2024
Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography
Tran A, Desser D, Zeevi T, Karam G, Zietz J, Dell’Orco A, Chen M, Malhotra A, Qureshi A, Murthy S, Majidi S, Falcone G, Sheth K, Nawabi J, Payabvash S. Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography. Applied Sciences 2024, 15: 111. PMID: 40046237, PMCID: PMC11882137, DOI: 10.3390/app15010111.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma expansionFollow-up CT scansFollow-up head computed tomographyPredictors of poor outcomeDeep learning classification modelFollow-up scansHead computed tomographyFalse-negative resultsHematoma segmentationAutomated segmentationMulticentre cohortCT scanValidation cohortPoor outcomeComputed tomographyFollow-upClassification modelOptimizational methodHematomaAnnotationHigher sensitivity of pericardial fluid cytology than biopsy in malignant effusions with potential explanation of false‐negative cytology: A multi‐institutional analysis
Takeda K, Gereg C, Liu X, Ma W, Bearse M, Tang H, Delfino I, Huang E, Lin X, Chandler J, Wang H. Higher sensitivity of pericardial fluid cytology than biopsy in malignant effusions with potential explanation of false‐negative cytology: A multi‐institutional analysis. Cytopathology 2024, 36: 31-40. PMID: 39301772, DOI: 10.1111/cyt.13447.Peer-Reviewed Original ResearchPericardial fluid cytologySensitivity of cytologyMalignant pericardial effusionMulti-institutional analysisFluid cytologyCytology casesPericardial effusionDiagnostic sensitivity of cytologyFalse-negative cytologyFalse-negative resultsSite of originConcurrent biopsyPericardial biopsyHistological subtypesMalignant effusionsHistologic reviewPericardial involvementRetrospective reviewMalignant casesPoor prognosisImmunohistochemistry studiesClinical historyDiagnostic superiorityBiopsyCytologyClinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections
Oh I. Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections. Kosin Medical Journal 2024, 39: 5-17. DOI: 10.7180/kmj.24.104.Peer-Reviewed Original ResearchMusculoskeletal infectionsS. aureus immune evasionIdentification of pathogensNext-generation sequencingConventional culture methodsComplicated clinical decisionsDevelopment of innovative diagnosticsPeripheral blood mononuclear cellsRemoval of infected implantsErythrocyte sedimentation rateMonitoring treatment responseTranscriptome of peripheral blood mononuclear cellsBlood mononuclear cellsC-reactive proteinFalse-negative resultsStaphylococcus aureusDominant pathogenAntibiotic therapySurgical debridementAbscess formationInfected implantsInflammatory markersAggressive debridementInfected tissuesOrthopedic infections
2022
Evaluation of a novel SARS‐CoV‐2 rapid antigenic test diagnostic value in respiratory samples; is the reported test accuracy similar to values in the real‐world? A cross‐sectional study
Hatami H, Rezaeian A. Evaluation of a novel SARS‐CoV‐2 rapid antigenic test diagnostic value in respiratory samples; is the reported test accuracy similar to values in the real‐world? A cross‐sectional study. Health Science Reports 2022, 5: e765. PMID: 35957970, PMCID: PMC9364431, DOI: 10.1002/hsr2.765.Peer-Reviewed Original Research
2021
Real-world assessment of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) nasopharyngeal swab testing in a region with a high burden of coronavirus disease 2019 (COVID-19)
Sangal RB, Peaper DR, Rothenberg C, Fadlallah H, Mobolaji-Lawal M, Landry ML, Sussman LS, Ulrich A, Venkatesh AK. Real-world assessment of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) nasopharyngeal swab testing in a region with a high burden of coronavirus disease 2019 (COVID-19). Infection Control And Hospital Epidemiology 2021, 43: 1051-1053. PMID: 33823949, PMCID: PMC8111191, DOI: 10.1017/ice.2021.153.Peer-Reviewed Original ResearchDetection of cytogenomic abnormalities by OncoScan microarray assay for products of conception from formalin-fixed paraffin-embedded and fresh fetal tissues
Wen J, Grommisch B, DiAdamo A, Chai H, Ng SME, Hui P, Bale A, Mak W, Wang G, Li P. Detection of cytogenomic abnormalities by OncoScan microarray assay for products of conception from formalin-fixed paraffin-embedded and fresh fetal tissues. Molecular Cytogenetics 2021, 14: 21. PMID: 33810806, PMCID: PMC8019165, DOI: 10.1186/s13039-021-00542-5.Peer-Reviewed Original ResearchPathogenic copy number variantsAbnormality detection rateCytogenomic abnormalitiesCulture failureNormal karyotypeHigh diagnostic yieldProducts of conceptionCell contaminationMaternal cell contaminationMolecular inversion probesFresh fetal tissuesParaffin-embedded tissuesFalse-negative resultsFetal resultsRetrospective studyPregnancy lossDiagnostic yieldClinical utilityMaternal cellsFetal tissuesAbnormalitiesNegative resultsChromosomal imbalancesChromosome abnormalitiesUnbalanced structural chromosome abnormalities
2020
Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome
Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Immune profileCOVID-19SARS-CoV-2 infectionCytokine release syndromeAdaptive immune cellsMultiple inflammatory cytokinesSARS-CoV-2 RNAFalse-negative resultsRelease syndromeInfectious complicationsIL-10Laboratory markersD-dimerInflammatory moleculesIP-10IL-6Inflammatory cytokinesMCP-1Acute diagnosisIL-2Immune cellsClinical severityTherapeutic benefitPathogenic contributionProfiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang Q, Xu S, Zhu H, Xu Y, Jin Q, Sharma L, Wang L, Wang J. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clinical Infectious Diseases 2020, 71: 778-785. PMID: 32198501, PMCID: PMC7184472, DOI: 10.1093/cid/ciaa310.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Humoral responseSymptom onsetIgM ELISAProbable casesEarly humoral responseHost humoral responseMajor healthcare threatCoronavirus disease 2019IgA antibody detectionCOVID-19Viral nucleic acidsQuantitative polymerase chain reactionNovel coronavirus diseaseFalse-negative resultsMedian durationAntibody testingIgG responsesIgM antibodiesInfected patientsPolymerase chain reactionPositive rateDisease 2019Healthcare threatSubclinical cases
2019
Prevalence of False-Negative Results of Intraoperative Consultation on Surgical Margins During Resection of Gastric and Gastroesophageal Adenocarcinoma
McAuliffe JC, Tang LH, Kamrani K, Olino K, Klimstra DS, Brennan MF, Coit DG. Prevalence of False-Negative Results of Intraoperative Consultation on Surgical Margins During Resection of Gastric and Gastroesophageal Adenocarcinoma. JAMA Surgery 2019, 154: 126-132. PMID: 30422226, PMCID: PMC6439656, DOI: 10.1001/jamasurg.2018.3863.Peer-Reviewed Original ResearchConceptsCurative-intent resectionSurgical marginsIOC resultsGastroesophageal adenocarcinomaNeoadjuvant radiotherapyIntraoperative consultationFN resultsClinical implicationsDuodenal marginsFalse-negative resultsSingle institution referral centerResection of gastricDisease-specific survivalStage of diseaseTrue-positive resultsGastric marginSurgical fitnessCurative intentReferral centerSubsequent resectionEsophageal resectionRetrospective studyGastrointestinal pathologistsDiffuse diseaseTumor location
2016
Initial Accuracy of HIV Rapid Test Kits Stored in Suboptimal Conditions and Validity of Delayed Reading of Oral Fluid Tests
Choko A, Taegtmeyer M, MacPherson P, Cocker D, Khundi M, Thindwa D, Sambakunsi R, Kumwenda M, Chiumya K, Malema O, Makombe S, Webb E, Corbett E. Initial Accuracy of HIV Rapid Test Kits Stored in Suboptimal Conditions and Validity of Delayed Reading of Oral Fluid Tests. PLOS ONE 2016, 11: e0158107. PMID: 27336161, PMCID: PMC4918937, DOI: 10.1371/journal.pone.0158107.Peer-Reviewed Original ResearchConceptsHIV self-testing programmesUni-GoldHIV rapid test kitsTest kitDetermine HIV-1/2Ndirande Health CentreRapid diagnostic test kitsOral fluid testRapid diagnostic testsDiagnostic reference standardQuality assurance studyLow-income settingsFalse-negative resultsConsecutive adultsDiagnostic test kitsHIV-1/2Rapid test kitsUrban BlantyreHealth centersReference standard resultsDay 1Income settingsOraQuickDelayed readingsDiagnostic tests
2012
Quantitative Assessment of Effect of Preanalytic Cold Ischemic Time on Protein Expression in Breast Cancer Tissues
Neumeister VM, Anagnostou V, Siddiqui S, England AM, Zarrella ER, Vassilakopoulou M, Parisi F, Kluger Y, Hicks DG, Rimm DL. Quantitative Assessment of Effect of Preanalytic Cold Ischemic Time on Protein Expression in Breast Cancer Tissues. Journal Of The National Cancer Institute 2012, 104: 1815-1824. PMID: 23090068, PMCID: PMC3514166, DOI: 10.1093/jnci/djs438.Peer-Reviewed Original ResearchMeSH KeywordsA Kinase Anchor ProteinsBiomarkers, TumorBiopsy, Large-Core NeedleBreast NeoplasmsCold IschemiaConfounding Factors, EpidemiologicFalse Negative ReactionsFemaleFixativesFluorescent Antibody TechniqueFormaldehydeGene Expression Regulation, NeoplasticHumansHypoxia-Inducible Factor 1, alpha SubunitKi-67 AntigenMastectomy, SegmentalMatched-Pair AnalysisMinor Histocompatibility AntigensProspective StudiesProto-Oncogene ProteinsReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneResearch DesignTime FactorsConceptsCold ischemic timeIschemic timeBreast cancer tissuesEstrogen receptorCancer tissuesLoss of antigenicityBreast cancer resectionProtein expressionCore needle biopsyCompanion diagnostic testsConditions of hypoxiaFalse-negative resultsBreast cancer biomarkersCancer resectionProgesterone receptorNeedle biopsyRecent guidelinesCold ischemiaBreast cancerTissue microarrayEvidence of lossQuantitative immunofluorescenceDiagnostic testsAntigenicityAQUA method
2011
Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells
Welsh AW, Moeder CB, Kumar S, Gershkovich P, Alarid ET, Harigopal M, Haffty BG, Rimm DL. Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells. Journal Of Clinical Oncology 2011, 29: 2978-2984. PMID: 21709197, PMCID: PMC3157961, DOI: 10.1200/jco.2010.32.9706.Peer-Reviewed Original ResearchConceptsER-positive patientsEstrogen receptorQuantitative immunofluorescenceBreast cancerTissue microarrayPositive cellsIndependent retrospective cohortsEstrogen receptor measurementsAssessment of survivalTMA cohortFalse-negative resultsRetrospective cohortER immunoreactivityTest discordancePrognostic outcomesIndependent cohortReceptor measurementsLimitations of immunohistochemistryPatientsDiscrepant casesCohortIHC methodPathologists' judgmentsDiscrepant resultsStandardized assays
2010
Estrogen and HER-2 Receptor Discordance Between Primary Breast Cancer and Metastasis
Pusztai L, Viale G, Kelly CM, Hudis CA. Estrogen and HER-2 Receptor Discordance Between Primary Breast Cancer and Metastasis. The Oncologist 2010, 15: 1164-1168. PMID: 21041379, PMCID: PMC3227913, DOI: 10.1634/theoncologist.2010-0059.Peer-Reviewed Original ResearchConceptsReceptors resultsBreast cancerHuman epidermal growth factor receptor 2 receptor statusRepeat tumor biopsiesRoutine repeat biopsyPrimary breast cancerReceptor-positive cancersReceptor-negative cancersEndocrine therapyFalse-negative resultsReceptor discordanceMetastatic diseaseReceptor statusRepeat biopsyClinical courseRecurrent cancerClinical groundsPrimary tumorTumor nestsEstrogen receptorTumor biopsiesHormone responsivenessReceptor assayCancerDiscordant results
2006
Rapid HIV testing at home: does it solve a problem or create one?
Walensky RP, Paltiel AD. Rapid HIV testing at home: does it solve a problem or create one? Annals Of Internal Medicine 2006, 145: 459-62. PMID: 16983134, DOI: 10.7326/0003-4819-145-6-200609190-00010.Peer-Reviewed Original ResearchConceptsRapid HIV testsHome HIV testHIV testHIV testingRapid home HIV testUnidentified HIV infectionRapid HIV testingHIV testing kitsHome HIV testingUndetectable diseaseFalse-negative resultsPublic health crisisHIV infectionHIV riskHIV detectionDrug AdministrationU.S. FoodHome testHIVHealth crisisHome useTesting kitsCareCautious perspectiveGreat need
2005
Adenomyosis interferes with accurate ultrasonographic detection of uterine leiomyomas
Harmanli O, Bevilacqua S, Dandolu V, Chatwani A, Hernandez E. Adenomyosis interferes with accurate ultrasonographic detection of uterine leiomyomas. Archives Of Gynecology And Obstetrics 2005, 273: 146-149. PMID: 16001190, DOI: 10.1007/s00404-005-0037-7.Peer-Reviewed Original ResearchConceptsBody mass indexUterine leiomyomaCharacteristics of womenPelvic ultrasonographyHigher body mass indexTransvaginal pelvic ultrasonographyPrevious pelvic surgeryCommon final diagnosisPostoperative pathologic findingsAccuracy of ultrasonographyNegative predictive valueFalse-negative resultsPelvic painMass indexPathologic findingsPelvic surgeryFinal diagnosisUltrasonographic detectionUltrasonographic diagnosisUltrasound reportsLeiomyomaPredictive valueUltrasonographyAdenomyosisWomen
2002
Routine intraoperative angiography during aneurysm surgery.
Chiang VL, Gailloud P, Murphy KJ, Rigamonti D, Tamargo RJ. Routine intraoperative angiography during aneurysm surgery. Journal Of Neurosurgery 2002, 96: 988-92. PMID: 12066932, DOI: 10.3171/jns.2002.96.6.0988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngiography, Digital SubtractionCerebral AngiographyCerebrovascular CirculationDiagnostic Tests, RoutineFemaleHumansIntracranial AneurysmIntraoperative CareMaleMiddle AgedOutcome and Process Assessment, Health CarePostoperative ComplicationsRetrospective StudiesConceptsParent vessel occlusionIntraoperative angiographyRoutine intraoperative angiographySurgical treatmentVessel occlusionResidual aneurysmRoutine useCareful intraoperative inspectionFalse-negative casesFalse-negative resultsResidual anteriorEight patientsPostoperative angiogramsPostoperative angiographyResidual lesionsArtery aneurysmAneurysm surgeryAngiographic studiesFalse-positive resultsIntraoperative inspectionPostoperative imagingVascular accessIntraoperative angiogramClip readjustmentAngiography
2001
Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye
Tafra L, Lannin D, Swanson M, Van Eyk J, Verbanac K, Chua A, Ng P, Edwards M, Halliday B, Henry C, Sommers L, Carman C, Molin M, Yurko J, Perry R, Williams A. Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye. Annals Of Surgery 2001, 233: 51-59. PMID: 11141225, PMCID: PMC1421166, DOI: 10.1097/00000658-200101000-00009.Peer-Reviewed Original ResearchConceptsSentinel node biopsyMulticenter trialTechnetium sulfur colloidNode biopsyIsosulfan blueFalse negative rateOlder patientsSulfur colloidBreast cancerComplete lymph node dissectionInexperienced surgeonsLymph node dissectionMetastatic axillary nodesIsosulfan blue dyeSingle-institution seriesSentinel node localizationBreast cancer metastasisAnalysis of tumorsFalse-negative resultsNode dissectionAxillary nodesIndependent predictorsSentinel nodesPoor success ratePatients
2000
Screening for Hepatitis C Virus in Human Immunodeficiency Virus-Infected Individuals
Thio C, Nolt K, Astemborski J, Vlahov D, Nelson K, Thomas D. Screening for Hepatitis C Virus in Human Immunodeficiency Virus-Infected Individuals. Journal Of Clinical Microbiology 2000, 38: 575-577. PMID: 10655348, PMCID: PMC86151, DOI: 10.1128/jcm.38.2.575-577.2000.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHCV RNANegative participantsHepatitis C virus antibody testHuman immunodeficiency virus-infected individualsHepatitis C virus screeningThird-generation enzyme immunoassayHIV-negative participantsVirus-infected individualsHepatitis C virusInjection drug usersThird-generation assaysCOBAS AMPLICOR systemFalse-negative testsThird-generation testsFalse-negative resultsAcute infectionHIV infectionImmunodeficiency virusC virusAntibody formationAntibody testHCVVirus screeningAmplicor system
1998
Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori.
Laine L, Estrada R, Trujillo M, Knigge K, Fennerty MB. Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Annals Of Internal Medicine 1998, 129: 547-50. PMID: 9758575, DOI: 10.7326/0003-4819-129-7-199810010-00007.Peer-Reviewed Original ResearchConceptsUrea breath testProton pump inhibitor therapyBreath test resultsProton pump inhibitorsBreath testInhibitor therapyH. pyloriDiagnostic testingCompletion of therapyProportion of patientsNegative breath test resultH. pylori infectionUrea breath test resultsLansoprazole therapyFalse-negative resultsGastroenterology clinicPylori infectionPatientsHelicobacter pyloriTherapyDuration of conversionPyloriPositive resultsLansoprazoleDays
1996
Transthoracic needle biopsy of mediastinal lymph nodes for staging lung and other cancers.
Protopapas Z, Westcott J. Transthoracic needle biopsy of mediastinal lymph nodes for staging lung and other cancers. Radiology 1996, 199: 489-96. PMID: 8668801, DOI: 10.1148/radiology.199.2.8668801.Peer-Reviewed Original ResearchConceptsNeedle biopsyMediastinal lymphadenopathyLymph nodesBiopsy procedureChest tube treatmentMediastinal lymph nodesNegative biopsy resultsTransthoracic needle biopsyFalse-negative resultsAdult patientsStaging procedureOutpatient basisTomographic guidanceBiopsy resultsSurgical confirmationPatientsBiopsyLymphadenopathyTube treatmentCarcinomaLymphomaLungCancerMediastinoscopyPneumothorax
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