2024
Li-Fraumeni Syndrome: Imaging Features and Guidelines.
Gosangi B, Dixe de Oliveira Santo I, Keraliya A, Wang Y, Irugu D, Thomas R, Khandelwal A, Rubinowitz A, Bader A. Li-Fraumeni Syndrome: Imaging Features and Guidelines. RadioGraphics 2024, 44: e230202. PMID: 39024172, DOI: 10.1148/rg.230202.Peer-Reviewed Original ResearchConceptsLi-Fraumeni syndromeLifetime risk of cancerRare autosomal dominant familial cancer syndromeIncreased riskRisk of cancerTreated with total mastectomyAutosomal dominant familial cancer syndromeImaging features of tumorsFamilial cancer syndromeWhole-body MRIAnnual screeningFeatures of tumorsCancer syndromesLifetime riskP53 transcription factorLi-FraumeniAdrenocortical cancerTotal mastectomyPrimary cancerBreast malignancyImaging guidelinesBreast cancerGermline mutationsColon cancerManagement guidelines
2021
Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis
Johnson CH, Golla JP, Dioletis E, Singh S, Ishii M, Charkoftaki G, Thompson DC, Vasiliou V. Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis. Cancers 2021, 13: 4404. PMID: 34503214, PMCID: PMC8431530, DOI: 10.3390/cancers13174404.Peer-Reviewed Original ResearchColorectal cancerColorectal carcinogenesisChronic alcohol consumptionMost CRC patientsSporadic colorectal cancerGenetic risk factorsEffects of alcoholBacterial translocationCRC patientsFamilial cancer syndromeIntestinal permeabilityRisk factorsAlcohol consumptionCancer syndromesCRC modelMechanisms of alcoholAlcohol metabolitesGermline mutationsOne-carbon metabolismExact mechanismReactive oxygen speciesSporadic cancersCarcinogenesisImmunosuppressionCancer
2012
Pediatric Thyroid Disease: When is Surgery Necessary, and Who Should be Operating on Our Children?
Breuer C, Tuggle C, Solomon D, Sosa JA. Pediatric Thyroid Disease: When is Surgery Necessary, and Who Should be Operating on Our Children? Journal Of Clinical Research In Pediatric Endocrinology 2012, 4: 79-85. PMID: 23149389, PMCID: PMC3608013, DOI: 10.4274/jcrpe.817.Peer-Reviewed Original ResearchConceptsDifferentiated thyroid cancerMedullary thyroid carcinomaPediatric thyroidectomyThyroid cancerHigh-volume thyroid surgeonRecurrent laryngeal nerve injuryCentral lymph node dissectionLaryngeal nerve injuryLymph node dissectionBetter clinical outcomesNuclear medicine physiciansSurgery NecessaryNode dissectionTotal thyroidectomyAppropriate surgeryNerve injuryFamilial cancer syndromeGraves' diseasePediatric patientsClinical outcomesPediatric populationSurgical managementCommon malignancyThyroid surgeonsToxic adenoma
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