2025
Modularity Measures of Functional Brain Networks Predict Individual Differences in Long‐Term Memory
Zhou M, Chun M, Lin Q. Modularity Measures of Functional Brain Networks Predict Individual Differences in Long‐Term Memory. European Journal Of Neuroscience 2025, 61: e70052. PMID: 40091538, DOI: 10.1111/ejn.70052.Peer-Reviewed Original ResearchConceptsLong-term memoryPredicting individual differencesRecollection memoryIndividual differencesBrain networksLong-term memory performanceLong-term memory capacityMeasures of brain activityBrain functional organizationBrain functional connectivityMode networkBrain activityFunctional connectivityConnector hubsMemoryFunctional organizationBrainModularity measureRecollectionConnectivity featuresEncodingCognitionNeuroanatomyLocal measurementsDifferencesIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activityBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-bodyAttachment as Prediction: Insights From Cognitive and Developmental Neuroscience
Tottenham N, Vannucci A. Attachment as Prediction: Insights From Cognitive and Developmental Neuroscience. Current Directions In Psychological Science 2025 DOI: 10.1177/09637214251313714.Peer-Reviewed Original ResearchEarly caregiving experiencesAttachment schemasEmotion regulationMidline cortical regionsCaregiving experienceNeurodevelopmental frameworkDevelopmental neuroscienceEmotional well-beingFunctional connectivityNeural circuitryCortical regionsNeural predictionPredictive inferenceWell-beingMemoryEmpirical findingsNeurobiologyCognitionSchemaAttachmentEmotionsNeuroscienceCircuitryFunctional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
Song Y, Zhu H, Wu Z, Hu W, Zhang S, Zhou Y, Peng Y, Yang Y, Li W, Shi H, Yang G, Zhang Y, Lv L. Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia. European Child & Adolescent Psychiatry 2025, 1-10. PMID: 39928122, DOI: 10.1007/s00787-025-02656-2.Peer-Reviewed Original ResearchPrefrontal-thalamic-cerebellar circuitMedial prefrontal cortexMiddle temporal gyrusPosterior cerebellar lobeFunctional connectivityReduced FCTemporal gyrusResting-state functional magnetic resonance imaging scansFunctional magnetic resonance imaging scansLeft medial prefrontal cortexEarly stages of schizophreniaCerebellar lobeRight middle temporal gyrusHealthy controlsPositive symptom scoresFirst-episode schizophreniaVisuospatial Memory TestStages of schizophreniaFunctional connectivity changesRight posterior cerebellar lobePrefrontal cortexMemory testLeft precuneusFC abnormalitiesBrain regionsStatic and Dynamic Cross‐Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients
Maksymchuk N, Miller R, Bustillo J, Ford J, Mathalon D, Preda A, Pearlson G, Calhoun V. Static and Dynamic Cross‐Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients. Human Brain Mapping 2025, 46: e70134. PMID: 39924889, PMCID: PMC11808047, DOI: 10.1002/hbm.70134.Peer-Reviewed Original ResearchConceptsSZ patientsCognitive controlBrain networksFunctional connectivityHealthy controlsBrain domainsConnection strengthAnalyzed fMRI dataFunctional brain networksDiagnosed mental health conditionDynamic functional connectivityMental health conditionsSchizophrenia patientsSchizophreniaFMRI dataBrain statesEntropy correlationBrainDiseased brain statesSensorimotorControl groupK-means cluster analysisDMNConnection levelHealth conditionsRepresenting brain-behavior associations by retaining high-motion minoritized youth
Ramduny J, Uddin L, Vanderwal T, Feczko E, Fair D, Kelly C, Baskin-Sommers A. Representing brain-behavior associations by retaining high-motion minoritized youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39921132, DOI: 10.1016/j.bpsc.2025.01.014.Peer-Reviewed Original ResearchBrain-behavior associationsFunctional MRIAdolescent Brain Cognitive Development<sup>SM<Effect sizeHispanic youthInternalizing psychopathologyCognitive performanceParticipant sexFunctional connectivityFMRI dataMinoritized individualsWhite youthHead motionMinoritized youthYouthSources of noisePsychopathologyDiverse populationsRacial/ethnic groupsAssociationPartial Spearman rank correlationsAdolescentsDisproportionate numberDynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts
Wang L, Hu W, Dong F, Sheng C, Wu J, Han Y, Jiang J, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowski J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Bernstein M, Thompson P, Schuff N, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Taylor-Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Thal L, Buckholtz N, Albert M, Frank R, Hsiao J, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, de Toledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Onyike C, D’Agostino D, Kielb S, Galvin J, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Hsiung G, Feldman H, Mudge B, Assaly M, Bernick C, Munic D, Kertesz A, Rogers J, Trost D, Kerwin D, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichae O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Preda A, Nguyen D, Tariot P, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Pasternak S, Rachinsky I, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B, Neylan T, Grafman J, Davis M, Morrison R, Hayes J, Finley S, Friedl K, Fleischman D, Arfanakis K, James O, Massoglia D, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A. Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts. GeroScience 2025, 1-16. PMID: 39888585, DOI: 10.1007/s11357-025-01528-6.Peer-Reviewed Original ResearchSuperior frontal gyrusSubjective cognitive declineLeft superior frontal gyrusCognitive declineFrontal gyrusResting-state functional magnetic resonance imaging dataFunctional magnetic resonance imaging dataSusceptible to individual differencesLongitudinal resting-state functional magnetic resonance imaging dataLoss of functional connectivityDiagnosis of subjective cognitive declineBrain network dynamicsMagnetic resonance imaging dataRisk of cognitive declineAlzheimer's diseaseIndividual differencesFunctional connectivityCognitively normal controlsNeuroimaging biomarkersDPLFCGyrusScale scoreNormal controlsAb depositionCognitionHypothalamic resting-state functional connectivity and self-evaluated aggression in young adults
Yao Y, Chen Y, Li C. Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults. Journal Of Psychiatric Research 2025, 182: 421-429. PMID: 39889403, PMCID: PMC11834083, DOI: 10.1016/j.jpsychires.2025.01.045.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAggression scoresLateral hypothalamusSex differencesHuman Connectome ProjectFunctional connectivityAchenbach Adult Self-ReportAdult Self-ReportYoung adultsManifestations of aggressionVoxel-wise regressionPublished routinesMotivated behaviorOccipital gyriAggressive behaviorSelf-reportMental healthAggressionConnectome ProjectNeural pathwaysBehavioral traitsRSFCHypothalamusScoresAdultsNeural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture
Yair N, Zalmenson T, Azriel O, Shamai-Leshem D, Alon Y, Tik N, Tatsa-Laur L, Ben-Yehuda A, Pine D, Winkler A, Tavor I, Bar-Haim Y. Neural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39824285, DOI: 10.1016/j.bpsc.2024.12.017.Peer-Reviewed Original ResearchFunctional magnetic resonance imaging studyBetween-network functional connectivityTrauma-related psychopathologyEffects of combat deploymentBetween-network connectivityVentral attention networkBrain functional architectureFunctional brain networksMagnetic resonance imaging studiesFunctional network architectureCognitive controlCombat exposureNeural basisBrain networksCombat deploymentFunctional connectivityResilient individualsGroup of university studentsResilient participantsAttention networkNeural adaptationSignificant groupComparison groupLongitudinal studyFunctional architectureAltered hippocampal effective connectivity predicts BMI and food approach behavior in children with obesity
Li W, Chen X, Gao X, Pang Q, Guo C, Song S, Liu Y, Shi P, Chen H. Altered hippocampal effective connectivity predicts BMI and food approach behavior in children with obesity. International Journal Of Clinical And Health Psychology 2025, 25: 100541. PMID: 39877891, PMCID: PMC11773239, DOI: 10.1016/j.ijchp.2024.100541.Peer-Reviewed Original ResearchFood approach behaviorsApproach behaviorEffective connectivityPediatric obesityExcess weightEating behaviorsResting-state functional connectivityFood reward processingAssessment of eating behaviorModels of obesityLeft postcentral gyrusResting-state fMRIFollow-up assessmentReward processingNormal weightDynamic casual modelingHippocampal connectivityRight hippocampusPostcentral gyrusFunctional connectivityBMIAppetite regulationChildhood obesityAdult obesityObesityDoes semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Klausen M, Kuzey T, Pedersen J, Justesen S, Rasmussen L, Knorr U, Mason G, Ekstrøm C, Holst J, Koob G, Benveniste H, Volkow N, Knudsen G, Vilsbøll T, Fink-Jensen A. Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial). BMJ Open 2025, 15: e086454. PMID: 39779270, PMCID: PMC11749217, DOI: 10.1136/bmjopen-2024-086454.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disorderGamma-aminobutyric acidComorbid obesityAlcohol cue reactivityCognitive behavioral therapyHeavy drinking daysWhite matter tract integrityBrain gamma-aminobutyric acidGlucagon-like peptide-1Alcohol consumptionMental health disordersReduce alcohol consumptionClinical trialsCue reactivityPlacebo-controlled clinical trialBehavioral therapyDrinking daysFunctional connectivityGLP-1 receptor agonist semaglutideWeeks of treatmentDouble-blind clinical trialTract integrityEthics Committee of the Capital Region of DenmarkHealth disordersInfants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025 PMID: 39760730, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor networkRadiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Droby A, Yoffe-Vasiliev A, Atias D, Fraser K, Mabrouk O, Omer N, Bar-Shira A, Gana-Weisz M, Goldstein O, Artzi M, Ben Bashat D, Alcalay R, Orr-Urtreger A, Shirvan J, Cedarbaum J, Giladi N, Mirelman A, Thaler A. Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients. Npj Parkinson's Disease 2025, 11: 7. PMID: 39753572, PMCID: PMC11698941, DOI: 10.1038/s41531-024-00854-4.Peer-Reviewed Original ResearchStriatal binding ratiosLRRK2-PD patientsFunctional connectivityLeft fronto-occipital fasciculusCerebrospinal fluidGray matter volumeDeep gray matter volumesRegional brain volumesWhole-brain gray matterNeuromelanin MRIFronto-occipital fasciculusLRRK2-PDWhite matterParkinson's diseaseLeft caudateMatter volumeReduced FCParkinson's disease patientsWhole-brainBrain volumeRadiological markersHealthy controlsFractional anisotropyRadiological measurementsPatientsImpaired spatial dynamic functional network connectivity and neurophysiological correlates in functional hemiparesis
Premi E, Cantoni V, Benussi A, Iraji A, Calhoun V, Corbo D, Gasparotti R, Tinazzi M, Borroni B, Magoni M. Impaired spatial dynamic functional network connectivity and neurophysiological correlates in functional hemiparesis. NeuroImage Clinical 2025, 45: 103731. PMID: 39764901, PMCID: PMC11762193, DOI: 10.1016/j.nicl.2025.103731.Peer-Reviewed Original ResearchDynamic functional network connectivitySomatomotor networkSalience networkFunctional network connectivityGABAergic neurotransmissionResting-state functional MRI scansResting-state fMRI dataFunctional MRI scansDynamic brain statesBrain network dynamicsStatic functional connectivityDynamic brain networksBrain networksGlutamatergic transmissionNeurophysiological correlatesFunctional connectivityTranscranial magnetic stimulation protocolFMRI dataGABAergic inhibitionMagnetic stimulation protocolBrain statesNeurotransmissionHealthy controlsDMNNetwork connectivityComparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach
Shearer H, Eilbott J, Vila-Rodriguez F, Noble S, Xu T, Vanderwal T. Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach. Imaging Neuroscience 2025, 3: imag_a_00411. DOI: 10.1162/imag_a_00411.Peer-Reviewed Original ResearchResting-state FCBrain regionsAbstract Functional connectivityFunctional connectivityPrecision psychiatryMeasures of functional connectivityField of precision psychiatryPre-supplementary motor areaSensitive to individual differencesDorsolateral prefrontal cortexWhole-brain levelMovie-watchingPrefrontal cortexTemporoparietal junctionROI-based approachIndividual differencesResting-stateResearch to clinical useMotor areaIntra-class correlation coefficientFC dataAcquisition statePsychiatryClinical useBrainErratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Erratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2025, 314: e249023. PMID: 39873610, PMCID: PMC11788710, DOI: 10.1148/radiol.249023.Peer-Reviewed Original Research
2024
Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia
Zhang Y, Gao S, Liang C, Bustillo J, Kochunov P, Turner J, Calhoun V, Wu L, Fu Z, Jiang R, Zhang D, Jiang J, Wu F, Peng T, Xu X, Qi S. Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia. NeuroImage Clinical 2024, 45: 103726. PMID: 39700898, PMCID: PMC11721508, DOI: 10.1016/j.nicl.2024.103726.Peer-Reviewed Original ResearchNon-treatment-resistant schizophreniaTreatment-resistant schizophreniaFunctional connectivityDiagnosis of SZHealthy controlsFrontal-parietalResting-state functional connectivityAutomated anatomical labelingDysfunctional brain connectivityBrain functional connectivityAffiliated Brain Hospital of Nanjing Medical UniversityFrontal limbBrain connectivitySchizophreniaMedication dosageTreatment resistanceNeural pathwaysNanjing Medical UniversityDisease progressionMedical UniversityClinical practiceSpecific biomarkersDiagnosisAnatomical labelingNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging data
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