2025
Validación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico
Lee J, Lee S, Kwon W, Kim H, Hong D, Kim H, Cho S, Shin D, Park K, Kim J, Moon J, Song H, Lee S, Ha D, Jang J, Ahn Y, Jeong M, Choi K, Park T, Yang J, Bin Song Y, Hahn J, Choi S, Gwon H, Hong Y. Validación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico. Revista Española De Cardiología 2025, 78: 521-532. DOI: 10.1016/j.recesp.2024.10.006.Peer-Reviewed Original ResearchStress perfusion defectsFractional flow reservePositron emission tomographyLeft anterior descending arteryHemodynamically significant stenosisAnterior descending arteryPerfusion defectsVascular occluderNecrotic myocardiumSignificant stenosisDescending arteryTTC stainingSignificantly higher areaMedian diameter stenosisExperimental animal modelsCoronary artery stenosisHyperemic stenosis resistanceOccluder implantationArtery stenosisDiameter stenosisFlow reserveAnimal modelsStenosisCoronary stenosisOcclusion severityTemporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes
Nikolakopoulos I, Csecs I, Liu Y, Sinusas A, Miller E, Feher A. Temporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes. Journal Of Nuclear Cardiology 2025, 48: 102194. PMID: 40139484, DOI: 10.1016/j.nuclcard.2025.102194.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingEvaluation of coronary artery diseasePositron emission tomographyClinical risk factorsMyocardial flow reserveCoronary artery diseasePositron emission tomography myocardial perfusion imagingRates of major-adverse cardiovascular eventsCardiovascular outcomesArtery diseaseFlow reserveMedian follow-up timeRisk factorsLong-term major adverse cardiovascular eventsHistory of heart transplantationC-statisticMedian interval timeKaplan-Meier methodFollow-up timeAdverse cardiovascular eventsChest painTransplant vasculopathyMyocardial blood flowHeart transplantationMachine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis
Narimani-Javid R, Moradi M, Mahalleh M, Najafi-Vosough R, Arzhangzadeh A, Khalique O, Mojibian H, Kuno T, Mohsen A, Alam M, Shafiei S, Khansari N, Shaghaghi Z, Nozhat S, Hosseini K, Hosseini S. Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Computed Tomography 2025, 19: 232-246. PMID: 39988511, DOI: 10.1016/j.jcct.2025.02.004.Peer-Reviewed Original ResearchArea under the curveDiagnostic odds ratioDiagnostic performanceComputed tomography-derived fractional flow reserveDiagnostic performance of FFRCTHemodynamically significant coronary artery stenosisSignificant coronary artery stenosisMeta-analysisPer-patient levelReceiver operating characteristic curveCoronary artery diseaseCoronary artery stenosisPer-vessel levelFractional flow reserveNoninvasive diagnostic techniquesMachine learningInvasive FFRPooled specificityArtery diseaseArtery stenosisFlow reserveOdds ratioCochrane LibraryFFRCTPatientsSkeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes
do A H Souza A, Troschel A, Marquardt J, Hadžić I, Foldyna B, Moura F, Hainer J, Divakaran S, Blankstein R, Dorbala S, Di Carli M, Aerts H, Lu M, Fintelmann F, Taqueti V. Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes. European Heart Journal 2025, 46: 1112-1123. PMID: 39827905, DOI: 10.1093/eurheartj/ehae827.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionBody mass indexCoronary flow reserveIntermuscular adipose tissueSubcutaneous adipose tissueHeart failureFat infiltrationMarker of coronary microvascular dysfunctionPreserved left ventricular ejection fractionCardiovascular outcomesAssociated with coronary microvascular dysfunctionHigher IMATIncreased IMATPresence of coronary microvascular dysfunctionSkeletal muscleFlow reserveIncreased risk of MACEMyocardial infarctionStress positron emission tomographyAssociated with increased MACERisk of heart failureLow coronary flow reserveThoracic vertebra levelVentricular ejection fractionIntermuscular adipose tissue area
