024, 81: 1090-1100. PMID: 39083325, PMCID: PMC11292566, DOI: 10.1001/jamapsychiatry.2024.2148.Peer-Reviewed Original ResearchPosttraumatic stress disorder trajectoriesPosttraumatic stress disorderNeural reactivityPTSD trajectoriesTrauma survivorsPosttraumatic stress disorder symptom severityDevelopment of posttraumatic stress disorderResidential greenspaceFunctional magnetic resonance imagingMonetary reward taskReactivity to rewardReward-related regionsCD-RISCCohort studyConnor-Davidson Resilience ScaleParticipant's home addressNeighborhood-level factorsCD-RISC scoreLongitudinal cohort studyReward reactivityReward taskSelf-reported characteristicsStress disorderIndividual-level factorsMultiple ecological levels
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply