2025
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories.
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, jnumed.124.267927. PMID: 39947910, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokineticsComputational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
Strigari L, Schwarz J, Bradshaw T, Brosch-Lenz J, Currie G, El-Fakhri G, Jha A, Mežinska S, Pandit-Taskar N, Roncali E, Shi K, Uribe C, Yusufaly T, Zaidi H, Rahmim A, Saboury B. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins. Journal Of Nuclear Medicine 2025, jnumed.124.268186. PMID: 39848769, DOI: 10.2967/jnumed.124.268186.Peer-Reviewed Original ResearchRadiopharmaceutical therapyNuclear oncologySociety of Nuclear MedicinePredictive dosimetryDosimetric informationTreatment planningTreatment outcomesLack of reimbursementTreatment personalizationDose responseTreatment optimizationEtiological mechanismsRobust security measuresPatient consentReal-world systemsNuclear medicineCross-border data sharingPatientsTreatmentEthical approval
2020
Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity
Lincoln MR, Axisa PP, Hafler DA. Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity. Current Opinion In Immunology 2020, 67: 50-56. PMID: 32977183, DOI: 10.1016/j.coi.2020.09.002.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMolecular mechanismsSusceptibility lociIndividual susceptibility lociFundamental genetic basisCausal molecular mechanismsPathogenic cell typesSpecific molecular mechanismsGenetic susceptibility lociEpigenetic techniquesGenetic basisGenetic lociAssociation studiesCell typesLociRecent advancesMechanismGeneticsAutoimmune diseasesSpectrum of autoimmunityCausal mechanismsEtiological mechanismsInflammatory diseasesTranslationAutoimmunity
2017
Annual Research Review: Suicide among youth – epidemiology, (potential) etiology, and treatment
B. C, Franz P, Guzmán E, Glenn C, Kleiman E, Nock M. Annual Research Review: Suicide among youth – epidemiology, (potential) etiology, and treatment. Journal Of Child Psychology And Psychiatry 2017, 59: 460-482. PMID: 29090457, PMCID: PMC5867204, DOI: 10.1111/jcpp.12831.Peer-Reviewed Original ResearchConceptsSuicidal thoughtsImprove etiological understandingHigh-risk populationPrevention of suicidal thoughtsDiverse high-risk populationsPrevalence of suicidal thoughtsSelf-report measuresEtiological understandingTechnology-based interventionsPsychotherapeutic treatmentPsychological treatmentComplex clinical outcomesPreliminary evidenceSociodemographic populationsPsychological factorsSample characteristicsPrevention effortsPrevention strategiesEtiological mechanismsSuicideThoughtsRisk factorsYouthEpidemiologyClinical outcomes
2008
The construct validity of rule-breaking and aggression in an adult clinical sample
Hopwood CJ, Burt SA, Markowitz JC, Yen S, Shea MT, Sanislow CA, Grilo CM, Ansell EB, McGlashan TH, Gunderson JG, Zanarini MC, Skodol AE, Morey LC. The construct validity of rule-breaking and aggression in an adult clinical sample. Journal Of Psychiatric Research 2008, 43: 803-808. PMID: 18789456, PMCID: PMC2696696, DOI: 10.1016/j.jpsychires.2008.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAggressionAntisocial Personality DisorderComorbidityCompulsive Personality DisorderFemaleHumansImpulsive BehaviorInterview, PsychologicalMaleMichiganMiddle AgedPersonalityPersonality AssessmentPsychiatric Status Rating ScalesRisk FactorsSocial DesirabilitySubstance-Related DisordersSuicideYoung AdultConceptsAdult clinical sampleAntisocial behaviorObsessive-compulsive personality disorderPersonality disorderClinical samplesCluster B personality disordersGender moderation effectConcurrent psychopathologyProspective behaviorB personality disordersPersonality traitsModeration effectSeparable componentsMeaningful correlatesLow conscientiousnessAggressionDifferent etiological mechanismsConstruct validityPrevious researchConscientiousnessCurrent studyPsychopathologySuicide riskEtiological mechanismsDisorders
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