2025
The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsLow Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility
Mollon J, Schultz L, Knowles E, Jacquemont S, Glahn D, Almasy L. Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility. Biological Psychiatry 2025 PMID: 40113122, DOI: 10.1016/j.biopsych.2025.03.006.Peer-Reviewed Original ResearchAlcohol use disorderPolygenic risk scoresSchizophrenia polygenic risk scoresPercentage of individualsHigh riskDepressive disorderLack of clinical utilityUse disorderValidity of polygenic risk scoresSchizophreniaClinical utilityMDDRisk scoreEffect sizeSNP effect sizesWhite British individualsDisordersHigh-risk individualsUK BiobankType 2 diabetesBritish individualsPRS-CSIndividualsT2DPsychiatryMendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis
Cornejo-Sanchez D, Bharadwaj T, Dong R, Wang G, Schrauwen I, DeWan A, Leal S. Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis. European Journal Of Human Genetics 2025, 1-10. PMID: 40055553, DOI: 10.1038/s41431-025-01789-x.Peer-Reviewed Original ResearchRare-variantsHearing loss genesAssociated with HLNon-syndromicAssociation analysisHL geneHearing phenotypeUK BiobankMinor allele frequencyOlder adultsSensorineural disorderARHLEffect sizeWhite EuropeansAssociated with genesAge-relatedIn silico analysisAnalysis of variantsExome dataAssociationGenes i.Allele frequenciesHLGenesPresbycusisThe case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interactionConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthRepresenting brain-behavior associations by retaining high-motion minoritized youth
Ramduny J, Uddin L, Vanderwal T, Feczko E, Fair D, Kelly C, Baskin-Sommers A. Representing brain-behavior associations by retaining high-motion minoritized youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39921132, DOI: 10.1016/j.bpsc.2025.01.014.Peer-Reviewed Original ResearchBrain-behavior associationsFunctional MRIAdolescent Brain Cognitive Development<sup>SM<Effect sizeHispanic youthInternalizing psychopathologyCognitive performanceParticipant sexFunctional connectivityFMRI dataMinoritized individualsWhite youthHead motionMinoritized youthYouthSources of noisePsychopathologyDiverse populationsRacial/ethnic groupsAssociationPartial Spearman rank correlationsAdolescentsDisproportionate numberEvaluating the Bias, type I error and statistical power of the prior Knowledge-Guided integrated likelihood estimation (PIE) for bias reduction in EHR based association studies
Jing N, Lu Y, Tong J, Weaver J, Ryan P, Xu H, Chen Y. Evaluating the Bias, type I error and statistical power of the prior Knowledge-Guided integrated likelihood estimation (PIE) for bias reduction in EHR based association studies. Journal Of Biomedical Informatics 2025, 163: 104787. PMID: 39904407, DOI: 10.1016/j.jbi.2025.104787.Peer-Reviewed Original ResearchConceptsType I errorIntegrated likelihood estimatorsElectronic health recordsUse-case analysisLikelihood estimationLow prevalence outcomesUse-casesBias reductionNaive methodEffect sizeSynthetic dataPhenotyping algorithmsEstimation biasReal-world scenariosStatistical inferenceSimulation studyAssociation effect sizesAccurate prior informationBinary outcomesPoint estimatesAssociation estimatesStatistical powerHealth recordsKnowledge-guidedOutcome prevalenceCorrelates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder
Havlik J, Rhee T, Rosenheck R. Correlates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 39836166, DOI: 10.1037/tra0001846.Peer-Reviewed Original ResearchImpaired sleep durationStress disorderSleep durationEffect sizePosttraumatic stress disorderClinically meaningful effect sizesNational Epidemiologic SurveyMeaningful effect sizesPsychiatric multimorbidityPTSDTrauma/PTSDImprove treatment outcomesMedical comorbiditySleep disturbanceImpaired sleepBehavioral variablesTreatment outcomesAllostatic loadNationally representative sampleAdjusted multivariable regressionEpidemiological surveyDisordersBody mass indexRepresentative sampleSleepPreliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial
O’Malley S, Miranda R, Book S, Chun T, Liss T, Malcolm R, Muvvala S, Padovano H, Schacht J, Blackburn B, Diamond I, Ransom J, Ryan M, Falk D, Litten R. Preliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial. Alcohol And Alcoholism 2025, 60: agaf001. PMID: 39829301, PMCID: PMC11744046, DOI: 10.1093/alcalc/agaf001.Peer-Reviewed Original ResearchAlcohol use disorderAldehyde dehydrogenase 2 inhibitorUse disorderTreat alcohol use disorderCue reactivity sessionsCue-elicited cravingCue-induced cravingHuman laboratory studiesTreatment-seeking adultsAlcohol use disorder pharmacotherapiesAldehyde dehydrogenase 2Multisite clinical trialDose to placeboWeeks of medicationEffect size estimatesReactivation sessionDrinking outcomesGroup differencesCravingMeasured 1 weekEffect sizeCohen's dDouble-blindPreliminary effectivenessAlcohol consumptionBeyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences.
