2025
Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis
Narimani-Javid R, Moradi M, Mahalleh M, Najafi-Vosough R, Arzhangzadeh A, Khalique O, Mojibian H, Kuno T, Mohsen A, Alam M, Shafiei S, Khansari N, Shaghaghi Z, Nozhat S, Hosseini K, Hosseini S. Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Computed Tomography 2025 PMID: 39988511, DOI: 10.1016/j.jcct.2025.02.004.Peer-Reviewed Original ResearchArea under the curveDiagnostic odds ratioDiagnostic performanceComputed tomography-derived fractional flow reserveDiagnostic performance of FFRCTHemodynamically significant coronary artery stenosisSignificant coronary artery stenosisMeta-analysisPer-patient levelReceiver operating characteristic curveCoronary artery diseaseCoronary artery stenosisPer-vessel levelFractional flow reserveNoninvasive diagnostic techniquesMachine learningInvasive FFRPooled specificityArtery diseaseArtery stenosisFlow reserveOdds ratioCochrane LibraryFFRCTPatientsArtificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.
Miller R, Kavanagh P, Lemley M, Liang J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Hayes S, Friedman J, Berman D, Dey D, Slomka P. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2025, jnumed.124.268079. PMID: 39978815, DOI: 10.2967/jnumed.124.268079.Peer-Reviewed Original ResearchObstructive coronary artery diseaseCoronary artery diseaseArea under the receiver operating characteristic curveMyocardial perfusion imagingPerfusion scoreDetection of obstructive coronary artery diseaseDiagnostic accuracy of myocardial perfusion imagingPerfusion imagingAccuracy of myocardial perfusion imagingInvasive coronary angiographyCohort of patientsHighest area under the receiver operating characteristic curveLeft main coronary arteryReceiver operating characteristic curveStress TPDDeep learningObstructive CADMedian ageCoronary angiographyArtificial intelligenceDiagnostic performanceDiagnostic accuracyArtery diseaseAI predictionsCoronary arteryThe Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis.
McCarty T, Shah R, Allencherril R, Moon N, Njei B. The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis. Journal Of Clinical Gastroenterology 2025 PMID: 39998988, DOI: 10.1097/mcg.0000000000002148.Peer-Reviewed Original ResearchConvolutional neural networkMalignant biliary stricturesAI-based systemsArtificial intelligence (AI)-based algorithmImage processing speedEndoscopic retrograde cholangiopancreatographyBiliary stricturesComputer visionPooled sensitivityNeural networkMachine learningDiagnostic performanceMeta-analysisIntelligent combinationIndeterminate biliary stricturesDiagnostic odds ratioImprove diagnostic yieldReceiver operating characteristic curveSystematic reviewOperating characteristics curveProcessing speedDiagnostic yieldRetrograde cholangiopancreatographyDiagnostic accuracyWorking group methodologyIs it solid enough? Diagnostic performance of solid-state detector technology without attenuation CT against invasive angiography
Feher A, Al-Mallah M. Is it solid enough? Diagnostic performance of solid-state detector technology without attenuation CT against invasive angiography. Journal Of Nuclear Cardiology 2025, 45: 102163. PMID: 39922531, DOI: 10.1016/j.nuclcard.2025.102163.Peer-Reviewed Original ResearchSolid-state detector technologyDetector technologyAttenuation CTInvasive angiographyDiagnostic performance
2024
Diagnostic performance of neural network algorithms in skull fracture detection on CT scans: a systematic review and meta-analysis
Sharifi G, Hajibeygi R, Zamani S, Easa A, Bahrami A, Eshraghi R, Moafi M, Ebrahimi M, Fathi M, Mirjafari A, Chan J, Dixe de Oliveira Santo I, Anar M, Rezaei O, Tu L. Diagnostic performance of neural network algorithms in skull fracture detection on CT scans: a systematic review and meta-analysis. Emergency Radiology 2024, 32: 97-111. PMID: 39680295, DOI: 10.1007/s10140-024-02300-7.Peer-Reviewed Original ResearchConceptsConvolutional neural networkArea under the receiver operating characteristic curveConvolutional neural network modelCT scanSkull fractureComputed tomographyDeep learningProspective clinical trialMeta-analysisReceiver operating characteristic curvePublication biasSkull fracture detectionSystematic reviewNeural network algorithmDetecting skull fracturesImprove diagnosis accuracyDiagnostic hurdlesShortage of radiologistsAutomated diagnostic toolTransfer learningDiagnostic performanceDiagnostic accuracyClinical trialsModel architectureNeural networkDiagnostic Performance of AAP-Recommended Inflammatory Markers in Febrile Infants Aged 60 Days or Younger.
