2025
Improvements in hearing loss with bone-targeted enzyme replacement therapy are associated with corrected hypomineralization and osteocyte properties of auditory ossicles in Enpp1-deficient mice
Ocokoljic A, Srivastava S, von Kroge S, Stabach P, Busse B, Weise K, Oheim R, Rolvien T, Braddock D. Improvements in hearing loss with bone-targeted enzyme replacement therapy are associated with corrected hypomineralization and osteocyte properties of auditory ossicles in Enpp1-deficient mice. Journal Of Bone And Mineral Research 2025, zjaf082. PMID: 40495691, DOI: 10.1093/jbmr/zjaf082.Peer-Reviewed Original ResearchEnzyme replacement therapyHearing lossReplacement therapyENPP1 deficiencyAuditory brainstem response thresholdsAutosomal recessive hypophosphatemic rickets type 2Markers of mineral metabolismArterial calcification of infancyBrainstem response thresholdsElevated hearing thresholdsPrevent hearing lossWild-type miceImpairment of hearingAuditory ossiclesHearing thresholdsHearing functionHearing deficitsArtery calcificationDose-dependentlyMiddle earMouse modelOssicular chainBone propertiesMineral metabolismEffective treatmentPharmacological and behavioral pain treatment strategies for patients with opioid use disorder
Ameral V, Hickey T, Reilly E, Patterson J, Sofuoglu M. Pharmacological and behavioral pain treatment strategies for patients with opioid use disorder. Expert Opinion On Pharmacotherapy 2025, 26: 1041-1054. PMID: 40366730, PMCID: PMC12202159, DOI: 10.1080/14656566.2025.2506688.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderChronic painUse disorderCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsEffective management of painPain treatment strategiesRegister of Controlled TrialsManagement of painCochrane Central RegisterAgonist treatmentPharmacological optionsTreatment strategiesPainOpioidEffective treatmentControlled trialsBehavioral treatmentTreatmentPatientsDisordersMedical careEffective managementEffective medical careMethadone for Opioid Use Disorder in the Fentanyl Era: Navigating Challenges and Evolving Strategies- a Narrative Review
Osagie E, Horton J, Lawrence D, Hermes G, Garcia-Vassallo G. Methadone for Opioid Use Disorder in the Fentanyl Era: Navigating Challenges and Evolving Strategies- a Narrative Review. Current Addiction Reports 2025, 12: 44. DOI: 10.1007/s40429-025-00655-6.Peer-Reviewed Original ResearchOpioid use disorderDosing flexibilityEffective treatmentMethadone treatmentCornerstone of treatmentOpioid use disorder treatmentMethadone initiationMethadone doseDosing daysDosing considerationsDose selectionTreatment outcomesUse disorderWithdrawal managementPresence of fentanylOpioidRate of titrationDoseMethadoneFentanylSummaryThis reviewSynthetic opioidsDrug overdose deathsInitial careClinical decisionsSex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome
Mogavero M, Peng G, Marchese G, Lanza G, Ferini-Strambi L, Ferri R, Koo B. Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome. Sleep 2025, zsaf112. PMID: 40289925, DOI: 10.1093/sleep/zsaf112.Peer-Reviewed Original ResearchRestless legs syndromeProteomic signatureCerebrospinal fluid proteomeUntreated RLS patientsObservational cross-sectional studyBody mass indexProteome of patientsCerebrospinal fluid samplesSex-specific mechanismsCross-sectional studyRLS patientsSex-specific analysesMass indexSex differencesTherapeutic strategiesImmune responseInflammatory pathwaysEffective treatmentCerebrospinal fluid proteome of patientsDisease pathophysiologyPatientsSyndromeProtein levelsFluid samplesProteomic alterationsKetamine Versus Electroconvulsive Therapy for the Treatment of Depression: A Guide for Clinicians
Elliott S, B Katz R, B Ostroff R, Ansari M, Holmes S, Sanacora G. Ketamine Versus Electroconvulsive Therapy for the Treatment of Depression: A Guide for Clinicians. FOCUS The Journal Of Lifelong Learning In Psychiatry 2025, 23: 195-205. PMID: 40235610, PMCID: PMC11995899, DOI: 10.1176/appi.focus.20240040.Peer-Reviewed Original ResearchTreatment-resistant depressionElectroconvulsive therapyCases of treatment-resistant depressionTreatment of depressionEfficacy of ketamineDepressive disorderSevere casesDepressionPatient selection criteriaPatient-specific factorsOptimal treatment choicePatient-specific considerationsKetamineStudy outcome measuresTreatment deliveryBenefit profileMeta-analysesTreatment choiceNoninferiority trialPublic health challengeEffective treatmentOutcome measuresGold standardUnique risksTherapyUK Hand and Upper Limb Transplant Service, functional outcomes of the first six patients: A case series.
Burdon J, Taplin S, Leonard D, Natalwala I, Bourke G, Kay S. UK Hand and Upper Limb Transplant Service, functional outcomes of the first six patients: A case series. Journal Of Hand Surgery (European Volume) 2025, 17531934251325654. PMID: 40119684, DOI: 10.1177/17531934251325654.Peer-Reviewed Original ResearchCanadian Occupational Performance Measure performanceHand Transplantation Score SystemReport functional outcomesArm Shoulder and Hand scoreUpper limb transplantationFunctional outcomesSatisfaction scoresHand scoreProtective sensationPower gripBilateral handsScoresTransplant servicesTransplant scoreHand transplantationCase seriesScoring systemOutcomesPatientsEffective treatmentTransplantationTransplant programmeLimb transplantationDisabilityGripEditorial: Where are the Trials on Adolescent Self-Harm and Suicide?
Kumpf K, Bloch M. Editorial: Where are the Trials on Adolescent Self-Harm and Suicide? Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40088968, DOI: 10.1016/j.jaac.2025.03.002.Peer-Reviewed Original ResearchNonsuicidal self-injurySelf-harmModerators of treatment effectsRandomized controlled trialsPublic health problemEvidence-based treatmentsAdolescent self-harmPrevent self-harmSelf-injuryHealth problemsRandom-effects meta-analysisRandom-effects meta-analysis of studiesTherapeutic interventionsSuicideMeta-analysis of studiesSource of morbidityAdolescentsIndividual patient dataSecondary analysisTreatment effectsNo significant differenceControlled trialsAggregate dataMeta-analysisEffective treatmentThe Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntington’s Disease
Goldberg Y, Navon-Perry L, Cruz-Herranz A, Chen K, Hecker-Barth G, Spiegel K, Cohen Y, Niethammer M, Tan A, Schuring H, Geva M, Hayden M. The Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntington’s Disease. CNS Drugs 2025, 39: 485-498. PMID: 40055280, PMCID: PMC11982116, DOI: 10.1007/s40263-025-01171-x.Peer-Reviewed Original ResearchSafety profileAdverse eventsAntidopaminergic medicationsOpen-label extension studySigma-1Sigma-1 receptor agonistCytosine-adenine-guaninePlacebo-controlled studySpectrum of disease severityAnalysis of pooled dataTotal Functional CapacityFirst-in-classRecommended human doseSigma-1 receptorTreatment of Huntington's diseaseUnmet medical needLong-term useDouble-blindReceptor agonistsPridopidineHuman doseSafety signalsEffective treatmentPlaceboExtension studyHarnessing precision nutrition to individualize weight restoration in anorexia nervosa
Rodriguez I, Huckins L, Bulik C, Xu J, Igudesman D. Harnessing precision nutrition to individualize weight restoration in anorexia nervosa. Journal Of Eating Disorders 2025, 13: 29. PMID: 39962541, PMCID: PMC11834214, DOI: 10.1186/s40337-025-01209-x.Peer-Reviewed Original ResearchWeight restorationPrecision nutritionAnorexia nervosaGut microbiotaIndividualized nutrition therapyPsychiatric comorbiditiesHabitual lifestyle behaviorsPrecision nutrition approachesDuration of illnessRestore microbial diversityNutrition therapySevere psychiatric disordersNutrition prescriptionKeystone taxaDietary interventionGenetic markersMicrobial diversityWeight outcomesMetabolic profileEffective treatmentDietary planNutritional approachFecal energy lossPatient recoveryMortality rateAn international perspective on the future of systemic sclerosis research
Abraham D, Black C, Denton C, Distler J, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney J, Martin J, Matucci-Cerinic M, McMahan Z, Mora A, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield M, Gabrielli A, Krieg T. An international perspective on the future of systemic sclerosis research. Nature Reviews Rheumatology 2025, 21: 174-187. PMID: 39953141, DOI: 10.1038/s41584-024-01217-2.Peer-Reviewed Original ResearchConceptsSystemic sclerosisSystemic sclerosis researchHistory of systemic sclerosisInnovative clinical trial designsSystemic autoimmune diseaseEarly pathogenetic eventClinical trial designCollaborative global effortAutoimmune phenomenaImprove patient outcomesDisease activityMicrovascular dysfunctionClinical historyEmergency therapyAutoimmune diseasesDisease-modifying treatmentsTissue fibrosisSingle-cell RNA sequencingClinical heterogeneityEffective disease-modifying treatmentsPersonalized therapyAnimal modelsComplex pathogenesisEffective treatmentNext-generation sequencingRepetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding
Michel A, Kang D, Fillingim R, Balderston N, Bond D, Steele V. Repetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding. Current Addiction Reports 2025, 12: 14. DOI: 10.1007/s40429-025-00620-3.Peer-Reviewed Original ResearchSubstance use disordersChronic painRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationDiverse chronic pain conditionsChronic pain conditionsCo-occurring diseasesRTMS interventionMagnetic stimulationMagnetic resonance imagingEffective interventionsPain fieldPain conditionsSubstance use disorders fieldRepetitive transcranial magnetic stimulation applicationPainEffective treatmentUse disorderNarrative reviewClinical populationsSubstance useResonance imagingInterventionEvaluate relative efficacyClinical samplesDrug interactions in people with HIV treated with antivirals for other viral illnesses
Okoli A, Ogbuagu O. Drug interactions in people with HIV treated with antivirals for other viral illnesses. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 383-397. PMID: 39836520, PMCID: PMC12169512, DOI: 10.1080/17425255.2025.2455401.Peer-Reviewed Original ResearchDrug-drug interactionsDrug interactionsManagement of drug interactionsTreatment of HIVViral coinfectionAntiviral therapyHepatitis CViral illnessHIV treatmentIncreased riskPrescribing informationEffective treatmentViral infectionHIVAntiviral agentsConference abstractsPWHPatient outcomesARVDrug prescribing informationTreatmentCoinfectionGoogle ScholarDrugMetabolic pathwaysPrevalence of resistance-associated substitutions (RAS) in hepatitis C virus in the Former Soviet Union countries
Mustafa A, Davlidova S, Abidi S, Begimbetova D, Heimer R, Vermund S, Ali S. Prevalence of resistance-associated substitutions (RAS) in hepatitis C virus in the Former Soviet Union countries. BMJ Open Gastroenterology 2025, 12: e001657. PMID: 39848793, PMCID: PMC11758705, DOI: 10.1136/bmjgast-2024-001657.Peer-Reviewed Original ResearchConceptsResistance-associated substitutionsResistance to daclatasvirHepatitis C virusEffective treatment of hepatitis C virusPresence of resistance-associated substitutionsPrevalence of HCV genotype 1bPrevalence of resistance-associated substitutionsC virusNS3 resistance-associated substitutionsNS5B resistance-associated substitutionsEmergence of resistance-associated substitutionsNS5A resistance-associated substitutionsTreatment of hepatitis C virusPrevalence of HCV genotypesDirect-acting antiviralsPrevalence of genotypesEffective treatment regimenHCV genotype 1bHCV-infected individualsSequences of hepatitis C virusTreatment regimenHCV genotypesGenotype 1bGenotype 3aEffective treatmentTrans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies
Consortium M, Adams M, Streit F, Meng X, Awasthi S, Adey B, Choi K, Chundru V, Coleman J, Ferwerda B, Foo J, Gerring Z, Giannakopoulou O, Gupta P, Hall A, Harder A, Howard D, Hübel C, Kwong A, Levey D, Mitchell B, Ni G, Ota V, Pain O, Pathak G, Schulte E, Shen X, Thorp J, Walker A, Yao S, Zeng J, Zvrskovec J, Aarsland D, Actkins K, Adli M, Agerbo E, Aichholzer M, Aiello A, Air T, Als T, Andersson E, Andlauer T, Arolt V, Ask H, Bäckman J, Badola S, Ballard C, Banasik K, Bass N, Beekman A, Belangero S, Bigdeli T, Binder E, Bjerkeset O, Bjornsdottir G, Børte S, Bränn E, Braun A, Brodersen T, Brückl T, Brunak S, Bruun M, Burmeister M, Buspavanich P, Bybjerg-Grauholm J, Byrne E, Cai J, Campbell A, Campbell M, Campos A, Castelao E, Cervilla J, Chaumette B, Chen C, Chen H, Chen Z, Cichon S, Colodro-Conde L, Corbett A, Corfield E, Couvy-Duchesne B, Craddock N, Dannlowski U, Davies G, de Geus E, Deary I, Degenhardt F, Dehghan A, DePaulo J, Deuschle M, Didriksen M, Dinh K, Direk N, Djurovic S, Docherty A, Domschke K, Dowsett J, Drange O, Dunn E, Eaton W, Einarsson G, Eley T, Elsheikh S, Engelmann J, Benros M, Erikstrup C, Escott-Price V, Fabbri C, Fang Y, Finer S, Frank J, Free R, Gallo L, Gao H, Gill M, Gilles M, Goes F, Gordon S, Grove J, Gudbjartsson D, Gutierrez B, Hahn T, Hall L, Hansen T, Haraldsson M, Hartman C, Havdahl A, Hayward C, Heilmann-Heimbach S, Herms S, Hickie I, Hjalgrim H, Hjerling-Leffler J, Hoffmann P, Homuth G, Horn C, Hottenga J, Hougaard D, Hovatta I, Huang Q, Hucks D, Huider F, Hunt K, Ialongo N, Ising M, Isometsä E, Jansen R, Jiang Y, Jones I, Jones L, Jonsson L, Kanai M, Karlsson R, Kasper S, Kendler K, Kessler R, Kloiber S, Knowles J, Koen N, Kraft J, Kranzler H, Krebs K, Kallak T, Kutalik Z, Lahtela E, Lake M, Larsen M, Lenze E, Lewins M, Lewis G, Li L, Lin B, Lin K, Lind P, Liu Y, MacIntyre D, MacKinnon D, Maher B, Maier W, Marshe V, Martinez-Levy G, Matsuda K, Mbarek H, McGuffin P, Medland S, Meinert S, Mikkelsen C, Mikkelsen S, Milaneschi Y, Millwood I, Molina E, Mondimore F, Mortensen P, Mulsant B, Naamanka J, Najman J, Nauck M, Nenadić I, Nielsen K, Nolt I, Nordentoft M, Nöthen M, Nyegaard M, O'Donovan M, Oddsson A, Oliveira A, Olsen C, Oskarsson H, Ostrowski S, Owen M, Packer R, Palviainen T, Pan P, Pato C, Pato M, Pedersen N, Pedersen O, Peyrot W, Potash J, Preisig M, Preuss M, Quiroz J, Renteria M, Reynolds C, Rice J, Sakaue S, Santoro M, Schoevers R, Schork A, Schulze T, Send T, Shi J, Sigurdsson E, Singh K, Sinnamon G, Sirignano L, Smeland O, Smith D, Sofer T, Sørensen E, Srinivasan S, Stefansson H, Stefansson K, Straub P, Su M, Tadic A, Teismann H, Teumer A, Thapar A, Thomson P, Thørner L, Topaloudi A, Tsai S, Tzoulaki I, Uhl G, Uitterlinden A, Ullum H, Umbricht D, Ursano R, Van der Auwera S, van Hemert A, Veluchamy A, Viktorin A, Völzke H, Walters G, Wang X, Wani A, Weissman M, Wellmann J, Whiteman D, Wildman D, Willemsen G, Williams A, Winsvold B, Witt S, Xiong Y, Zillich L, Zwart J, Team T, Group C, Team E, Team G, Psychiatry H, Project T, Program V, Andreassen O, Baune B, Berger K, Boomsma D, Børglum A, Breen G, Cai N, Coon H, Copeland W, Creese B, Cruz-Fuentes C, Czamara D, Davis L, Derks E, Domenici E, Elliott P, Forstner A, Gawlik M, Gelernter J, Grabe H, Hamilton S, Hveem K, John C, Kaprio J, Kircher T, Krebs M, Kuo P, Landén M, Lehto K, Levinson D, Li Q, Lieb K, Loos R, Lu Y, Lucae S, Luykx J, Maes H, Magnusson P, Martin H, Martin N, McQuillin A, Middeldorp C, Milani L, Mors O, Müller D, Müller-Myhsok B, Okada Y, Oldehinkel A, Paciga S, Palmer C, Paschou P, Penninx B, Perlis R, Peterson R, Pistis G, Polimanti R, Porteous D, Posthuma D, Rabinowitz J, Reichborn-Kjennerud T, Reif A, Rice F, Ricken R, Rietschel M, Rivera M, Rück C, Salum G, Schaefer C, Sen S, Serretti A, Skalkidou A, Smoller J, Stein D, Stein F, Stein M, Sullivan P, Tesli M, Thorgeirsson T, Tiemeier H, Timpson N, Uddin M, Uher R, van Heel D, Verweij K, Walters R, Wassertheil-Smoller S, Wendland J, Werge T, Zwinderman A, Kuchenbaecker K, Wray N, Ripke S, Lewis C, McIntosh A. Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell 2025, 188: 640-652.e9. PMID: 39814019, PMCID: PMC11829167, DOI: 10.1016/j.cell.2024.12.002.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCell-type enrichment analysisSingle-cell dataTrans-ancestryAdmixed ancestrySingle-cell analysisFine-mappingPotential repurposing opportunitiesAssociation studiesGene associationsEnrichment analysisReceptor clusteringPolygenic scoresRepurposing opportunitiesPostsynaptic densityCell typesStudies of depressionMedium spiny neuronsAncestryAntidepressant targetSpiny neuronsAmygdala neuronsLociBiological targetsEffective treatment
2024
Tertiary amine modification enables triterpene nanoparticles to target the mitochondria and treat glioblastoma via pyroptosis induction
Gao X, Tang X, Tu Z, Yu J, Bao Y, Long G, Sheu W, Wu H, Liu J, Zhou J. Tertiary amine modification enables triterpene nanoparticles to target the mitochondria and treat glioblastoma via pyroptosis induction. Biomaterials 2024, 317: 123035. PMID: 39731842, PMCID: PMC11827167, DOI: 10.1016/j.biomaterials.2024.123035.Peer-Reviewed Original ResearchConceptsSurvival of tumor-bearing miceBrain tumorsEffective treatmentPenetrate brain tumorsEffective treatment of glioblastomaTumor-bearing micePrimary brain tumorTreatment of glioblastomaMitochondria-targeted effectsTreating glioblastomaCancer treatmentGlioblastomaEffective killingTherapeutic targetHexokinase inhibitorGBM cellsPyroptosis inductionMitochondriaTumorGlycyrrhetinic acidTargeting effectTreatmentThe International Society of Nephrology Collaborative Quality Framework to Support Safe and Effective Dialysis Provision in Resource-Challenged Settings
Davies S, Naicker S, Liew A, Vachharajani T, Pecoits-Filho R, Jha V, Finkelstein F, Harris D. The International Society of Nephrology Collaborative Quality Framework to Support Safe and Effective Dialysis Provision in Resource-Challenged Settings. Kidney International Reports 2024, 10: 663-672. PMID: 40225391, PMCID: PMC11993199, DOI: 10.1016/j.ekir.2024.11.1366.Peer-Reviewed Original ResearchCatastrophic healthcare expenditureContinuous quality improvementQuality frameworkHealthcare commissionersPatient safetyLack of resourcesSub-optimal qualityHealthcare expendituresIterative reviewResource-challenged settingsInequitable accessQuality improvementResource settingsDialysis provisionDialysis planningProvidersExternal validationInternational SocietyPatient groupPolicy makersEffective treatmentHealthcarePatientsSetsFundersSuccess of Bone Ossification After Posterior Vault Distraction Osteogenesis in Patients With Craniosynostosis
Sayadi J, Lujan-Hernandez J, Givechian K, Mackay D, Lorenz H, Grant G, Mahaney K, Hong D, Khosla R. Success of Bone Ossification After Posterior Vault Distraction Osteogenesis in Patients With Craniosynostosis. Journal Of Craniofacial Surgery 2024, 36: 870-875. PMID: 39819807, DOI: 10.1097/scs.0000000000010844.Peer-Reviewed Original ResearchPosterior vault distraction osteogenesisDistraction osteogenesisTitanium mesh cranioplastyTime of surgeryComputed tomography scanAssociated with ageMesh cranioplastySyndromic craniosynostosisTomography scanDefinitive reconstructionOlder patientsEffective treatmentPatientsStudy populationOperative detailsLatency periodIncreasing ageDistraction areaComplete ossificationDistraction siteCranial defectsDegree of ossificationCraniosynostosisOssificationBone ossificationIntrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Cheng H, Chen N, Chen W, Wu Z, Sun Y, Teng W, Su F, Sung C, Wen Z. Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis. The Journal Of Headache And Pain 2024, 25: 207. PMID: 39587478, PMCID: PMC11590346, DOI: 10.1186/s10194-024-01916-x.Peer-Reviewed Original ResearchConceptsLactate dehydrogenase ANeuropathic painNociceptive sensitizationLDHA inhibitorsTreat neuropathic painType of painUpregulation of glycolysisCCI-induced neuroinflammationCentral nervous systemBackgroundNeuropathic painNeuropathic ratsSpinal roleNociceptive behaviorBlood vessel growthImmunohistochemical analysisControl inflammationPainEffective treatmentConclusionIn conclusionHIF-1aCellular mechanismsNervous systemTherapeutic targetVessel growthWestern blottingProceedings from an international consensus meeting on ablation in urogenital diseases
Iezzi R, Contegiacomo A, De Filippis A, Gunn A, Atwell T, Mcclure T, Jing Z, Posa A, Scrofani A, Maresca A, Madoff D, Goldberg S, Kelekis A, Filippiadis D, Sala E, Ahmed M. Proceedings from an international consensus meeting on ablation in urogenital diseases. Insights Into Imaging 2024, 15: 267. PMID: 39514046, PMCID: PMC11549275, DOI: 10.1186/s13244-024-01841-2.Peer-Reviewed Original ResearchInternational Consensus MeetingAblation techniqueIntermediate-risk prostate cancerImage-guided ablation techniquesPreoperative surgical riskManagement of oncological diseasesRenal cell carcinomaConsensus meetingTraditional surgical treatmentGenitourinary tract diseaseFibroid SymptomCell carcinomaProstate cancerSurgical riskAblation therapyImprove patient outcomesTumor managementSurgical treatmentMechanism of actionEffective alternativeTherapeutic alternativeSite of applicationEffective treatmentUrogenital diseasesOncological diseasesPrecision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report
Lehmann M, Krishnan R, Sucre J, Kulkarni H, Pineda R, Anderson C, Banovich N, Behrsing H, Dean C, Haak A, Gosens R, Kaminski N, Zagorska A, Koziol-White C, Metcalf J, Kim Y, Loebel C, Neptune E, Noel A, Raghu G, Sewald K, Sharma A, Suki B, Sperling A, Tatler A, Turner S, Rosas I, van Ry P, Wille T, Randell S, Pryhuber G, Rojas M, Bourke J, Königshoff M. Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2024, 72: 16-31. PMID: 39499861, PMCID: PMC11707673, DOI: 10.1165/rcmb.2024-0479st.Peer-Reviewed Original ResearchPrecision cut lung slicesClinically relevant readoutsDevelopment of tailored therapiesChronic lung diseaseLung disease patientsClinical metadataPatient endotypesPreclinical platformTailored therapyLung diseasePulmonary medicineEffective treatmentLung slicesDisease patientsRelevant readoutsMultiomics analysisPatientsLung researchEndotypesTherapy
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply