2024
Palliative Care and End-of-Life Care in Metastatic Pancreatic Cancer
O’Brien J, Halsey B, Connors M, Deng M, Handorf E, Berardi G, Lynch S, Sorice K, Reddy S, Meyer J, Bauman J, Dotan E. Palliative Care and End-of-Life Care in Metastatic Pancreatic Cancer. Journal Of Palliative Medicine 2024, 28: 217-223. PMID: 39636708, DOI: 10.1089/jpm.2024.0313.Peer-Reviewed Original ResearchEnd of lifeAggressive EOL carePalliative careDay of deathEOL carePC consultationIntegration of palliative careEnd of life careEnd-of-life careAssociated with worse qualityHealth care resourcesMetastatic pancreatic cancerQuality of lifePC teamAggressive careCare resourcesHospiceAverage length of timeTertiary cancer centerCareWorse qualityAverage timeCancer CenterBenefit patientsPancreatic cancerPain Outcomes Among Medical Centers With High vs Low Specialist Palliative Care Reach Among People With Heart Failure.
Feder S, Han L, Zhan Y, Abel E, Akgün K. Pain Outcomes Among Medical Centers With High vs Low Specialist Palliative Care Reach Among People With Heart Failure. American Journal Of Hospice And Palliative Medicine® 2024, 10499091241304695. PMID: 39631749, DOI: 10.1177/10499091241304695.Peer-Reviewed Original ResearchSpecialist palliative careVeterans Affairs Medical CenterEnd of lifeBereaved Family SurveyUncontrolled painMedical CenterMultilevel logistic regressionFamilies of peopleAffairs Medical CenterFacility covariatesPalliative careRetrospective cohort studyPain outcomesAssociated with ratesSymptomatic populationCohort studyFacility rateLogistic regressionHeart failureGeneralized linear modelStudy outcomesFamily SurveyPainPain controlAdvanced HFUse of Hospice and End-of-Life Care Quality Among Medical Centers with High Versus Lower Specialist Palliative Care Reach Among People with Heart Failure: An Observational Study
Feder S, Han L, Zhan Y, Abel E, Akgün K, Fried T, Ersek M, Redeker N. Use of Hospice and End-of-Life Care Quality Among Medical Centers with High Versus Lower Specialist Palliative Care Reach Among People with Heart Failure: An Observational Study. Journal Of Palliative Medicine 2024, 27: 1583-1590. PMID: 39515377, DOI: 10.1089/jpm.2024.0182.Peer-Reviewed Original ResearchSpecialist palliative careVeterans Affairs Medical CenterEnd of lifeCare qualityInpatient hospiceEnd of life outcomesUse of hospiceInpatient hospice careMedical CenterMultilevel logistic regressionFamilies of patientsAffairs Medical CenterHospice carePalliative careRetrospective cohort studyAdvanced heart failureBlack adultsHospiceCohort studyFacility rateLogistic regressionStudy outcomesObservational studyCareHeart failureSystemic anti-cancer treatment and healthcare utilization at end of life: A SEER Medicare analysis.
Adelson K, Canavan M, Niu J, Zhao H, Nortje N, Xiang J, Giordano S, Cheng L. Systemic anti-cancer treatment and healthcare utilization at end of life: A SEER Medicare analysis. Journal Of Clinical Oncology 2024, 20: 276-276. DOI: 10.1200/op.2024.20.10_suppl.276.Peer-Reviewed Original ResearchEnd-of-lifeSystemic anticancer therapyDay of deathIntensive care unit useIntensive care unitHealthcare utilizationEmergency departmentCombined chemo-immunotherapyEnd-of-life chemotherapy useAssociated with healthcare utilizationImmunotherapy useChemo-immunotherapyIncreased healthcare useEnd of lifeAdverse quality of lifeAssociated with higher EDCare unitQuality of lifeSystemic anti-cancer treatmentHospice useDay hospiceHospice enrollmentSEER-Medicare databaseUse of chemotherapyHealthcare useHarnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer
Lindsay M, de Oliveira S, Sciacca K, Lindvall C, Ananth P. Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400134. PMID: 39265122, PMCID: PMC11407740, DOI: 10.1200/cci.24.00134.Peer-Reviewed Original ResearchConceptsEnd-of-life carePalliative care consultationGoals of careLocation of deathProportion of decedentsDocumented discussionCare consultationEvidence-based quality measuresMeasure quality of careGold standard manual chart reviewQuality measuresQuality of careEnd of lifeContent of clinical notesLife-sustaining treatmentEnd-of-lifeManual chart reviewCancer decedentsEfficient quality measureCohort of childrenAssess qualityMulti-center researchQuality improvementMeasure qualityCareTalking About Suffering in the Intensive Care Unit
Kious B, Vick J, Ubel P, Sutton O, Blumenthal-Barby J, Cox C, Ashana D. Talking About Suffering in the Intensive Care Unit. AJOB Empirical Bioethics 2024, 16: 52-59. PMID: 39250770, PMCID: PMC11785475, DOI: 10.1080/23294515.2024.2399534.Peer-Reviewed Original ResearchSecondary qualitative content analysisIntensive care unitInductive approach to data analysisEnd of lifeSuffering of personsAdult intensive care unitQualitative content analysisCare unitFamily meetingsReviewed transcriptsEmotional distressPatient's familyCritically ill patientsApproach to data analysisLimited treatmentCoding guideStudy authorsResearch teamContent analysisMulticenter trialPoor prognosisCliniciansLow qualityIll patientsSufferingCauses of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era
Lee D, McNamara M, Yang A, Yaskolko M, Kluger H, Tran T, Olino K, Clune J, Sznol M, Ishizuka J. Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era. Pigment Cell & Melanoma Research 2024, 37: 847-853. PMID: 39073002, PMCID: PMC11809125, DOI: 10.1111/pcmr.13188.Peer-Reviewed Original ResearchSite of metastasisPattern of metastatic diseaseMelanoma mortalityRetrospective observational cohort studyCause of cancer mortalityDistant lymph nodesObservational cohort studyDiagnosis to deathImmunotherapy eraAdvanced melanomaMetastatic diagnosisMetastatic diseaseMetastatic melanomaImmunotherapy treatmentRespiratory failureCause of deathMedian timeLymph nodesTherapeutic advancesCohort studyMelanomaImmunotherapyMechanism of deathPatientsEnd of lifeSystemic Anticancer Therapy and Overall Survival in Patients With Very Advanced Solid Tumors
Canavan M, Wang X, Ascha M, Miksad R, Showalter T, Calip G, Gross C, Adelson K. Systemic Anticancer Therapy and Overall Survival in Patients With Very Advanced Solid Tumors. JAMA Oncology 2024, 10: 887-895. PMID: 38753341, PMCID: PMC11099840, DOI: 10.1001/jamaoncol.2024.1129.Peer-Reviewed Original ResearchNational Quality ForumQuintile 5Quintile 1Improve end-of-life careEnd-of-life careCohort studyNationwide population-based cohort studyPopulation-based cohort studyEnd of lifeElectronic health record databaseHealth care practicesColorectal cancerPopulation of patientsCox proportional hazards modelsAmerican Society of Clinical OncologyQuality ForumCare practicesOverall survivalPayment incentivesProportional hazards modelHighest quintileMultivariate Cox proportional hazards modelQuintileFlatiron HealthHazard ratioSystemic anti-cancer therapy and cost at end of life: A SEER Medicare analysis.
Adelson K, Cheng L, Huang Y, Niu J, Zhao H, Nortje N, Xiang J, Giordano S, Canavan M. Systemic anti-cancer therapy and cost at end of life: A SEER Medicare analysis. Journal Of Clinical Oncology 2024, 42: 11092-11092. DOI: 10.1200/jco.2024.42.16_suppl.11092.Peer-Reviewed Original ResearchSystemic anticancer therapyCombined chemo-immunotherapyLiquid tumorsSolid tumorsDay of deathEmergency departmentRates of systemic therapySystemic anti-cancer therapySEER-Medicare databaseAnti-cancer therapyChemo-immunotherapyLT patientsSystemic therapyCI patientsSEER-MedicareST patientsIdentified patientsCost of drugsAssociated with higher costsEnd of lifeAnticancer therapyImmunotherapyChemotherapyPatientsTherapyTrauma-informed palliative care for humanitarian crises
de Groot J, Miller D, Willis K, Green T, Calman L, Feldstain A, Rao S, Bahcivan O, Fehon D. Trauma-informed palliative care for humanitarian crises. Journal Of Psychosocial Oncology Research And Practice 2024, 6: 132. DOI: 10.1097/or9.0000000000000132.Peer-Reviewed Original ResearchHealth care providersCare providersHumanitarian crisisPalliative care approachPalliative care expertsEnd of lifePrevention of sufferingPromoting cultural sensitivityTrauma-informed principlesPalliative carePsychosocial needsCare approachCare expertsLife-threatening experiencesCaregiversResearch partnershipsCultural sensitivityProvidersSupport healingResearch designPractice literatureGroup initiativesCrisisSaving livesPatientsWhen Differences in Belief Intensify Family Tensions at End of Life
Andersen L, Segar N. When Differences in Belief Intensify Family Tensions at End of Life. Journal Of Pain And Symptom Management 2024, 67: e556. DOI: 10.1016/j.jpainsymman.2024.02.346.Peer-Reviewed Original ResearchSpiritual conflictPalliative care chaplainsMedical decisionsChristian churchesFaith traditionsPatients' medical decisionsChurch leadersEnd of lifeReligious womenReligious beliefsGodSpiritual beliefsFamily wishesDeep listeningBeliefsChurchFaithInterdisciplinary palliative care teamChaplainsPalliative care teamInterdisciplinary team membersConflictFamily tensionsMatriarchHistory of homelessnessSurvivorship Care for People Affected by Advanced or Metastatic Cancer: MASCC-ASCO Standards and Practice Recommendations
Hart N, Nekhlyudov L, Smith T, Yee J, Fitch M, Crawford G, Koczwara B, Ashbury F, Lustberg M, Mollica M, Smith A, Jefford M, Chino F, Zon R, Agar M, Chan R. Survivorship Care for People Affected by Advanced or Metastatic Cancer: MASCC-ASCO Standards and Practice Recommendations. JCO Oncology Practice 2024, 20: 1160-1172. PMID: 38684036, DOI: 10.1200/op.23.00716.Peer-Reviewed Original ResearchQuality survivorship careSurvivorship carePractice recommendationsUnmet supportive care needsPalliative care frameworkSupportive care needsSystematic reviewModified Delphi consensus processPerson-centered careEnd of lifeData-driven careMultinational Association for Supportive CareDelphi consensus processSupportive careCancer survivorshipCare goalsIntegrated careCare experiencesCare needsCare frameworkHealth outcomesCommunicating careResourcing carePerson-centeredConsensus processGeriatric Emergency Medication Safety Recommendations (GEMS-Rx): Modified Delphi Development of a High-Risk Prescription List for Older Emergency Department Patients
Skains R, Koehl J, Aldeen A, Carpenter C, Gettel C, Goldberg E, Hwang U, Kocher K, Southerland L, Goyal P, Berdahl C, Venkatesh A, Lin M. Geriatric Emergency Medication Safety Recommendations (GEMS-Rx): Modified Delphi Development of a High-Risk Prescription List for Older Emergency Department Patients. Annals Of Emergency Medicine 2024, 84: 274-284. PMID: 38483427, PMCID: PMC11343681, DOI: 10.1016/j.annemergmed.2024.01.033.Peer-Reviewed Original ResearchOlder ED patientsHigh-risk prescriptionsED patientsHigh-risk medication usePrescribed high-risk medicationsEmergency departmentHigh-risk medicationsEnd of lifeShort-term adverse eventsAdverse drug eventsQuestionnaire response rateEmergency department patientsDrug eventsRound 2Prescription refillsPhysician expertsMedication useSkeletal muscle relaxantsDepartment patientsMedication categoriesAdverse eventsRisk of short-term adverse eventsMedication classesMedical indicationsPrescription listHigh-Intensity Care for Nursing Home Residents with Severe Dementia Hospitalized at the End of Life: A Mixed Methods Study
Cohen A, McDonald W, O'Leary J, Omer Z, Fried T. High-Intensity Care for Nursing Home Residents with Severe Dementia Hospitalized at the End of Life: A Mixed Methods Study. Journal Of The American Medical Directors Association 2024, 25: 871-875. PMID: 38462230, PMCID: PMC11065599, DOI: 10.1016/j.jamda.2024.02.001.Peer-Reviewed Original ResearchNursing home residentsHigh-intensity careSevere dementiaMixed methods studyHome residentsIntensive care unit transferVeterans AffairsIntensive care unitMethods studyHealth system-level factorsDepartment of Veterans AffairsMinimum Data SetEnd of lifeSystem-level factorsNon-Hispanic whitesEnd-of-lifeElectronic medical recordsQualitative content analysisNursing homesLiving willsVA hospitalsHigh-intensity treatmentIdentified veteransNursesPatient preferencesImmunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US
Kerekes D, Frey A, Prsic E, Tran T, Clune J, Sznol M, Kluger H, Forman H, Becher R, Olino K, Khan S. Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. JAMA Oncology 2024, 10: 342-351. PMID: 38175659, PMCID: PMC10767643, DOI: 10.1001/jamaoncol.2023.6025.Peer-Reviewed Original ResearchNon-small cell lung cancerEnd of lifeMonth of deathImmunotherapy initiationCohort studyMAIN OUTCOMEStage IV non-small cell lung cancerCharlson-Deyo comorbidity indexHigh metastatic burdenInitiation of immunotherapyNational prescribing patternsRisk-adjusted patientsImmune checkpoint inhibitorsRetrospective cohort studyStage IV melanomaPercentage of patientsHigh-volume centersLocation of metastasesLow-volume centersOdds of deathCell lung cancerNational Clinical DatabaseLow-volume facilitiesDrug Administration approvalCheckpoint inhibitors
2023
Oncology hospitalist impact on hospice utilization
Prsic E, Morris J, Adelson K, Parker N, Gombos E, Kottarathara M, Novosel M, Castillo L, Rothberg BE. Oncology hospitalist impact on hospice utilization. Cancer 2023, 129: 3797-3804. PMID: 37706601, DOI: 10.1002/cncr.35008.Peer-Reviewed Original ResearchConceptsMedical oncology serviceOncology servicesEnd of lifeAdvanced cancerInpatient hospiceHospice utilizationHigher total health care costsTotal health care costsComfort-focused careInpatient oncology serviceSmilow Cancer HospitalAdjusted odds ratioLength of staySolid tumor malignanciesLong-term survivalMultivariable linear regressionHealth care costsElectronic medical recordsHospice transitionUnplanned hospitalizationDischarge dispositionHospice referralInpatient managementLate referralCancer HospitalThe Cost of Cancer Care at the End of Life: Implications for Centers for Medicare and Medicaid Services and for Radiation Oncology
Yu J. The Cost of Cancer Care at the End of Life: Implications for Centers for Medicare and Medicaid Services and for Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2023, 116: 736-738. PMID: 37355309, DOI: 10.1016/j.ijrobp.2023.02.012.Peer-Reviewed Original ResearchThe roles of preparation, location, and palliative care involvement in parent-perceived child suffering at the end of life
Broden E, Mazzola E, DeCourcey D, Blume E, Wolfe J, Snaman J. The roles of preparation, location, and palliative care involvement in parent-perceived child suffering at the end of life. Journal Of Pediatric Nursing 2023, 72: e166-e173. PMID: 37355461, DOI: 10.1016/j.pedn.2023.06.024.Peer-Reviewed Original ResearchConceptsComplex chronic conditionsChild sufferingParents' perceptionsPalliative care involvementCare-related factorsEnd of lifeEffective support interventionsMultivariate logistic regression modelHeart diseasePerception of sufferingLogistic regression modelsEOL careCare involvementSupport interventionsSurvey of parentsIllness experienceDying processChronic conditionsBereavement experiencesFamily supportAdvanced heart diseaseIdentified factorsEOLMultivariate modelRegression modelsEnd-of-Life Systemic Oncologic Treatment in the Immunotherapy Era: The Role of Race, Insurance, and Practice Setting
Canavan M, Wang X, Ascha M, Miksad R, Showalter T, Calip G, Gross C, Adelson K. End-of-Life Systemic Oncologic Treatment in the Immunotherapy Era: The Role of Race, Insurance, and Practice Setting. Journal Of Clinical Oncology 2023, 41: 4729-4738. PMID: 37339389, PMCID: PMC10602547, DOI: 10.1200/jco.22.02180.Peer-Reviewed Original ResearchConceptsSystemic treatmentEnd of lifeWhite patientsBlack patientsOdds ratioLarge real-world populationPractice settingsTreatment ratesPatient-level factorsEmergency department useIntensive care unitReal-world populationDay of deathImmunotherapy eraSystemic therapyOncologic treatmentCare unitDeidentified databaseDepartment usePatient raceInsurance typeMetastatic cancerDownstream careMedicaid patientsHigher oddsThe association between systemic anticancer therapy (SACT) at the end of life (EOL) and acute care use among patients treated at oncology practices participating in the Oncology Care Model (OCM).
Canavan M, Sheth K, Scott J, Westvold S, Adelson K. The association between systemic anticancer therapy (SACT) at the end of life (EOL) and acute care use among patients treated at oncology practices participating in the Oncology Care Model (OCM). Journal Of Clinical Oncology 2023, 41: 6580-6580. DOI: 10.1200/jco.2023.41.16_suppl.6580.Peer-Reviewed Original ResearchSystemic anticancer therapyDay of deathOncology Care ModelEnd of lifeAcute care useIntensive care unitInpatient admissionsED visitsCare useReceipt of chemotherapyAcute care utilizationEmergency department useProportion of decedentsRates of chemotherapyChi-square testICU stayIO therapyCare unitCare utilizationInpatient stayCT patientsDepartment useHospice useCare metricsOncology practice
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