2024
Experimental validation of coronary stenosis severity and development of ischemic myocardium
Lee J, Lee S, Kwon W, Kim H, Hong D, Kim H, Cho S, Shin D, Park K, Kim J, Moon J, Song H, Lee S, Ha D, Jang J, Ahn Y, Jeong M, Choi K, Park T, Yang J, Song Y, Hahn J, Choi S, Gwon H, Hong Y. Experimental validation of coronary stenosis severity and development of ischemic myocardium. Revista Española De Cardiología (English Edition) 2024, 78: 521-532. PMID: 39490529, DOI: 10.1016/j.rec.2024.10.006.Peer-Reviewed Original ResearchStress perfusion defectsFractional flow reserveLeft anterior descending arteryHemodynamically significant stenosisAnterior descending arteryPerfusion defectsVascular occluderNecrotic myocardiumSignificant stenosisDescending arteryTTC stainingIschemic myocardiumStenosis severitySignificantly higher areaMedian diameter stenosisExperimental animal modelsCoronary artery stenosisCoronary stenosis severityHyperemic stenosis resistanceOccluder implantationArtery stenosisDiameter stenosisFlow reserveAnimal modelsStenosisTemporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes
Nikolakopoulos I, Liu Y, Sinusas A, Miller E, Feher A. Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.099. DOI: 10.1093/ehjci/jeae142.099.Peer-Reviewed Original ResearchPositron emission tomographyMyocardial flow reserveCoronary artery diseaseCardiovascular outcomesArtery diseaseFlow reserveEvaluation of coronary artery diseaseHistory of heart transplantationMedian interval timeKaplan-Meier methodPredictive of cardiovascular outcomesLong-term outcomesPerioperative risk stratificationCoronary bloodChest painHeart transplantationRisk stratificationSerial examsCox regressionMyocardial infarctionInterquartile rangeC-statisticEmission tomographyPatientsContinuous variablesLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. 2024, 3-12. DOI: 10.1093/med/9780190095659.003.0001.Peer-Reviewed Original ResearchEvaluate left ventricular (LV) functionQuantification of coronary blood flowPerfusion imagingRadiation dose reductionPET-FDG studiesStress perfusion imagingEvaluate myocardial perfusionCoronary flow reserveMyocardial perfusion studiesComputed tomography CTCardiac sarcoidosisCoronary blood flowDose reductionMyocardial inflammationSPECT approachAssess prognosisMyocardial stress perfusion imagingStress imagingMyocardial perfusionFlow reservePerfusion studiesCardiac studiesRadionuclide imagingBlood flowAttenuation correctionNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. 2024, 1-1. DOI: 10.1093/med/9780197521434.003.0001.Peer-Reviewed Original ResearchEvaluate left ventricular (LV) functionQuantification of coronary blood flowPerfusion imagingRadiation dose reductionPET-FDG studiesStress perfusion imagingEvaluate myocardial perfusionCoronary flow reserveMyocardial perfusion studiesComputed tomography CTCardiac sarcoidosisCoronary blood flowDose reductionMyocardial inflammationSPECT approachAssess prognosisMyocardial stress perfusion imagingStress imagingMyocardial perfusionFlow reservePerfusion studiesCardiac studiesRadionuclide imagingBlood flowAttenuation correction
2023
Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveThe imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study)
Ilic I, Timcic S, Milosevic M, Boskovic S, Odanovic N, Furtula M, Dobric M, Aleksandric S, Otasevic P. The imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study). Frontiers In Cardiovascular Medicine 2023, 10: 1112198. PMID: 37456821, PMCID: PMC10348888, DOI: 10.3389/fcvm.2023.1112198.Peer-Reviewed Original ResearchIndex of microcirculatory resistanceIndex of microcirculatory resistance valuesPercutaneous coronary interventionFractional flow reserveCoronary flow reserveElective percutaneous coronary interventionFractional flow reserve valuesEffect of trimetazidineStandard therapyPrior to elective percutaneous coronary interventionTrimetazidine groupMicrocirculatory resistanceFlow reserveCompared to standard therapyStable coronary artery diseaseProtective effect of trimetazidineEpicardial coronary artery stenosisCoronary artery diseaseCoronary artery lesionsNative coronary artery lesionsCoronary artery stenosisImpact of trimetazidinePromotes glucose oxidationReduced myocardial injuryRisk profileNon-hyperemic pressure ratios – theoretical basis, clinical applications, and limitations
Chamié D, Maia J, Raminho T, Eurípedes L, Sant'Anna L, Caixeta A, Sant'Anna F. Non-hyperemic pressure ratios – theoretical basis, clinical applications, and limitations. Journal Of Transcatheter Interventions 2023, 31: 1-16. DOI: 10.31160/jotci202331a202208.Peer-Reviewed Original ResearchFractional flow reserveClinical outcome dataPercutaneous coronary interventionFlow reserveInstantaneous wave-free ratioPressure ratioCoronary interventionOutcome dataAtherosclerotic diseaseNon-hyperemic pressure ratiosAnatomical scenariosRobust body of evidenceStandard of careIdentification of myocardial ischemiaSuccess of percutaneous coronary interventionGuideline recommendationsCoronary atherosclerotic diseaseTranscatheter interventionsProcedure timeFunctional successHyperemic agentsClinical indicationsPatient discomfortMyocardial ischemiaClinical use
2022
How much flow is enough: the use of fractional flow reserve in chronic limb-threatening ischemia in a series of patients with isolated occlusive tibial disease
Ahmed Z, Ochoa-Prieto M, Bhalla A, Strosberg D, Dardik A, Altin S. How much flow is enough: the use of fractional flow reserve in chronic limb-threatening ischemia in a series of patients with isolated occlusive tibial disease. Journal Of Vascular Surgery Cases And Innovative Techniques 2022, 9: 101017. PMID: 38204765, PMCID: PMC10777480, DOI: 10.1016/j.jvscit.2022.08.022.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaLimb-threatening ischemiaFractional flow reserveFlow reserveLower extremity peripheral vascular interventionsLower extremity endovascular interventionsPeripheral vascular interventionsSeries of patientsTibial diseaseEndovascular interventionVascular interventionsIschemiaPatientsInterventionDiseaseFractional flow reserve: physiological bases, clinical applications and limitations
Sant'Anna F, Bandeira D, Sant'Anna L, Casagrande B, Maia J, Caixeta A, Zokowski C, Chamié D. Fractional flow reserve: physiological bases, clinical applications and limitations. Journal Of Transcatheter Interventions 2022, 30: 1-17. DOI: 10.31160/jotci202230a202208.Peer-Reviewed Original ResearchEvaluation of Non-infarct-Related Arteries Using C-11 Acetate PET in STEMI With Multivessel Disease
Cho S, Kim M, Lee S, Park K, Kim J, Moon J, Song H. Evaluation of Non-infarct-Related Arteries Using C-11 Acetate PET in STEMI With Multivessel Disease. Journal Of Cardiovascular Imaging 2022, 30: 169-180. PMID: 35879252, PMCID: PMC9314231, DOI: 10.4250/jcvi.2021.0189.Peer-Reviewed Original ResearchC-11 acetate positron emission tomographyAcetate positron emission tomographyNon-infarct-related arteryST-elevation myocardial infarctionInfarct-related arteryMyocardial flow reservePositron emission tomographyMyocardial blood flowRelative flow reserveMultivessel diseaseReduced stress myocardial blood flowFlow reserveStress myocardial blood flowAngiographic parametersNoninvasive modalityNon-stenoticStenosisMyocardial infarctionEmission tomographyBlood flowPatientsArteryDisease
2021
Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction
Nowroozpoor A, Sharp E, Gordon R, Malicki C, Hwang U, Dziura J, D'Onofrio' G, Safdar B. Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction. European Heart Journal 2021, 42: ehab724.2744. DOI: 10.1093/eurheartj/ehab724.2744.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionCoronary flow reservePerfusion defectsCognitive impairmentMean ageCMD patientsCardiac positron emission tomography/Chest pain observation unitPositron emission tomography/Coronary artery diseaseSmall vessel diseaseEmission tomography/Montreal Cognitive AssessmentChest discomfortHypertensive urgencyMicrovascular dysfunctionArtery diseaseHeart failureVessel diseaseMyocardial infarctionTomography/Odds ratioFlow reserveNormal groupYears of educationAssociation Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease
Feher A, Boutagy NE, Oikonomou EK, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease. Circulation Cardiovascular Imaging 2021, 14: e012208. PMID: 34503339, PMCID: PMC8475774, DOI: 10.1161/circimaging.120.012208.Peer-Reviewed Original ResearchConceptsAutoimmune rheumatic diseasesMyocardial flow reserveLower myocardial flow reserveCox regression analysisAdverse eventsARDS diagnosisIndependent predictorsRheumatic diseasesPerfusion defectsFlow reserveNormal myocardial flow reserveLeft ventricular ejection fractionEnd pointGlobal myocardial flow reserveImpaired Myocardial Flow ReserveComorbidity-matched patientsSevere coronary calcificationCombined end pointCoronary microvascular dysfunctionHeart failure admissionsComposite end pointEvent-free survivalFramingham risk scoreLarge perfusion defectsRetrospective cohort analysisDynamic cardiac PET motion correction using 3D normalized gradient fields in patients and phantom simulations
Nye J, Piccinelli M, Hwang D, Cooke C, Paeng J, Lee J, Cho S, Folks R, Bom H, Koo B, Garcia E. Dynamic cardiac PET motion correction using 3D normalized gradient fields in patients and phantom simulations. Medical Physics 2021, 48: 5072-5084. PMID: 34174095, PMCID: PMC8455441, DOI: 10.1002/mp.15059.Peer-Reviewed Original ResearchConceptsMotion correction accuracyXCAT simulationPET motion correctionPatient studiesGradient fieldAdenosine infusionCenter of massMotion correctionAttenuation correctionFlow reservePhantom simulationsBlood poolCorrection accuracyMyocardial flow reserveImplementation of three-dimensionalNoninvasive clinical measurementsDynamic PET/CTRigid body algorithmClinical studiesRelative flow reserveWeighted similarity metricImage intensityPatientsFieldMotionImpaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.
Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.Peer-Reviewed Original ResearchConceptsReduced Myocardial Flow ReserveMyocardial flow reserveRaynaud's phenomenonPrimary Raynaud's phenomenonSecondary Raynaud's phenomenonPatient controlsHealthy participantsFlow reservePositron Emission Tomography/Computed TomographyEmission Tomography/Computed TomographyTomography/Computed TomographyPositron emission tomography/Impaired Myocardial Flow ReserveCoronary microvascular dysfunctionLarge prospective studiesMultivariable logistic regressionEmission tomography/PET/CTSSc-RPMicrovascular dysfunctionClinical predictorsIndependent predictorsSystemic sclerosisPrognostic valueProspective studyUse of peripheral arterial tonometry in detection of abnormal coronary flow reserve
Gaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, PMCID: PMC10227886, DOI: 10.1016/j.mvr.2021.104223.Peer-Reviewed Original ResearchConceptsLower coronary flow reserveCoronary flow reserveCoronary microvascular dysfunctionCoronary artery diseaseClinical screening toolPET/CTFlow reserveRubidium-82 positron emission tomography/Large vessel coronary artery diseaseNormal coronary flow reserveTraditional CAD risk factorsVessel coronary artery diseaseAbnormal coronary flow reservePositron emission tomography/Screening toolPeripheral arterial tonometryCAD risk factorsEmission tomography/Presence of calcificationLower RHIHyperemia indexArterial tonometryMicrovascular dysfunctionArtery diseaseAugmentation index
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