2025
Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes
McLaren N, Roy B, Nowak R. Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes. Neurology Clinical Practice 2025, 15: e200503. PMID: 40584640, PMCID: PMC12204767, DOI: 10.1212/cpj.0000000000200503.Peer-Reviewed Original ResearchLong-term outcomes of patientsOutcomes of patientsLong-term outcomesAA patientsNon-Hispanic patientsMyasthenia gravisWhite patientsHistory of thymomaLong-term outcome analysisRetrospective cohort studyYears of follow-up dataDiagnosis of MGRepetitive nerve stimulationFollow-up dataSingle-fiber electromyographyMG crisisClinical featuresClinical profileLogistic regression modelsEthnic differencesAntibody seropositivityCohort studyNerve stimulationOutcome analysisPatientsLong-term clinical outcomes with nivolumab/ipilimumab with or without Clostridium butyricum MIYAIRI588 in metastatic renal cell carcinoma (mRCC): A randomized phase Ib clinical trial.
Zugman M, Ebrahimi H, Meza L, Barragan-Carrillo R, Li X, Llamas-Quitiquit M, Hsu J, Zengin Z, Castro D, Mercier B, Jaime-Casas S, Chehrazi-Raffle A, Trent J, Lee P, Takahashi M, Dorff T, Caporaso G, Lee K, Pal S, Dizman N. Long-term clinical outcomes with nivolumab/ipilimumab with or without Clostridium butyricum MIYAIRI588 in metastatic renal cell carcinoma (mRCC): A randomized phase Ib clinical trial. Journal Of Clinical Oncology 2025, 43: 4550-4550. DOI: 10.1200/jco.2025.43.16_suppl.4550.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaProgression-free survivalClinical outcomesOverall survivalMedian progression-free survivalRandomized phase I trialTime of data cutoffPhase Ib clinical trialLong-term follow-up dataLong-term clinical outcomesObjective response rateDisease control ratePhase I trialRenal cell carcinomaSystemic immune responsesNewly diagnosed patientsFollow-up dataImproving clinical outcomesMedian OSSarcomatoid histologyCell histologyData cutoffIntermediate/high riskCell carcinomaI trialARCHES: 5-year follow-up overall survival (OS) analysis of enzalutamide (ENZA) plus androgen-deprivation therapy (ADT) in patients (pts) with metastatic hormone-sensitive prostate cancer (mHSPC).
Armstrong A, Petrylak D, Shore N, Szmulewitz R, Holzbeierlein J, Villers A, Alcaraz A, Alekseev B, Iguchi T, Gomez-Veiga F, Croitoru R, Wu R, Kalac M, Tang Y, Stenzl A, Azad A. ARCHES: 5-year follow-up overall survival (OS) analysis of enzalutamide (ENZA) plus androgen-deprivation therapy (ADT) in patients (pts) with metastatic hormone-sensitive prostate cancer (mHSPC). Journal Of Clinical Oncology 2025, 43: 5005-5005. DOI: 10.1200/jco.2025.43.16_suppl.5005.Peer-Reviewed Original ResearchMetastatic hormone-sensitive prostate cancerAndrogen deprivation therapyOverall survivalOS analysisRadiographic progression-free survivalHormone-sensitive prostate cancerLong-term follow-upGlobal phase 3Low-volume patientsOpen-label enzalutamideProgression-free survivalEfficacy of enzalutamideMedian follow-upOpen-label extensionKaplan-Meier methodLong-term efficacyStandard-of-careClinically relevant subgroupsCox regression modelsFollow-up dataARCH trialDocetaxel useMedian OSAndrogen deprivationDisease volumeAir Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights
Jiang M, Wang Y, Tian S, Liu S, Luo Y, Song H, Qin J, Lv Y, Baccarelli A, Zhang Z, Shi X, Gao X. Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights. Environmental Science And Technology 2025, 59: 9907-9917. PMID: 40353491, DOI: 10.1021/acs.est.4c13675.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity StudyAssociated with PM<sub>2.5</sub> exposure inOlder adultsAir quality improvementHealth and Aging StudyClean Air ActEnvironmental policy interventionsQuasi-experimental studyRisk of worsening frailtyAir ActRange reductionKnowledge gapsLikelihood of improvementFrailty progressionNationwide cohortFollow-up visitFrailty burdenQuality improvementProspective cohortSurvey wavesAging StudyFrailtyMultistate modelling analysisFollow-up dataHealth benefitsVolumetric Abdominal Aortic Aneurysm Analysis in Post EVAR Surveillance Settings
