2025
Microbiome's Effect on White Matter in Autism
Canada K, Evans T, Pelphrey K. Microbiome's Effect on White Matter in Autism. Journal Of Neurophysiology 2025 PMID: 39998297, DOI: 10.1152/jn.00607.2024.Peer-Reviewed Original ResearchAutism spectrum disorderCore ASD symptomsAutism spectrum disorder managementRepetitive behavior patternsBrain imaging dataWhite matter developmentDiffusion tensor imagingNeuroimaging studiesSymptom severitySpectrum disorderGut-brain axisSocial skillsLanguage acquisitionSensory processingSocial communicationBidirectional relationshipOligodendrocyte functionTensor imagingShort-chain fatty acidsLongitudinal studyMotor performanceAutismDevelopmental patternsReduced myelinationNeuroinflammatory pathwaysGenetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Rodrigue A, Knowles E, Mollon J, Mathias S, Peralta J, Leandro A, Fox P, Kochunov P, Olvera R, Almasy L, Curran J, Blangero J, Glahn D. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Human Brain Mapping 2025, 46: e70101. PMID: 39757975, PMCID: PMC11702472, DOI: 10.1002/hbm.70101.Peer-Reviewed Original ResearchConceptsGenetic correlationsDiffusion tensor imagingCirculating cytokine levelsPeripheral inflammatory responseWhite matter architectureFA measurementsCytokine levelsCytokine measurementsWhite matter integrityProinflammatory cytokinesSingle-compartment modelIL-8Inflammatory processInflammatory responseFree water volumeFree waterGenetic relationshipsWhite matterWhite matter microstructureExtracellular free waterGenetic association
2024
Gut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataOVERTURE Phase 2 MRI Analysis Demonstrates Reduced Corpus Callosum Atrophy in Alzheimer's Disease
Da X, Hempel E, Hajos M, Kern R, Cimenser A. OVERTURE Phase 2 MRI Analysis Demonstrates Reduced Corpus Callosum Atrophy in Alzheimer's Disease. Alzheimer's & Dementia 2024, 20: e085446. PMCID: PMC11714734, DOI: 10.1002/alz.085446.Peer-Reviewed Original ResearchMagnetic resonance imagingMonth 3Midsagittal planeDiffusion tensor imagingPhase 3 clinical trialsRegional structural alterationsCorpus callosumT1w MRI imagesMonths of treatmentCommissural white matter tractsCorpus callosum atrophyWhite matter atrophyAlzheimer's diseaseSensory stimulationMonth 6CC atrophyClinical trialsSham groupWhite matter tractsGamma frequenciesVisual stimulationResonance imagingEffect of brain network scale on Persistence Cycles: An ADNI comparative study
Garai S, Liu M, Xu F, Goñi J, Duong‐Tran D, Zhao Y, Shen L, for the ADNI. Effect of brain network scale on Persistence Cycles: An ADNI comparative study. Alzheimer's & Dementia 2024, 20: e092343. PMCID: PMC11716291, DOI: 10.1002/alz.092343.Peer-Reviewed Original ResearchStructural connectomeFunctional connectomeBOLD signal fluctuationsBrain networksHomologation cycleAlzheimer's diseaseDiffusion tensor imagingStages of AD progressionAverage persistenceFMRI neuroimagingTopological featuresAlzheimer's Disease Neuroimaging InitiativeStages of disease progressionSignal fluctuationsConnectomeGroup differencesResolution scaleAD progressionImage resolutionResolution imagesTopological pointIncrease image resolutionDeath timeRegion-of-interestBarcodingThe White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratumStructural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speedTesting the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participantsNon-dominant, Lesional Frontal Lobe Epilepsy in the Vicinity of Motor Cortex
Herlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy in the Vicinity of Motor Cortex. 2024, 431-468. DOI: 10.1007/978-3-031-23828-4_19.Peer-Reviewed Original ResearchDisrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts
Li H, Zhang H, Qin K, Yin L, Chen Z, Zhang F, Wu B, Chen T, Sweeney J, Gong Q, Jia Z. Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts. Brain Imaging And Behavior 2024, 18: 741-752. PMID: 38407738, DOI: 10.1007/s11682-024-00870-1.Peer-Reviewed Original ResearchNon-suicidal depressed patientsSuicidal depressed patientsDepressed patientsSuicide planNodal efficiencyHealthy controlsMedial orbitofrontal cortexWhite matter structural networksDecreased nodal efficiencyProximal risk factorsWhite matter networksGraph theory analysisOrbitofrontal cortexSuicide brainDiffusion tensor imagingRolandic operculumOlfactory cortexStructural networkNodal network propertiesMotor areaDeterministic tractographySuicideLocal efficiencyTensor imagingStructural connectomeWhite matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Kim B, Kim G, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Balachander S, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Bertolín S, Beucke J, Bollettini I, Brem S, Brennan B, Buitelaar J, Calvo R, Castelo-Branco M, Cheng Y, Chhatkuli R, Ciullo V, Coelho A, Couto B, Dallaspezia S, Ely B, Ferreira S, Fontaine M, Fouche J, Grazioplene R, Gruner P, Hagen K, Hansen B, Hanna G, Hirano Y, Höxter M, Hough M, Hu H, Huyser C, Ikuta T, Jahanshad N, James A, Jaspers-Fayer F, Kasprzak S, Kathmann N, Kaufmann C, Kim M, Koch K, Kvale G, Kwon J, Lazaro L, Lee J, Lochner C, Lu J, Manrique D, Martínez-Zalacaín I, Masuda Y, Matsumoto K, Maziero M, Menchón J, Minuzzi L, Moreira P, Morgado P, Narayanaswamy J, Narumoto J, Ortiz A, Ota J, Pariente J, Perriello C, Picó-Pérez M, Pittenger C, Poletti S, Real E, Reddy Y, van Rooij D, Sakai Y, Sato J, Segalas C, Shavitt R, Shen Z, Shimizu E, Shivakumar V, Soreni N, Soriano-Mas C, Sousa N, Sousa M, Spalletta G, Stern E, Stewart S, Szeszko P, Thomas R, Thomopoulos S, Vecchio D, Venkatasubramanian G, Vriend C, Walitza S, Wang Z, Watanabe A, Wolters L, Xu J, Yamada K, Yun J, Zarei M, Zhao Q, Zhu X, Thompson P, Bruin W, van Wingen G, Piras F, Piras F, Stein D, van den Heuvel O, Simpson H, Marsh R, Cha J. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry 2024, 29: 1063-1074. PMID: 38326559, DOI: 10.1038/s41380-023-02392-6.Peer-Reviewed Original ResearchObsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderDiffusion tensor imagingENIGMA-OCD working groupClassification of obsessive-compulsive disorderGray matter morphometryWhite matter integrityCross-site generalizabilityHealthy controlsWhite matter pathwaysPosterior thalamic radiationWhite matter featuresMachine learning findingsLeave-one-site-out cross-validationOCD studiesThalamic radiationMedication effectsMultivariate patternsAdult participantsTensor imagingLearning interpretationNeurobiologyCorpus callosumLearning findingsInternal capsuleAssociations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study
Liang M, Chen P, Tang Y, Liang Y, Li S, Hu G, Sun Z, Yu Y, Molassiotis A, Knobf M, Ye Z. Associations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study. Depression And Anxiety 2024, 2024 PMCID: PMC11919035, DOI: 10.1155/2024/5595912.Peer-Reviewed Original ResearchInferior fronto-occipital fasciculusBreast cancerIntegrated discrimination improvementDiagnosed breast cancerIncremental predictive valueDiffusion tensor imagingQuantitative anisotropyPredictive valueDiffusion tensor imaging studiesDemoralization Scale-IIFronto-occipital fasciculusWhite matter tractsSelf-reported dataImaging studiesDiscrimination improvementLongitudinal diffusion tensor imaging studyCancerPatientsCorrelational tractographyNeural pathwaysBrain structural connectivityTensor imagingLongitudinal programBreastScale IIA Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer
Liang M, Zhou J, Chen P, Song Y, Li S, Liang Y, Hu G, Hu Q, Sun Z, Yu Y, Molassiotis A, Knobf M, Ye Z. A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer. Depression And Anxiety 2024, 2024 PMCID: PMC11918802, DOI: 10.1155/2024/9294268.Peer-Reviewed Original ResearchDepressive disorderMultivoxel pattern analysisDiffusion tensor imagingPsychological resilienceRs-fMRICorrelational tractographyResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingLongitudinal correlational studyDSM-5Frontal poleBrain areasRisk of DDHigher psychological resilienceBreast cancerMediator variablesTensor imagingConnectomeBrainMagnetic resonance imagingDepressionDisordersPsychiatry physiciansPattern analysisResonance imaging
2023
Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury
Mihailovic J, Sanganahalli B, Hyder F, Chitturi J, Elkabes S, Heary R, Kannurpatti S. Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury. Neuroscience Letters 2023, 820: 137607. PMID: 38141752, PMCID: PMC10797561, DOI: 10.1016/j.neulet.2023.137607.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryDiffusion tensor imagingCord injurySpinal cordCervical spinal cordState functional connectivitySpinal cord samplesSpinal cord diffusion tensor imagingMagnetic resonance imagingBrain functional MRIInjury epicenterSpinal reorganizationPost-SCINeuroplastic changesCord samplesCortical sensoryRat modelTraumatic injuryMD changeMotor networkNervous systemResonance imagingSingle-subject levelFunctional MRIAutism spectrum disorder-specific changes in white matter connectome edge density based on functionally defined nodes
Weber C, Lake E, Haider S, Mozayan A, Bobba P, Mukherjee P, Scheinost D, Constable R, Ment L, Payabvash S. Autism spectrum disorder-specific changes in white matter connectome edge density based on functionally defined nodes. Frontiers In Neuroscience 2023, 17: 1285396. PMID: 38075286, PMCID: PMC10702224, DOI: 10.3389/fnins.2023.1285396.Peer-Reviewed Original ResearchWhite matterPositive symptom correlationAutism spectrum disorderSymptom severity scoresBetween-group differencesAbnormal connectivity patternsCortical nodesVoxel-wise analysisDiffusion tensor imagingSeverity scoreWM fiber tractsSymptom correlationClinical dataConnectome disruptionConnectome changesEarly changesCortical regionsInfantsED reductionWM disruptionDisorder-specific changesTensor imagingFunctional imagingFiber tractsProbabilistic tractographyCorrelation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivityImpact of postnatal weight gain on brain white matter maturation in very preterm infants
Bobba P, Weber C, Higaki A, Mukherjee P, Scheinost D, Constable R, Ment L, Taylor S, Payabvash S. Impact of postnatal weight gain on brain white matter maturation in very preterm infants. Journal Of Neuroimaging 2023, 33: 991-1002. PMID: 37483073, PMCID: PMC10800683, DOI: 10.1111/jon.13145.Peer-Reviewed Original ResearchConceptsBirth weight z-scoreMagnetic resonance imagingVery preterm infantsPostnatal weight gainWeight z-scoreWhite matter maturationBirth weightDiffusion tensor imagingNeurological outcomePreterm infantsGestational ageWeight gainCorpus callosumHigher birth weight z-scoresBrain white matter maturationLong-term neurological deficitsZ-scoreBrain developmentWeight z-score changeWM tractsZ-score changeWM maturationWeeks of lifeNeurological deficitsNutritional interventionMulti-shell versus single-shell cardiac diffusion imaging
Elsaid N, Peters D, Galiana G, Sinusas A. Multi-shell versus single-shell cardiac diffusion imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/4288.Peer-Reviewed Original ResearchSymmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter
Colmenares A, Hefner M, Calhoun V, Salerno E, Fanning J, Gothe N, McAuley E, Kramer A, Burzynska A. Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter. Frontiers In Neurology 2023, 14: 1094313. PMID: 37139071, PMCID: PMC10149813, DOI: 10.3389/fneur.2023.1094313.Peer-Reviewed Original ResearchDiffusion tensor imagingAge differencesExamination of age differencesPattern of age differencesFractional anisotropyRadial diffusivityJoint independent component analysisCognitively healthy adultsWhite matterDiffusion tensor imaging parametersFluid abilitiesPrefrontal WMProcessing speedDiagnostic classificationWM pathologyDiffusion tensor imaging datasetsAging WMUnimodal analysisTensor imagingIndependent component analysisClinical samplesHealthy agingCognitionCorpus callosumHealthy adults
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