DeYoung C, Hilger K, Hanson J, Abend R, Allen T, Beaty R, Blain S, Chavez R, Engel S, Feilong M, Fornito A, Genç E, Goghari V, Grazioplene R, Homan P, Joyner K, Kaczkurkin A, Latzman R, Martin E, Nikolaidis A, Pickering A, Safron A, Sassenberg T, Servaas M, Smillie L, Spreng R, Viding E, Wacker J. Beyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences. Journal Of Cognitive Neuroscience 2025, 1-12. PMID: 39792657, DOI: 10.1162/jocn_a_02297.Peer-Reviewed Original ResearchIndividual differencesNeuroimaging researchEffect sizeStable individual differencesBetween-person effectsNeuroimaging tasksNeuroimaging studiesFocal hypothesisIncreased effect sizePsychological measuresBehavioral constructsSample sizeTheoretical matchingMultivariate approachUnivariate approachNeurobiologyCognitionNeuroimagingEmotionsIndividualsNeuroscienceBrainDifferencesTaskParticipantsQuantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study
Terry-Lorenzo R, Albrecht D, Crouch S, Wong R, Loewen G, Giri N, Skor H, Lin K, Sandiego C, Pajonas M, Rabiner E, Gunn R, Russell D, Haubenberger D. Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study. Neuropsychopharmacology 2025, 1-9. PMID: 39757283, DOI: 10.1038/s41386-024-02046-3.Peer-Reviewed Original ResearchVesicular monoamine transporter type 2Treatment of tardive dyskinesiaPositron emission tomographyVesicular monoamine transporter type 2 inhibitorsTarget occupancyTreatment of chorea associated with Huntington's diseaseTreatment of TDChorea associated with Huntington's diseaseCentral nervous systemTardive dyskinesiaVMAT2 inhibitorsValbenazineClinical developmentEffect sizeAssociated with efficacyPET studiesEmission tomographyGold standard biomarkerDosing regimensClinical benefitDaily doseHuntington's diseaseActive metabolitePlasma concentrationsAcceptable dose
2024
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz L, Knowles E, Cox S, Porteous D, Davies G, Redmond P, Harris S, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer S, Sebat J, Almasy L, Glahn D, Jacquemont S. Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genomics 2024, 4: 100721. PMID: 39667348, PMCID: PMC11701252, DOI: 10.1016/j.xgen.2024.100721.Peer-Reviewed Original ResearchConceptsCopy-number variantsGenome-wide association studiesAssociation studiesCognitive abilitiesBiological processesEffect of gene dosageNeurodevelopmental disordersAssociated with cognitionHigher cognitive performanceGene dosageGene setsAssociated with higher cognitive performanceCognitive performanceGenesCell typesEffect sizeCognitionDeletionDuplicationDisordersNon-brain tissuesMedical comorbiditiesAbilityVariantsBrainMultimodal interpersonal synchrony: Systematic review and meta-analysis
Ohayon S, Gordon I. Multimodal interpersonal synchrony: Systematic review and meta-analysis. Behavioural Brain Research 2024, 480: 115369. PMID: 39653120, DOI: 10.1016/j.bbr.2024.115369.Peer-Reviewed Original ResearchBehavioral synchronySignificant medium effect sizeEffect sizeMultimodal integrationMedium effect sizeSmall effect sizesBrain regionsInterpersonal synchronyPhysiological synchronyFrontocentral regionsMeta-analysisSocial experienceHuman dyadsParticipantsFuture inquiriesSynchronySystematic reviewReport dataUnique aspectDyadsBrainPsycINFOSample sizeAssociationTheoretical frameworkLow Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy
Meisner J, Renberg A, Smith E, Tsan Y, Elder B, Bullard A, Merritt O, Zheng S, Lakdawala N, Owens A, Ryan T, Miller E, Rossano J, Lin K, Claggett B, Ashley E, Michels M, Lampert R, Stendahl J, Abrams D, Semsarian C, Parikh V, Wheeler M, Ingles J, Olivotto I, Day S, Saberi S, Russell M, Previs M, Ho C, Ware J, Helms A. Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy. Circulation 2024, 151: 783-798. PMID: 39633578, PMCID: PMC11913586, DOI: 10.1161/circulationaha.124.069398.Peer-Reviewed Original ResearchPathogenic sarcomeric variantsOvert hypertrophic cardiomyopathySarcomere variantsHypertrophic cardiomyopathyGeneral populationSarcomeric genesCardiac magnetic resonance imaging analysisSarcomeric Human Cardiomyopathy RegistryInduced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesAssociated with disease severityDisease severityCardiac magnetic resonance imaging dataCell-derived cardiomyocytesMagnetic resonance imaging analysisMild hypertrophic cardiomyopathyIncreased disease severityCardiomyopathy RegistryDisease riskClinical outcomesAdverse eventsSignificant additive effectsEffect sizePolygenic contributionThe role of epistemic trust and epistemic disruption in vaccine hesitancy, conspiracy thinking and the capacity to identify fake news
