2025
Acute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide
Gustafson A, Trinh K, Lomasney J, Shah S, Hinchcliff M. Acute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide. JACC Case Reports 2025, 30: 102948. PMID: 39972702, PMCID: PMC11862153, DOI: 10.1016/j.jaccas.2024.102948.Peer-Reviewed Original ResearchSystemic sclerosisEndomyocardial biopsyDiffuse cutaneous systemic sclerosisCutaneous systemic sclerosisAssociated with increased mortalityT lymphocyte infiltrationAcute heart failureIntravenous cyclophosphamideDiagnosing myocarditisDiastolic dysfunctionSystolic dysfunctionT lymphocytesHeart failureProlonged recoveryPatientsCardiomyopathy treatmentCyclophosphamideBiopsyCardiomyopathyGlucocorticoidDysfunctionMyopericarditisMyocarditis
2024
Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicAssociation of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024 PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysisHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13: rp95867. PMID: 39331464, PMCID: PMC11434618, DOI: 10.7554/elife.95867.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroHIV viremiaDiastolic dysfunctionHIV patientsCardiomyocyte relaxationSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesCytokinesHIVPatientsRelaxation defectsPLWHSerumHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13 DOI: 10.7554/elife.95867.3.Peer-Reviewed Original ResearchHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroCa 2HIV viremiaDiastolic dysfunctionCardiomyocyte relaxationHIV patientsSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesHIVCytokinesRelaxation defectsPatientsPLWHDiastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Fava A, Popovic Z, Alashi A, Thamilarasan M, Xu B, Desai M. Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity. The American Journal Of Cardiology 2024, 232: 34-40. PMID: 39307332, DOI: 10.1016/j.amjcard.2024.09.017.Peer-Reviewed Original ResearchTreadmill exercise echocardiographyHypertrophic cardiomyopathyCongestive heart failureDiastolic parametersExercise capacityStress echocardiographyAssociated with reduced exercise capacityPrecipitate congestive heart failureLeft ventricular (LVAsymptomatic/minimally symptomatic patientsDiastolic stress echocardiographyMultivariate logistic regression analysisSymptomatic HCM patientsEtiology of dyspneaHigher body mass indexBody mass indexReduced exercise capacityExercise functional capacityLogistic regression analysisAssociated with <Incremental diagnostic utilityHigher LAViLVOT gradientE/e' ratioDiastolic dysfunction
2023
The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Zhuo H, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization. Annals Of Vascular Surgery 2023, 98: 210-219. PMID: 37802138, DOI: 10.1016/j.avsg.2023.08.009.Peer-Reviewed Original ResearchMajor adverse limb eventsReduced ejection fractionLower extremity revascularizationPeripheral arterial diseaseMALE-free survivalAdverse limb eventsCoronary artery diseaseEjection fractionExtremity revascularizationArtery diseaseLimb eventsChronic limb-threatening ischemiaLimb-threatening ischemiaTricuspid valve regurgitationKaplan-Meier curvesElectronic medical recordsMajor amputationSevere mitralDiastolic dysfunctionEchocardiographic findingsTransthoracic echocardiogramHeart failureValve regurgitationArterial diseaseSingle centerQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin use2.5D Flow MRI: 2D phase-contrast of the tricuspid valvular flow with automated valve-tracking
Lamy J, Xiang J, Seemann F, Gonzales R, Huber S, Steele J, Heiberg E, Peters D. 2.5D Flow MRI: 2D phase-contrast of the tricuspid valvular flow with automated valve-tracking. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0930.Peer-Reviewed Original ResearchAssociated with diastolic dysfunctionTricuspid regurgitation velocityRV stroke volumePhase contrastDiastolic dysfunctionTricuspid regurgitationPulmonary hypertensionRegurgitation velocityPressure overloadRight heartHealthy subjectsTricuspidPhase contrast methodStroke volumeFlow MRIRegurgitationValvular flowPatientsPhase-dependent mannerFlow volumeEchocardiographyBiomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria
Murtada S, Kawamura Y, Cavinato C, Wang M, Ramachandra A, Spronck B, Li D, Tellides G, Humphrey J. Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria. Biomechanics And Modeling In Mechanobiology 2023, 22: 1333-1347. PMID: 37149823, PMCID: PMC10544720, DOI: 10.1007/s10237-023-01722-5.Peer-Reviewed Original ResearchConceptsPulse wave velocitySmooth muscle cell deathMuscle cell deathDisease processOsteochondrogenic phenotypeAdverse extracellular matrix remodelingImportant cardiovascular implicationsProgressive aortic diseaseProximal elastic arteriesVentricular diastolic dysfunctionProgressive disease processSmooth muscle cellsCell deathCardiovascular sequelaeDiastolic dysfunctionCardiovascular implicationsExtracellular matrix remodelingAortic diseasePrimary diagnosisVascular diseaseAccumulation of proteoglycansMuscular arteriesAortic structureAortic wallLate calcificationEcho Doppler Parameters of Diastolic Function
Anthony C, Akintoye E, Wang T, Klein A. Echo Doppler Parameters of Diastolic Function. Current Cardiology Reports 2023, 25: 235-247. PMID: 36821063, DOI: 10.1007/s11886-023-01844-3.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionEcho-Doppler parametersDiastolic functionDoppler parametersEvaluation of DDAbnormal diastolic functionDoppler echocardiography techniquesLV filling pressureModest diagnostic performanceSignificant inter-observer variabilityEchocardiographic parametersRecent guidelinesAppropriate diagnosisFilling pressureInvasive measuresReviewThe purposeEchocardiography techniquesInter-observer variabilityEuropean AssociationCardiovascular imagingDiagnostic performanceEchocardiographyAmerican SocietyGuideline documentsDiagnosis
2022
Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study)
Berg C, Patel B, Reynolds M, Tuzovic M, Chew K, Sico J, Bhattacharya D, Butt A, Lim J, Bedimo R, Brown S, Gottdiener J, Warner A, Freiberg M, So-Armah K, Nguyen K. Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study). The American Journal Of Cardiology 2022, 186: 50-57. PMID: 36343446, PMCID: PMC10193525, DOI: 10.1016/j.amjcard.2022.10.035.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionDiastolic functionAtrial mechanicsLA strainHuman immunodeficiency virus (HIV) infectionLogistic regressionCross-sectional cohort analysisCohort of PLWHHIV uninfected controlsLA conduit strainLA phasic strainLA reservoir strainLeft Atrial MechanicsLV diastolic dysfunctionHIV viral loadHIV viral suppressionImmunodeficiency virus infectionVentricular diastolic functionHuman immunodeficiency virusPropensity weightingPLWH cohortSubclinical cardiomyopathyAntiretroviral therapyCardiovascular deathViral suppressionChanges in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study
Posada-Martinez EL, Cox ZL, Cano-Nieto MM, Ibarra-Marquez ND, Moreno-Villagomez J, Gudiño-Bravo P, Arias-Godinez JA, Lopez-Gil S, Madero M, Rao VS, Mebazaa A, Burkhoff D, Cowie MR, Fudim M, Damman K, Borlaug BA, Testani JM, Ivey-Miranda JB. Changes in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study. Journal Of Cardiac Failure 2022, 29: 463-472. PMID: 36243338, DOI: 10.1016/j.cardfail.2022.09.012.Peer-Reviewed Original ResearchConceptsInferior vena cava diameterPeripheral venous pressureCentral venous pressureVenous pressureUltrafiltration volumeHeart failureVolume statusMean ultrafiltration volumeManagement of patientsVena cava diameterInferior vena cavaDiastolic dysfunctionCardiac dysfunctionStable hemodialysisVena cavaHemodialysis sessionFluid removalPatientsDialysisHemodialysisDysfunctionConcept studyGreater magnitudeStatusCava
2021
Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers
Peters DC, Lamy J, Sinusas AJ, Baldassarre LA. Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers. European Heart Journal - Cardiovascular Imaging 2021, 23: 14-30. PMID: 34718484, PMCID: PMC8685602, DOI: 10.1093/ehjci/jeab221.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementAtrial fibrillationCardiovascular magnetic resonanceDiastolic dysfunctionEjection fractionAF recurrenceAtrial fibrosisNew-onset atrial fibrillationPost-operative atrial fibrillationLongitudinal LA strainExtent of fibrosisLong-axis cine imagesCine imagesAtrial imagingCardiovascular eventsLA volumeRisk stratificationAF subjectsPrognostic informationHypertrophic cardiomyopathyLA strainGadolinium enhancementSensitive markerAblation proceduresMagnetic resonanceLoss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. The Journal Of General Physiology 2021, 153: e202012640. PMID: 34319370, PMCID: PMC8321830, DOI: 10.1085/jgp.202012640.Peer-Reviewed Original ResearchConceptsHypertrophic cardiomyopathyHeart tissueCellular hypertrophyEngineered Heart TissuePathological cardiac hypertrophyThin filament mutationsMavacamten treatmentDiastolic dysfunctionDisease featuresHypertrophic effectCardiac hypertrophyContractile differencesHypertrophyFundamental disease mechanismsCrossbridge activityInherited disorderOverall Ca2Uncertain significancePatient phenotypesDisease mechanismsLow Ca2PatientsK mutationMavacamtenTissue
2020
Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity
Fava A, Mathias I, Alashi A, Saijo Y, Popovic Z, Thamilarasan M, Lever H, Desai M. Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity. European Heart Journal 2020, 41: ehaa946.2087. DOI: 10.1093/ehjci/ehaa946.2087.Peer-Reviewed Original ResearchDiastolic dysfunctionExercise capacityLVOT gradientMaximal exerciseHCM patientsLate mitral inflow velocityLateral mitral annular velocityMitral E/eAbnormal diastolic responseSymptomatic HCM patientsAtrial volume indexReduced exercise capacityVentricular filling pressureMitral annular velocityMitral inflow velocityHypertrophic cardiomyopathy patientsLogistic regression analysisHypertrophy cardiomyopathyDiastolic responseMetabolic equivalentsCardiomyopathy patientsAnnular velocityFilling pressureFunctional capacityPatientsAnti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis
Norouzi S, Javinani A, Aminorroaya A, Masoumi M. Anti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis. BMC Cardiovascular Disorders 2020, 20: 390. PMID: 32847506, PMCID: PMC7448352, DOI: 10.1186/s12872-020-01676-x.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCardiac systolic dysfunctionCardiovascular diseaseSystolic dysfunctionRheumatoid arthritisReduced left ventricular ejection fractionPredictors of left ventricular ejection fractionAnti-modified citrullinated vimentinEchocardiographic parameters of systolicDisease Activity Score-28Anti-MCV levelsParameters of systolicAssociation of autoantibodiesVentricular ejection fractionConcomitant cardiovascular diseaseExclusion of patientsSusceptibility to cardiovascular diseaseReceiver operating characteristic curveDuration of diseaseCardiovascular disease risk factorsAnti-citrullinated proteinFramingham risk scoreCross-sectional studyTransthoracic echocardiographyDiastolic dysfunctionParadoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome
Murtada SI, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD. Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome. Journal Of The Royal Society Interface 2020, 17: 20200066. PMID: 32453981, PMCID: PMC7276555, DOI: 10.1098/rsif.2020.0066.Peer-Reviewed Original ResearchConceptsHutchinson-Gilford progeria syndromeSubsequent cardiac dysfunctionSmooth muscle functionPulse wave velocityUltra-rare disordersCardiovascular eventsDevastating sequelaeDiastolic dysfunctionSystolic functionCardiac dysfunctionProgeria syndromeVascular functionAortic functionMuscle functionEarly deathMouse modelTherapeutic windowCardiovascular dataBiomechanical phenotypingDysfunctionSyndromeExcessive accumulationBiomechanical functionArterial developmentPressure-related effectsDifferential contributions of sarcomere and mitochondria-related multigene variants to the endophenotype of hypertrophic cardiomyopathy
Chung H, Kim Y, Cho SM, Lee HJ, Park CH, Kim JY, Lee SH, Min PK, Yoon YW, Lee BK, Kim WS, Hong BK, Kim TH, Rim SJ, Kwon HM, Choi EY, Lee KA. Differential contributions of sarcomere and mitochondria-related multigene variants to the endophenotype of hypertrophic cardiomyopathy. Mitochondrion 2020, 53: 48-56. PMID: 32380161, DOI: 10.1016/j.mito.2020.04.010.Peer-Reviewed Original ResearchConceptsNon-apical hypertrophic cardiomyopathyApical hypertrophic cardiomyopathyHypertrophic cardiomyopathyHCM patientsIndividualized risk stratificationComprehensive genetic testAtrium remodelingDiastolic dysfunctionRisk stratificationPoor prognosisSarcomere mutationsPatientsPathogenic variantsRare variant analysisAsian populationsPathogenic mutationsAtrial Function and Its Role in the Non-invasive Evaluation of Diastolic Function in Congenital Heart Disease
Ta HT, Alsaied T, Steele JM, Truong VT, Mazur W, Nagueh SF, Kutty S, Tretter JT. Atrial Function and Its Role in the Non-invasive Evaluation of Diastolic Function in Congenital Heart Disease. Pediatric Cardiology 2020, 41: 654-668. PMID: 32342149, DOI: 10.1007/s00246-020-02351-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCongenital heart diseaseAtrial functionDiastolic functionNon-invasive assessmentHeart diseaseDiastolic dysfunctionVentricular diastolic dysfunctionDiastolic function assessmentNon-invasive evaluationAtrial dysfunctionAdult patientsAtrial sizeAdverse outcomesConduit functionBody of evidenceContractile functionFunction assessmentCompensatory increaseDysfunctionCommon pathwayDiseaseAtrial formCurrent knowledgePivotal roleMost forms
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