2025
Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver. NMR In Biomedicine 2025, 38: e70014. PMID: 39994887, DOI: 10.1002/nbm.70014.Peer-Reviewed Original ResearchConceptsH-MRSHepatic DNLMRS dataLiver tissueMeasurement of lipogenesisDietary interventionLiver lipidsHepatic de novo lipogenesisLow density lipoproteinDetection of deuteriumGold standard measureMetabolic diseasesIncreased hepatic DNLLiverDensity lipoproteinDrinking waterDeuterium labelingIn vivo measurementsNMR dataExcised liver tissueTissueDeuteriumMRSMethylene resonancesDeuterated waterProtective effects of flavonoids on fluoride-induced testicular DNA damage in mice
Zhang D, Li M, shi T, Wang J, Zhao H, Li H, Zhao Y, Wang J, Wang J. Protective effects of flavonoids on fluoride-induced testicular DNA damage in mice. Free Radical Biology And Medicine 2025, 228: 79-92. DOI: 10.1016/j.freeradbiomed.2024.12.047.Peer-Reviewed Original ResearchInhibition of NHEJ repairTesticular DNA damageExpression of apoptosis-related genesMale reproductive toxicityEnvironmental contaminationEnhanced DNA repairIncreased antioxidant enzyme activitiesAntioxidant enzyme activitiesDNA damageVitamin C supplementationMale reproductive systemApoptosis-related genesFluoride-exposed miceDNA repair pathwaysReproductive toxicityProtective effects of flavonoidsDrinking waterSemen qualityReduced DNA damageEffects of flavonoidsC supplementationFlavonoidsDNA repairHR repairRepair pathways
2024
Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California
Smalling K, Romanok K, Bradley P, Hladik M, Gray J, Kanagy L, McCleskey R, Stavreva D, Alexander-Ozinskas A, Alonso J, Avila W, Breitmeyer S, Bustillo R, Gordon S, Hager G, Jones R, Kolpin D, Newton S, Reynolds P, Sloop J, Ventura A, Von Behren J, Ward M, Solomon G. Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California. Water Research 2024, 267: 122485. PMID: 39368187, DOI: 10.1016/j.watres.2024.122485.Peer-Reviewed Original ResearchImprove water qualityHuman health concernsDrinking waterWater quality challengesDrinking-water sourcesHuman health outcomesDrinking water supplyContaminant exposureFrequent exceedancesHazard indexOrganic chemicalsMixture exposurePublic water systemsWater qualityHealth advisoriesMultiple exceedancesHealth risksHuman healthYears of droughtData gapsDrinking-waterContaminationClimate changeCentral ValleyTapwater samplesCYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesNitrate exposure from drinking water and dietary sources among Iowa farmers using private wells
Skalaban T, Thompson D, Madrigal J, Blount B, Espinosa M, Kolpin D, Deziel N, Jones R, Beane Freeman L, Hofmann J, Ward M. Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells. The Science Of The Total Environment 2024, 919: 170922. PMID: 38350573, PMCID: PMC11665930, DOI: 10.1016/j.scitotenv.2024.170922.Peer-Reviewed Original ResearchConceptsMaximum contaminant levelUrinary nitrate concentrationDietary intakeNitrate concentrationsNitrate excretionNitrate exposureDietary nitrateDrinking waterDietary assessment toolsPrivate wellsAssociated with adverse health risksVulnerable to nitrate contaminationWater nitrate concentrationsNitrate ingestionAdverse health risksAgricultural Health StudyDrinking water intakeMedian intakeProspective cohortUrinary nitrateDietary nitrate ingestionContamination levelsNitrate contaminationNitrate intakeHealth Study
2023
Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
Liew Z, Meng Q, Yan Q, Schullehner J, Hansen B, Kristiansen S, Voutchkova D, Olsen J, Ersbøll A, Ketzel M, Raaschou-Nielsen O, Ritz B. Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark. Obstetrical & Gynecological Survey 2023, 78: 713-715. DOI: 10.1097/ogx.0000000000001228.Peer-Reviewed Original ResearchLong-term exposure to arsenic in drinking water and risk of cardiovascular diseases among women living in California
Medgyesi D, Spielfogel E, Bangia K, Acien A, Madrigal J, Fisher J, Jones R, Ward M, Lacey J, Sanchez T. Long-term exposure to arsenic in drinking water and risk of cardiovascular diseases among women living in California. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.ep-046.Peer-Reviewed Original ResearchLong-term exposureDrinking water
2021
Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach
Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicological Sciences 2021, 183: 338-351. PMID: 33693819, PMCID: PMC8921626, DOI: 10.1093/toxsci/kfab030.Peer-Reviewed Original ResearchConceptsDX exposureBile acid quantificationRepair responseBDF-1 miceDNA damageDose-dependent DNA damageEffects of exposureHistopathological studySubchronic exposureImmunohistochemical analysisLiver carcinogenLiver carcinogenicityLiver transcriptomicsDrinking waterMetabolomic profilingMicePotential mechanismsLiverEnvironmental chemicalsState maximum contaminant levelToxic effectsCell deathExposureOxidative stress responsePresent study
2020
Comparing spatial exposure surrogates with detections and concentrations of unconventional oil and gas-related chemicals in residential drinking water
Clark C, Xiong B, Gutchess K, Ryan E, Siegel H, Cassell K, Soriano Jr M, Elliott E, Li Y, Brenneis R, Plata D, Saiers J, Deziel N. Comparing spatial exposure surrogates with detections and concentrations of unconventional oil and gas-related chemicals in residential drinking water. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1263.Peer-Reviewed Original ResearchMagnetically recoverable carbon-coated iron carbide with arsenic adsorptive removal properties
Powell C, Guo S, Godret-Miertschin L, Ventura K, Lounsbury A, Clark C, Villagran D, Zimmerman J, Atkinson A, Westerhoff P, Wong M. Magnetically recoverable carbon-coated iron carbide with arsenic adsorptive removal properties. Discover Applied Sciences 2020, 2: 1690. DOI: 10.1007/s42452-020-03491-7.Peer-Reviewed Original ResearchIron carbideAdsorptive removal propertiesSimulated drinking waterContinuous flow conditionsMagnetic recoverabilityGraphic abstractAMagnetic separabilityChemical stabilityAdsorptive propertiesAdsorption capacityMagnetic removalWater contaminantsGraphitic shellsRemoval propertiesArsenic removalFe3O4Material integrityMagnetic saturationMagnetic particlesCarbideMagnetic characteristicsDrinking waterContaminantsWaterExperimental results
2018
Phthalate Exposure from Drinking Water in Romanian Adolescents
Sulentic RO, Dumitrascu I, Deziel NC, Gurzau AE. Phthalate Exposure from Drinking Water in Romanian Adolescents. International Journal Of Environmental Research And Public Health 2018, 15: 2109. PMID: 30257478, PMCID: PMC6209931, DOI: 10.3390/ijerph15102109.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsChronic low-level exposureAdverse health outcomesLow-level exposureDifferent exposure measuresPhthalate exposurePhthalate metabolitesMunicipal drinking waterUrinary metabolitesHealth outcomesSignificant associationHigher maximum concentrationUrine samplesConsumer product usePotential health risksAdolescent groupExposure sourcesExposure measuresDrinking waterExposure determinantsProduct useMetabolite concentrations
2016
A systematic evaluation of chemicals in hydraulic-fracturing fluids and wastewater for reproductive and developmental toxicity
Elliott EG, Ettinger AS, Leaderer BP, Bracken MB, Deziel NC. A systematic evaluation of chemicals in hydraulic-fracturing fluids and wastewater for reproductive and developmental toxicity. Journal Of Exposure Science & Environmental Epidemiology 2016, 27: 90-99. PMID: 26732376, DOI: 10.1038/jes.2015.81.Peer-Reviewed Original ResearchConceptsWater quality standardsFederal water quality standardsQuality standardsHuman health impactsNatural gas developmentEnvironmental concentrationsHundreds of substancesDevelopmental toxicityReprotox databasesHuman exposureToxicity informationGas developmentExposure assessmentIncorporation of dataHealth StudyHealth impactsSystematic screening approachHydraulic-fracturing fluidsChemical Abstract Service Registry NumbersCandidate analytesChemicalsDrinking waterLikely etiologic agentWastewaterUnconventional oil
2015
Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka
Jayasumana C, Paranagama P, Agampodi S, Wijewardane C, Gunatilake S, Siribaddana S. Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka. Environmental Health 2015, 14: 6. PMID: 25596925, PMCID: PMC4417209, DOI: 10.1186/1476-069x-14-6.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseHigh riskImportant public health issueResultsMajority of patientsCase-control studyPublic health issueMultivariable analysisUnknown etiologyEntry criteriaRisk factorsEffect modificationHigh prevalenceOccupational exposureEndemic areasDrinking waterCKDu patientsControl studyPersonnel protective equipmentProtective equipmentHealth issuesPatientsHospitalMale farmersCKDu
2013
Blood pressure hyperreactivity
Kunrath J, Gurzau E, Gurzau A, Goessler W, Gelmann ER, Thach TT, McCarty KM, Yeckel CW. Blood pressure hyperreactivity. Journal Of Hypertension 2013, 31: 361-369. PMID: 23203141, PMCID: PMC3542419, DOI: 10.1097/hjh.0b013e32835c175f.Peer-Reviewed Original ResearchConceptsBlood pressure hyperreactivityBlood pressure recoveryHypertensive responseUnexposed groupMiddle-aged menCold pressor testInorganic arsenic exposureInorganic arsenicCardiovascular stress reactivityNormotensive menBlood pressureEssential hypertensionHypertension riskPressor testHyperreactivityChronic exposureArsenic exposureArsenic-endemic regionEarly signsStress-induced changesFunctional evaluationUrine samplesDrinking waterStress reactivityGreater probability
2012
Relationship between Use of Water from Community-Scale Water Treatment Refill Kiosks and Childhood Diarrhea in Jakarta
Sima LC, Desai MM, McCarty KM, Elimelech M. Relationship between Use of Water from Community-Scale Water Treatment Refill Kiosks and Childhood Diarrhea in Jakarta. American Journal Of Tropical Medicine And Hygiene 2012, 87: 979-984. PMID: 23128290, PMCID: PMC3516100, DOI: 10.4269/ajtmh.2012.12-0224.Peer-Reviewed Original Research
2010
Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence
Heath CJ, Horst NK, Picciotto MR. Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. Physiology & Behavior 2010, 101: 764-769. PMID: 20826170, PMCID: PMC2975773, DOI: 10.1016/j.physbeh.2010.08.021.Peer-Reviewed Original ResearchConceptsNicotine administrationMaternal behaviorNeuropharmacological effectsSignificant between-group differencesDrinking water administrationNicotine-exposed micePostnatal weight gainBetween-group differencesOral nicotine consumptionPersistent behavioral alterationsExposure-induced changesNursing miceTransient hyperactivityDrinking waterNicotine exposureEffects of exposureC57BL/6J miceHuman smokingBehavioral alterationsNicotine consumptionPassive nursingWeight gainMiceAdministrationMaternal care
1998
Effect of Heparin on Dextran Sulfate Sodium-Induced Colitis
Korzenik J, Hsu A, Robert M. Effect of Heparin on Dextran Sulfate Sodium-Induced Colitis. Digestive Diseases And Sciences 1998, 43: 1800-1805. PMID: 9724172, DOI: 10.1023/a:1018800207063.Peer-Reviewed Original ResearchConceptsBowel diseaseDextran Sulfate Sodium-Induced ColitisDextran sulfate-induced colitisSeverity of colitisSulfate-induced colitisInduction of colitisEffect of heparinMurine colitisSubcutaneous injectionWebster miceColitisHeparinized animalsHeparinAnticoagulant propertiesDiseaseMiceDextran sulfateOpposite effectSulfated polysaccharidesAnimalsDrinking waterSimilar pathwaysDosesSeverity
1992
Cancer of the Pancreas and Drinking Water: A Population-based Case-Control Study in Washington County, Maryland
IJsselmuiden C, Gaydos C, Feighner B, Novakoski W, Serwadda D, Caris L, Vlahov D, Comstock G. Cancer of the Pancreas and Drinking Water: A Population-based Case-Control Study in Washington County, Maryland. American Journal Of Epidemiology 1992, 136: 836-842. PMID: 1442749, DOI: 10.1093/aje/136.7.836.Peer-Reviewed Original Research
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