2025
Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver. NMR In Biomedicine 2025, 38: e70014. PMID: 39994887, DOI: 10.1002/nbm.70014.Peer-Reviewed Original ResearchConceptsH-MRSHepatic DNLMRS dataLiver tissueMeasurement of lipogenesisDietary interventionLiver lipidsHepatic de novo lipogenesisLow density lipoproteinDetection of deuteriumGold standard measureMetabolic diseasesIncreased hepatic DNLLiverDensity lipoproteinDrinking waterDeuterium labelingIn vivo measurementsNMR dataExcised liver tissueTissueDeuteriumMRSMethylene resonancesDeuterated waterHarnessing precision nutrition to individualize weight restoration in anorexia nervosa
Rodriguez I, Huckins L, Bulik C, Xu J, Igudesman D. Harnessing precision nutrition to individualize weight restoration in anorexia nervosa. Journal Of Eating Disorders 2025, 13: 29. PMID: 39962541, PMCID: PMC11834214, DOI: 10.1186/s40337-025-01209-x.Peer-Reviewed Original ResearchWeight restorationPrecision nutritionAnorexia nervosaGut microbiotaIndividualized nutrition therapyPsychiatric comorbiditiesHabitual lifestyle behaviorsPrecision nutrition approachesDuration of illnessRestore microbial diversityNutrition therapySevere psychiatric disordersNutrition prescriptionKeystone taxaDietary interventionGenetic markersMicrobial diversityWeight outcomesMetabolic profileEffective treatmentDietary planNutritional approachFecal energy lossPatient recoveryMortality rate
2024
Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
Rinne C, Soultoukis G, Oveisi M, Leer M, Schmidt-Bleek O, Burkhardt L, Bucher C, Moussa E, Makhlouf M, Duda G, Saraiva L, Schmidt-Bleek K, Schulz T. Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice. Frontiers In Endocrinology 2024, 15: 1394263. PMID: 38904042, PMCID: PMC11188307, DOI: 10.3389/fendo.2024.1394263.Peer-Reviewed Original ResearchConceptsBone marrow adipose tissueTrabecular bone lossAged miceCaloric restrictionBone lossEndocrine profileMale C57BL6J miceCardio-metabolic diseasesTime of CRAge-matched littermatesBiochemical lipid profilesAssess bone microstructureFree food accessC57BL6J miceBone healthYoung miceContext of agingMale miceDietary interventionNutritional interventionAnatomical localizationLipid profileAdipogenic gene expressionBone dysfunctionTrabecular bone structureIntermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction
Plummer J, Horowitz M, Johnson J. Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction. Aging Biology 2024, 2: 20230019. PMID: 38550776, PMCID: PMC10977905, DOI: 10.59368/agingbio.20230019.Peer-Reviewed Original ResearchMetabolic health benefitsBone massMethionine restrictionContinuous MRStatic histomorphometric analysisAccumulation of marrow fatMarrow fat accumulationLean body massMethionine-restricted dietLong-term adherenceCortical boneFemale miceMale miceDietary interventionHistomorphometric analysisDeleterious effectsContinuous interventionMarrow fatMiceAge-related pathologiesIntermittent formMammalian healthspanBoneConsistent with such findingsStrength of bone
2023
Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort
Judd S, Howard G, Tangney C, Pearson K, Shikany J, Cushman M, Wilson N, Howard V, Sawyer R, Oladele C, Manly J. Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072481.Peer-Reviewed Original ResearchMIND diet scoreDiet scoreMIND dietDementia mortalityHigher MIND diet scoresDementia-related mortalityHistory of strokeNational Death IndexProportional hazards regressionBi-racial cohortMediterranean-DASH InterventionRate of dementiaBaseline cognitive impairmentNeurodegenerative Delay (MIND) dietDeath HRDementia deathCohort studyPrimary outcomeREGARDS cohortStroke cohortDietary interventionDeath IndexDecreased riskHazards regressionMedical conditionsEffect of Diet Patterns in the Prevention of Alzheimer’s Disease
Cosio D, Rodriguez S, Jayakumar A, Paidas M. Effect of Diet Patterns in the Prevention of Alzheimer’s Disease. Nutritional Neurosciences 2023, 197-222. DOI: 10.1007/978-981-99-0677-2_13.Peer-Reviewed Original ResearchWestern pattern dietDiet patternProgression of ADMediterranean dietMediterranean-DASH InterventionAlzheimer's diseaseCase-control studyRandomized controlled trialsPrevention of Alzheimer's diseaseDementia casesNeurodegenerative DelayRates of retentionStop HypertensionPathogenesis of ADRandomized case-control studyAD prevalenceControlled trialsDietary ApproachesDementiaTreatment of ADCognitive measuresDietary interventionEarly stages of disease progressionInterventionPreventionDietary Patterns Among Individuals with Plasma Cell Disorders Compared to the General US Population
Traore K, Taneja A, Gorshein E, Castro F, Derkach A, Martinez J, Serrano E, Lesokhin A, Ahlstrom J, Block T, Hydren J, Usmani S, Shah U. Dietary Patterns Among Individuals with Plasma Cell Disorders Compared to the General US Population. Blood 2023, 142: 7363. DOI: 10.1182/blood-2023-186913.Peer-Reviewed Original ResearchBody mass indexPlasma cell disordersHigher HEI scoresFood frequency questionnaireGeneral US populationHEI scoresDietary patternsTotal fruit consumptionMultiple myelomaUS populationDietary interventionDietary guidelinesFruit consumptionCell disordersHealthy dietBlock Food Frequency QuestionnaireElevated body mass indexLower body mass indexCancer-specific mortalityLong-term outcomesHealthy Eating IndexNutrition Examination SurveyHealthy dietary habitsRole of nutritionOlder age groupsPolycystic Kidney Disease Diet
Chebib F, Nowak K, Chonchol M, Bing K, Ghanem A, Rahbari-Oskoui F, Dahl N, Mrug M. Polycystic Kidney Disease Diet. Clinical Journal Of The American Society Of Nephrology 2023, 19: 664-682. PMID: 37729939, PMCID: PMC11108253, DOI: 10.2215/cjn.0000000000000326.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseDietary interventionCaloric restrictionIntermittent fastingMetabolic healthClinical trialsProgressive kidney function lossUncertain clinical benefitKidney function lossIdeal body weightExtensive clinical researchHigh fluid intakeLimited clinical evidenceDominant polycystic kidney diseasePolycystic kidney diseasePersonalized dietary guidelinesConcentrated sweetsAdverse eventsKetogenic dietClinical benefitClinical evidenceKidney diseaseADPKD progressionWeight managementFavorable outcomePotential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors
Wang Y, Lu L, Ling C, Zhang P, Han R. Potential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors. Nutrients 2023, 15: 3984. PMID: 37764768, PMCID: PMC10537481, DOI: 10.3390/nu15183984.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsPD-1/PD-L1 inhibitorsPD-L1 inhibitorsICI therapyDietary interventionBC patientsBreast cancerTherapeutic strategiesNovel immune checkpoint inhibitorsHDAC2 inhibitorsIntegrated therapeutic strategiesOptimal clinical benefitKaplan-Meier plotter platformNew therapeutic strategiesAnti-cancer effectsCheckpoint inhibitorsSupportive therapyClinical benefitHigh morbidityCombination therapyTreatment outcomesLethal malignancyTherapeutic effectEffective treatmentPrognostic analysisAssociations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults
Jia H, Bao P, Yao S, Zhang X, Mu J, Hu G, Du M, Chu C, Zhang X, Wang L, Liao Y, Wang D, Ma Q, Yan Y, Niu Z, Gao W, Li H, Wu G, Chang J, Wang Y. Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. Hypertension Research 2023, 46: 1795-1803. PMID: 37160967, DOI: 10.1038/s41440-023-01301-2.Peer-Reviewed Original ResearchConceptsLongitudinal BP changesLow-salt dietDevelopment of hypertensionBlood pressureHypertension incidenceBP changesSodium-glucose cotransporter 2 inhibitorsSalt sensitivityCotransporter 2 inhibitorsIncidence of hypertensionHigh-salt dietSystolic blood pressureBlood pressure changesGenetic polymorphismsIncident hypertensionSystolic BPDietary interventionSBP changeUsual dietHypertensionChinese adultsSalutary effectsIncidenceDietSGLT2
2022
The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients
Bennouna D, Orchard T, Lustberg M, Kopec R. The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients. Current Developments In Nutrition 2022, 6: 6009237. PMCID: PMC9193887, DOI: 10.1093/cdn/nzac052.004.Peer-Reviewed Original ResearchPlasma concentrationsCognitive impairmentLong-term cognitive impairmentNutritional targetsDocosahexaenoic acidNervonic acidEicosapentaenoic acidOmega-3 fatty acidsNeo-adjuvant chemotherapyBreast cancer patientsEffect of chemotherapyBreast cancer chemotherapyFatty acidsBreast cancer treatmentHippocampal concentrationsDietary interventionSolid tumor treatmentCancer patientsChemotherapy treatmentFatty acid concentrationsObjective biomarkersBreast cancerImpact of visitsChemotherapyMead acidTDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Loganathan S, Wilson B, Carey S, Manzo E, Joardar A, Ugur B, Zarnescu D. TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS. Metabolites 2022, 12: 101. PMID: 35208176, PMCID: PMC8876928, DOI: 10.3390/metabo12020101.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisTDP-43 proteinopathyTDP-43Dopamine levelsMotor neuronsMetabolic alterationsModel of ALSMetabolic changesTDP-43 expressionMotor neuron diseaseComplex neurodegenerative disorderGlobal metabolomic profilingTDP-43 aggregationALS patientsDietary interventionDopamine agonistsGlucose toleranceInsulin resistanceNeuron diseaseNeurotransmitter levelsSelective degenerationTricarboxylic acid cycle metabolitesLateral sclerosisLocomotor functionLocomotor dysfunction
2021
Chronic Pain, Dietary Intake and Exercise Behaviors in a Nationally Representative Sample of US Adults
Vernarelli J, MacLean R. Chronic Pain, Dietary Intake and Exercise Behaviors in a Nationally Representative Sample of US Adults. Current Developments In Nutrition 2021, 5: 1101. PMCID: PMC8180694, DOI: 10.1093/cdn/nzab053_094.Peer-Reviewed Original ResearchChronic painUS adultsDietary intakeDietary patternsTotal fatDietary pattern differencesOverall fat intakeChronic pain statusDietary intake patternsHistory of painPhysical activity dataRepresentative sampleCycles of NHANESComplex survey designInflammatory markersPain locationPain statusNationally Representative SampleDietary interventionPain assessmentCurrent painExamination visitsFat intakeMusculoskeletal healthLow intakeOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials Registry
2020
Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults
Kahleova H, Petersen KF, Shulman GI, Alwarith J, Rembert E, Tura A, Hill M, Holubkov R, Barnard ND. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults. JAMA Network Open 2020, 3: e2025454. PMID: 33252690, PMCID: PMC7705596, DOI: 10.1001/jamanetworkopen.2020.25454.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdultAgedBlood GlucoseBody CompositionBody WeightC-PeptideCholesterolCholesterol, HDLCholesterol, LDLDiet, Fat-RestrictedDiet, VeganEnergy IntakeEnergy MetabolismFemaleGlycated HemoglobinHepatocytesHumansInsulinInsulin ResistanceIntra-Abdominal FatLipid MetabolismLiverMaleMiddle AgedMuscle Fibers, SkeletalMuscle, SkeletalObesityOverweightPostprandial PeriodProton Magnetic Resonance SpectroscopyTriglyceridesConceptsLow-fat vegan dietHomeostasis model assessment indexIntramyocellular lipid levelsModel assessment indexIntervention groupLipid levelsBody weightInsulin resistancePostprandial metabolismVegan dietOverweight adultsDietary interventionInsulin sensitivityThermic effectControl groupPlant-based dietary interventionDual X-ray absorptiometryInsulin resistance leadExcess body weightInsulin sensitivity indexType 2 diabetesMajor health problemProton magnetic resonance spectroscopyX-ray absorptiometrySubset of participantsA Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weight
2019
