2025
Zika virus: advancing a priority research agenda for preparedness and response
Lackritz E, Ng L, Marques E, Rabe I, Bourne N, Staples J, Méndez-Rico J, Harris E, Brault A, Ko A, Beasley D, Leighton T, Wilder-Smith A, Ostrowsky J, Mehr A, Ulrich A, Velayudhan R, Golding J, Fay P, Cehovin A, Moua N, Moore K, Osterholm M, Barrett A, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Zika virus: advancing a priority research agenda for preparedness and response. The Lancet Infectious Diseases 2025 PMID: 40024263, DOI: 10.1016/s1473-3099(24)00794-1.Peer-Reviewed Original Research
2024
Strength of evidence underlying the CMS-FDA parallel review of comprehensive genomic profiling tests in the cancer setting
Stackland S, Schnabel D, Dinan M, Presley C, Gross C. Strength of evidence underlying the CMS-FDA parallel review of comprehensive genomic profiling tests in the cancer setting. Journal Of The National Cancer Institute 2024, 117: 144-151. PMID: 39288939, PMCID: PMC11717411, DOI: 10.1093/jnci/djae196.Peer-Reviewed Original ResearchComprehensive genomic profilingComprehensive genomic profiling testCenter for Medical Technology PolicyClinical careClinical outcomesDiagnostic testsAssessed clinical outcomesOutcomes of patientsStrength of evidenceCourse of clinical careEfficacy of diagnostic testsNovel diagnostic testsPeer-reviewed literatureGenomic profiling testsFoundationOne CDxGenomic testingSolid tumorsStudy designGenomic alterationsGenomic profilingF1CDxCancer settingClinical utilityCancer typesCompare groupsCffDNA screening for Niemann–pick disease, type C1: a case series
Lau S, Fawaz R, Rigobello R, Bawazeer S, Alajaji N, Faqeih E, Li Y, Feng Y, Xia F, Eng C, Abedalthagafi M. CffDNA screening for Niemann–pick disease, type C1: a case series. Frontiers In Medicine 2024, 11: 1390693. PMID: 39161410, PMCID: PMC11330825, DOI: 10.3389/fmed.2024.1390693.Peer-Reviewed Original ResearchNext-generation sequencingInvasive diagnostic testsCffDNA screeningNiemann-Pick diseaseCustom data analysis pipelineAmplicon next-generation sequencingAmplicon-based next-generation sequencingDisease-causing variantsType C1Biallelic pathogenic variantsData analysis pipelinesCell-free fetal DNADetect chromosomal abnormalitiesMaternal peripheral bloodDiagnostic testsWeeks of gestationNPC1 geneHigh-risk pregnanciesPathogenic variantsAnalysis pipelineFamilial variantFetal DNAProgressive neurodegenerationChromosomal abnormalitiesPeripheral bloodA set of diagnostic tests for detection of active Babesia duncani infection
Chand M, Vydyam P, Pal A, Thekkiniath J, Darif D, Li Z, Choi J, Magni R, Luchini A, Tonnetti L, Horn E, Tufts D, Ben Mamoun C. A set of diagnostic tests for detection of active Babesia duncani infection. International Journal Of Infectious Diseases 2024, 147: 107178. PMID: 39025200, PMCID: PMC11914778, DOI: 10.1016/j.ijid.2024.107178.Peer-Reviewed Original ResearchB. microtiB. duncaniBlood samplesLife-threatening infectionsAntigen capture assayTick-borne diseasesFatal tick-borne diseaseP. falciparumBabesia genusScreening of blood samplesBabesia speciesB. divergensActive infectionAccurate diagnosisEffective disease managementPoint-of-care testingDiagnostic testsReservoir hostsBabesiaInfectionHuman babesiosisIntraerythrocytic parasitesImmunodominant antigensMolecular assaysCapture assayAssessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis
Yin X, Li Y, Rönn M, Li S, Yuan Y, Gift T, Hsu K, Salomon J, Grad Y, Yaesoubi R. Assessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis. PLOS Medicine 2024, 21: e1004424. PMID: 38976754, PMCID: PMC11262662, DOI: 10.1371/journal.pmed.1004424.Peer-Reviewed Original ResearchDrug susceptibility testingQuality-adjusted life yearsFirst-line therapyFirst-line antibioticsNet health benefitFirst-lineRetreatment regimensResistance prevalenceRapid drug susceptibility testingRate of treatment failureTreatment of gonorrheaIncidence of gonorrheaAssociated with gonorrheaEmpirical therapyTreatment failureEmpirical treatmentGonococcal infectionSusceptibility testingGonorrhea casesMSM populationGonorrheaCost-effectiveness analysisDiagnostic testsResistant strainsTherapyReported Incidence of Infections Caused by Pathogens Transmitted Commonly Through Food: Impact of Increased Use of Culture-Independent Diagnostic Tests — Foodborne Diseases Active Surveillance Network, 1996–2023
Shah H, Jervis R, Wymore K, Rissman T, LaClair B, Boyle M, Smith K, Lathrop S, McGuire S, Trevejo R, McMillian M, Harris S, Kufel J, Houck K, Lau C, Devine C, Boxrud D, Weller D. Reported Incidence of Infections Caused by Pathogens Transmitted Commonly Through Food: Impact of Increased Use of Culture-Independent Diagnostic Tests — Foodborne Diseases Active Surveillance Network, 1996–2023. MMWR Morbidity And Mortality Weekly Report 2024, 73: 584-593. PMID: 38959172, PMCID: PMC11221634, DOI: 10.15585/mmwr.mm7326a1.Peer-Reviewed Original ResearchConceptsCulture-independent diagnostic testsFoodborne Diseases Active Surveillance NetworkActive Surveillance NetworkShiga toxin-producing Escherichia coli infectionDisease incidenceFoodborne disease incidentsPercentage of infectionDiagnosis of infectionIncidence of infectionPercentage of casesSurveillance networkDiagnostic practiceCulture-independentPublic health priorityImpact of increased useContinuous surveillanceDiagnostic testsTargeted prevention effortsInfectionFoodNet dataDiseaseFoodNetIncidenceHealth priorityDisease trendsConventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis.
Jiménez-Serrano S, Páez-Carpio A, Doménech-Ximenos B, Cornellas L, Sánchez M, Revzin M, Vollmer I. Conventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis. RadioGraphics 2024, 44: e230171. PMID: 38935548, DOI: 10.1148/rg.230171.Peer-Reviewed Original ResearchConceptsPeripheral lung diseaseContrast-enhanced USDiagnosis of peripheral lung diseasePercutaneous biopsyLung USEnhancement patternLung diseaseImage-guided percutaneous biopsyAccurate differential diagnosisDiagnostic chest imagingLung biopsySubpleural lesionsConventional USDifferential diagnosisPathological findingsPulmonary physiologyChest imagingArterial supplyBiopsyLungDiagnostic testsDiagnosisSoft tissueDiseaseImaging timeSociety for Healthcare Epidemiology of America position statement on pandemic preparedness for policymakers: mitigating supply shortages
Weber D, Malani A, Shenoy E, Banach D, Batshon L, Branch-Elliman W, Dumyati G, Haessler S, Hsu V, Jump R, Mathew T, Murthy R, Pergam S. Society for Healthcare Epidemiology of America position statement on pandemic preparedness for policymakers: mitigating supply shortages. Infection Control And Hospital Epidemiology 2024, 45: 813-817. PMID: 38835229, DOI: 10.1017/ice.2024.67.Peer-Reviewed Original ResearchPersonal protective equipmentSociety for Healthcare EpidemiologyComponents of infection controlStockpiling of personal protective equipmentPublic health responseNational Strategic StockpileHealthcare settingsShortage of personal protective equipmentHealth responseSupply chain deficienciesDiagnostic testsInfection controlPosition statementChain deficiencySupply chain failuresProducts ActMedical equipmentPandemic preparednessProtective equipmentUnited StatesRecommendationsSupply shortagesMitigate shortagesDefense Production ActPatient Priorities Care: Priorities Aligned Decision Making for Persons with Multiple Chronic Conditions
Ouellet J, Samper-Ternent R, Tinetti M, Bonds Johnson K, Mecca M. Patient Priorities Care: Priorities Aligned Decision Making for Persons with Multiple Chronic Conditions. 2024, 353-358. DOI: 10.1007/978-3-031-56204-4_37.ChaptersMultiple chronic conditionsChronic conditionsOlder adultsHealth outcome goalsSelf-management tasksFragmented careGuideline-recommended treatmentSpecialist visitsDisease-basedCombination of medicationsOutcome goalsSilo approachAdultsDecision-makingDiagnostic testsCareClinical trialsHealthVisitsCliniciansHarmMedicationPersonsRecommendationsSyndromic Gastrointestinal Panel Diagnostic Tests Have Changed our Understanding of the Epidemiology of Yersiniosis—Foodborne Diseases Active Surveillance Network, 2010-2021
Ray L, Payne D, Rounds J, Trevejo R, Wilson E, Burzlaff K, Garman K, Lathrop S, Rissman T, Wymore K, Wozny S, Wilson S, Watkins L, Bruce B, Weller D. Syndromic Gastrointestinal Panel Diagnostic Tests Have Changed our Understanding of the Epidemiology of Yersiniosis—Foodborne Diseases Active Surveillance Network, 2010-2021. Open Forum Infectious Diseases 2024, 11: ofae199. PMID: 38868306, PMCID: PMC11167669, DOI: 10.1093/ofid/ofae199.Peer-Reviewed Original ResearchActive Surveillance NetworkCommunity-level social determinants of healthCulture methodLaboratory-diagnosed infectionsSocial determinants of healthCulture-independent diagnostic testsDiagnostic testsDeterminants of healthFoodborne Diseases Active Surveillance NetworkState health departmentsLocation of residenceAfrican American infantsSurveillance networkYersinia enterocoliticaProportion of infectionsDetect Y. enterocoliticaHealth departmentsAssociated with winter monthsAsian childrenAmerican infantsInfectionDiarrheal diseaseAsian personsWinter monthsDiagnostic methodsDistribution of Connectivity Strengths Across Functional Regions has Higher Entropy in Schizophrenia Patients than in Controls
Maksymchuk N, Miller R, Calhoun V. Distribution of Connectivity Strengths Across Functional Regions has Higher Entropy in Schizophrenia Patients than in Controls. 2024, 00: 37-40. DOI: 10.1109/ssiai59505.2024.10508663.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingGroup independent component analysisSchizophrenia patientsCognitive controlResting-state functional magnetic resonance imagingIntrinsic connectivity networksHealthy controlsGender-matched healthy controlsSZ patientsNeuropsychiatric disordersBrain areasBrain networksSchizophreniaDisrupted integrityBrain domainsConnection strengthIndependent component analysisConnectivity networksMagnetic resonance imagingSomatomotorDistribution of connection strengthsResonance imagingCross-sectional dataPatientsDiagnostic testsInternational Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward
Brackel C, Noij L, Vijverberg S, Legghe C, Maitland-van der Zee A, van Goudoever J, Buonsenso D, Munblit D, Sigfrid L, McFarland S, Anmyr L, Ashkenazi-Hoffnung L, Bellinat A, Dias N, Edwards A, Fashina T, Juraški R, Gonçalves A, Hansted E, Herczeg V, Hertting O, Jankauskaite L, Kaswandani N, Kevalas R, Krivácsy P, Lorenz M, Malone L, McVoy M, Miller D, Morrow A, Nugawela M, Oliveira C, Oliveira P, Osmanov I, Overmars I, Paintsil E, Pinto Pereira S, Prawira Y, Putri N, Ramos R, Rasche M, Ryd-Rinder M, De Rose C, Samitova E, Jovanović T, Say D, Scott J, Shachar-Lavie I, Shafran R, Shmueli E, Snipaitiene A, Stephenson T, Ténai N, Tosif S, Turkalj M, Valentini P, Vasconcelos L, Villard L, Vilser D, Hashimoto S, Terheggen-Lagro S. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward. Pediatric Research 2024, 96: 319-324. PMID: 38287106, DOI: 10.1038/s41390-023-03015-0.Peer-Reviewed Original ResearchCare programPost-COVID conditionsPhysical therapyPsychological supportIn-person visitsDiagnostic testsCare pathwaysLack of standardized careFramework of prioritiesGuideline developmentStandard careIn-personMultidisciplinary teamIdentified prioritiesDaily lifeCareResearch cohortManagement of childrenAggregate dataClinically treated childrenLong-term COVID-19 sequelaePatient characteristicsConcentration difficultiesReal-life managementSpecific diagnostic tests
2023
Evaluation and management of hypotensive patients in the emergency department.
Srica N, Strunk C. Evaluation and management of hypotensive patients in the emergency department. Emergency Medicine Practice 2023, 25: 1-28. PMID: 37976547.Peer-Reviewed Original ResearchConceptsDisease courseSignificant underlying pathologyPatient's disease courseTreatment of hypotensionPhysical examination findingsHypotensive patientsOrgan injuryExamination findingsEmergency departmentUnderlying pathologyBedside evaluationSerial reassessmentPatient's conditionHypotensionDiagnostic testsRapid initiationPatientsEtiologyTreatmentInjuryPathologyEvaluationIRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma
Wong J, Roy S, McNiff J, Xu M. IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma. The American Journal Of Surgical Pathology 2023, 47: 1425-1431. PMID: 37767989, DOI: 10.1097/pas.0000000000002133.Peer-Reviewed Original ResearchConceptsSubcutaneous panniculitis-like T-cell lymphomaLupus erythematosus panniculitisPanniculitis-like T-cell lymphomaCase of SPTCLT-cell lymphomaPlasmacytoid dendritic cell differentiationPlasmacytoid dendritic cellsExpression of IRF8Dendritic cell differentiationCharacteristic curve analysisImportant clinical implicationsRegulatory factor 8Dendritic cellsCutaneous biopsyLymphoid aggregatesDiagnostic challengeImmunohistochemical panelImmunohistochemical expressionCD123CD20Distinct patientsClinical implicationsSubcutaneous fatDiagnostic testsPositive markersLymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original ResearchThe potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity
Laxton C, Peno C, Hahn A, Allicock O, Perniciaro S, Wyllie A. The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity. The Lancet Microbe 2023, 4: e837-e850. PMID: 37516121, DOI: 10.1016/s2666-5247(23)00135-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSARS-CoV-2Respiratory pathogensPotential of salivaUsefulness of salivaUse of salivaRespiratory specimenRespiratory secretionsDisease burdenImmunological componentsImmunity surveillanceClinical utilityHost immunityClinical useDiagnostic testsNon-invasive natureSalivaCOVID-19 pandemicSample typesMethodological factorsPathogensImmunitySecretionExploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study
Velosa J, Gómez J, Zúñiga C, Díaz G, Ferro B, Davis J, Grau L. Exploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study. Frontiers In Public Health 2023, 11: 1204862. PMID: 37564424, PMCID: PMC10411903, DOI: 10.3389/fpubh.2023.1204862.Peer-Reviewed Original ResearchConceptsTB contact investigationContact investigationPublic health staffHealth workersHousehold contactsTB knowledgeTB casesTest uptakeHealth staffHousehold visitsHealth OrganizationTuberculosis case findingNational public health authoritiesPublic health authoritiesWorld Health OrganizationPublic health organizationsMiddle-income countriesTB controlCase findingThematic analysisHealth authoritiesDiagnostic testsInductive thematic analysisSemi-structured interviewsMain barriersThe Value-of-Information and Value-of-Implementation from Clinical Trials of Diagnostic Tests for HIV-Associated Tuberculosis: A Modeling Analysis
Pei P, Fitzmaurice K, Le M, Panella C, Jones M, Pandya A, Horsburgh C, Freedberg K, Weinstein M, Paltiel A, Reddy K. The Value-of-Information and Value-of-Implementation from Clinical Trials of Diagnostic Tests for HIV-Associated Tuberculosis: A Modeling Analysis. MDM Policy & Practice 2023, 8: 23814683231198873. PMID: 37743931, PMCID: PMC10517616, DOI: 10.1177/23814683231198873.Peer-Reviewed Original ResearchIncremental net monetary benefitOptimal decisionsOptimal strategyNet monetary benefitDecision makers' willingnessHealth economic standpointSputum XpertClinical trialsEconomic outcomesHigh VOTMonetary benefitsNew clinical trial evidenceDiagnostic testsHIV-Associated TuberculosisEconomic standpointClinical trial evidenceVOI analysisPublic health decision makingValue of trialsDownstream health outcomesSouth AfricaEvaluation of trialsHealth decision makingWillingnessDecisionsAn international research agenda for clozapine-resistant schizophrenia
Luykx J, Gonzalez-Diaz J, Guu T, van der Horst M, van Dellen E, Boks M, Guloksuz S, DeLisi L, Sommer I, Cummins R, Shiers D, Lee J, Every-Palmer S, Mhalla A, Chadly Z, Chan S, Cotes R, Takahashi S, Benros M, Wagner E, Correll C, Hasan A, Siskind D, Endres D, MacCabe J, Tiihonen J. An international research agenda for clozapine-resistant schizophrenia. The Lancet Psychiatry 2023, 10: 644-652. PMID: 37329895, DOI: 10.1016/s2215-0366(23)00109-8.Peer-Reviewed Original ResearchConceptsClozapine-resistant schizophreniaQuality of lifeTreatment optionsTreatment-resistant symptomsThird of patientsNew treatment optionsHealth care providersMiddle-income countriesFunctional outcomeInterventional studyUnmet needEpidemiological researchTranslational approachDiagnostic testsPatientsSchizophreniaHealth policyEarly detectionOptionsSymptomsDiagnosisTrials“I’m looking through you”: What consumers and manufacturers need to know about non-invasive diagnostic tests for endometriosis
Vigano’ P, Vercellini P, Somigliana E, Chapron C, Petraglia F, Griffith L, Mueller M, Martin D, Nap A, Romano A, Reis F, Carmona F, Burns K, Taylor H, Santulli P, Canis M, Koninckx P, Guo S. “I’m looking through you”: What consumers and manufacturers need to know about non-invasive diagnostic tests for endometriosis. Journal Of Endometriosis And Uterine Disorders 2023, 2: 100031. DOI: 10.1016/j.jeud.2023.100031.Peer-Reviewed Original ResearchNon-invasive diagnostic testsDiagnostic tests
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