Tanzer M, Campbell C, Saunders R, Booker T, Luyten P, Fonagy P. The role of epistemic trust and epistemic disruption in vaccine hesitancy, conspiracy thinking and the capacity to identify fake news. PLOS Global Public Health 2024, 4: e0003941. PMID: 39630644, PMCID: PMC11616851, DOI: 10.1371/journal.pgph.0003941.Peer-Reviewed Original ResearchEpistemic trustField of developmental psychopathologyExposure to childhood adversityFake newsConspiracy thinkingDevelopmental psychopathologyChildhood adversityInterpersonal processesPsychological resilienceSocial functioningConspiracy beliefsEffect sizeEpistemic disruptionPsychopathologyNewsCredulityConspiracyEnhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design
Duarte I, Hoffmann M, Salum G, Leffa D, Belangero S, Santoro M, Ota V, Ito L, Pan P, Farhat L, Murray A, Miguel E, Kieling C, Rohde L, Caye A. Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 39625683, DOI: 10.1007/s00787-024-02622-4.Peer-Reviewed Original ResearchNeurobiological measuresADHD polygenic scoresBrazilian High-Risk CohortAttention-deficit/hyperactivity disorderPoorer executive functionPolygenic scoresADHD symptomsExecutive functionHigh-risk subgroupsAttention-deficit/hyperactivitySubcortical volumesHigh-risk cohortMental disordersADHD casesEffect sizeADHDMental conditionDifferential riskClinical practiceRisk cohortBiomarkers to clinical practiceLow-risk groupCalculated riskParticipantsAdolescentsMinimal Variation in Functional Connectivity in Relation to Daily Affect
Godfrey K, Rai S, Graff K, Yin S, Merrikh D, Tansey R, Vanderwal T, Harris A, Bray S. Minimal Variation in Functional Connectivity in Relation to Daily Affect. ENeuro 2024, 11: eneuro.0209-24.2024. PMID: 39592226, PMCID: PMC11680495, DOI: 10.1523/eneuro.0209-24.2024.Peer-Reviewed Original ResearchAffective disorder symptomsFunctional connectivityBrain functional connectivityDaily affectDisorder symptomsEffect sizeDay-to-day affectFunctional magnetic resonance imagingNetwork-level functional connectivityBetween-network connectivityWithin-network connectivityNon-clinical cohortPassive viewing conditionsParticipants self-reportedDorsal attentionPANAS-XIndividual differencesSubcortical regionsMultiple sessionsVisual networkSelf-reportAffectResearchers planning studiesConnectivity patternsMagnetic resonance imagingDisparities in Receipt of Medications for Opioid Use Disorder Before and During the COVID-19 Pandemic in the US Veterans Health Administration
Sung M, León C, Reisman J, Gordon K, Kerns R, Li W, Liu W, Mitra A, Yu H, Becker W. Disparities in Receipt of Medications for Opioid Use Disorder Before and During the COVID-19 Pandemic in the US Veterans Health Administration. Substance Use & Addiction Journal 2024, 46: 369-376. PMID: 39569566, DOI: 10.1177/29767342241293334.Peer-Reviewed Original ResearchMOUD receiptElixhauser Comorbidity IndexOpioid use disorderSocial determinants of healthVeterans Health Administration electronic health record dataElectronic health record dataUS Veterans Health AdministrationDeterminants of healthVeterans Health AdministrationHealth record dataProportion of veteransReceipt of medicationsSubstance useComorbidity indexTargeted outreach effortsUse disorderCOVID-19 pandemicProportion of patientsSocial determinantsReceipt of MOUDHealth AdministrationRecord dataEffect sizeMOUD engagementCalculated proportionsCross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages
Castro-Calvo J, Beltrán-Martínez P, Ballester-Arnal R, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Chen L, Ciocca G, Corazza O, Csakó R, Fernandez D, Fernandez E, Fujiwara H, Fuss J, Gabrhelík R, Gewirtz-Meydan A, Gjoneska B, Gola M, Grubbs J, Hashim H, Hsieh Y, Islam S, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee S, Lewczuk K, Lin C, Lochner C, Lopez-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosova O, Orosz G, Team S, Ponce F, Quintana G, Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Štulhofer A, Ünsal B, Vaillancourt-Morel M, Van Hout M, Bőthe B. Cross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages. The Journal Of Sex Research 2024, ahead-of-print: 1-14. PMID: 39560207, DOI: 10.1080/00224499.2024.2417023.Peer-Reviewed Original ResearchSexual Desire InventorySexual desireDesire InventorySDI-2Non-clinical sampleMeasurement invariance testingPsychometrically robust measureSexuality-related variablesConfirmatory factor analysisGroup-based differencesCross-cultural validitySexual orientationCross-cultural studiesPsychometric propertiesInvariance testingEffect sizeFactor analysisWell-beingExpression of sexual desireWeak-to-moderateSexual functionInventorySex surveysLanguageDesire
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