Simmons K, Weiss D, Aboian M, Lin M, Bousabarah K, Renninghoff D, Holler W, Deuschl C, Fischer U, Aboian E. Volumetric Abdominal Aortic Aneurysm Analysis in Post EVAR Surveillance Settings. Annals Of Vascular Surgery 2025, 114: 241-250. PMID: 40049548, DOI: 10.1016/j.avsg.2025.02.009.Peer-Reviewed Original ResearchAbdominal aortic aneurysmEndovascular aortic repairEarly detection of abdominal aortic aneurysmsDetection of abdominal aortic aneurysmsLong-term follow-up dataAneurysm-related mortalityVolumetric analysisAneurysm sac enlargementAssociated with older ageSubgroup of patientsFollow-up dataHigh-risk aneurysmsMaximum diameter measurementsAortic repairSac enlargementAAA enlargementCT angiogramMetformin therapyPatient cohortAortic aneurysmClinical factorsUnivariate analysisClinical variablesAneurysm volumeMedical recordsEstablishing a Structured Hypospadias Biobank Cohort for Integrated Research: Methodology, Comprehensive Database Integration, and Phenotyping
Abbas T, Al-Shafai K, Jamil A, Mancha M, Azzah A, Arar S, Kumar S, Al Massih A, Mackeh R, Tomei S, Saraiva L. Establishing a Structured Hypospadias Biobank Cohort for Integrated Research: Methodology, Comprehensive Database Integration, and Phenotyping. Diagnostics 2025, 15: 561. PMID: 40075808, PMCID: PMC11898921, DOI: 10.3390/diagnostics15050561.Peer-Reviewed Original ResearchHypospadias severitySurgical outcomesEvidence-based surgical techniquesImprove long-term resultsPatient outcomesSeverity of hypospadiasTranslational researchGroup of patientsLong-term resultsFollow-up dataDiverse group of patientsLongitudinal follow-up dataPersonalized care strategiesPostoperative complicationsClinical presentationCongenital anomaliesImprove patient outcomesSurgical dataSurgical interventionBiobank cohortSurgical techniquePhenotypic spectrumClinical dataCongenital conditionHypospadiasEndovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study
Hufnagle J, Fish A, Schlachter T. Endovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study. Journal Of Vascular And Interventional Radiology 2025, 36: 988-993.e1. PMID: 39938714, DOI: 10.1016/j.jvir.2025.02.001.Peer-Reviewed Original ResearchCongenital renal arteriovenous malformationRenal arteriovenous malformationType I AVMArteriovenous malformationsEndovascular embolizationAdverse eventsImaging review of patientsReview of patientsArteriovenous malformation ruptureFollow-up dataYakes classificationTransarterial embolizationEmbolization groupPresenting symptomsPatient demographicsRetrospective studyProcedural imagingImaging reviewEmbolizationPatientsObservation groupMalformationsComplicationsVessel sizeNephrectomyIncidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study
Moran J, Gouzoulis M, Kunze K, LaPrade C, Grauer J, Hewett T, Chahla J, Jimenez A, McKay S, Fabricant P, LaPrade R, Franklin C. Incidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study. Orthopaedic Journal Of Sports Medicine 2025, 13: 23259671251313754. PMID: 39926589, PMCID: PMC11806457, DOI: 10.1177/23259671251313754.Peer-Reviewed Original ResearchPrimary ACLRAnterior cruciate ligament (ACL) reconstructionRisk factorsPosttraumatic osteoarthritisPediatric patientsMale sexRestorative proceduresTibial eminence avulsion fractureLysis of adhesionsYears of follow-up dataPrimary ACL reconstructionACL injury diagnosisMultiligament knee injuriesNational database studyCase-control studyConcomitant partial meniscectomyFollow-up dataMultivariate logistic regressionLevel of evidenceJuvenile idiopathic arthritisDevelopment of posttraumatic osteoarthritisInjury diagnosisKnee injuriesKnee osteoarthritisCartilage procedures