Nepal Pioneer Worksite Intervention Study to lower cardio-metabolic risk factors: design and protocol
Shrestha A, Tamrakar D, Karmacharya BM, Shrestha A, Shrestha R, Bhatta RD, Pyakurel P, Khudyakov P, Malik V, Mattei J, Spiegelman D. Nepal Pioneer Worksite Intervention Study to lower cardio-metabolic risk factors: design and protocol. BMC Cardiovascular Disorders 2019, 19: 48. PMID: 30819098, PMCID: PMC6393979, DOI: 10.1186/s12872-019-1025-3.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesDiet, HealthyExerciseFemaleFood ServicesHealth Knowledge, Attitudes, PracticeHumansMaleMetabolic SyndromeNepalOccupational Health ServicesPatient Education as TopicProtective FactorsRandomized Controlled Trials as TopicRisk FactorsRisk Reduction BehaviorTime FactorsTreatment OutcomeConceptsCardio-metabolic riskWorksite intervention studiesIntervention studiesBlood sugarCardiovascular disease prevention effortsPrevention programsCardio-metabolic risk factorsBehavioral interventionsCardio-metabolic outcomesTrial registrationThe trialElevated blood pressureDiabetes Prevention ProgramCardiovascular disease burdenProportion of participantsDisease prevention effortsHealthy food choicesChi-square testEnvironmental-level changesIndividual behavioral interventionsDhulikhel HospitalBlood pressureDietary interventionPre-post designLifestyle factorsDisease burden
2018
Food withdrawal alters the gut microbiota and metabolome in mice
Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Qu C, Ge K, Huang F, Hernandez B, Yu H, Panee J, Chen T, Jia W, Jia W. Food withdrawal alters the gut microbiota and metabolome in mice. The FASEB Journal 2018, 32: 4878-4888. PMID: 29620942, PMCID: PMC9292403, DOI: 10.1096/fj.201700614r.Peer-Reviewed Original ResearchConceptsHigh-fat dietFood withdrawalGut microbiotaObese miceWithdrawal altersAbundance of microbesHost metabolic changesFree fatty acid metabolismBeneficial effectsNormal chow groupAbundance of metabolitesNormal lean miceFatty acid metabolismPathogenic ProteobacteriaMolecular mechanismsBranched-chain amino acidsHost serum metabolomeChain amino acidsCecal microbiomeAmino acidsHFD groupHFD miceDietary interventionLean miceNormal miceDietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis
Shrestha A, Karmacharya BM, Khudyakov P, Weber MB, Spiegelman D. Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis. Journal Of Occupational Health 2018, 60: 31-45. PMID: 29187673, PMCID: PMC5799099, DOI: 10.1539/joh.17-0121-ra.Peer-Reviewed Original ResearchConceptsRandom-effects modelDietary interventionWorksite settingWorkplace dietary interventionsBlood sugar levelsAllied Health LiteraturePooled effect sizeFemale participantsMultivariate meta-regression modelWeb of ScienceIndividual-level interventionsLifestyle interventionGlucose toleranceMeta-regression modelsBorderline significanceMore effective interventionsCumulative IndexReference listsStudy heterogeneityHealth LiteratureEffective interventionsSugar levelsSearch termsInterventionEffect size
2017
Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial
Schneider T, Johns C, Palumbo M, Murphy K, Cahill K, Laidlaw T. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. The Journal Of Allergy And Clinical Immunology In Practice 2017, 6: 825-831. PMID: 29133219, PMCID: PMC5945343, DOI: 10.1016/j.jaip.2017.10.011.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseUrinary leukotriene EDietary interventionLeukotriene ERespiratory diseaseTreatment of AERDDietary fatty acid modificationAsthma Control Questionnaire scoreNasal Outcome Test (SNOT-22) scoresAdjunct treatment optionProspective pilot trialPatient-reported questionnaireFatty acid consumptionTreatment of aspirinOutcome Test scoresAdult patientsAdverse eventsLung functionPrimary outcomeClinical efficacyVital capacityTreatment optionsWomen's HospitalIntervention periodPilot trial
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