2025
Vascular segmental exclusion for recurrent vulvar squamous cell carcinoma invading the femoral vessels
Schwartz A, Azodi M, Cardella J, Chaar C. Vascular segmental exclusion for recurrent vulvar squamous cell carcinoma invading the femoral vessels. Journal Of Vascular Surgery Cases And Innovative Techniques 2025, 11: 101753. DOI: 10.1016/j.jvscit.2025.101753.Peer-Reviewed Original ResearchRecurrent vulvar squamous cell carcinomaVulvar squamous cell carcinomaInvasive vulvar carcinomaExtensive local invasionProgression of oncological diseasesSquamous cell carcinomaLower limb ischemiaSuperficial femoral arteryVulvar carcinomaFemoral artery embolismAbdomen-pelvisUnresectable tumorsArtery embolizationCell carcinomaLeft axillaryPopliteal artery bypassWide resectionThree-month follow-upLocal invasionArtery bypassComputed tomographyFollow-upNecrotic massLimb ischemiaFemoral veinResistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionA phase 2 trial of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability (NCT02899793): Updated survival and response analyses
Ettorre V, Bellone S, Greenman M, McNamara B, Palmieri L, Sethi N, Demirkiran C, Papatla K, Kailasam A, Siegel E, Ratner E, Santin A. A phase 2 trial of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability (NCT02899793): Updated survival and response analyses. Gynecologic Oncology 2025, 197: 110-115. PMID: 40334308, DOI: 10.1016/j.ygyno.2025.04.591.Peer-Reviewed Original ResearchProgression free survivalWhole-exome sequencingImmune checkpoint inhibitorsOverall survivalEndometrial cancerMicrosatellite instability-highCheckpoint inhibitorsFree survivalFollow-upResponse to immune checkpoint inhibitorsPatients treated with pembrolizumabProspective phase II studyExome sequencingResponse rateRecurrent platinum-resistantPhase II studyPhase 2 trialOverall survival dataEndometrial cancer patientsMLH-1MSI-H patientsFoundationOne platformImproved OSUpdate survivalPrognostic significanceIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysisEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025 PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsOutcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsHigh Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis.
Skef W, Haydel J, Rao A, Allencherril R, George R, Ketwaroo G, Thrift A, El-Serag H, Wenker T. High Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis. The American Journal Of Gastroenterology 2025 PMID: 40052679, DOI: 10.14309/ajg.0000000000003383.Peer-Reviewed Original ResearchFollow-up EGDRisk of dysplasiaBody mass indexBarrett's esophagusPersistent BEFollow-upCohort of United States veteransWhite raceLong segment BEUnited States veteransHispanic ethnicityPredictor of dysplasiaFollow-up endoscopyClinical risk factorsRetrospective cohort studyNon-Hispanic Black patientsNon-HispanicRisk of persistenceProportion of non-HispanicChi-square testConsecutive patientsStates veteransPathology databaseHighest risk of persistenceBE diagnosisThe Association Between Sex and Lung Cancer Screening Adherence to Follow-Up in a Cohort of Veterans
Bernstein E, Bade B, DeRycke E, Lerz K, Zeghlache R, Rose M, Kravetz J, Farmer M, Bastian L, Akgün K, Cain H. The Association Between Sex and Lung Cancer Screening Adherence to Follow-Up in a Cohort of Veterans. Journal Of Women's Health 2025 PMID: 40045919, DOI: 10.1089/jwh.2024.0780.Peer-Reviewed Original ResearchLung cancer screeningFemale veteransLung-RADSRates of nonadherencePrimary careUnited States Preventive Services Task Force guidelinesAdherence to lung cancer screeningCancer screening adherenceLung-RADS 1Lung-RADS scoreLung-RADS 3Associated with greater nonadherenceTask Force guidelinesCohort of veteransFollow-upFollow-up recommendationsLogistic regression modelsScreening adherenceCancer screeningReduce disparitiesForce guidelinesRetrospective cohort studySubstance use disordersSocioeconomic statusScreening programEvaluating Major Bleeding Risks with Concomitant Use of Direct Oral Anticoagulants and Selective Serotonin Reuptake Inhibitors in Nonvalvular Atrial Fibrillation Patients
Yao S, Kocis P, Murphy T, Hwang W. Evaluating Major Bleeding Risks with Concomitant Use of Direct Oral Anticoagulants and Selective Serotonin Reuptake Inhibitors in Nonvalvular Atrial Fibrillation Patients. Pharmacoepidemiology 2025, 4: 6. DOI: 10.3390/pharma4010006.Peer-Reviewed Original ResearchDirect oral anticoagulantsNonvalvular atrial fibrillationNonvalvular atrial fibrillation patientsVitamin K antagonistsSerotonin reuptake inhibitorsHazard ratioBleeding eventsConcomitant useOral anticoagulantsReuptake inhibitorsFollow-upConfidence intervalsElectronic health recordsEstimate hazard ratiosCause-specific proportional hazards modelDOAC prescriptionsHAS-BLED scoreAtrial fibrillation patientsBaseline CHA2DS2-VASc scoreCHA2DS2-VASc scoreRetrospective cohort studyInverse probability of treatmentHealth recordsProportional hazards modelDrug-drug interactionsMedical therapy and outcomes in REVIVED-BCIS2 and STICHES: an individual patient data analysis
Ryan M, Petrie M, Kontopantelis E, Dodd M, Tong G, Marquis-Gravel G, Docherty K, Clayton T, Lansky A, Mamas M, Rouleau J, Velazquez E, Perera D. Medical therapy and outcomes in REVIVED-BCIS2 and STICHES: an individual patient data analysis. European Heart Journal 2025, ehaf080. PMID: 40048661, DOI: 10.1093/eurheartj/ehaf080.Peer-Reviewed Original ResearchCoronary artery bypass graftingPercutaneous coronary interventionMedical therapyPrimary outcome eventFollow-upPrimary outcomePatients treated with coronary artery bypass graftingOutcome eventsIndividual patient data analysisCoronary artery bypass graft surgeryIschaemic left ventricular dysfunctionMedian follow-upMulticentre randomized trialLeft ventricular dysfunctionOutcomes of patientsBenefit of coronary artery bypass graftingCompleteness of follow-upArtery bypass graftingCoronary artery diseasePatient data analysisIschaemic cardiomyopathyVentricular dysfunctionSurgical treatmentHeart failurePooled analysisProspective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.Peer-Reviewed Original ResearchFollow-up periodMepolizumab treatmentAdverse eventsSevere asthmaRate of clinically significant asthma exacerbationsFollow-upMonoclonal antibodies targeting interleukin-5Clinically significant asthma exacerbationsMaintenance oral corticosteroidsAssociated with sustained reductionsProportion of patientsACQ-5 scoresAsthma Control QuestionnaireForced expiratory volumeOral corticosteroidsWell-toleratedACQ-5Clinical benefitMepolizumabProspective studyWeeks 0Asthma exacerbationsInterleukin-5Expiratory volumeSustained reductionAdvancements in minimally invasive interventional oncology procedures for painful sacral metastases under imaging guidance
Jiang W, Gan D, Johnson M, Latich I, Lee F. Advancements in minimally invasive interventional oncology procedures for painful sacral metastases under imaging guidance. EngMedicine 2025, 2: 100051. DOI: 10.1016/j.engmed.2024.100051.Peer-Reviewed Original ResearchPainful sacral metastasesIntra-operative image guidanceSacral metastasesImage guidancePreoperative baselineFollow-upPercutaneous interventionFunction scoresLong-term follow-upRisk of cement leakageO-arm navigationImprovement of painRetrospective cohort reviewImage guidance techniquesAverage follow-upInterventional oncology proceduresIntra-operative imaging techniquesO-armPercutaneous ablationSingle-institutionCohort reviewPrimary cancerClinical improvementMultiple myelomaCement leakageTranscatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials
Reddy R, Howard J, Mack M, Reardon M, Jørgensen T, Hørsted Thyregod H, Toff W, Van Mieghem N, Vora A, Makkar R, Kapadia S, Forrest J, Leon M, Ahmad Y. Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2025, 85: 926-940. PMID: 40044297, DOI: 10.1016/j.jacc.2024.12.031.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementLower-risk patientsAortic valve replacementPooled survival analysisValve replacementIndividual participant dataPairwise meta-analysesFollow-upMeta-analysis of randomized controlled trialsLonger-term clinical outcomesReduced hazard of deathSevere aortic stenosisFixed effect assumptionsComposite of deathLonger-term follow-upAll-cause deathMean survival time modelsMeta-analysesHazard of deathRate of strokeRandomized controlled trialsSurvival time modelFrailty termProportional odds modelApixaban to Prevent Covert Infarcts After Cryptogenic Stroke in Patients With Atrial Cardiopathy
Lansberg M, Wintermark M, Chen H, Howard G, Cassarly C, Pauls Q, Kemp S, Harris T, Krishnaiah B, Stanton R, Lyerly M, Miller B, Smith E, Tirschwell D, Sheth K, Kamel H, Longstreth W, Elkind M, Broderick J, Lazar R. Apixaban to Prevent Covert Infarcts After Cryptogenic Stroke in Patients With Atrial Cardiopathy. JAMA Neurology 2025, 82: 220-227. PMID: 39869342, PMCID: PMC11773411, DOI: 10.1001/jamaneurol.2024.4838.Peer-Reviewed Original ResearchConceptsCovert infarctsResearch magnetic resonance imagingCompletion of participationParticipant completionAtrial cardiopathyMain OutcomesParent studyRandomized clinical trialsPrimary outcomeFollow-up magnetic resonance imagingMagnetic resonance imagingParticipantsFollow-up periodRecurrent strokeStrokeIschemic strokeFollow-upBaseline characteristicsAncillary studiesCryptogenic strokeBaselineInsufficient qualityPreventionInfarctionIQRPrediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection
Sandoval G, Saade G, Hughes B, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection. Obstetrics And Gynecology 2025, 145: 449-452. PMID: 40014859, PMCID: PMC11925659, DOI: 10.1097/aog.0000000000005872.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionPerinatal transmissionHepatitis C virusHepatitis C virus perinatal transmissionPregnant individualsEunice Kennedy Shriver National Institute of Child HealthTransmission of HCV infectionPerinatal transmission rateHCV RNA titersNeonatal follow-upC virus infectionPositive HCV antibodyMulticenter observational studyArea under the curveNational Institute of Child HealthInstitute of Child HealthAntibody-positive participantsAntepartum bleedingHCV infectionHCV antibodiesFollow-upRNA titersC virusObservational studyClinical counselingHematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Walters M, Eapen M, Liu Y, El Rassi F, Waller E, Levine J, Strouse J, Antin J, Parikh S, Bakshi N, Dampier C, Jaroscak J, Bergmann S, Wong T, Kota V, Pace B, Lekakis L, Lulla P, Nickel R, Kasow K, Popat U, Smith W, Yu L, DiFronzo N, Geller N, Kamani N, Klings E, Hassell K, Mendizabal A, Sullivan K, Neuberg D, Krishnamurti L. Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease. Blood Advances 2025, 9: 955-965. PMID: 39471440, PMCID: PMC11907447, DOI: 10.1182/bloodadvances.2024013926.Peer-Reviewed Original ResearchHematopoietic cell transplantationVaso-occlusive painStandard of careSickle cell diseaseCell transplantationCell diseaseSCD-related eventsHLA-matched siblingTransplant-related mortalityPeriod of follow-upSurvival 2 yearsIntent-to-treat principleComparison of survivalDisease-modifying therapiesDisease-related mortalityUnrelated donorPrimary endpointCurative potentialTreatment armsDonor searchFollow-upCompare outcomesEligibility confirmationFunctional outcomesSecondary outcomesA roadmap for uniform comprehensive long- term follow up after curative therapy for sickle cell disease
Shenoy S, Kanter J, Kassim A, Fitzhugh C, Stenger E, Bhatia M, Pecker L, Krishnamurti L, King A. A roadmap for uniform comprehensive long- term follow up after curative therapy for sickle cell disease. Blood Advances 2025 PMID: 39993235, DOI: 10.1182/bloodadvances.2024013953.Peer-Reviewed Original ResearchIndependent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry
Di Vincenzo M, Prachason T, Sampogna G, Arias-Magnasco A, Lin B, Pries L, van Os J, Rutten B, Barzilay R, Fiorillo A, Guloksuz S. Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry. Schizophrenia 2025, 11: 26. PMID: 39984505, PMCID: PMC11845623, DOI: 10.1038/s41537-025-00569-2.Peer-Reviewed Original ResearchRisk due to interactionDistressing psychotic experiencesExcess risk due to interactionPsychotic experiencesEuropean ancestryMultilevel logistic regression modelsPolygenic risk scoresAdditive interactionStrength of associationLogistic regression modelsEarly adolescenceJoint associationsExposome scoreIncreasing strength of associationSecondary outcomesRisk scorePrimary outcomeRegression modelsStudy dataAdolescent brainSchizophreniaAdolescentsFollow-upJoint effectsOutcomesSignificance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesCombined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis.
Singh S, Garg A, Tantry U, Bliden K, Gurbel P, Kochar A, Nanna M, Damluji A. Combined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis. Journal Of Invasive Cardiology 2025 PMID: 39993271, DOI: 10.25270/jic/24.00312.Peer-Reviewed Original ResearchCalcified coronary lesionsProcedural success rateCoronary lesionsIntravascular lithotripsyCoronary perforationRisk of procedural complicationsRisk of adverse CV eventsAcute procedural successSuccess rateAcute coronary syndromeAdverse CV eventsTarget vessel revascularizationSeverely calcified coronary lesionsRandom-effects modelTreatment of severely calcified coronary lesionsPeriprocedural complicationsPooled proportionProcedural complicationsProcedural successCV deathCoronary syndromeCV eventsFollow-upProcedural outcomesCV outcomes
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