2024
A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort
Group M, Vasavada K, Vasavada V, Moran J, Devana S, Lee C, Hame S, Jazrawi L, Sherman O, Huston L, Haas A, Allen C, Cooper D, DeBerardino T, Spindler K, Stuart M, Amendola A, Annunziata C, Arciero R, Bach B, Baker C, Bartolozzi A, Baumgarten K, Berg J, Bernas G, Brockmeier S, Brophy R, Bush-Joseph C, Butler J, Carey J, Carpenter J, Cole B, Cooper J, Cox C, Creighton R, David T, Dunn W, Flanigan D, Frederick R, Ganley T, Gatt C, Gecha S, Giffin J, Hannafin J, Harris N, Hechtman K, Hershman E, Hoellrich R, Johnson D, Johnson T, Jones M, Kaeding C, Kamath G, Klootwyk T, Levy B, Benjamin C, Maiers G, Marx R, Matava M, Mathien G, McAllister D, McCarty E, McCormack R, Miller B, Nissen C, O’Neill D, Owens B, Parker R, Purnell M, Ramappa A, Rauh M, Rettig A, Sekiya J, Shea K, Slauterbeck J, Smith M, Spang J, Svoboda S, Taft T, Tenuta J, Tingstad E, Vidal A, Viskontas D, White R, Williams J, Wolcott M, Wolf B, Wright R, York J. A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241291920. PMID: 39555321, PMCID: PMC11565622, DOI: 10.1177/23259671241291920.Peer-Reviewed Original ResearchRevision anterior cruciate ligament reconstructionMulticenter ACL Revision StudyGraft failureRisk of graft failureAnterior cruciate ligament reconstructionLogistic regressionFollow-up dataCruciate ligament reconstructionACL reconstruction failureLevel of evidencePatient-reported outcomesCohort dataIntraoperative findingsTibial tunnel sizesModerate predictive abilityReconstruction failureFollow-upGraft typeAllograft useCohort studyPreoperative radiographsLigament reconstructionRisk factorsCohortPatientsComplications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up
Yalcin S, Seals K, Joo P, Fulkerson J, Farrow L. Complications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241278722. PMID: 39430114, PMCID: PMC11489970, DOI: 10.1177/23259671241278722.Peer-Reviewed Original ResearchMidterm follow-upTibial tubercle osteotomyComplication rateFollow-upLogistic regression analysisRadiographic outcomesYears of clinical follow-up dataClinical follow-up dataRisk factorsUnivariate logistic regression analysisMultivariate logistic regression analysisGrades 3 to 4Tubercle osteotomyTreatment of patellofemoral instabilityHistory of smokingCase series studyFollow-up periodRate of patientsLong-term outcomesFollow-up dataLevel of evidenceRegression analysisPatient demographicsCase seriesPatellofemoral instabilityCohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA
Vanegas S, Curado S, Gujral A, Valverde G, Parraga S, Aleman J, Reid M, Elbel B, Schmidt A, Heffron S, Segal E, Li H, Abrams C, Sevick M, Popp C, Armijos E, Merriwether E, Ivezaj V, Ren-Fielding C, Parikh M, Jay M. Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA. BMJ Open 2024, 14: e081201. PMID: 39181563, PMCID: PMC11344502, DOI: 10.1136/bmjopen-2023-081201.Peer-Reviewed Original ResearchConceptsObesity-related comorbiditiesMonths post-surgerySleeve gastrectomyPost-surgeryWeight maintenanceAmelioration of obesity-related comorbiditiesPredictive factors of weight lossRemission of obesity-related comorbiditiesLong-term follow-up dataLong-term weight maintenanceFactors of weight lossWeight loss cohortBariatric surgery clinicYears post-surgeryWeight loss outcomesFollow-up dataWeight loss successSocial determinants of healthDeterminants of healthBaseline characteristicsPredictive factorsSurgery clinicNon-Hispanic blacksClinical dataStudy cohortRefining Cardiovascular Calcification in the Appraisal of Ischemic Heart
Nguyen V, Fan J, Hafeez I, Nguyen A, Mojibian H. Refining Cardiovascular Calcification in the Appraisal of Ischemic Heart. Cureus 2024, 16: e64328. PMID: 39130835, PMCID: PMC11316457, DOI: 10.7759/cureus.64328.Peer-Reviewed Original ResearchCoronary artery calcificationCardiovascular calcificationPositron emission tomographySuspected ischemiaPerfusion defectsArtery calcificationMedical historyPredictor of myocardial ischemiaNon-contrast computed tomographyRate of cardiovascular eventsAssociation of ischemiaCT attenuation correctionChest computed tomography imagesNegative predictive valueSignificant perfusion defectsAtherosclerotic coronary artery diseaseNuclear stress testingMyocardial perfusion defectsMyocardial perfusion imagingMyocardial perfusion scanCoronary artery diseaseFollow-up dataPatient's medical historyCoronary CTAInvasive angiographyCombined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 141: 1527-1535. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisTumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina
Roy S, Baig J, DeCoste R, Finch S, Sennik S, Kakadekar A, Sade S, Micevic G, Chergui M, Rahimi K, Flaman A, Trinh V, Osmond A. Tumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina. Pathology 2024, 56: 854-864. PMID: 38906758, DOI: 10.1016/j.pathol.2024.03.008.Peer-Reviewed Original ResearchTumor necrosisVaginal melanomaPrognostic factorsDisease-specific mortalitySurvival outcomesKaplan-Meier log-rankAssociated with disease-specific mortalityKaplan-Meier survival analysisPositive lymph nodesHistopathological prognostic parametersMedian follow-upMetastasis-free survivalNon-metastatic patientsMultivariate Cox regressionTime to metastasisFollow-up dataTertiary Canadian hospitalProgression-freeTumor ulcerationMelanoma patientsPrognostic parametersLymph nodesAggressive malignancyImmunohistochemical markersLog-rankCost‐effectiveness of sutimlimab in cold agglutinin disease
Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost‐effectiveness of sutimlimab in cold agglutinin disease. American Journal Of Hematology 2024, 99: 1475-1484. PMID: 38733355, DOI: 10.1002/ajh.27358.Peer-Reviewed Original ResearchPrimary cold agglutinin diseaseCold agglutinin diseaseStandard-of-careIncremental cost-effectiveness ratioUS willingness-to-pay thresholdRare autoimmune hemolytic anemiaPhase 3 studyWillingness-to-pay thresholdsAutoimmune hemolytic anemiaTime-limited treatmentHuman monoclonal antibodyCold-reactive antibodiesBinding to red blood cellsFollow-up dataCost-effectiveness ratioComplement-mediated hemolysisDeterministic sensitivity analysisHealth resource utilizationProbabilistic sensitivity analysesTransfusion-dependentClinical remissionTransfusion supportImprove quality of lifeRed blood cellsHemolytic anemia157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. 157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant. Neurosurgery 2024, 70: 36-37. DOI: 10.1227/neu.0000000000002809_157.Peer-Reviewed Original ResearchNeurogenic Bladder Symptom ScoreComposite outcome scoreNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusOutcome scoresVentriculo-peritoneal shunt surgeryTimed Up &Treatment of idiopathic normal pressure hydrocephalusPressure hydrocephalusTreat communicating hydrocephalusFavorable risk profileFunctional outcome scoresMinimally invasive treatmentFollow-up dataMontreal Cognitive AssessmentCompared to baselineGait improvementFollow-up phaseShunt surgeryUrinary continenceCSF shuntingUrinary incontinenceElderly patientsPre-treatment scoresFollow-upSurvival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic
Janczewski L, Browner A, Cotler J, Palis B, Chan K, Joung R, Bentrem D, Merkow R, Boffa D, Nelson H. Survival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e240160. PMID: 38441896, PMCID: PMC10915687, DOI: 10.1001/jamanetworkopen.2024.0160.Peer-Reviewed Original ResearchConceptsStage IV diseaseRetrospective cohort studyCohort studyQuality care deliveryIV diseaseOperative mortalityHigh riskPandemic-related stressorsAssociated with increased 1-year mortalityDiagnosis of stage IMultivariate logistic regressionCOVID-19 pandemicCare deliveryNational Cancer DatabaseKaplan-Meier curvesEvaluate 30-dayMain OutcomesFollow-up dataCancer communityPrepandemic levelsLogistic regressionCancer DatabaseCOVID-19COVID-19 infectionMalignant neoplasmsCombined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy
Xu L, Gan T, Li Y, Chen P, Shi S, Liu L, Lv J, Zhang H, Zhou X. Combined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy. Kidney Diseases 2024, 10: 167-180. PMID: 38835407, PMCID: PMC11149991, DOI: 10.1159/000537987.Peer-Reviewed Original ResearchGd-IgA1IgA nephropathyHealthy controlsProteasome subunitsLevels of Gd-IgA1Genetic associationPeripheral blood mononuclear cellsExpression levelsEnd-stage renal diseaseSusceptibility to IgANBlood mononuclear cellsGd-IgA1 productionImmune cell typesBlood mRNA levelsFollow-up dataGalactose-deficient IgA1Cell typesUbiquitin-proteasome systemProcess of glycosylationPathogenesis of IgANAssociation of variantsDevelopment of IgANHigher proteinuriaLow eGFRHighest expression levelBuckle me up! A randomised controlled trial using a tablet-based emergency department intervention for child car safety education
Zhang A, Leviter J, Baird J, Charles-Chauvet D, Frackiewicz L, Duffy S, Dessie A. Buckle me up! A randomised controlled trial using a tablet-based emergency department intervention for child car safety education. Injury Prevention 2024, 30: ip-2023-044998. PMID: 38302281, DOI: 10.1136/ip-2023-044998.Peer-Reviewed Original ResearchPaediatric emergency departmentRandomised controlled trialsBehavioral changesEmergency department interventionsChild car restraintsTablet-based toolMotor vehicle crashesFollow-up surveyPositive behavior changePatients aged 0Programme acceptabilityRisk of deathIntervention groupRestraint useEducational interventionCar restraintsEmergency departmentVehicle crashesChildren rideImproper restraintLogistic regressionControlled trialsPositive attitudesKnowledge retentionFollow-up dataExtremely Long-Term Follow-Up of Dr William Glenn's Original Patient Cohort With Superior Cavopulmonary Anastomosis (1958-1990)
Lee M, Amabile A, Geirsson A, Gruber P, Kopf G. Extremely Long-Term Follow-Up of Dr William Glenn's Original Patient Cohort With Superior Cavopulmonary Anastomosis (1958-1990). World Journal For Pediatric And Congenital Heart Surgery 2024, 15: 298-302. PMID: 38263670, DOI: 10.1177/21501351231224342.Peer-Reviewed Original ResearchSuperior cavopulmonary anastomosisFollow-upGlenn operationCavopulmonary anastomosisRetrospective evaluation of patientsLost to follow-upAdult congenital patientsTetralogy of FallotYears of follow-upOriginal patient cohortEvaluation of patientsGroup of patientsFollow-up dataGlenn patientsCongenital patientsPalliative procedureSurviving patientsPediatric patientsAge of survivorsPatient cohortRetrospective evaluationSurvival ratePatientsMedical recordsElectronic medical records
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply