2025
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories.
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, jnumed.124.267927. PMID: 39947910, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokinetics
2024
Clinical use of Gafchromic EBT4 film for in vivo dosimetry for total body irradiation
Draeger E, Guan F, Lee M, Han D, Donahue W, Chen Z. Clinical use of Gafchromic EBT4 film for in vivo dosimetry for total body irradiation. Journal Of Applied Clinical Medical Physics 2024, 26: e14574. PMID: 39611814, PMCID: PMC11905243, DOI: 10.1002/acm2.14574.Peer-Reviewed Original ResearchOptically stimulated luminescence dosimetersIn vivo dosimetryTotal body irradiation patientsIon chamberThermoluminescent dosimetersDiode readingsDose measurementsFilm measurementsTotal body irradiationOSLD measurementsAccurate in vivo dosimetryExit dose measurementsSolid water phantomAccurate dose measurementsFilm calibration curvesWater phantomExit doseLuminescence dosimetersAccurate dosimetryMeasured entranceBody irradiationDosimetryTotal body irradiation conditioningDosimetersDiodesRadiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imaging
2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2016
SU‐F‐T‐325: On the Use of Bolus in Dosimetry and Dose Reduction for Pacemaker and Defibrillator
Liu W, Zhu D, Trumpore S, Kenneth R, Higgins S, Nath R, Chen Z. SU‐F‐T‐325: On the Use of Bolus in Dosimetry and Dose Reduction for Pacemaker and Defibrillator. Medical Physics 2016, 43: 3537-3538. DOI: 10.1118/1.4956510.Peer-Reviewed Original ResearchUse of bolusVivo dosimetryHigh-energy beamsWater phantom measurementsContaminant electronsNeutron productionParallel plate chamberDose measurementsHead leakagePlate ChambersTPS calculationElectronic devicesField doseDosimetryBeamRange of dosePhantom measurementsAccurate estimationDifferent depthsField edgeSurfaceSkin surfaceElectronsDeeper depthsDepth
2015
SU‐E‐J‐215: Towards MR‐Only Image Guided Identification of Calcifications and Brachytherapy Seeds: Application to Prostate and Breast LDR Implant Dosimetry
Elzibak A, Fatemi‐Ardekani A, Soliman A, Mashouf S, Safigholi H, Han D, Ravi A, Morton G, Song W. SU‐E‐J‐215: Towards MR‐Only Image Guided Identification of Calcifications and Brachytherapy Seeds: Application to Prostate and Breast LDR Implant Dosimetry. Medical Physics 2015, 42: 3315-3315. DOI: 10.1118/1.4924301.Peer-Reviewed Original ResearchBrachytherapy seedsLow dose rateImplant dosimetryPhase imagesAccurate organ delineationSusceptibility weighted imagingCorrected phase imagesMR-onlyAccurate dosimetryOrgan delineationSoft tissue contrastDose ratePhase noiseGel phantomDosimetryDipole effectAppearance of calcificationHead coilIdentification of calcificationsBrachytherapyMRI imagesMagnitude imagesMR scannerTissue contrastProstateTU‐AB‐201‐11: A Novel Theoretical Framework for MRI‐Only Image Guided LDR Prostate and Breast Brachytherapy Implant Dosimetry
Soliman A, Elzibak A, Fatemi A, Safigholi H, Han D, Ravi A, Morton G, Song W. TU‐AB‐201‐11: A Novel Theoretical Framework for MRI‐Only Image Guided LDR Prostate and Breast Brachytherapy Implant Dosimetry. Medical Physics 2015, 42: 3596-3596. DOI: 10.1118/1.4925549.Peer-Reviewed Original ResearchModel-based dose calculationsImplant dosimetryDose calculationMRI-onlyDose calculation methodologyPhase imagesInterseed attenuationTG-186Patient dosimetryDelineation uncertaintyMulti-modal registrationField inhomogeneitySeed implant brachytherapyDosimetryMass densitySusceptibility-weighted imagingImplant brachytherapyImage volumesMR signalTissue compositionMR imagingMRI acquisitionCalculationsQuantitative MRI acquisitionsProstate
2013
SU‐E‐T‐118: Small Dynamic Field Dosimetry by Gfachromic Film (EBT3) and 2D‐Array Diode
Chu A, Feng W, Lincoln H, Su F, Nath R. SU‐E‐T‐118: Small Dynamic Field Dosimetry by Gfachromic Film (EBT3) and 2D‐Array Diode. Medical Physics 2013, 40: 230-231. DOI: 10.1118/1.4814553.Peer-Reviewed Original ResearchFilm dosimetryField dosimetryChamber measurementsCentral axisAbsolute dose comparisonDynamic MLC fieldsVarian iX linacDiode arraySAD setupMLC fieldsSun NuclearIntrinsic buildupAbsolute doseFilm measurementsDose pointsDose comparisonDose valuesDosimetryDosimetersLow-doseEnergy-dependentSystematic noiseDose accuracyMapCHECKDiode performance
2007
Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain
Lim R, Fahey F, Drubach L, Connolly L, Treves S. Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain. Journal Of Pediatric Orthopaedics 2007, 27: 277-282. PMID: 17414009, DOI: 10.1097/bpo.0b013e31803409ba.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBack painYounger patientsPotential sources of back painSource of back painFluorine-18Evaluating young patientsRadiation dosimetryNaF PET scanEnhanced patient throughputPET scansApophyseal injuriesPainTechnetium-99Tracer administrationPatientsRadiation doseSkeletal abnormalitiesPET acquisitionEmission tomographySodium fluorideScintigraphyNinety-fourPatient throughputDosimetry
2006
2866 Optimal Timing of Conventional Post-Implant Dosimetry for Prostate Seed Implants Utilizing the New Cs-131 Radioactive Seeds and Effective Dose Compensation of Edema-Induced Dose Deficit
Chen Z, Deng J, Roberts K, Nath R. 2866 Optimal Timing of Conventional Post-Implant Dosimetry for Prostate Seed Implants Utilizing the New Cs-131 Radioactive Seeds and Effective Dose Compensation of Edema-Induced Dose Deficit. International Journal Of Radiation Oncology • Biology • Physics 2006, 66: s699-s700. DOI: 10.1016/j.ijrobp.2006.07.1285.Peer-Reviewed Original ResearchEvaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams
Ahmad M, Chen Z, Song H, Deng J, Nath R. Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams. Radiation Protection Dosimetry 2006, 120: 159-162. PMID: 16644932, DOI: 10.1093/rpd/ncj006.Peer-Reviewed Original ResearchConceptsEDR-2 filmsElectron beamRelative dosimetryHigh-energy photonsClinical radiation dosimetryDose profilesPhotonsRadiation dosimetryBeamDose distributionRadiographic filmsSensitometric studyFilmsDosimetryTreatment planning techniquesElectronsDiodesSymmetryKVFlatnessPlanning techniquesDistribution
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