2025
Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score?
Munoz-Acuna R, Charchaflieh J, Deshpande R. Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score? Obstetric Anesthesia Digest 2025, 45: 19-20. DOI: 10.1097/01.aoa.0001097560.30255.cc.Peer-Reviewed Original ResearchUltrasound scoreVenous excess ultrasound scoreVenous hemodynamic dysfunctionVolume overloadPulmonary edemaCardiac functionHemodynamic dysfunctionEndothelial dysfunctionVenous disordersTailored treatmentCapillary permeabilityMultisystem conditionPreeclampsiaDysfunctionScoresEdemaVExUSPathophysiologyMultisystem8 Pathology of the endothelium
Eghrari A, Fliotsos M. 8 Pathology of the endothelium. 2025, 104-116. DOI: 10.1016/b978-0-443-12046-6.00017-0.Peer-Reviewed Original Research
2024
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell'Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. PMID: 39768092, PMCID: PMC11672977, DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficientStructural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases
Zhao Y, Schubert H, Blakely A, Forbush B, Smith M, Rinehart J, Cao E. Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nature Communications 2024, 15: 7006. PMID: 39143061, PMCID: PMC11324901, DOI: 10.1038/s41467-024-51381-y.Peer-Reviewed Original ResearchConceptsNa+-Cl- cotransporterFamilial hyperkalemic hypertensionRenal salt retentionThiazide diuretic drugsNa+-Cl-Cotransporter inhibitionNCC activitySalt reabsorptionDiuretic drugsBlood pressureBalanced electrolyteTreat hypertensionIon translocation pathwayIon translocationThiazideHypertensionSalt retentionOrthosteric siteCo-structureCarboxyl-terminal domainKinase cascadeEdemaChlorthalidoneCotransporterTranslocationCerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey
Greige T, Tao B, Dangayach N, Gilmore E, O’Hana Nobleza C, Hinson H, Chou S, Jha R, Wahlster S, Gebrewold M, Lele A, Ong C. Cerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey. Neurocritical Care 2024, 42: 207-221. PMID: 39085504, PMCID: PMC11782636, DOI: 10.1007/s12028-024-02077-0.Peer-Reviewed Original ResearchCerebral edemaPractice variationLife-threatening complicationsAttending physiciansFactors associated with practice variationFisher's exact testCritically ill patientsUniversity-affiliated centerAcute brain injuryMonitoring cerebral edemaOsmotic therapyExact testDecompressive hemicraniectomyBackgroundCerebral edemaRadiographic findingsTreatment strategiesIll patientsRadiographic indicatorsPractice patternsUniversity affiliationEdemaSociety web sitesLogistic regressionProvider preferencesPractice survey
2023
The Pulsating Stent Sign in May-Thurner Syndrome.
Attaran R, Jamil Y. The Pulsating Stent Sign in May-Thurner Syndrome. Journal Of Endovascular Therapy 2023, 15266028231219673. PMID: 38115161, DOI: 10.1177/15266028231219673.Peer-Reviewed Original ResearchMay-Thurner syndromeVenous stentsIntravascular ultrasoundExtrinsic compressionRight iliac veinExternal iliac arteryCalf edemaArterial compressionIliac veinStent patencyEndovenous stentingIliac arteryLimb edemaRight thighAdjacent arteriesStent deploymentPsoas muscleSignificant resolutionStent expansionExternal compressionArteryStentsEdemaPatientsSyndromeReport from the 2023 workshop on endothelial permeability, edema and inflammation
Vestweber D, Claesson-Welsh L, McDonald D, Williams T, Schwartz M, Scallan J, Gavins F, van Buul J, Gamble J, Vadas M, Annex B, Messe S, Perretti M, André H, Ferrara N, Hla T, Nourshargh S, Simons M. Report from the 2023 workshop on endothelial permeability, edema and inflammation. Nature Cardiovascular Research 2023, 2: 1120-1124. PMID: 39196154, DOI: 10.1038/s44161-023-00385-w.Peer-Reviewed Original ResearchPACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study
Kaur M, Petersen G, Jekel L, von Reppert M, Varghese S, de Oliveira Santo I, Avesta A, Aneja S, Omuro A, Chiang V, Aboian M. PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study. Cancers 2023, 15: 4822. PMID: 37835516, PMCID: PMC10571649, DOI: 10.3390/cancers15194822.Peer-Reviewed Original ResearchPost-SRTStereotactic radiotherapyLung cancer brain metastasesCancer brain metastasesPost-contrast T1-weighted imagesSignificant clinical symptomsContrast-enhancing tumorT1-weighted imagesCritical additional informationEdema changesBrain metastasesClinical symptomsCare treatmentHyperintense volumeEdema assessmentLesion changesLesion sizeEdemaDifferent timepointsPilot studyRadiotherapyLesionsVolumetric changesAdditional informationMETSPersistence of Atypical Femoral Fracture 14 Years After Initial Diagnosis
Gerber B, Gibbons K, Egol K. Persistence of Atypical Femoral Fracture 14 Years After Initial Diagnosis. JBJS Case Connector 2023, 13: e23.00308. PMID: 37683075, DOI: 10.2106/jbjs.cc.23.00308.Peer-Reviewed Original ResearchConceptsAtypical femur fracturesManagement of atypical femur fracturesFemur fracturesIncomplete atypical femur fracturesChronic medical conditionsDeclined surgical interventionInitial surgical managementAtypical femoral fracturesRecurrence of painLeft thigh painPeriosteal edemaMagnetic resonance imagingBisphosphonate useMarrow edemaSurgical interventionMedical conditionsThigh painOriginal diagnosisSymptom improvementFemoral fracturesResonance imagingDiagnosisPainEdemaPatientsChronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy
Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaLow-dose radiation therapyPeriorbital edemaRadiation therapyChronic Lymphocytic Leukemia PresentingBilateral periorbital edemaLeukemia cutisOcular involvementOcular manifestationsPrompt diagnosisBlood dyscrasiasCase reportNeoplastic lymphocytesLymphocytic leukemiaTissue infiltrationTherapeutic interventionsEdemaPatientsTherapyLeukemiaInfiltrationEcchymosisPresentingDyscrasiasLymphocytesUltrasound Evaluation of Chronic Venous Insufficiency
Zalaquett E, Gunabushanam G, Vallejos A, Dahiya N. Ultrasound Evaluation of Chronic Venous Insufficiency. Ultrasound Quarterly 2023, 39: 2-9. PMID: 36651650, DOI: 10.1097/ruq.0000000000000634.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic venous insufficiencyVenous insufficiencyVenous systemLower extremity venous systemDeep venous systemExtent of refluxPreferred imaging modalityMild painValvular incompetenceVenous ulcersClinical presentationUltrasound evaluationVaricose veinsAppropriate treatmentRadiation-free mannerCommon conditionDoppler ultrasoundImaging modalitiesScanning protocolInsufficiencyRelevant findingsPainEdemaUlcersActionable reports
2022
Recurrent Periorbital Edema Associated With Retained Foreign Body After Filler Injection
Shoji M, Maeng M, Khzam R, Dubovy S, Johnson T. Recurrent Periorbital Edema Associated With Retained Foreign Body After Filler Injection. Ophthalmic Plastic And Reconstructive Surgery 2022, 39: e30-e33. PMID: 36700871, DOI: 10.1097/iop.0000000000002274.Peer-Reviewed Original ResearchConceptsForeign bodyFiller injectionMetallic foreign bodyRight upper cheekBilateral periorbital swellingPeriorbital swellingPeriorbital edemaVision lossSurgical explorationLower eyelidGranulomatous inflammationTender nodulesFacial fillersUpper cheekAesthetic proceduresInflammatory reactionSoft tissueComplicationsEdemaIron depositionInjectionInjection techniqueNIMG-07. APPLYING A GLIOMA-TRAINED DEEP LEARNING AUTO-SEGMENTATION TOOL ON BM PRE- AND POST-RADIOSURGERY
Kaur M, Varghese S, Jekel L, Tillmanns N, Merkaj S, Bousabarah K, Lin M, Bhawnani J, Chiang V, Aboian M. NIMG-07. APPLYING A GLIOMA-TRAINED DEEP LEARNING AUTO-SEGMENTATION TOOL ON BM PRE- AND POST-RADIOSURGERY. Neuro-Oncology 2022, 24: vii162-vii163. PMCID: PMC9660643, DOI: 10.1093/neuonc/noac209.626.Peer-Reviewed Original ResearchStereotactic radiosurgeryPosttreatment lesionsBoard-certified neuroradiologistsRoutine clinical useWhole tumorTumor coreMulticentric lesionsTreatment responsePeritumoral edemaBM preLesionsClinical useVolumetric segmentationEdemaPatientsT2w FLAIRTherapy planningTumorsDedicated trainingLesion detectionBM dataVolumetric measurementsBMMRIPreTreatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 634-636. DOI: 10.1097/01.ogx.0000899456.24100.71.Peer-Reviewed Original ResearchHypertension During PregnancyAcute kidney injuryAdverse neonatal outcomesChronic hypertensionKidney injuryMaternal outcomesNeonatal outcomesPlacental abruptionPreterm birthHeart failureMaternal deathsGestational agePerinatal deathPulmonary edemaPregnancyBlack womenDeathOutcomesHypertensionAbruptionPreeclampsiaEdemaInjuryStrokeWomenSingle brain metastasis versus glioblastoma multiforme: a VOI-based multiparametric analysis for differential diagnosis
Romano A, Moltoni G, Guarnera A, Pasquini L, Di Napoli A, Napolitano A, Espagnet M, Bozzao A. Single brain metastasis versus glioblastoma multiforme: a VOI-based multiparametric analysis for differential diagnosis. La Radiologia Medica 2022, 127: 490-497. PMID: 35316518, PMCID: PMC9098536, DOI: 10.1007/s11547-022-01480-x.Peer-Reviewed Original ResearchConceptsArea under the curveReceiver operating characteristicSolitary BMBrain metastasesDifferential diagnosisPerfusion curvesMultiparametric MRI modelValues of rCBVSingle brain metastasisSolitary brain metastasisMethodsForty-one patientsReceiver operating characteristic analysisEnhancing tumorValues of ADCResidual edemaRCBV valuesPeritumoral edemaPerilesional edemaTwo-sample t-testMethodsForty-oneCerebral edemaBM groupGlioblastoma multiformeEdemaROC curveImaging biomarkers for diagnosis and treatment response in patients with lymphedema
Maita K, Garcia JP, Torres RA, Avila FR, Kaplan JL, Lu X, Manrique OJ, Ciudad P, Forte AJ. Imaging biomarkers for diagnosis and treatment response in patients with lymphedema. Biomarkers In Medicine 2022, 16: 303-316. PMID: 35176878, DOI: 10.2217/bmm-2021-0487.Peer-Reviewed Original Research
2021
Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management
Hampson K, Gay M, Band M. Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management. Nutrition In Clinical Practice 2021, 36: 331-343. PMID: 33469930, DOI: 10.1002/ncp.10622.Peer-Reviewed Original ResearchConceptsNephrotic syndromeSteroid-refractory diseaseLong-term complicationsSteroid-sparing therapiesMetabolic bone diseaseCommon kidney diseaseSodium restrictionFrequent relapsesMost patientsCalcineurin inhibitorsDietary modificationKidney diseaseGlomerular filtrationNutrition interventionsBone diseaseAppropriate managementNutrition cliniciansNutrition managementDiseaseMicronutrient deficienciesEdemaPatientsSyndromeSerious casesTherapy
2020
Sodium‐Glucose Cotransporter 2 Inhibitors Ameliorate Ascites and Peripheral Edema in Patients With Cirrhosis and Diabetes
Montalvo‐Gordon I, Chi‐Cervera L, García‐Tsao G. Sodium‐Glucose Cotransporter 2 Inhibitors Ameliorate Ascites and Peripheral Edema in Patients With Cirrhosis and Diabetes. Hepatology 2020, 72: 1880-1882. PMID: 32294260, DOI: 10.1002/hep.31270.Peer-Reviewed Original ResearchTalar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases.
Kohring JM, Oh I, Baumhauer JF. Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases. JBJS Case Connector 2020, 10: e19.00389. PMID: 32649148, DOI: 10.2106/jbjs.cc.19.00389.Peer-Reviewed Original ResearchConceptsCalcium phosphate injectionBone marrow lesionsAvascular necrosisMarrow lesionsExtensive avascular necrosisBone marrow edemaTalar avascular necrosisPoor patient outcomesPhosphate injectionEquivocal improvementPatient's symptomsMarrow edemaPatient outcomesInjection treatmentAnkle jointPatientsLesionsNecrosisPoor qualityOutcomesTreatmentInjectionAvailable researchSubchondroplastyEdemaGenetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery
Kirsch E, Szejko N, Falcone GJ. Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery. Neuroscience Letters 2020, 730: 135046. PMID: 32464484, PMCID: PMC7372633, DOI: 10.1016/j.neulet.2020.135046.Peer-Reviewed Original ResearchConceptsAcute brain injuryCerebral edemaBrain injuryEdema formationIntracerebral hemorrhageWorse outcomesBlood-brain barrier disruptionSecondary brain injuryBrain edema formationTraumatic brain injuryApolipoprotein E geneSecondary injuryBarrier disruptionVasogenic edemaCytotoxic edemaInflammatory processUseful intermediate phenotypeEdemaTherapeutic targetAquaporin-4Haptoglobin geneInjuryHp 2Novel susceptibility genesNon-white populations
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