Yankova L, McDaniel C, Kerns E, Shine A, Ruiz B, Caruso H, Aronson P. Diagnostic Performance of AAP-Recommended Inflammatory Markers in Febrile Infants Aged 60 Days or Younger. Pediatrics 2024, 155 PMID: 39636262, DOI: 10.1542/peds.2024-068856.Peer-Reviewed Original ResearchIncorporation of the central vein sign into the McDonald criteria
Amin M, Nakamura K, Daboul L, O'Donnell C, Cao Q, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prčkovska V, Raza P, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Incorporation of the central vein sign into the McDonald criteria. Multiple Sclerosis And Related Disorders 2024, 93: 106182. PMID: 39622133, PMCID: PMC11779579, DOI: 10.1016/j.msard.2024.106182.Peer-Reviewed Original ResearchCentral vein signDIS criteriaDiagnostic performanceMultiple sclerosisDeep white matter lesionsDiagnosis of multiple sclerosisMulti-center studyInternational multi-center studyWhite matter lesionsNorth American ImagingMcDonald CriteriaProspective studyDiagnostic accuracyMRI disseminationDemyelinating diseaseBackground DiagnosisMS diagnosisDiagnostic biomarkersCompare sensitivityLesionsBrain locationsMethods DataBrain imagingBrainSignsDiagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
Toljan K, Daboul L, Raza P, Martin M, Cao Q, O’Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Multiple Sclerosis Journal 2024, 30: 1268-1277. PMID: 39234802, PMCID: PMC11421977, DOI: 10.1177/13524585241271988.Peer-Reviewed Original ResearchConceptsCentral vein signPositive predictive valueOligoclonal bandsDiagnostic performanceMS diagnosisCerebrospinal fluidMultiple sclerosisPredictive valueNegative predictive valueCerebrospinal fluid testingRadiological suspicionDiagnostic accuracyImaging biomarkersDiagnosisDiagnostic biomarkersMonthsSclerosisBiomarkersPilot studyBaselineSelection 3Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting
Randall P, Mutsvangwa J, Nliwasa M, Wilson L, Makamure B, Makambwa E, Meldau R, Dheda K, Munyati S, Siddiqi O, Corbett E, Esmail A. Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting. Open Forum Infectious Diseases 2024, 11: ofae496. PMID: 39286031, PMCID: PMC11403475, DOI: 10.1093/ofid/ofae496.Peer-Reviewed Original ResearchUnstimulated interferon-gammaTuberculous meningitisPolymerase chain reaction productsCerebrospinal fluidXpert UltraDNA-based assaysInterferon-gammaHuman immunodeficiency virus (HIV)-infectedSuspected TBM patientsRule-in testPositive predictive valueGeneXpert UltraStage 2 evaluationTBM patientsSame-day testingNon-TBMZambian samplesUninfected participantsDiagnostic performanceAfrican samplesImmunodiagnostic assaysXpertMicrobiological resultsAssayBiobank samplesDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVProstate-specific antigen screening for prostate cancer: Diagnostic performance, clinical thresholds, and strategies for refinement
Sundaresan V, Smani S, Rajwa P, Renzulli J, Sprenkle P, Kim I, Leapman M. Prostate-specific antigen screening for prostate cancer: Diagnostic performance, clinical thresholds, and strategies for refinement. Urologic Oncology Seminars And Original Investigations 2024, 43: 41-48. PMID: 39019723, DOI: 10.1016/j.urolonc.2024.06.003.Peer-Reviewed Original ResearchProstate specific antigenProstate cancerPSA-based prostate cancer screeningDiagnostic performanceProstate specific antigen densityProstate specific antigen velocityLow-grade prostate cancerProstate-specific antigen screeningFree prostate specific antigenTreatment of prostate cancerProstate cancer screeningClinical action thresholdsProstate volumeAntigen screeningMalignant cellsSpecific antigenCancer screeningScreening biomarkerProstateClinical roleTest characteristicsCancerClinical applicationClinical thresholdEarly detectionRace- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing
Brown S, Biswas D, Wu J, Ryan M, Bernstein B, Fairhurst N, Kaye G, Baral R, Cannata A, Searle T, Melikian N, Sado D, Lüscher T, Teo J, Dobson R, Bromage D, McDonagh T, Vazir A, Shah A, O’Gallagher K. Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing. JACC Advances 2024, 3: 101064. PMID: 39050815, PMCID: PMC11268103, DOI: 10.1016/j.jacadv.2024.101064.Peer-Reviewed Original ResearchBlack patientsPro-B-type natriuretic peptide levelsN-terminal pro-B-type natriuretic peptide levelsEuropean Society of Cardiology criteriaDiagnosis of HFpEFNatriuretic peptide levelsHeterogeneous clinical syndromeEuropean SocietyCardiology criteriaHFpEF diagnosisClinical presentationFPEF scoreAsian patientsPatient demographicsEthnicity-related differencesMetabolic comorbiditiesAtrial fibrillationHeart failureHFpEFDiagnostic performancePeptide levelsWhite patientsClinical syndromePatientsQuantify health inequalitiesDiagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity
Tas E, Sundararajan D, Lo J, Morelli N, Garcia-Reyes Y, Ware M, Rahat H, Ou X, Na X, Sundaram S, Severn C, Pyle L, Børsheim E, Vajravelu M, Muzumdar R, Dranoff J, Cree M. Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity. Journal Of The Endocrine Society 2024, 8: bvae110. PMID: 38895640, PMCID: PMC11185182, DOI: 10.1210/jendso/bvae110.Peer-Reviewed Original ResearchMRI fat fractionMagnetic resonance imagingPolycystic ovary syndromeVibration-controlled transient elastographyTransient elastographyDiagnostic accuracyDiagnostic accuracy of transient elastographyAccuracy of transient elastographyReceiver-operating characteristic curveFat fractionHepatosteatosis groupSignificant obesityDiagnostic performanceClinical trialsYouden indexLiver diseaseChildhood obesityHigh riskSteatotic liver diseaseLiver fatObesityResonance imagingCharacteristic curveHepatosteatosisDiagnostic methodsAutomated HEART score determination via ChatGPT: Honing a framework for iterative prompt development
Safranek C, Huang T, Wright D, Wright C, Socrates V, Sangal R, Iscoe M, Chartash D, Taylor R. Automated HEART score determination via ChatGPT: Honing a framework for iterative prompt development. Journal Of The American College Of Emergency Physicians Open 2024, 5: e13133. PMID: 38481520, PMCID: PMC10936537, DOI: 10.1002/emp2.13133.Peer-Reviewed Original ResearchPrompt designsChest pain evaluationRule-based logicScore determinationLanguage modelPrivacy safeguardsPrompt improvementExtract insightsPain evaluationClinical notesRate of responseDiagnostic performancePhysician assessmentPrompt testingDetermination of heartChatGPTDesign frameworkNote analysisHeartSubscoresSimulated patientsClinical spaceImpact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Castillo M, Liang J, Miller R, Dey D, Berman D, Slomka P, Einstein A. Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography. European Heart Journal - Cardiovascular Imaging 2024, 25: 996-1006. PMID: 38445511, DOI: 10.1093/ehjci/jeae055.Peer-Reviewed Original ResearchSPECT myocardial perfusion imagingMyocardial perfusion imagingCoronary artery diseaseCardiac sizeDetect obstructive coronary artery diseasePerfusion imagingObstructive coronary artery diseaseDetection of coronary artery diseaseNegative predictive valueLeft ventricular volumeSolid-state scannersSmall cardiac sizeCoronary angiographyMale patientsYounger patientsElderly patientsMale sexDiagnostic performanceVentricular volumeArtery diseaseVisual assessmentPatientsPredictive valueElderly ageSPECTThe diagnostic value of the central vein sign in radiologically isolated syndrome
Landes‐Chateau C, Levraut M, Okuda D, Themelin A, Cohen M, Kantarci O, Siva A, Pelletier D, Mondot L, Lebrun‐Frenay C, Lebrun‐Frenay C, Kantarci O, Siva A, Pelletier D, Azevedo C, Makhani N, Okuda D. The diagnostic value of the central vein sign in radiologically isolated syndrome. Annals Of Clinical And Translational Neurology 2024, 11: 662-672. PMID: 38186317, PMCID: PMC10963291, DOI: 10.1002/acn3.51986.Peer-Reviewed Original ResearchConceptsRadiologically isolated syndromeCentral vein signCVS+ lesionsNon-MSMultiple sclerosisControl group of sex-RIS diagnosisAge-matched subjectsDetectable preclinical phaseProportion of lesionsWhite matter lesionsGroup of sex-Effective imaging biomarkerMagnetic resonance imagingDiagnostic performanceDiagnostic accuracyDiagnostic valueLesion criteriaImaging biomarkersLesionsResonance imagingLesion-specificAbsolute numberControl groupROC comparisons
2023
Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis
Kanaparthy N, Loza A, Hauser R. Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis. PLOS ONE 2023, 18: e0296180. PMID: 38127992, PMCID: PMC10734915, DOI: 10.1371/journal.pone.0296180.Peer-Reviewed Original ResearchA multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis
Daboul L, O’Donnell C, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prchkovska V, Raza P, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis. Multiple Sclerosis Journal 2023, 30: 25-34. PMID: 38088067, PMCID: PMC11037932, DOI: 10.1177/13524585231214360.Peer-Reviewed Original ResearchConceptsCentral vein signMultiple sclerosisPositive lesionsInter-rater agreementDiagnosis of MSMagnetic resonance imaging (MRI) biomarkersDiagnostic performancePossible multiple sclerosisInter-rater reliability assessmentGood diagnostic performanceMcDonald criteriaMulticenter studyVein assessmentMean ageVein signImaging biomarkersLesionsMRI sequencesCharacteristic curveSclerosisPatientsDiagnosisAssessmentParticipantsOptimal methodJS09.5.A18F-FLUCICLOVINE PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY: IMAGE INTERPRETATION CRITERIA RESULTS FROM PURSUE, A PROSPECTIVE PHASE 2 TRIAL
Kotecha R, Chiang V, Tom M, Nabavizadeh A, Zan E, Peddi S, Sulman E, Siegel B, Huang J, Brem S, Ware M, Kesari S, Parent E, Pope W, Holmes R, Chau A, Teoh E, Chao S, Aboian M. JS09.5.A18F-FLUCICLOVINE PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY: IMAGE INTERPRETATION CRITERIA RESULTS FROM PURSUE, A PROSPECTIVE PHASE 2 TRIAL. Neuro-Oncology 2023, 25: ii12-ii13. PMCID: PMC10489492, DOI: 10.1093/neuonc/noad137.034.Peer-Reviewed Original ResearchRecurrent brain metastasesImage interpretation criteriaBrain metastasesRadiation therapyLesion uptakeDiagnostic performancePredictive valueProspective phase 2 trialSolid tumor brain metastasesTumor brain metastasesPhase 2 trialInterpretation criteriaNegative predictive valueLow background uptakePositive predictive valueExcellent diagnostic performanceBM recurrencePost-MRIPrimary endpointSecondary endpointsRadiation necrosisReference lesionsUnnecessary surgeryHistopathological analysisInitial cohortNEIM-05 PURSUE: RESULTS FROM A PROSPECTIVE, PHASE 2B TRIAL TO DEFINE IMAGE INTERPRETATION CRITERIA FOR18F-FLUCICLOVINE-PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY
Kotecha R, Chiang V, Tom M, Nabavizadeh A, Zan E, Peddi S, Sulman E, Siegel B, Huang J, Brem S, Ware M, Kesari S, Parent E, Pope W, Holmes R, Chau A, Teoh E, Chao S, Aboian M. NEIM-05 PURSUE: RESULTS FROM A PROSPECTIVE, PHASE 2B TRIAL TO DEFINE IMAGE INTERPRETATION CRITERIA FOR18F-FLUCICLOVINE-PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY. Neuro-Oncology Advances 2023, 5: iii15-iii15. PMCID: PMC10402431, DOI: 10.1093/noajnl/vdad070.057.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply